Medicine and Health Sciences Commons^™

Recurrent Knee Effusions In Gymnast, S. Carey, S. Phillips

International Journal of Exercise Science: Conference Proceedings

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Hand Injury In A Motorcycle Rider, C. Basadre Quiroz, B. Sandella

International Journal of Exercise Science: Conference Proceedings

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Abnormal Uterine Bleeding - Rugby, E. Albright, P. Seidenberg

International Journal of Exercise Science: Conference Proceedings

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Whey Protein Supplementation Post Resistance Exercise In Elderly Men Induces Changes In Muscle Mirna's Compared To Resistance Exercise Alone, Randall F. D'Souza, Nina Zeng, James F. Markworth, Vandre C. Figueiredo, Christopher P. Hedges, Aaron C Petersen, Paul A Della Gatta, David Cameron-Smith, Cameron J. Mitchell

Center for Muscle Biology Faculty Publications

Progressive muscle loss with aging results in decreased physical function, frailty, and impaired metabolic health. Deficits in anabolic signaling contribute to an impaired ability for aged skeletal muscle to adapt in response to exercise and protein feeding. One potential contributing mechanism could be exerted by dysregulation of microRNAs (miRNAs). Therefore, the aim of this study was to determine if graded protein doses consumed after resistance exercise altered muscle miRNA expression in elderly men. Twenty-three senior men (67.9 ± 0.9 years) performed a bout of resistance exercise and were randomized to consume either a placebo, 20 or 40 g of whey …

Long–Term Patency Of Arteriovenous Fistula After Endovascular Salvage Procedure And It's Affecting Factors, Patrianef Darwis, Londung B. Sitorus, Akhmadu Muradi

The New Ropanasuri Journal of Surgery

Introduction. The limited durability of vascular access referred to the great challenges in hemodialysis. An immature arteriovenous fistula (AVF) that inadequately develops to support dialysis noted as the leading cause to immature AVF if stenosis found after creation. The endovascular fistula salvage (EFS) addressed for the preemptive repair of immature AVF despite surgicalrevision. However, no study on EFS proceeded in Indonesia with its specific characteristics. Thus, this study aimed to evaluate the efficacy of EFS and its influencing factors. Method. A retrospective cohort study carried out on those with immature AFV who underwent EFS procedures during the period ofJanuary 2016 …

A New Era For Real-World Evidence, Neal J. Meropol, Md

College of Population Health Forum

This presentation will use cancer therapeutic development as a use case for exploring the emerging role of real-world evidence. The current availability of electronic health records with rich information about patients gathered during their routine care is rapidly changing the landscape of evidence generation in medicine. Recent advances have accelerated the introduction of new diagnostics and treatments into clinical practice.

Learning Objectives:

1. Understand potential sources of real-world data for use in evidence generation to guide drug development and patient care.
2. Describe the opportunities and limitations of observational research using real-world data derived from electronic health records.
3. Review examples of real-world …

Nash-Wo-Numa (Childhood Growth & Development) Study Protocol: Factors That Impact Linear Growth In Children 9 To 15 Years Of Age In Matiari, Pakistan, Susan C. Campisi, Yaqub Wasan, Sajid Bashir Soofi, Suneeta Monga, Daphne J. Korczak, Wendy Lou, Olle Soder, Ashley Vandermorris, Khadija N Humayun, Ayesha Mian, Peter Szatmari, Zulfiqar Ahmed Bhutta

Department of Paediatrics and Child Health

Introduction: Adolescence is a time of significant physical and emotional change, and there is emerging concern that adolescents living in low- and middle-income countries (LMIC) may face substantial challenges in relation to linear growth and mental health. Data on the global burden of stunting after 5 years of age are limited, but estimates suggest up to 50 per cent of all adolescents in some LMIC are stunted. Additionally, many LMIC lack robust mental health care delivery systems. Pakistan has one of the world's largest populations of adolescents (10 to 19 years) at approximately 40 million. The Nash-wo-Numa study's primary objective …

Overexpression Of Mirna-25-3p Inhibits Notch1 Signaling And Tgf-Β-Induced Collagen Expression In Hepatic Stellate Cells, Berit Genz, Miranda A. Coleman, Katharine M. Irvine, Jamie R. Kutasovic, Mariska Miranda, Francis D. Gratte, Janina E. E. Tirnitz-Parker, John K. Olynyk, Diego A. Calvopina, Anna Weis, Nicole Cloonan, Harley Robinson, Michelle M. Hill, Fares Al-Ejeh, Grant A. Ramm

Research outputs 2014 to 2021

During chronic liver injury hepatic stellate cells (HSCs), the principal source of extracellular matrix in the fibrotic liver, transdifferentiate into pro-fibrotic myofibroblast-like cells - a process potentially regulated by microRNAs (miRNAs). Recently, we found serum miRNA-25-3p (miR-25) levels were upregulated in children with Cystic Fibrosis (CF) without liver disease, compared to children with CF-associated liver disease and healthy individuals. Here we examine the role of miR-25 in HSC biology. MiR-25 was detected in the human HSC cell line LX-2 and in primary murine HSCs, and increased with culture-induced activation. Transient overexpression of miR-25 inhibited TGF-β and its type 1 receptor …

Stray Radiation Dose From X-Ray And Proton Beam Radiation Therapies, Christopher William Schneider

LSU Doctoral Dissertations

The growing population of cancer survivors at risk of radiation induced side-effects is a public health concern. These side-effects include serious conditions such as second cancers, the majority of which occur outside of the primary treatment volume. Radiotherapy treatment planning systems systematically underestimate the dose to tissues out-of-field. Attempts to predict and reduce the risks of radiogenic side effects require accurate and personalized knowledge of the out-of-field radiation dose to patients. The long-term goal of this research is to provide clinical and research tools necessary to reduce the risk of radiotherapy side effects and improve the health outcomes of radiotherapy …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Georgia Southern: Collaborates on New Perspectives on Public Health Workforce

Mortality And Functional Outcomes After A Spontaneous Subarachnoid Haemorrhage: A Retrospective Multicentre Cross-Sectional Study In Kenya, Peter Waweru, Samwel Gatimu

School of Nursing & Midwifery, East Africa

Introduction: Despite a reduction in poor outcomes in recent decades, spontaneous subarachnoid haemorrhage (SAH) remains associated with severe disability and high mortality rates. The exact extent of these outcomes is however unknown in Africa. This study aimed to determine the mortality and functional outcomes of patients with SAH in Kenya.

Methods: We conducted a retrospective multicentre cross-sectional study involving patients admitted with SAH to three referral hospitals in Nairobi. All patients with a confirmed (primary) discharge diagnosis of first-time SAH between January 2009 and November 2017 were included (n = 158). Patients who had prior head trauma or cerebrovascular disease …

Microrna Expression Profiling Screen Mir-3557/324-Targeted Camk/Mtor In The Rat Striatum Of Parkinson's Disease In Regular Aerobic Exercise, Wenfeng Liu, Li Li, Shaopeng Liu, Zhiyuan Wang, Heyu Kuang, Yan Xia, Changfa Tang, Dazhong Yin

Health Sciences & Kinesiology: Faculty Publications

This study aimed to screen the target miRNAs and to investigate the differential miR-3557/324-targeted signal mechanisms in the rats’ model of Parkinson’s disease (PD) with regular aerobic exercise. Rats were divided into sedentary control PD group (SED-PD, n = 18) and aerobic exercise PD group (EX-PD, n = 22). After 8 weeks of regular aerobic exercise, a 6-hydroxydopamine- (6-OHDA-) induced PD lesion model was constructed. Preregular aerobic exercises enhanced the injury resistance of rats with 6-OHDA-induced PD. The rotational behavior after injection of apomorphine hydrochloride was alleviated. Under the scanning electron microscopy, we found the neurons, axons, and villi of …

“Smoking Evolved?” Perceptions And Use Of Juul Products Amongst College Students, Ty Meka

Sociology Between the Gaps: Forgotten and Neglected Topics

No abstract provided.

2019 June 11 - Medical Student Education Committee Retreat Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

2019 June 11 - Medical Student Education Committee Annual Meeting Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

A National Survey Of Resources To Address Sepsis In Children In Tertiary Care Centers In Nigeria., Odiraa C Nwankwor, Brianna Mckelvie, Meg Frizzola, Krystal Hunter, Halima S Kabara, Abiola Oduwole, Tagbo Oguonu, Niranjan Kissoon

Paediatrics Publications

Background:
Infections leading to sepsis are major contributors to mortality and morbidity in children world-wide. Determining the capacity of pediatric hospitals in Nigeria to manage sepsis establishes an important baseline for quality-improvement interventions and resource allocations.

Objectives:
To assess the availability and functionality of resources and manpower for early detection and prompt management of sepsis in children at tertiary pediatric centers in Nigeria.

Methods:
This was an online survey of tertiary pediatric hospitals in Nigeria using a modified survey tool designed by the World Federation of Pediatric Intensive and Critical Care Societies (WFPICCS). The survey addressed all aspects of pediatric …

Prevalence And Correlates Of Hiv Infection Among People Who Use Drugs In Cambodia: A Cross-Sectional Survey Using Respondent Driven Sampling Method., Sovannary Tuot, Gitau Mburu, Phalkun Mun, Pheak Chhoun, Navy Chann, Kiesha Prem, Siyan Yi

BACKGROUND: Most of studies on the relationship between drug use and HIV have focused largely on people who inject drugs. Non-injecting drug use is much more common than injecting drug use, and although it can also predispose people to HIV infection, it is not widely explored. We therefore conducted this study to explore the prevalence of HIV and identify risk factors for HIV infection among people who use non-injecting drugs (PWUD) in Cambodia.

METHODS: This cross-sectional study was conducted in 2017. The Respondent Driven Sampling method was used to recruit the study participants who were interviewed face-to-face using a structured …

Small‐Molecule Activators Of Glucose‐6‐Phosephate Dehydrogenase (G6pd) Bridging The Dimer Interface, Andrew G. Raub, Sunhee Hwang, Naoki Horikoshi, Anna D. Cunningham, Simin Rahighi, Soichi Wakatsuki, Daria Mochly-Rosen

Pharmacy Faculty Articles and Research

We have recently identified AG1, a small-molecule activator that functions by promoting oligomerization of glucose-6- phosphate dehydrogenase (G6PD) to the catalytically competent forms. Biochemical experiments indicate activation of G6PD by the original hit molecule (AG1) is noncovalent and that one C2-symmetric region of the G6PD homodimer is important for ligand function. Consequently, the disulfide in AG1 is not required for activation of G6PD and a number of analogs were prepared without this reactive moiety. Our Study supports a mechanism of action whereby AG1 bridges the dimer interface at the structural nicotinamide adenine dinucleotide phosphate (NADP+)-binding sites of two interacting G6PD …

A Multivalent Kaposi Sarcoma-Associated Herpesvirus-Like Particle Vaccine Capable Of Eliciting High Titers Of Neutralizing Antibodies In Immunized Rabbits, David H. Mulama, Lorraine Z. Mustvunguma, Jennifer Totonchy, Peng Ye, Joslyn Foley, Gabriela M. Escalante, Esther Rodriguez, Ramina Nabiee, Murali Muniraju, Felix Wussow, Anne K. Barasa, Javier Gordon Ogembo

Pharmacy Faculty Articles and Research

Kaposi sarcoma-associated herpesvirus (KSHV) is an emerging pathogen and the causative agent of multiple cancers in immunocompromised patients. To date, there is no licensed prophylactic KSHV vaccine. In this study, we generated a novel subunit vaccine that incorporates four key KSHV envelope glycoproteins required for viral entry in diverse cell types (gpK8.1, gB, and gH/gL) into a single multivalent KSHV-like particle (KSHV-LP). Purified KSHV-LPs were similar in size, shape, and morphology to KSHV virions. Vaccination of rabbits with adjuvanted KSHV-LPs generated strong glycoprotein-specific antibody responses, and purified immunoglobulins from KSHV-LP-immunized rabbits neutralized KSHV infection in epithelial, endothelial, fibroblast, and B …

Packed Red Blood Cell Transfusion Associates With Acute Kidney Injury After Transcatheter Aortic Valve Replacement, Akeel M. Merchant, Javier A. Neyra, Abu Minhajuddin, Lauren E. Wehrmann, Richard A. Mills, Sarah K. Gualano, Dharam J. Kumbhani, Lynn C. Huffman, Michael E. Jessen, Amanda A. Fox

Internal Medicine Faculty Publications

Background: Acute kidney injury after cardiac surgery significantly associates with morbidity and mortality. Despite not requiring cardiopulmonary bypass, transcatheter aortic valve replacement patients have an incidence of post-procedural acute kidney injury similar to patients who undergo open surgical aortic valve replacement. Packed red blood cell transfusion has been associated with morbidity and mortality after cardiac surgery. We hypothesized that packed red blood cell transfusion independently associates with acute kidney injury after transcatheter aortic valve replacement, after accounting for other risk factors.

Methods: This is a single-center retrospective cohort study of 116 patients undergoing transcatheter aortic valve replacement. Post-transcatheter aortic valve …

Diagnosis, Treatment And Follow Up Of Acute Pulmonary Embolism: Consensus Practice From The Pert Consortium, Belinda Rivera-Lebron, Michael Mcdaniel, Kamran Ahrar, Abdulah Alrifai, David M. Dudzinski, Christina Fanola, Danielle Blais, David Janicke, Roman Melamed, Kerry Mohrien, Elizabeth Rozycki, Charles B. Ross, Andrew J. Klein, Parth Rali, Nicholas R. Teman, Leoara Yarboro, Eugene Ichinose, Aditya M. Sharma, Jason A. Bartos, Mahir Elder, Brent Keeling, Harold Palevsky, Soophia Naydenov, Parijat Sen, Nancy Amoroso, Josanna M. Rodriguez-Lopez, George A. Davis, Rachel Rosovsky, Kenneth Rosenfield, Christopher Kabrhel, James Horowitz, Jay S. Giri, Victor Tapson, Richard Channick, Pert Consortium

Pharmacy Practice and Science Faculty Publications

Pulmonary embolism (PE) is a life-threatening condition and a leading cause of morbidity and mortality. There have been many advances in the field of PE in the last few years, requiring a careful assessment of their impact on patient care. However, variations in recommendations by different clinical guidelines, as well as lack of robust clinical trials, make clinical decisions challenging. The Pulmonary Embolism Response Team Consortium is an international association created to advance the diagnosis, treatment, and outcomes of patients with PE. In this consensus practice document, we provide a comprehensive review of the diagnosis, treatment, and follow-up of acute …

Integration Of Random Forest Classifiers And Deep Convolutional Neural Networks For Classification And Biomolecular Modeling Of Cancer Driver Mutations, Steve Agajanian, Odeyemi Oluyemi, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

Development of machine learning solutions for prediction of functional and clinical significance of cancer driver genes and mutations are paramount in modern biomedical research and have gained a significant momentum in a recent decade. In this work, we integrate different machine learning approaches, including tree based methods, random forest and gradient boosted tree (GBT) classifiers along with deep convolutional neural networks (CNN) for prediction of cancer driver mutations in the genomic datasets. The feasibility of CNN in using raw nucleotide sequences for classification of cancer driver mutations was initially explored by employing label encoding, one hot encoding, and embedding to …

Failure Of Oxysterols Such As Lanosterol To Restore Lens Clarity From Cataracts, Damian M. Daszynski, Puttur Santhoshkumar, Ashutosh S. Phadte, K. Krishna Sharma, Haizhen A. Zhong, Marjorie F. Lou, Peter F. Kador

School of Veterinary and Biomedical Sciences: Faculty Publications

The paradigm that cataracts are irreversible and that vision from cataracts can only be restored through surgery has recently been challenged by reports that oxysterols such as lanosterol and 25-hydroxycholesterol can restore vision by binding to αB-crystallin chaperone protein to dissolve or disaggregate lenticular opacities. To confirm this premise, in vitro rat lens studies along with human lens protein solubilization studies were conducted. Cataracts were induced in viable rat lenses cultured for 48 hours in TC-199 bicarbonate media through physical trauma, 10 mM ouabain as Na+/K+ ATPase ion transport inhibitor, or 1 mM of an experimental compound that induces water …

Integrative Review On Cognitive Behavioral Therapy In Chronic Diseases: The Responses Predictors, Nada Lukkahatai, Jillian Inouye, Diane Thomason, Jennifer Kawi, Bruce Leonard, Kirsten Connelly

Nursing Faculty Research

Background: Cognitive behavioral therapy (CBT) is a self-management strategy used by patients with chronic diseases. Studies consistently report the effectiveness of this therapy in managing symptoms and improving patients’ quality of life. However, evidence also shows that not all patients benefit from the therapy. Methods: This article presents findings from an integrative review of studies published between 2010 and 2014 that investigated outcome predictors of CBT in chronic illness. The use of CBT in psychological disorders was excluded from the review. Result: Eleven studies were included into this review. Every study supported the effectiveness of CBT for both immediate and …

Week Of June 11, 2019, New York Medical College

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Solutions To Reduce Unnecessary Imaging., David C. Levin, Vijay M. Rao

Department of Radiology Faculty Papers

No abstract provided.

Pediatric Amplification Management: Parent Experiences Monitoring Children’S Aided Hearing, Karen F. Munoz, Makynzie Larsen, Lauri Nelson, Sarah E. Yoho, Michael P. Twohig

Journal of Early Hearing Detection and Intervention

Objective: Investigate parents’ experiences monitoring aided hearing for children who use hearing aids, bone conduction hearing aids, and cochlear implants.

Design: A cross-sectional survey design, using three survey instruments, was used to collect parent data.

Study Sample: A total of 178 parents of children birth to six years were included in the analysis (81 hearing aid; 61 cochlear implant; 36 bone conduction hearing aid).

Results: Surveys explored hearing device use and monitoring. Variability was found for hearing aid use, and many parents reported being unaware if their child’s device has data logging capability. Parents varied widely in how often they …

Listen To Us: Dad-Endorsed Strategies For Ehdi Professionals, Holly F. Pedersen Dr., Jerusha Olthoff

Journal of Early Hearing Detection and Intervention

While fathers play an increasingly important role in today’s families, there is an imbalance of research regarding fathers of children with disabilities compared to mothers. Modest research with mothers of children who are deaf/hard of hearing exists; however, very limited research is available specific to fathers of that population. With the advent of newborn hearing screening, the number of children who have hearing loss being identified within the first six months of life has significantly increased. Thus, the number of fathers participating in EHDI services has also increased. Seeking to answer the question, What do fathers’ experiences in the early …

Involvement Of Adults Who Are Deaf Or Hard Of Hearing In Ehdi Programs, Elizabeth Shuler-Krause, Karl R. White

Journal of Early Hearing Detection and Intervention

Consistent with a position statement of the Joint Committee on Infant Hearing (JCIH, 2007), several key organizations and groups have supported involving deaf and hard of hearing (DHH) adults in Early Hearing Detection and Intervention (EHDI) systems, including providing families of children who are DHH with opportunities to interact with adults who are DHH. This article reviews the available data on the involvement of adults who are DHH in EHDI systems to determine the availability of opportunities for families who have children who are DHH to interact with adults who are DHH, how families feel about these experiences, and to …

Family Impact Of Pediatric Hearing Loss: Findings From Parent Interviews And A Parent Support Group, Kristen L. Haddad, Wendy W. Steuerwald, Lori Garland

Journal of Early Hearing Detection and Intervention

Parents experience numerous stressors tied to their child's diagnosis as deaf or hard of hearing (DHH). This study sought to inquire about the lived experiences of parents with children who are DHH to inform the types of supports that should be provided within an audiology care coordination system. Semi-structured phone interviews were conducted with parents of children under the age of five who are DHH and patients of the Division of Audiology at Cincinnati Children’s Hospital Medical Center (CCHMC). Interview findings informed focus group questions, which were facilitated in a parent support group with parents of children who are DHH …