Medicine and Health Sciences Commons^™

Vitamin D Level In Rheumatoid Arthritis And Its Correlation With The Disease Activity, Amany Fayez Hakim, Soha Sayed Shaaban

Journal of Medicine in Scientific Research

Objective Vitamin D has an immunomodulatory and anti-inflammatory action, and its deficiency may cause several autoimmune disorders, including rheumatoid arthritis (RA). The relationship between vitamin D level and the severity of RA is of mere interest to several researchers. Patients and methods This prospective study included 40 cases of RA and 20 healthy controls, of age group between 40–70 years. Serum Vitamin D levels were measured and compared in RA patients and controls. Vitamin D levels in RA patients were measured in three different groups; active RA group, inactive RA group and control. Results Sixty-five percent patients of active RA …

Stripping Of Membranes Versus Vaginal Misoprostol In Induction Of Labor, Azza M. Youssef, Azza Elias, Hesham M. Kamal

Journal of Medicine in Scientific Research

Background The objective of this study was to evaluate the safety and efficacy of membrane stripping and vaginal misoprostol in the induction of labor in low-risk patients at term pregnancy (38–40 gestational weeks). Aim This study was done to compare the efficacy and safety of the two techniques for cervical ripening/labor induction by stripping of membranes and low-dose vaginal misoprostol on the outcome of labor induction in singleton pregnancies between 38 and 40 weeks. Patients and methods This prospective study was conducted for 9 months. The study included 100 women divided randomly into two groups: group I (n = …

Development And Usability Assessment Of A Connected Resistance Exercise Band Application For Strength-Monitoring, John A. Batsis, George G. Boateng, Lillian M. Seo, Curtis L. Petersen, Karen L. Fortuna, Emily V. Wechsler, Ronald J. Peterson, Summer B. Cook, Dawna Pidgeon, Rachel S. Dokko, Ryan J. Halter, David F. Kotz

Dartmouth Scholarship

Resistance exercise bands are a core component of any physical activity strengthening program. Strength training can mitigate the development of sarcopenia, the loss of muscle mass or strength and function with aging. Yet, the adherence of such behavioral exercise strategies in a home-based setting are fraught with issues of monitoring and compliance. Our group developed a Bluetooth-enabled resistance exercise band capable of transmitting data to an open-source platform. In this work, we developed an application to capture this information in real-time, and conducted three usability studies in two mixed-aged groups of participants (n=6 each) and a group of older adults …

Psychosocial Well-Being And Efforts To Quit Smoking In Pregnant Women Of South-Central Appalachia, Brittney Stubbs, Valerie Hoots, Andrea D. Clements, Beth Bailey

ETSU Faculty Works

Introduction: Psychosocial well-being variables from the Tennessee Intervention for Pregnant Smokers (TIPS) study, a longitudinal smoking cessation study in South-Central Appalachia, were investigated as potential predictors of smoking status.

Methods: A sample of 1031 pregnant women participated in an expanded 5A's (Ask, Advise, Assess, Assist, Arrange) program, from 2008 to 2011. Measures of stress, self-esteem, depressive symptoms, and disordered eating collected by interview during the first trimester, or during the third trimester in a combined interview if participants began prenatal care late, were hypothesized to differ among three groups of participants: pregnant women who never smoked, pregnant women who smoked …

My Preferred Pronoun Is She: Understanding Transgender Identity And Oral Health Care Needs, Diana V. Macri, Kate Wolfe

Publications and Research

This literature review summarizes current research and evidence regarding transgender persons and oral health. Methods: A search of the literature was conducted in the following databases: PubMed, Google Scholar, EBSCO Host, Science Direct, and Wiley Online Library using the keywords "transgender identity, gender non-conforming, discrimination, transition, binary systems, transgender oral cavity, transgender, transgender oral health, transgender dental health." Articles published from 2000 to 2017 in both peer-reviewed and non-peer reviewed journals, which reported information regarding the oral health status of transgender populations, were selected for review. Results: The search revealed 18 articles, only 7 of which pertained to the oral …

Sociability In Children With Developmental Language Disorder, Miranda Elizabeth Miller

Theses and Dissertations

This study employed the Teacher Behavior Rating Scale (TBRS) to investigate two aspects of sociability, likeability and prosocial behavior, in 143 children with developmental language disorder (DLD) and 131 of their typically developing peers. Initially, measurement invariance analysis was performed to determine if teachers evaluated likeability and sociability in a similar manner for both children with DLD and their typically developing peers. Likeability items on the TBRS were invariant, and 4 of the 5 prosociability items were invariant. Subsequent analysis revealed that teachers rated children with DLD lower in both likeability and prosociability in comparison to their typically developing peers. …

Kinematic And Acoustic Vowel Changes In Adult Bite Block Speech, Tanner Keith Low

Theses and Dissertations

The current study examined the lingual kinematic and acoustic effects of bite blocks on vowels in a sentence context. Twenty adult native English speakers (10 male, 10 female) with no speech, language, or hearing deficits participated in the study. The corner vowels found in the sentence, The blue spot is on the black key again (i.e., /u/, /É‘/, /æ/, /i/), were measured kinematically and acoustically immediately before and after bite block insertion. The participants' speech was audio-recorded and their lingual articulatory movements were measured with a Northern Digital Instruments Wave electromagnetic articulograph. The sensor coils were attached to three different …

Retrospective Estimation Of Prevalence And Likelihood Ratio Of General Symptoms Of 29 Less Frequently Prescribed Homoeopathic Medicines By Clinical Verification, Raj Manchanda, Chakraborty Parthasarathi, Munmun Koley, Dinesh Singh, Pramodji Singh, Ojit Singh, Varanasi Prasad, Jai Singh, Surinder Nain

Indian Journal of Research in Homoeopathy

Context: Scientific assessment of proving symptoms or already recorded symptoms in patients refers to Clinical Verification (CV). There are serious shortcomings of existing methods of CV, mostly arising from qualitative observations made on absolute occurrence of symptoms instead of relative ones. This problem can be resolved by the use of the Likelihood Ratio (LR). Aim: This study aims to estimate the prevalence and LRs of general symptoms of 29 less frequently prescribed homoeopathic medicines. Methods: The study was multicentric, open and observational. Patients were enrolled as per pre-specified eligibility criteria. Alongside, presenting complaints and general symptoms were taken into account …

The Role Of Homoeopathic Treatment In Women Suffering From Post-Caesarean Backache: An Open Observational Clinical Trial, Arunava Nath, De Mahadeb, Subhas Singh, Nivedita Kundu, James Michael, Satarupa Sadhukhan, Deepak Kumar, Munmun Koley, Subhranil Saha

Indian Journal of Research in Homoeopathy

Context: An open observational trial was carried out at National Institute of Homoeopathy, India, to assess the possible effects of individualised Homoeopathy in individuals suffering from post-caesarean backache. Aim: The aim of the study was to find the role of homoeopathic treatment in individuals suffering from post-caesarean backache. Methods: Fifty subjects were enrolled. The Short-Form McGill Pain Questionnaire (SF-MPQ) and Oswestry Low Back Pain Disability Questionnaire (ODQ) were used as the outcome measures, assessed at baseline and after 3 months of treatment. Medicines prescribed followed homoeopathic principles. Non-parametric Wilcoxon signed rank test was applied to compare the dependent observations. P < 0.05 two-tailed was considered statistically significant. Results: Five subjects dropped out and 45 completed the trial. Intention-to-treat sample (n = 50) was analysed. There were statistically significant reductions in pain rating index percentage score (median 83.3 (IQR 66.7 to 100) vs. median 66.7 (IQR 33.3 to 71.1), P < 0.001); visual analogue scale score (median 7.0 (IQR 6.0 to 8.0) vs. median 6.0 (IQR 4.8 to 7.0), P < 0.001); present pain index score (median 3.0 (IQR 2.0 to 3.0) vs. median 2.0 (IQR 2.0 to 3.0), P = 0.019) and ODQ% score (median 44.0 (IQR 39.5 to 50.0) vs. median 39.0 (IQR 31.9 to 44.0), P < 0.001) over 3 months of treatment. Natrum muriaticum (n = 11, 22%); Staphysagria (n = 8, 16%); Bryonia alba and Rhus toxicodendron (n = 6 each, 12%) and Pulsatilla nigricans (n = 4, 8%) were prescribed frequently. Conclusion: Indicated homoeopathic medicines reduced SF-MPQ and ODQ scores. Further randomised trials are warranted with enhanced methodological rigour.

Evaluation Of Antibacterial And Antioxidant Potential Of Some Homoeopathic Mother Tinctures, Tayyeba Rehman, Ahmad Saeed

Indian Journal of Research in Homoeopathy

Objectives: In homoeopathic system of medicine, mother tinctures are prescribed for several diseases especially for septic conditions and cure of many illnesses. This study was done to evaluate the antibacterial and antioxidant potential of ten commonly used homoeopathic mother tinctures. Materials and Methods: Ten prepared mother tinctures were tested against five clinically important human pathogenic bacteria (Salmonella typhi [S.T], Escherichia coli [E.C], Bacillus subtilis [B.S], Staphylococcus aureus [S.A], and Pseudomonas aeruginosa [P.A]) by broth micro-dilution method with ciprofloxacin as positive control. Antioxidant activity was estimated by 2,2-diphenyl 1-picryl hydrazyl (DPPH) inhibition assay. Ascorbic acid was taken as positive standard in …

Case Of Lumbar Spondylosis Treated With Homoeopathic Medicine Calcarea Fluorica, Ranjit Sonny

Indian Journal of Research in Homoeopathy

Chronic Low Back Pain (CLBP) is one of the most common problems with which people of all age groups report to physicians. It is a very troublesome complaint affecting day-to-day life, leading to decreased productivity. Amongst all the causes, lumbar spondylosis is one of the major causes of CLBP. Lumbar spondylosis commonly affects middle to later age groups. This case report describes patient with symptoms of recurrent pain in low back for the last 10 years. X-ray of the lumbosacral (L.S.) spine showed features of osteophyte confirming the diagnosis of lumbar spondylosis. After careful case-taking, homoeopathic medicine Calcarea fluorica in …

Research Highlights, Daisy Katarmal

Indian Journal of Research in Homoeopathy

No abstract provided.

Book Review: Prognostic Factor Research In Homoeopathy, Laxmikanta Nanda

Indian Journal of Research in Homoeopathy

No abstract provided.

Application Of Bone Cement For Ossicular Chain Defects, Adly Tantawy, Ahmed Amin, Essam Fathey, Mohammed Mobasher, Wael Alzamil

Journal of Medicine in Scientific Research

Objective To evaluate the postoperative results and usefulness of bone cement application in repairing ossicular chain defects, to discuss surgical technique, and to compare preoperative and postoperative ABG. Study design This was a prospective case series study. Patients and methods This study was carried out in the ORL-HNS Department, Zagazig University Hospital and Hearing and Speech Institute, from March 2014 to March 2017, on 20 patients with ossicular chain defect. Rebridging of ossicular discontinuity was done by glass monomer bone cement in all patients. Results In this study, successful hearing restoration could be achieved in 95% of the patients represented, …

Panretinal Photocoagulation Versus Intravitreal Injection Of Bevacizumab As A Preoperative Adjuvant Before Vitrectomy In The Management Of Proliferative Diabetic Retinopathy, Mohammed S. Ahmed

Journal of Medicine in Scientific Research

Background Proliferative diabetic retinopathy (PDR) characterized by neovascularization of the optic disk, retina, and/or iris may be an aberrant attempt to alleviate hypoxia in eyes with severe capillary closure or other retinal ischemia. The new vessels grow perpendicular to the plane of the retina into the scaffolding provided by the vitreous cortex, typically from venules at the junction of the perfused and nonperfused retina. Objective This work aims to study the effect of panretinal photocoagulation (PRP) versus intravitreal injection of bevacizumab (Avastin) before vitrectomy in the management of PDR. Patients and methods Our clinical study was conducted on 60 eyes …

A Reason To Live: Hiv And Animal Companions, Vicki Hutton

Purdue University Press Book Previews

A Reason to Live explores the human-animal relationship through the narratives of eleven people living with HIV and their animal companions. The narratives, based on a series of interviews with HIV-positive individuals and their animal companions in Australia, span the entirety of the HIV epidemic, from public awareness and discrimination in the 1980s and 1990s to survival and hope in the twenty-first century. Each narrative is explored within the context of theory (for example, attachment theory, the "biophilia hypothesis," neurochemical and neurophysiological effects, laughter, play, death anxiety, and stigma) in order to understand the unique bond between human and animal …

Bicyclic Peptides: Types, Synthesis And Applications, Shahrzad Ahangarzadeh, Mohammad M. Kanafi, Simzar Hosseinzadeh, Ahad Mokhtarzadeh, Mahmood Barati, Javad Ranjbari, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Bicyclic peptides form one of the most promising platforms for drug development owing to their biocompatibility, similarity and chemical diversity to proteins, and they are considered as a possible practical tool in various therapeutic and diagnostic applications. Bicyclic peptides are known to have the capability of being employed as an effective alternative to complex molecules, such as antibodies, or small molecules. This review provides a summary of the recent progress on the types, synthesis and applications of bicyclic peptides. More specifically, natural and synthetic bicyclic peptides are introduced with their different production methods and relevant applications, including drug targeting, imaging …

Malnutrition In The Elderly, Clodagh Corcoran, Craig Murphy, Eamonn P. Culligan, Janette Walton, Roy D. Sleator

Department of Biological Sciences Publications

Changes that occur naturally throughout the ageing process place the elderly population at greater risk of malnourishment. This review discusses the significance, causes, consequences and assessment of malnutrition in the elderly.

Multi-Campus Dpt Programmatic Development In A Public University: Leadership Considerations, Betsy J. Becker, Teresa Cochran, Joseph Norman, Kyle Meyer

Posters and Presentations: Physical Therapy

Background/Purpose: Institutional pressure for expanded revenue streams, coupled with workforce development needs to insure patient access of health resources both drive programmatic expansion of healthcare education programs across multiple campus sites. Such expansion is predicated on deliberate planning and resource acquisition for effective course delivery and successful programmatic outcomes. The University of Nebraska Medical Center’s College of Allied Health Professions opened a second campus site in 2016, located 185 miles from the main campus and the urban corridor of the state. The Doctor of Physical Therapy (DPT) program (and four additional allied health professions) modified traditional course delivery to create …

Atrial Fibrillation And Exercise: Exercise Recommendations, Paul Sorace, Peter Ronai, Robert Berry

Exercise Science Faculty Publications

Atrial fibrillation (AF), characterized by a rapid pulse rate and an irregular heart rhythm. It is a more common cardiac arrhythmia. AF may lack symptoms, although fatigue and an impaired exercise ability are common symptoms. This column will discuss exercise testing and training recommendations as well as special considerations.

Epidemiology Of Characteristics And Risk Factors For Overweight In Cats Visiting An Animal Hospital In Bangkok, Thailand, Vachira Hunprasit, Chaiyot Tanrattana, Siwaporn Pengpis

The Thai Journal of Veterinary Medicine

A cross-sectional study aimed to estimate the prevalence and to investigate the characteristics of overweight/obese cats visiting an animal hospital in Bangkok, Thailand. Electronic medical records of feline patient visiting the Small Animal Teaching Hospital, Chulalongkorn University between January 1, 2017 and December 31, 2017 were reviewed. The cat’s information included age, breed, sex, neutering status and body condition score. Associated demographic factors and overweight/obesity using idealweight as a reference was performed by logistic regression. The prevalence of feline overweight/obesity was 8.1% (95%CI: 7.4% - 8.9%). From the multivariable logistic regression, age, sex, neutering status, breed and interaction of age …

Efficacy Of Ultrasonic Dissection Device In Staphylectomy Surgery In Brachycephalic Airway Obstructive Syndrome (Baos) Dogs, Sunisa Thunyodom, Marissak Kalpravidh, Chanin Kalpravidh, Wijit Banlunara, Pasakorn Brikshavana

The Thai Journal of Veterinary Medicine

The ultrasonic scalpel instrument was compared with the conventional staphylectomy technique in elongated soft palate surgery in twenty brachycephalic airway obstructive syndrome (BAOS) canines. Patients were randomly divided into the conventional incisional and ultrasonic scalpel group. Operation time (minute), bleeding volume (ml), respiratory distress score, postoperative complications score, pain scores, epithelialization score and inflammatory score were assessed. Two weeks after surgery, soft palates tissues were biopsied from 7 conventional surgery dogs and 8 ultrasonic dissection device applied dogs. The operation time and bleeding volume in the conventional surgery group were significantly higher than that in conventional group (P<0.01 and P<0.001, respectively). In addition, the respiratory distress score was significantly higher in the conventional surgery group compared with the ultrasonic dissection device group on day 3 and day 28 post-operation (P<0.05). There were no significantly different postoperative complication scores, pain scores or inflammatory scores between two groups. The epithelialization score of the UD was significantly higher than that of the conventional group (P<0.05). The ultrasonic dissection device is user friendly, has decreased surgical time, complete hemostasis and provides fewer postoperative complications. The ultrasonic dissection device is recommended in high-risk patients such as those displaying senility, chronic inflammation, or bleeding disorders.

Teaching Physical Education Skills To A Student With A Disability Through Video Modeling, Robin Huddleston

Theses and Dissertations

Video modeling (VM) is a video-based intervention (VBI) that has been implemented with individuals with disabilities to teach various life and educational skills. It is a tool that allows learners to watch a target skill modeled on a pre-recorded video. The learner is able to re-watch a new skill as many times as needed, and the teacher is given the flexibility needed to work with multiple students while providing individualized instruction. The participant in this study was a 13-year-old male with a traumatic brain injury (TBI) and intellectual disability (ID). The participant was enrolled in a life skills class at …

The Top 10 Things To Know About Transfusion Medicine Before Intern Year: An Evidence-Based Course For Graduating Medical Students., Alexis R. Peedin, Irina Perjar, Marshall A. Mazepa, Marian A. Rollins-Raval, Yara A. Park, Jay S. Raval

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Background: Transfusion medicine (TM) knowledge varies widely among physician trainees. In addition, there have been few instances in which curricular changes have been meaningfully assessed for TM education in medical school.

Methods: We created and presented a novel lecture to improve TM knowledge for graduating medical students using eight objectives designed to reinforce critical information about blood management. Each objective was coded according to unique color schemes, fonts, and graphics to create visual associations while quickly and clearly presenting complex concepts. The validated BEST Collaborative exam was used to measure changes in student TM knowledge, while a survey was conducted …

Biomarkers In Patients With Mucopolysaccharidosis Type Ii And Iv., Honoka Fujitsuka, Kazuki Sawamoto, Hira Peracha, Robert W. Mason, William Mackenzie, Hironori Kobayashi, Seiji Yamaguchi, Yasuyuki Suzuki, Kenji Orii, Tadao Orii, Toshiyuki Fukao, Shunji Tomatsu

Department of Pediatrics Faculty Papers

Glycosaminoglycans (GAGs), dermatan sulfate (DS), heparan sulfate (HS), and keratan sulfate (KS), are the primary biomarkers in patients with mucopolysaccharidoses (MPS); however, little is known about other biomarkers. To explore potential biomarkers and their correlation with GAGs, blood samples were collected from 46 MPS II patients, 34 MPS IVA patients, and 5 MPS IVB patients. We evaluated the levels of 8 pro-inflammatory factors (EGF, IL-1β, IL-6, MIP-1α, TNF-α, MMP-1, MMP-2, and MMP-9), collagen type II, and DS, HS (HS0S, HSNS), and KS (mono-sulfated, di-sulfated) in blood. Eight biomarkers measured were significantly elevated in untreated MPS II patients, compared with those …

Whole Genome Metagenomic Analysis Of The Gut Microbiome Of Differently Fed Infants Identifies Differences In Microbial Composition And Functional Genes, Including An Absent Crispr/Cas9 Gene In The Formula-Fed Cohort, Matthew D. Di Guglielmo, Karl Franke, Courtney Cox, Erin L. Crowgey

Department of Pediatrics Faculty Papers

Background: Advancements in sequencing capabilities have enhanced the study of the human microbiome. There are limited studies focused on the gastro-intestinal (gut) microbiome of infants, particularly the impact of diet between breast-fed (BF) versus formula-fed (FF). It is unclear what effect, if any, early feeding has on short- term or long-term composition and function of the gut microbiome.

Results: Using a shotgun metagenomics approach, differences in the gut microbiome between BF (n = 10) and FF (n = 5) infants were detected. A Jaccard distance principle coordinate analysis was able to cluster BF versus FF infants based on the presence …

Identification Of Novel Cyp2e1 Inhibitor To Investigate Cellular And Exosomal Cyp2e1-Mediated Toxicity, Mohammad Arifur Rahman

Theses and Dissertations (ETD)

Cytochrome P450 2E1 (CYP2E1)-mediated hepatic and extra-hepatic toxicity is of significant clinical importance. Diallyl sulfide (DAS) has been shown to prevent xenobiotics such as alcohol- (ALC/ETH), acetaminophen- (APAP) induced toxicity and disease (e.g. HIV-1) pathogenesis. DAS imparts its beneficial effect by inhibiting CYP2E1-mediated metabolism of xenobiotics, especially at high concentration. However, DAS also causes toxicity at relatively high dosages and with long exposure times. The objective of the first project was to find potent DAS analogs which can replace DAS as a research tool or as potential adjuvant therapy in CYP2E1-mediated pathologies.

Regulation Of Cyp3a5 In Pancreatic Ductal Adenocarcinoma, Jessica D. Hoyer

Theses and Dissertations (ETD)

CYP3A5 is a drug metabolism enzyme that is polymorphically expressed in normal tissues and expressed in high amounts in some cancers, including pancreatic ductal adenocarcinoma (PDAC). There have been several published studies regarding CYP3A5 regulators, but there is still much to be discovered concerning CYP3A5 regulation in cancer. To further understand the regulation of CYP3A5, a high-throughput screen was performed in the AsPC-1 PDAC cell line. This screen employed small interfering RNA (siRNA) targeting transcription factors and chromatin-associated proteins. We identified siRNA that decreased CYP3A5 mRNA and protein levels in AsPC-1 cells and probed into the potential mechanisms. Taken together, …

Eradication Of Human Immunodeficiency Virus Type-1 (Hiv-1)-Infected Cells, Nejat Düzgüneş, Krystyna Konopka

All Dugoni School of Dentistry Faculty Articles

Predictions made soon after the introduction of human immunodeficiency virus type-1 (HIV-1) protease inhibitors about potentially eradicating the cellular reservoirs of HIV-1 in infected individuals were too optimistic. The ability of the HIV-1 genome to remain in the chromosomes of resting CD4+ T cells and macrophages without being expressed (HIV-1 latency) has prompted studies to activate the cells in the hopes that the immune system can recognize and clear these cells. The absence of natural clearance of latently infected cells has led to the recognition that additional interventions are necessary. Here, we review the potential of utilizing suicide gene therapy …

2019 Spring Newsletter, Morehead State University. Nursing Department.

Nursing Department Publications Archive

2019 Spring Newsletter of the Department of Nursing at Morehead State University.