Medicine and Health Sciences Commons^™

Mccallum, Elizabeth Elliott (Cherry), 1890-1985 (Sc 3355), Manuscripts & Folklife Archives

Manuscript Collection Finding Aids

Finding aid and scan (Click on "additional files" below) for Manuscripts Small Collection 3355. Typescripted account of Elizabeth (Cherry) McCallum’s experiences after she entered nursing school in 1913 in Kentucky. She subsequently served as a Red Cross nurse during World War I and as superintendent of nurses at Louisville Children’s Hospital. Includes her note about writing the piece, and her short article about rural life, published in the (Louisville) Courier-Journal.

2018-2019 Acip Immunization Updates: Highlights For Pharmacists, Laressa Bethishou, Luma Munjy, Jeff Goad

Pharmacy Faculty Articles and Research

"Vaccinations have significantly reduced the burden of infectious diseases, preventing almost 6 million deaths worldwide.^1,2 In the United States, vaccines have led to a decrease in incidence of vaccine-preventable illness, mortality, and disease sequelae.³ Despite the proven benefit of vaccines, misinformation and failure to vaccinate has led to outbreaks of vaccine-preventable diseases. As of December 29, 2018, 372 cases of measles (from 17 outbreaks) and 2251 cases of mumps were reported in the United States in 2018.^4,5 These outbreaks support the need for continued education of patients and active immunization by pharmacists."

Functional And Transcriptomic Characterization Of Carboplatin-Resistant A2780 Ovarian Cancer Cell Line, Tamara Viscarra, Kurt Buchegger, Ignacio Jofre, Ismael Riquelme, Louise Zanella, Michel Abanto, Alyssa C. Parker, Stephen R. Piccolo, Juan Carlos Roa, Carmen Ili, Priscilla Brebi

Faculty Publications

Background

Ovarian cancer is a significant cancer-related cause of death in women worldwide. The most used chemotherapeutic regimen is based on carboplatin (CBDCA). However, CBDCA resistance is the main obstacle to a better prognosis. An in vitro drug-resistant cell model would help in the understanding of molecular mechanisms underlying this drug-resistance phenomenon. The aim of this study was to characterize cellular and molecular changes of induced CBDCA-resistant ovarian cancer cell line A2780.

Methods

The cell selection strategy used in this study was a dose-per-pulse method using a concentration of 100 μM for 2 h. Once 20 cycles of exposure to …

Investigating Air Pollution And Equity Impacts Of A Proposed Transportation Improvement Program For Tampa, Talha Kemal Kocak

USF Tampa Graduate Theses and Dissertations

Transportation infrastructure is important for human mobility and population well-being. However, it can also have detrimental impacts on health and equity, including through increased air pollution and its unequal social distribution. There is a need for better understanding of these impacts and for better approaches that improve health and equity outcomes of transportation planning programs. In this study, we are investigating the air pollution and health equity impacts of an ongoing large-scale metropolitan transportation improvement program, Tampa Bay Next (TBNext). Specific objectives are: 1) to characterize and quantify the air pollution levels and population exposures resulting from the roadway expansion …

The Ability Of The U.S. Military’S Wbgt-Based Flag System To Recommend Safe Heat Stress Exposures, David R. Almario

USF Tampa Graduate Theses and Dissertations

The U.S. military currently uses a flag system based on wet-bulb globe temperature (WBGT) and metabolic rate to recommend heat stress exposure limits. This paper addresses the ability of the flag system to recommend safe heat exposures in a non-military population.

Two progressive heat stress studies provided data on 528 observations of safe or unsafe exposures of 4 hours over a range of WBGT conditions and metabolic rates using 29 participants wearing woven cotton clothing. For the two studies, range of WBGT conditions was 25 to 42C, and the range of metabolic rates was 100 to 650 watts. These exposures …

Canadian Children From Food Insecure Households Experience Low Self-Esteem And Self-Efficacy For Healthy Lifestyle Choices, Stephanie L. Godrich, Olivia K. Loewen, Rosanne Blanchet, Noreen Willows, Paul Veugelers

Research outputs 2014 to 2021

The objectives of this cross-sectional study were to: (i) determine whether there are differences in self-esteem and self-efficacy for healthy lifestyle choices between children living in food secure and food insecure households; and (ii) determine whether the association between household food insecurity (HFI), self-esteem and self-efficacy differs by gender. Survey responses of 5281 fifth-grade students (10 and 11 years of age) participating in the Canadian Children's Lifestyle and School Performance Study II were analyzed using logistic and linear regression. HFI status was determined by the six-item short-form Household Food Security Survey Module (HFSSM). Students from food insecure households had significantly …

Speeding Diagnosis And Saving Money Using Point Of Care Ultrasound Rather Than Mri For Work-Related Msk Injuries, Jared A. Jeffries

USF Tampa Graduate Theses and Dissertations

This descriptive retrospective cohort study utilized a large workers comp insurer database. All MRI's performed on peripheral joints during calendar year 2017 that were (a) 2 weeks after the initial clinic visit, or (b) greater than 6 weeks after injury, but (c) not more than 3 months after the date of injury were evaluated in this study. Individual diagnoses rendered on MRI reports for these cases were categorized as to whether ultrasound alone or ultrasound + xray could adequately provide the same diagnoses. Results showed that, ultrasound + xray would be able to provide all of the same diagnoses compared …

Stress Inoculation Training Outcomes Among Veterans With Ptsd And Tbi, Sarah E. Jackson, Matthew Baity, Jeannette Giorgio, Diane Swick

Faculty, Staff and Student Publications

Objective: Stress inoculation training (SIT) is a cognitive-behavioral treatment that has demonstrated potential as a nontrauma based intervention for veterans with posttraumatic stress disorder (PTSD). The purpose of this study was to explore the efficacy of a novel 3-phase group formulation of SIT applied to a naturalistic population of veterans with PTSD and traumatic brain injury (TBI). The goals were to reduce symptoms of PTSD and depression, improve perceived functioning, and increase treatment initiation among veterans who were reticent to initiate established evidence-based and trauma-focused therapies. Method: A program development and evaluation archival analysis of 65 veterans engaged in SIT …

Do Midwifery International Clinical Placements Influence Students' Practice And Employment Decisions?, Sadie Geraghty, Carol Davidson, Annemarie Deleo, Dianne Bloxsome

Research outputs 2014 to 2021

AIM: The aim of this study was to investigate whether an International two-week clinical maternity placement enhances, and is beneficial, to midwifery students' future practice and employment decisions during the final year of an undergraduate degree.

BACKGROUND: International placements are common in undergraduate pre-registration nursing midwifery university curricula, with the emphasis on preparing students to work with diverse women in multicultural environments whilst incorporating cultural competence. However, little is known as to whether an International placement influences future graduate's work place choice.

METHODS: Using a qualitative approach, focus groups were undertaken with 16 final year midwifery students from a University …

2019 Prep Symposium Agenda, School Of Medicine

Postbaccalaureate Research Education Program in Biomedical Sciences (PREP)

No abstract provided.

Factors Associated With Condom Use With Non-Commercial Partners Among Sexually-Active Transgender Women In Cambodia: Findings From A National Survey Using Respondent-Driven Sampling., Siyan Yi, Amelia Plant, Sovannary Tuot, Phalkun Mun, Srean Chhim, Navy Chann, Pheak Chhoun, Carinne M. Brody

BACKGROUND: Globally, the prevalence of HIV among transgender women is much higher than that of the general adult population. This can be explained by the persistently low rate of consistent condom use among this population. This study was therefore conducted to explore factors associated with consistent condom use among sexually-active transgender women in Cambodia, specifically with their non-commercial partners.

METHODS: Data used for this study were collected as part of the National Integrated Biological and Behavioral Survey 2016. Participants were recruited from the capital city of Phnom Penh and 12 other provinces with high burden of HIV using the Respondent-Driven …

Exploring And Understanding Factors That Affect The Adoption Of Personal Health Records Among Healthcare Providers, Lujain Samarkandi

Seton Hall University Dissertations and Theses (ETDs)

Statement of the problem: Lately, there has been increasing recognition of the importance of PHRs in achieving healthcare transformation in the U.S. Regardless significant consumer interest and expected benefits, generally the adoption of PHRs remains relatively low. For the continuing development of patient PHRs, exploring factors that affect the behavior intentions of healthcare providers to adopt PHRs is significant. The Purpose of this study was to create a valid tool entitled “Personal Health Record Assessment Survey” (PHRAS) then implement this tool in the population to understand the predictive relationship, if any, that may exist between perceptions of knowledge, attitudes, subjective …

The Atpase Mechanism Of Uvra2 Reveals The Distinct Roles Of Proximal And Distal Atpase Sites In Nucleotide Excision Repair, Brandon C. Case, Silas Hartley, Memie Osuga, David Jeruzalmi, Manju M. Hingorani

Publications and Research

The UvrA2 dimer finds lesions in DNA and initiates nucleotide excision repair. Each UvrA monomer contains two essential ATPase sites: proximal (P) and distal (D). The manner whereby their activities enable UvrA2 damage sensing and response remains to be clarified. We report three key findings from the first pre-steady state kinetic analysis of each site. Absent DNA, a P2ATP-D2ADP species accumulates when the low-affinity proximal sites bind ATP and enable rapid ATP hydrolysis and phosphate release by the highaffinity distal sites, and ADP release limits catalytic turnover. Native DNA stimulates ATP hydrolysis by all four sites, causing UvrA2 to transition …

Buparlisib In Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase Ii Trial., Patrick Y Wen, Mehdi Touat, Brian M Alexander, Ingo K Mellinghoff, Shakti Ramkissoon, Christine S Mccluskey, Kristine Pelton, Sam Haidar, Sankha S Basu, Sarah C Gaffey, Loreal E Brown, Juan Emmanuel Martinez-Ledesma, Shaofang Wu, Jungwoo Kim, Wei Wei, Mi-Ae Park, Jason T Huse, John G Kuhn, Mikael L Rinne, Howard Colman, Nathalie Y R Agar, Antonio M Omuro, Lisa M Deangelis, Mark R Gilbert, John F De Groot, Timothy F Cloughesy, Andrew S Chi, Thomas M Roberts, Jean J Zhao, Eudocia Q Lee, Lakshmi Nayak, James R Heath, Laura L Horky, Tracy T Batchelor, Rameen Beroukhim, Susan M Chang, Azra H Ligon, Ian F Dunn, Dimpy Koul, Geoffrey S Young, Michael D Prados, David A Reardon, W K Alfred Yung, Keith L Ligon

Articles, Abstracts, and Reports

PURPOSE: Phosphatidylinositol 3-kinase (PI3K) signaling is highly active in glioblastomas. We assessed pharmacokinetics, pharmacodynamics, and efficacy of the pan-PI3K inhibitor buparlisib in patients with recurrent glioblastoma with PI3K pathway activation.

METHODS: This study was a multicenter, open-label, multi-arm, phase II trial in patients with PI3K pathway-activated glioblastoma at first or second recurrence. In cohort 1, patients scheduled for re-operation after progression received buparlisib for 7 to 13 days before surgery to evaluate brain penetration and modulation of the PI3K pathway in resected tumor tissue. In cohort 2, patients not eligible for re-operation received buparlisib until progression or unacceptable toxicity. Once …

Dual Complementary Liposomes Inhibit Triple-Negative Breast Tumor Progression And Metastasis, Peng Guo, Jiang Yang, Daxing Liu, Lan Huang, Gillian Fell, Jin Huang, Marsha A. Moses, Debra T. Auguste

Publications and Research

Distinguishing malignant cells from non-neoplastic ones is a major challenge in triple-negative breast cancer (TNBC) treatment. Here, we developed a complementary targeting strategy that uses precisely matched, multivalent ligand-receptor interactions to recognize and target TNBC tumors at the primary site and metastatic lesions. We screened a panel of cancer cell surface markers and identified intercellular adhesion molecule–1 (ICAM1) and epithelial growth factor receptor (EGFR) as optimal candidates for TNBC complementary targeting. We engineered a dual complementary liposome (DCL) that precisely complements the molecular ratio and organization of ICAM1 and EGFR specific to TNBC cell surfaces. Our in vitro mechanistic studies …

Threats To Adhesive/Dentin Interfacial Integrity And Next Generation Bio-Enabled Multifunctional Adhesives, Paulette Spencer, Qiang Ye, Linyong Song, Ranganathan Parthasarathy, Kyle Boone, Anil Misra, Candan Tamerler

Civil and Architectural Engineering Faculty Research

Nearly 100 million of the 170 million composite and amalgam restorations placed annually in the United States are replacements for failed restorations. The primary reason both composite and amalgam restorations fail is recurrent decay, for which composite restorations experience a 2.0–3.5-fold increase compared to amalgam. Recurrent decay is a pernicious problem—the standard treatment is replacement of defective composites with larger restorations that will also fail, initiating a cycle of ever-larger restorations that can lead to root canals, and eventually, to tooth loss. Unlike amalgam, composite lacks the inherent capability to seal discrepancies at the restorative material/tooth interface. The low-viscosity adhesive …

Global Variation Of Nutritional Status In Children Undergoing Chronic Peritoneal Dialysis: A Longitudinal Study Of The International Pediatric Peritoneal Dialysis Network., Franz Schaefer, Laura Benner, Dagmara Borzych-Dużałka, Joshua Zaritsky, Hong Xu, Lesley Rees, Zenaida L Antonio, Erkin Serdaroglu, Nakysa Hooman, Hiren Patel, Lale Sever, Karel Vondrak, Joseph Flynn, Anabella Rébori, William Wong, Tuula Hölttä, Zeynep Yuruk Yildirim, Bruno Ranchin, Ryszard Grenda, Sara Testa, Dorota Drożdz, Attila J. Szabo, Loai Eid, Biswanath Basu, Renata Vitkevic, Cynthia Wong, Stephen J. Pottoore, Dominik Müller, Ruhan Dusunsel, Claudia Gonzalez Celedon, Marc Fila, Lisa Sartz, Anja Sander, Bradley A. Warady, International Pediatric Peritoneal Dialysis Network (Ippn) Registry

Manuscripts, Articles, Book Chapters and Other Papers

While children approaching end-stage kidney disease (ESKD) are considered at risk of uremic anorexia and underweight they are also exposed to the global obesity epidemic. We sought to investigate the variation of nutritional status in children undergoing chronic peritoneal dialysis (CPD) around the globe. The distribution and course of body mass index (BMI) standard deviation score over time was examined prospectively in 1001 children and adolescents from 35 countries starting CPD who were followed in the International Pediatric PD Network (IPPN) Registry. The overall prevalence of underweight, and overweight/obesity at start of CPD was 8.9% and 19.7%, respectively. Underweight was …

Staying Upright By Shutting Down? Evidence For Global Suppression Of The Motor System When Recovering Balance, Caleigh Goode, David M. Cole, David A.E. Bolton

Kinesiology and Health Science Faculty Publications

Background

When automatic, yet unwanted action is quickly inhibited, short-lived suppression throughout the motor system ensues. This effect is referred to as global suppression. Although response inhibition is essential for behavioral flexibility, widespread motor suppression may delay action reprogramming. In reactive balance control, even fleeting suppression of the motor system could interfere with our ability to adapt compensatory reactions quickly enough to avoid a fall.

Research Question

Is muscle activity in the hand suppressed when a prepotent compensatory step becomes suddenly blocked in a balance recovery task?

Methods

Nineteen young adults were tested using a lean and release apparatus. …

Coming Together To Define Membrane Contact Sites., Luca Scorrano, Maria Antonietta De Matteis, Scott Emr, Francesca Giordano, György Hajnóczky, Benoît Kornmann, Laura L. Lackner, Tim P. Levine, Luca Pellegrini, Karin Reinisch, Rosario Rizzuto, Thomas Simmen, Harald Stenmark, Christian Ungermann, Maya Schuldiner

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Close proximities between organelles have been described for decades. However, only recently a specific field dealing with organelle communication at membrane contact sites has gained wide acceptance, attracting scientists from multiple areas of cell biology. The diversity of approaches warrants a unified vocabulary for the field. Such definitions would facilitate laying the foundations of this field, streamlining communication and resolving semantic controversies. This opinion, written by a panel of experts in the field, aims to provide this burgeoning area with guidelines for the experimental definition and analysis of contact sites. It also includes suggestions on how to operationally and tractably …

Health & Kinesiology News, Georgia Southern University

Health Sciences & Kinesiology: News & Publications (2015-2023)

• Sport Management Students Compete in Case Study Competition

Differential Methylation In Apoe (Chr19; Exon Four; From 44,909,188 To 44,909,373/Hg38) And Increased Apolipoprotein E Plasma Levels In Subjects With Mild Cognitive Impairment, Oscar Mancera-Páez, Kelly Estrada-Orozco, María Fernanda Mahecha, Francy Cruz, Kely Bonilla-Vargas, Nicolás Sandoval, Esneyder Guerrero, David Salcedo-Tacuma, Jesus Melgarejo, Edwin Vega

School of Medicine Publications

Background: Biomarkers are essential for identification of individuals at high risk of mild cognitive impairment (MCI) for potential prevention of dementia. We investigated DNA methylation in the APOE gene and apolipoprotein E (ApoE) plasma levels as MCI biomarkers in Colombian subjects with MCI and controls. Methods: In total, 100 participants were included (71% women; average age, 70 years; range, 43–91 years). MCI was diagnosed by neuropsychological testing, medical and social history, activities of daily living, cognitive symptoms and neuroimaging. Using multivariate logistic regression models adjusted by age and gender, we examined the risk association of MCI with plasma ApoE and …

The Relationship Of Age, Ethnicity, Parity, And Awareness Of The Midwife’S Role In Selection Of Pregnancy Care Provider In Childbearing Age Women, Marquida Morgan

Grace Peterson Nursing Research Colloquium

Abstract

Background: Birthing centers inside hospitals may offer women the choice of a pregnancy care provider. Mothers can choose either a physician or a midwife. The rise of birthing centers is parallel to the rise in the demand for midwives. It is essential for the continuous growth of midwives to examine the maternal selection process of pregnancy care providers.

Objectives: The object of the descriptive survey study was examining age, ethnicity, parity, and the awareness of the midwife’s role influence on a woman’s selection of pregnancy care provider. This information would provide midwives with a framework to understand the …

Great Save! Old Chapel Pews Find New Homes, Children's Mercy Hospital

Our Story Continues

Discusses the preservation of historical artifacts from Children's Mercy Hospital in Kansas City, specifically the restoration of three chapel pews circa 1917 that have new homes in the hospital's marketing and fund-raising departments, and in the new Children's Research Institute building.

2019 March 19 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Genomic And Molecular Characterization Of Preterm Birth., Theo A Knijnenburg, Joseph G Vockley, Nyasha Chambwe, David L Gibbs, Crystal Humphries, Kathi C Huddleston, Elisabeth Klein, Prachi Kothiyal, Ryan Tasseff, Varsha Dhankani, Dale L Bodian, Wendy S W Wong, Gustavo Glusman, Denise E Mauldin, Michael Miller, Joseph Slagel, Summer Elasady, Jared C Roach, Roger Kramer, Kalle Leinonen, Jasper Linthorst, Rajiv Baveja, Robin Baker, Benjamin D Solomon, Greg Eley, Ramaswamy K Iyer, George L Maxwell, Brady Bernard, Ilya Shmulevich, Leroy Hood, John E Niederhuber

Articles, Abstracts, and Reports

Preterm birth (PTB) complications are the leading cause of long-term morbidity and mortality in children. By using whole blood samples, we integrated whole-genome sequencing (WGS), RNA sequencing (RNA-seq), and DNA methylation data for 270 PTB and 521 control families. We analyzed this combined dataset to identify genomic variants associated with PTB and secondary analyses to identify variants associated with very early PTB (VEPTB) as well as other subcategories of disease that may contribute to PTB. We identified differentially expressed genes (DEGs) and methylated genomic loci and performed expression and methylation quantitative trait loci analyses to link genomic variants to these …

Human Trafficking Identification Among Nurse Practitioner Students During Objective Structured Clinical Examinations, Zoe Onyun

Dissertations

Problem: Human trafficking (HT) is a significant worldwide and domestic issue affecting all ages, races, and genders resulting in over 40 million victims globally. Nurse practitioners (NP) often unknowingly come into contact with victims of HT, however, few NP’s have had formal education on the topic and may fail to recognize signs and risk factors. The purpose of this study was to initiate HT training for NP students.

Methods: A quality improvement (QI) initiative for a university college of nursing (CON) utilizing a prospective, observational, descriptive, cohort design. A plan-do-study-act (PDSA) methodology was implemented. A written case study given …

Rethinking Health Services Measurement For Indigenous Populations, Angela Mashford-Pringle, Ian Ring, Fadwa Al-Yaman, John Waldon, Michelle Chino

School of Public Health Faculty Research

Indigenous people around the world experience shorter life expectancy, poorer health outcomes, and on average have less social capital, than non-Indigenous people in their respective countries. While national goals are to lower mortality and morbidity rates of Indigenous people, much evidence exists that indicates there is almost no Indigenous involvement in data collection, policy development, program implementation and development and measurement of services. A more holistic and culturally relevant framework is presented to improve services and outcomes for Indigenous populations.

Alterations In Phosphorylation Of Hepatocyte Ribosomal Protein S6 Control Plasmodium Liver Stage Infection., Elizabeth K K Glennon, Laura S Austin, Nadia Arang, Heather S Kain, Fred D Mast, Kamalakannan Vijayan, John D Aitchison, Stefan H I Kappe, Alexis Kaushansky

Articles, Abstracts, and Reports

Plasmodium parasites are highly selective when infecting hepatocytes and induce many changes within the host cell upon infection. While several host cell factors have been identified that are important for liver infection, our understanding of what facilitates the maintenance of infection remains incomplete. Here, we describe a role for phosphorylated ribosomal protein S6 (Ser235/236) (p-RPS6) in Plasmodium yoelii-infected hepatocytes. Blocking RPS6 phosphorylation prior to infection decreases the number of liver stage parasites within 24 h. Infected hepatocytes exhibit elevated levels of p-RPS6 while simultaneously abrogating the induction of phosphorylation of RPS6 in response to insulin stimulation. This is in contrast …

Mental Health Services For Youth In The Eastern Mediterranean Region: Challenges And Opportunities (Editorial), Atif Rahman, Hesham M. Hamoda, Afarin Rahimi-Movaghar, Murad M. Khan Dr., Khalid Saeed

Department of Psychiatry

The Global Burden of Disease study shows that the burden from mental and substance use disorders, measured in Disability Adjusted Life Years (DALYs), has steadily risen in the Eastern Mediterranean Region (EMR) over the last three decades and is higher than the global average for almost all EMR countries). Even more alarming is the finding that depression, self-harm, anxiety and conduct disorders constitute four of the top 10 causes of DALYs among girls and boys aged 15-19 years and suicide is a leading cause of adolescent mortality.

Alterations In Phosphorylation Of Hepatocyte Ribosomal Protein S6 Control Plasmodium Liver Stage Infection., Elizabeth K K Glennon, Laura S Austin, Nadia Arang, Heather S Kain, Fred D Mast, Kamalakannan Vijayan, John D Aitchison, Stefan H I Kappe, Alexis Kaushansky

Articles, Abstracts, and Reports

Plasmodium parasites are highly selective when infecting hepatocytes and induce many changes within the host cell upon infection. While several host cell factors have been identified that are important for liver infection, our understanding of what facilitates the maintenance of infection remains incomplete. Here, we describe a role for phosphorylated ribosomal protein S6 (Ser235/236) (p-RPS6) in Plasmodium yoelii-infected hepatocytes. Blocking RPS6 phosphorylation prior to infection decreases the number of liver stage parasites within 24 h. Infected hepatocytes exhibit elevated levels of p-RPS6 while simultaneously abrogating the induction of phosphorylation of RPS6 in response to insulin stimulation. This is in contrast …