Medicine and Health Sciences Commons^™

Technology And The Management Of Diabetes In Older Adults - Cost Effectiveness, Shannon Pitt

Nursing Capstones

No abstract provided.

Hypothyroidism And Hypertension; Links To Consider When Providing Patient Care, Becca Trebil

Nursing Capstones

No abstract provided.

Medical Laboratory Professionals Week

Andrews Agenda: Campus News

No abstract provided.

Long-Term Use Of Metformin And Vitamin B12 Deficiency, Josalyn Joy Grueneich

Nursing Capstones

No abstract provided.

Status Of Teaching Certificate Programs Offered By Us Colleges And Schools Of Pharmacy, Mohammed Islam, Rose Bagheri, Lydia Lung, Sung Y. Park, Rahmat Talukder

Pharmacy Faculty Publications and Presentations

Purpose: Teaching certificate programs have been developed by US colleges and schools of pharmacy to provide organized instruction for pharmacy residents seeking competence in classroom teaching or clinical precepting. The objective of this study is to appraise current status of teaching certificate programs offered by US colleges and schools of pharmacy. Method: A survey instrument was developed and sent to pharmacy practice department chairs/vice chairs at 132 US colleges/schools of Pharmacy. In addition, data collection was conducted by visiting websites of 132 colleges and schools of pharmacy. Descriptive statistics and content analysis methods were used for data analysis. Results: Out …

My Husband Will Love Me More If I Give Birth To More Children: Rural Women’S Perceptions And Beliefs On Family Planning Services Utilization In A Low Resource Setting, Agnes Msoka, Eunice Pallangyo, Sharon Brownie, Eleanor Holroyd

School of Nursing & Midwifery, East Africa

Introduction: Responsibility for family planning in low resource settings is almost solely delegated to women, with very low male involvement. This study investigated rural Tanzanian women’s perceptions and cultural beliefs of the barriers to family planning services utilization.

Methods: This study used a qualitative descriptive approach drawing on four group discussions with 20 purposively selected married women with two or more children. The study followed COREQ guidelines for reporting qualitative studies. Data were collected from participants at four health facilities in Bagamoyo and Kisarawe districts in Pwani, Tanzania.

Results: Participants’ occupations included housewives, small-scale farmers, and entrepreneurs. Most women were …

Signal Intensity Analysis And Optimization For In Vivo Imaging Of Cherenkov And Excited Luminescence., Ethan P. M. Larochelle, Jennifer R. Shell, Jason R. Gunn, Scott C. Davis, Brian W. Pogue

Dartmouth Scholarship

During external beam radiotherapy (EBRT), in vivo Cherenkov optical emissions can be used as a dosimetry tool or to excite luminescence, termed Cherenkov-excited luminescence (CEL) with microsecond-level time-gated cameras. The goal of this work was to develop a complete theoretical foundation for the detectable signal strength, in order to provide guidance on optimization of the limits of detection and how to optimize near real time imaging. The key parameters affecting photon production, propagation and detection were considered and experimental validation with both tissue phantoms and a murine model are shown. Both the theoretical analysis and experimental data indicate that the …

A Virtual Reality System For Practicing Conversation Skills For Children With Autism, Natalia Stewart Rosenfield, Kathleen Lamkin, Jennifer Re, Kendra Day, Louanne E. Boyd, Erik J. Linstead

Engineering Faculty Articles and Research

We describe a virtual reality environment, Bob’s Fish Shop, which provides a system where users diagnosed with Autism Spectrum Disorder (ASD) can practice social interactions in a safe and controlled environment. A case study is presented which suggests such an environment can provide the opportunity for users to build the skills necessary to carry out a conversation without the fear of negative social consequences present in the physical world. Through the repetition and analysis of these virtual interactions, users can improve social and conversational understanding.

Health Leadership & Administration And Quality Improvement Process Measurement And Information Leading To Ms Healthcare, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Targeting Primary Cilia Immune Receptor Proteins For The Treatment Of Polycystic Kidney Disease Mechanisms, Nedaa Alomari

Pharmaceutical Sciences (MS) Theses

Background: Primary cilia are cellular organelles project from the cell surface of mammalian cell and play important roles in vertebrate development, organogenesis, health, and others genetic diseases. Primary cilium functions as a mechano-sensor and chemo-sensor. Defect in primary cilia causes the progression of polycystic kidney disease (PKD) which further leads to the inflammatory responses. We, therefore, investigated the role of Toll-like receptors 4 and 9 (TLR) in primary cilia towards PKD.

Purpose: The main purpose of the proposed study is to identify and target the immune reactive proteins i.e. TLRs in the primary cilia. By targeting those primary cilia immune …

Identifying Structural Factors Associated With Central Line-Associated Bloodstream Infections (Clabsi) Risk In A Single-Center Pediatric Academic Hospital, Elizabeth Monsees, Paul N. Bauer, Yolanda Ballam, Brian R. Lee

Posters

Objective: compare unit structure and process-related factors against unit-specific CLABSI rate.

Conclusion: CLABSI mitigation requires more than individual competence with task-related practices; the unique work ecology of each clinical area may broadly influence CLABSI as an outcome; extending analyses to consider organizational structure can inform resource allocation and recalibrate traditional prevention strategies.

Association Between Inflammatory Potential Of Diet And Bone-Mineral Density In Korean Postmenopausal Women: Data From Fourth And Fifth Korea National Health And Nutrition Examination Surveys, Woori Na, Susan Park, Nitin Shivappa, James F. Thrasher, Mi Kyung Kim, Cheongmin Sohn

Faculty Publications

Post menopause is considered a critical period for bone-mass loss. Impaired bone metabolism during this phase can increase the risk of fractures in old age. Inflammation is a risk factor for bone health, and diet is a potential source of inflammation. However, few studies have examined the association between the dietary inflammatory index (DII^®) and bone-mineral density (BMD) in postmenopausal women in Korea. The objective of this study was to determine, by means of a Korean cross-sectional investigation, whether higher DII scores are associated with decreased BMD in postmenopausal women. To that end, the raw data from the …

The Association Between Metabolic Syndrome And Gallstone Disease: A Case Report, Paul Rodenbiker

Nursing Capstones

No abstract provided.

The Correlation Between The Microbiome And Neurodegenerative Disorders Such As Alzheimer Disease, Aurora Mokris

Honors Theses

Recent studies suggest that there are 1.3 times as many microbial cells as human cells in the body (Abbot, 2016). Another study claims that the combined genomes of this microbiota is 150 times that of the human genome (Zhuang & Shen, 2018). If you have ever had the feeling that you are not alone in an empty room you are most certainly correct. Your body is teeming with millions of organisms living in mutualistic symbiosis with you and surrounding microbes, but at times, this seemingly harmonious relationship can be disturbed, resulting in serious physical and psychological changes to the human …

Relationship Of Grip Strength And Quality Of Life Among Community-Dwelling Older Adults, Melissa Van Omen

Honors Theses

Loss of muscle strength is one of the key features of aging. Quality of life is a factor that affects productive aging and loss of muscle strength. A literature review was completed to assess the possible relationship between grip strength and quality of life among community-dwelling older adults, as measured through physical health in terms of independence with ADLs/IADLs, physical disability, and mobility. Articles were collected from various peer-reviewed, publish journals using the available databases of Western Michigan University libraries. Databases used include PubMed, Clinical Keys, the National Institute of Health (NIH), Springer Link, Scopus, BioMed Central, Wiley, and Oxford …

An Exploration Of Resources Available To Deaf Children Attending Public And Deaf Community Schools, Katelyn Reid

Honors Theses

The purpose of this paper is to explore current literature surrounding the similarities, differences, advantages and disadvantages that Deaf children experience while attending mainstream schools compared to the experiences of Deaf children attending all-Deaf and signing schools. A literature review was conducted using the terms: “mainstream schools” , “signing schools” , “resources” , and “Deaf children” were used. Areas of specific interest included social skills, academic performance, overall mood, and the availability of classroom and communication resources. A review of the literature in these four specific areas revealed mixed findings about which academic environment is more beneficial for Deaf children. …

Stimulation Of Heat Shock Protein 90 Chaperone Function Through Binding Of A Novobiocin Analog Ku-32, Bhaskar K. Chatterjee, Abhilash Jayaraj, Vinay Kumar, Brian Blagg, Rachel E. Davis, B Jayaram, Shashank Deep, Tapan K. Chaudhuri

Faculty Publications

Heat shock protein 90 (Hsp90) is a eukaryotic chaperone responsible for the folding and functional activation of numerous client proteins, many of which are oncoproteins. Thus, Hsp90 inhibition has been intensely pursued, resulting in the development of many potential Hsp90 inhibitors, not all of which are well-characterized. Hsp90 inhibitors not only abrogate its chaperone functions, but also could help us gain insight into the structure-function relationship of this chaperone. Here, using biochemical and cell-based assays along with isothermal titration calorimetry, we investigate KU-32, a derivative of the Hsp90 inhibitor novobiocin (NB), for its ability to modulate Hsp90 chaperone function. Although …

Online Video Instruction On Hand Expression Of Colostrum In Pregnancy Is An Effective Educational Tool, Therese A. O'Sullivan, Joy Cooke, Chris Mccafferty, Roslyn Giglia

Research outputs 2014 to 2021

The use of antenatal colostrum expression in the weeks prior to birth may help improve long-term breastfeeding, but few large-scale studies exist. Typically, antenatal colostrum expression instruction relies on face-to-face education, making large interventions costly. We aimed to determine whether an expert online instructional video can improve knowledge and confidence around antenatal colostrum expressing. Pregnant women were asked to complete a questionnaire pre- and post-watching the instructional video online. Ninety five pregnant women completed both pre- and post-questionnaires. Total antenatal colostrum expression knowledge scores improved after watching the video, from a mean of 3.05 ± 1.70 correct out of a …

Overall Microbial Activity On Shopping Carts Handles: Relationship With Ambient Temperature, Relative Humidity, Moisture, And Ultraviolet Radiations, Grayson Rentz, Atin Adhikari

GS4 Student Scholars Symposium

Goals and Objectives: Microbial contamination in shopping cart handles were previously reported but how the microbial load in shopping cart handles vary in different seasons and its relationship with ambient temperature (T), relative humidity (RH), surface moisture, and ultraviolet radiations (UV) are largely understudied. This study aims at exploring microbial loads on shopping cart handles in three grocery stores during fall and winter and its relationship with real-time T, RH, moisture, and UV levels.

Theoretical Framework: Most of us do not realize that microbes are often present on many common stuffs outdoors. When we touch shopping cart handles by bare …

The Santa Clara, 2019-04-18, Santa Clara University

The Santa Clara

No abstract provided.

Understanding And Impact Of Negative Direct-To-Consumer Brca Test Results: A Pilot Study, Kristen Pauley, Zohra Ali-Khancatts, Rachael Brandt, Cristina Nixon, Robert Sterling

Department of Biochemistry and Molecular Biology Posters

Many people pursue direct-to-consumer (DTC) DNA testing to learn about health risks. While DTC testing for breast cancer genes BRCA1 and BRCA2 may provide vital information to those testing positive, it is unclear whether individuals testing negative understand the implications of these results. Furthermore, it is unknown how such findings may influence future cancer risk management. Ninety-six individuals who underwent BRCA testing through the DTC service, 23andMe, completed a survey designed to assess their understanding of a negative result and how this result may impact cancer risk management. Respondents were recruited via social media sources Reddit and Facebook. All participants …

Ucp1 Expression-Associated Gene Signatures Of Human Epicardial Adipose Tissue., Kanta Chechi, Jinchu Vijay, Pierre Voisine, Patrick Mathieu, Yohan Bossé, Andre Tchernof, Elin Grundberg, Denis Richard

Manuscripts, Articles, Book Chapters and Other Papers

Multiple reports of uncoupling protein 1 (UCP1) expression have established its presence in human epicardial adipose tissue (eAT). Its functional relevance to eAT, however, remains largely unknown. In a recent study, we reported that adrenergic stimulation of eAT was associated with downregulation of secreted proteins involved in oxidative stress-related and immune-related pathways. Here, we explored the UCP1-associated features of human eAT using next-generation deep sequencing. Paired biopsies of eAT, mediastinal adipose tissue (mAT), and subcutaneous adipose tissue (sAT) obtained from cardiac surgery patients, with specific criteria of high and low expression of UCP1 in eAT, were subjected to RNA sequencing. …

Single-Cell Gene Expression Analysis Identifies Chronic Alcohol-Mediated Shift In Hepatocyte Molecular States After Partial Hepatectomy., Sirisha Achanta, Aalap Verma, Ankita Srivastava, Harshavardhan Nilakantan, Jan B. Hoek, Rajanikanth Vadigepalli

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The analysis of molecular states of individual cells, as defined by their mRNA expression profiles and protein composition, has gained widespread interest in studying biological phenomena ranging from embryonic development to homeostatic tissue function and genesis and evolution of cancers. Although the molecular content of individual cells in a tissue can vary widely, their molecular states tend to be constrained within a transcriptional landscape partly described by the canonical archetypes of a population of cells. In this study, we sought to characterize the effects of an acute (partial hepatectomy) and chronic (alcohol consumption) perturbation on the molecular states of individual …

Speech-Language Pathologist Preferences For Treatment Types For Childhood Apraxia Of Speech, Meeghan Hoose

Honors Theses

Childhood Apraxia of Speech (CAS), also known as developmental apraxia is, “a motor speech disorder that makes it hard for children to speak” (American Speech-Language-Hearing Association). While the child knows what he/she wants to say, the signals going from the brain to the mouth are not delivered correctly, resulting in the mouth not moving appropriately to produce the desired sounds. There are several methods used by speech-language pathologists to treat CAS including moto-programming, a linguistic approach, a combination of motor-programming and linguistic methods, sensory cuing and rhythmic approaches. Through surveying local practicing school speech-language pathologists, I will learn their preferred …

Exploring A Child’S History For Optimal Treatment Of Food Selectivity., Briana Lear

Honors Theses

Food selectivity is defined as “food refusal based on type, texture, temperature, or appearance of food, leading to a self-restricted diet” (Suarez, 2015). Food selectivity affects children of all ages. Food selectivity refers to when a child is eating as few as 5-10 different foods and demonstrates food refusal behaviors, which can make mealtime a challenge for children and their families (Suarez, 2015). Occupational therapy addresses activities of daily living (ADLS), therefore feeding, including food selectivity is included within the OT scope of practice. There is a need to create a comprehensive and thorough document to collect a client’s history …

Increasing Upstream Chromatin Long-Range Interactions May Favor Induction Of Circular Rnas In Lysopc-Activated Human Aortic Endothelial Cells., Angus Li, Yu Sun, Charles Drummer, Yifan Lu, Daohai Yu, Yan Zhou, Xinyuan Li, Simone J. Pearson, Candice Johnson, Catherine Yu, William Y. Yang, Kevin Mastascusa, Xiaohua Jiang, Jianxin Sun, Thomas Rogers, Wenhui Hu, Hong Wang, Xiaofeng Yang

Center for Translational Medicine Faculty Papers

Circular RNAs (circRNAs) are non-coding RNAs that form covalently closed continuous loops, and act as gene regulators in physiological and disease conditions. To test our hypothesis that proatherogenic lipid lysophosphatidylcholine (LPC) induce a set of circRNAs in human aortic endothelial cell (HAEC) activation, we performed circRNA analysis by searching our RNA-Seq data from LPC-activated HAECs, and found: (1) LPC induces significant modulation of 77 newly characterized cirRNAs, among which 47 circRNAs (61%) are upregulated; (2) 34 (72%) out of 47 upregulated circRNAs are upregulated when the corresponding mRNAs are downregulated, suggesting that the majority of circRNAs are upregulated presumably via …

Bova Is Superior To Spesi In Identification Of High Risk Pulmonary Embolism Patients, Joseph Dibello

Sigma Xi Student Research Day

No abstract provided.

Different Effects Of Static And Vibrating Foam Rollers On Ankle Plantar Flexion Flexibility And Neuromuscular Activation, Brianna G. Mazzei

Honors College Theses

The relatively new implementation of vibration into foam rollers was developed in response to the positive feedback of whole-body vibration treatment and foam rolling therapy. The purpose of the study is to research the changes in range of motion and myoelectric activity of the ankle dorsiflexors in female NCAA Division I swimmers when using a vibrating foam roller in comparison to a static foam roller. Combining the self-myofascial release with the increased blood flow and muscle temperature exerted from vibration could possibly enhance the effects of foam-rolling treatment. The different effects of ankle flexibility and motor unit activation after static …

Sustainability In Quality Improvement And Patient Safety Initiatives, Angelo P. Giardino, Eileen R. Giardino

Journal of Nursing & Interprofessional Leadership in Quality & Safety

The question often asked of a quality improvement initiative is whether the improvement process has been sustained within the organization. Rarely is the question answered satisfactorily. The sustainability of an improvement process is important as it justifies the investment of human and financial capital. The term 'evaporation of improvements' addresses the dilemma that between 33% to 70% of all innovations are reportedly not sustained (Fleiszer, Semenic, Ritchie, Richer, & Denis, 2015) . This evaporation of improvement captures the frustrating inability of many institutions to maintain the achieved improvement after the newness of the initial effort wears off (Buchanan, Fitzgerald, & …

Higher Education And Nation Building In Southeastern Africa, International Student Organization

Bryant REDay (Research and Engagement Day)

No abstract provided.