Medicine and Health Sciences Commons^™

Medication-Related Osteonecrosis Of The Jaws After Tooth Extraction In Senescent Female Mice Treated With Zoledronic Acid: Microtomographic, Histological And Immunohistochemical Characterization, Cláudia Cristina Biguetti, André Hergesel De Oliva, Kent Healy, Ramez Hassan Mahmoud, Isabela Do Carmo Custódio, Dulce Helena Constantino, Edilson Ervolino, Marco Antonio Hungaro Duarte, Walid D. Fakhouri, Mariza Akemi Matsumoto

School of Podiatric Medicine Publications

Treatment with cumulative dosages of zoledronic acid (ZA) in elderly patients is a risk factor for the development of medication-related osteonecrosis of the jaws (MRONJ), mainly related to surgical triggers such as tooth extraction. However, animal models for the investigation and understanding of MRONJ pathophysiology in senescent and postmenopausal stages remains to be developed and characterized. The aim of this study was to analyze MRONJ development in senescent female mice treated with cumulative dosages of ZA. For this purpose, twenty 129/Sv female mice, 64 weeks old, were treated with 0.9% saline solution as control group (n = 10), and with …

Are Pre-Existing Conditions Returning, And Obamacare Ending?, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Patient And Student Experience On An Interprofessional Hotspotting Team, Steven Elsesser, Md, Elizabeth Feeney, Bsn, Katherine Petty, Spt, Kevin Shaloo, Spt, Nancy Tang, Pharmd

JCIPE Posters

The purpose of the Student Hotspotting initiative is to identify these individuals, understand their barriers and intervene by:

• Connecting them with community resources
• Improving coordination and communication between both providers and the patient
• Empowering these individuals to better manage their health

Our patient (DW) lives in a close-knit, 4-generation household that just welcomed their newest member: a black-and-white kitten

DW is a 61 year-old female who recently received orthotopic heart transplant. Her comorbidities include sleep apnea, GERD, OA, chronic pain syndrome, COPD and a history of a CVA

We identified 3 main barriers to address with DW

• Transportation difficulties
• Management …

Bridging The Gaps: Team 6 Hotspotting Experience, Sean O'Sullivan, Rebecca Schuck, Sean Tonnesen, Gabrielle Sallade, Emily Osisek, Avninder Ubhi

JCIPE Posters

Healthcare spending in the U.S. reached $3.5 trillion in 20171. Half of this spending was due to only 5% of patients. Hotspotting is the practice of identifying high-utilizing patients and providing them ancillary care. Supporting such patients with nutrition information, care coordination, clinician communication, health education, and treatment adherence coaching benefits the patients, clinicians, and healthcare system. The Jefferson Interprofessional Student Hotspotting Program places students of different educational programs into teams to identify high-utilizing patients and provide them individualized and holistic care. It is an intimate longitudinal clinical experience for students and an opportunity to improve the health of complex …

Conversion Disorder (Functional Neurological Symptom Disorder) Masquerading As Multiple Sclerosis: A Case Report., Derman Ozdemir, Sonu Sahni

Touro College of Osteopathic Medicine (New York) Publications and Research

Conversion disorder, also referred to as functional neurological symptom disorder, is a DSM-5 identified somatic disorder that presents with one or more neurological symptoms that does not clinically correlate with recognized neurological or medical conditions brought on by intense stress, emotions, or an associated psychiatric disorder. Multiple sclerosis (MS) is the most common immune-mediated inflammatory demyelinating disease of the central nervous system and usually presents in young adults with clinical manifestations that range from cognitive abnormalities, eye movement problems, motor and sensory impairments such as weakness and numbness, bowel/bladder dysfunction, fatigue, and/or pain. This case report presents a patient with …

Interprofessional Student Hotspotting: Impact Of Federally Qualified Health Centers (Fqhc) On Complex Patients, Alexis Amendola, Pallavi Chary, Andrew Day, Graziella Holland, Michelle Murray, Jesse Simpson

JCIPE Posters

Individuals with complex health and social needs drive much of the total cost of care, accounting for nearly 50% of annual costs. Studies show that patients’ use of community health centers is associated with lower health care costs, less frequent use of emergency departments, and fewer preventable hospitalizations, compared to patients who do not use the health centers. Federally qualified health centers (FQHCs) provide patients with medical homes where they can build ongoing, personal relationships with treatment teams, resulting in continuous, comprehensive and integrated care.

Additionally, addressing these individuals' needs and decreasing costs requires interprofessional teams to engage with communities …

Interprofessional Student Hotspotting Learning Collaborative: A Student Initiative To Together Help Patients In Tangible And Intangible Ways, Kristin Brannon, Saskia Levy-Sheon, Michael Murphy, Megan Rankel, Caroline Christianson, Carly Alexander, Tejash Patel, Mariana Kuperman, Md, Leigh Ann Hewston, Pt, Dpt, Med, Ceeaa

JCIPE Posters

The Interprofessional Student Hotspotting Learning Collaborative brings together a team of students who work closely with individual patients with complex medical histories who are “super-utilizers” of health care resources.

Our goals:

• Provide a targeted, patient-centered approach to patient care
• Learn about our patient’s health from their perspective and develop a plan based on the patient’s goals and perceived needs
• Minimize misuse and miscommunication that had previously hindered the patient healthcare experience.
• Bring unique perspectives from each of our respective disciplines to improve upon inefficiencies in care
• Our team consisted of students from the colleges of Occupational Therapy, Physical Therapy, Nursing, …

Interprofessional Perspectives: Challenges & Lessons Learned From Participation In The Student Hotspotting Program, Alex Faus, Bs, Jennifer Newman, Ba, Stephanie Quist, Bm, John Ra, Bs, Madeline Runyen, Ba, Kelsie Wilhelm, Bsfs

JCIPE Posters

By participating in the Student Hotspotting Program, students learned that:

• Coordinating the care of a complex patient requires an interprofessional team
• Hotspotting interventions can often be complicated by uncontrollable circumstances
• Building trust is key to working with patients who may be hesitant to engage with the healthcare system
• Successful interprofessional healthcare teams are characterized by specific attributes
• As future healthcare practitioners, we can apply these lessons into our own interprofessional interactions to optimize our treatment plans for complex patients

An Overview And An Experience Of Hotspotting, Adam Myer, Allyson Psillos, Brianna Brown, Anne Bono, Stephen Kern, Phd, Otr/L, Faota, Jamie Smith, Michele Zawora, Md

JCIPE Posters

United States Healthcare Dilemma

In the United States, a large proportion of healthcare resources and costs are utilized by a small percentage of the population.

• Approximately 25% of the United States healthcare costs are incurred by 1 percent of the population, while 5% are of healthcare costs are incurred by 50% of the population. The small percentage of the individuals who consume large amounts of resources has led to the term “super-utilizers.”
• These patients usually have complex and hard-to-manage conditions, as well as socioeconomic barriers to care, which frequently lead to potentially avoidable emergency department and hospital admissions and complications. …

Student Hotspotting: A Novel Dynamic For Learners And Patients, Richard Jeffries, Lydia Glick, Katherine O'Rourke, Mi Bui, Jennifer Morelli, Katherine Cambareri, Florencia Campbell, Miranda Aragon, Tracey Vause-Earland

JCIPE Posters

About the Student Hotspotting Program:

A team of interdisciplinary students working with patients with complex medical and social needs

Identify "super-utilizers" of the healthcare system

• These patients frequently use the Emergency Department as primary source of medical care
• A "super-utilizer" of the ED is costly to the patient and system

Goals:

• Build relationships
• Identify needs and goals
• Provide support to navigate healthcare system and increase independence

Fostering Bioinformatics Education Through Skill Development Of Professors: Big Genomic Data Skills Training For Professors., Yingqian Ada Zhan, Charles Gregory Wray, Sandeep Namburi, Spencer T Glantz, Reinhard Laubenbacher, Jeffrey H Chuang

Faculty Research 2019

Bioinformatics has become an indispensable part of life science over the past 2 decades. However, bioinformatics education is not well integrated at the undergraduate level, especially in liberal arts colleges and regional universities in the United States. One significant obstacle pointed out by the Network for Integrating Bioinformatics into Life Sciences Education is the lack of faculty in the bioinformatics area. Most current life science professors did not acquire bioinformatics analysis skills during their own training. Consequently, a great number of undergraduate and graduate students do not get the chance to learn bioinformatics or computational biology skills within a structured …

Changes In The Gut Microbiome And Fermentation Products Concurrent With Enhanced Longevity In Acarbose-Treated Mice., Byron J Smith, Richard A Miller, Aaron C Ericsson, David E Harrison, Randy Strong, Thomas M Schmidt

Faculty Research 2019

BACKGROUND: Treatment with the α-glucosidase inhibitor acarbose increases median lifespan by approximately 20% in male mice and 5% in females. This longevity extension differs from dietary restriction based on a number of features, including the relatively small effects on weight and the sex-specificity of the lifespan effect. By inhibiting host digestion, acarbose increases the flux of starch to the lower digestive system, resulting in changes to the gut microbiota and their fermentation products. Given the documented health benefits of short-chain fatty acids (SCFAs), the dominant products of starch fermentation by gut bacteria, this secondary effect of acarbose could contribute to …

Integrated Analysis Of Clinical And Microbiome Risk Factors Associated With The Development Of Oral Candidiasis During Cancer Chemotherapy., Patricia I Diaz, Bo-Young Hong, Amanda K Dupuy, Linda Choquette, Angela Thompson, Andrew L Salner, Peter K Schauer, Upendra Hegde, Joseph A Burleson, Linda D Strausbaugh, Douglas E Peterson, Anna Dongari-Bagtzoglou

Faculty Research 2019

Oral candidiasis is a common side effect of cancer chemotherapy. To better understand predisposing factors, we followed forty-five subjects who received 5-fluorouracil- or doxorubicin-based treatment, during one chemotherapy cycle. Subjects were evaluated at baseline, prior to the first infusion, and at three additional visits within a two-week window. We assessed the demographic, medical and oral health parameters, neutrophil surveillance, and characterized the salivary bacteriome and mycobiome communities through amplicon high throughput sequencing. Twenty percent of all subjects developed oral candidiasis. Using multivariate statistics, we identified smoking, amount of dental plaque, low bacteriome and mycobiome alpha-diversity, and the proportions of specific …

Preclinical Evaluation Of An Unconventional Ruthenium‐Gold‐ Based Chemotherapeutic: Rance‐1, In Clear Cell Renal Cell Carcinoma, Benelita Elie, Karen Hubbard, Yuriy Pechenyy, Buddhadev Layek, Swayam Prabha, Maria Contel

Publications and Research

Background: There are few effective treatments for patients with advanced clear cell renal cell carcinoma (CCRCC). Recent findings indicate that ruthenium‐gold containing compounds exhibit significant antitumor efficacy against CCRCC in vitro affecting cell viability as well as angiogenesis and markers driving those 2 phenomena. However, no in vivo preclinical evaluation of this class of compounds has been reported.

Methods: Following the dose‐finding pharmacokinetic determination, NOD. CB17‐Prkdc SCID/J mice bearing xenograft CCRCC Caki‐1 tumors were treated in an intervention trial for 21 days at 10 mg/kg/72h of RANCE‐1. At the end of the trial, tumor samples were analyzed for histopathological and …

A Rule-Based Data Quality Assessment System In Electronic Health Records, Zhan Wang

Theses and Dissertations

Measuring and managing data quality in healthcare has remained largely uncharted territory. Rule-based data quality assessment in healthcare was explored through compilation of 63,397 data quality rules. This work applied a design science framework to design, demonstrate and test a scalable framework with which data quality rules can be managed, executed, and used in healthcare facilities for data quality assessment and monitoring. Rules were acquired by multiple methods including iterative design meetings with stakeholders. The system was validated using a mixed methods approach. System function was validated through iterative testing to assure that the system was working properly. Rule performance …

An Integrative Cross-Omics Analysis Of Dna Methylation Sites Of Glucose And Insulin Homeostasis, Jun Liu, Elena Carnero-Montoro, Jenny Van Dongen, Samantha Lent, Ivana Nedeljkovic, Symen Ligthart, Pei-Chien Tsai, Tiphaine C. Martin, Pooja R. Mandaviya, Rick Jansen, Marjolein J. Peters, Liesbeth Duijts, Vincent W. V. Jaddoe, Henning Tiemeier, Janine F. Felix, Gonneke Willemsen, Eco J. C. De Geus, Audrey Y. Chu, Daniel Levy, Shih-Jen Hwang, Jan Bressler, Rahul Gondalia, Elias L. Salfati, Christian Herder, Bertha A. Hidalgo, Toshiko Tanaka, Ann Zenobia Moore, Rozenn N. Lemaitre, Min A. Jhun, Jennifer A. Smith, Donna K. Arnett

Epidemiology and Environmental Health Faculty Publications

Despite existing reports on differential DNA methylation in type 2 diabetes (T2D) and obesity, our understanding of its functional relevance remains limited. Here we show the effect of differential methylation in the early phases of T2D pathology by a blood-based epigenome-wide association study of 4808 non-diabetic Europeans in the discovery phase and 11,750 individuals in the replication. We identify CpGs in LETM1, RBM20, IRS2, MAN2A2 and the 1q25.3 region associated with fasting insulin, and in FCRL6, SLAMF1, APOBEC3H and the 15q26.1 region with fasting glucose. In silico cross-omics analyses highlight the role of differential methylation …

Collaborative Molecular Epidemiology Study Of Metabolic Dysregulation, Dna Methylation, And Breast Cancer Risk Among Nigerian Women: Mend Study Objectives And Design, Tomi Akinyemiju, Omolola Salako, Adetola Daramola, Olusegun Alatise, Adewale Adeniyi, Gabriel Ogun, Omobolaji Ayandipo, Thomas Olajide, Olalekan Olasehinde, Olukayode Arowolo, Adewale Adisa, Oludolapo Afuwape, Aralola Olusanya, Aderemi Adegoke, Akinlolu Ojo, Trygve Tollefsbol, Donna K. Arnett

Epidemiology and Environmental Health Faculty Publications

PURPOSE To elucidate the role of metabolic dysregulation and associated DNA methylation changes on breast cancer risk and aggressive subtypes among Nigerian women. We describe the design and methods of a collaborative molecular epidemiology study of breast cancer in Nigerian hospitals.

METHODS The Mechanisms for Novel and Established Risk Factors for Breast Cancer in Women of Nigerian Descent (MEND) study was designed as a matched case-control study of 350 patients, age 18 to 75 years, with newly diagnosed, treatment-naïve breast cancer and 350 age-matched healthy controls from surrounding geographic areas. Patients with breast cancer seen for initial diagnosis at four …

Taking Advantage Of External Mechanical Work To Reduce Metabolic Cost: The Mechanics And Energetics Of Split-Belt Treadmill Walking, Natalia Sánchez, Surabhi N. Simha, J. Maxwell Donelan, James M. Finley

Physical Therapy Faculty Articles and Research

No abstract provided.

Dietary Inflammatory Index And Sleep Quality In Southern Italian Adults, Justyna Godos, Raffaele Ferri, Filippo Caraci, Filomena I. I. Cosentino, Sabrina Castellano, Nitin Shivappa, James R. Hébert, Fabio Galvano, Giuseppe Grosso

Faculty Publications

Background: Current evidence supports the central role of a subclinical, low-grade inflammation in a number of chronic illnesses and mental disorders; however, studies on sleep quality are scarce. The aim of this study was to test the association between the inflammatory potential of the diet and sleep quality in a cohort of Italian adults. Methods: A cross-sectional analysis of baseline data of the Mediterranean healthy Eating, Aging, and Lifestyle (MEAL) study was conducted on 1936 individuals recruited in the urban area of Catania during 2014-2015 through random sampling. A food frequency questionnaire and other validated instruments were used to calculate …

Extreme Peripheral Blood Plasmacytosis Mimicking Plasma Cell Leukemia As A Presenting Feature Of Angioimmunoblastic T-Cell Lymphoma (Aitl)., Kelsey Sokol, Saritha Kartan, William T. Johnson, Onder Alpdogan, Neda Nikbakht, Bradley M. Haverkos, Jerald Z. Gong, Pierluigi Porcu

Department of Medical Oncology Faculty Papers

Angioimmunoblastic T-cell lymphoma (AITL) is one of four major subtypes of nodal peripheral T cell lymphoma, characterized by its cell of origin, the follicular helper T-cell (TFH). Patients typically present with prominent constitutional (B) symptoms, generalized lymphadenopathy, hepatosplenomegaly, cytopenias, and rash. Here we present a case of a 62-year-old male with progressive cervical adenopathy, fevers and weight loss presenting with extreme polyclonal plasmacytosis and high plasma EBV viral load. While the initial presentation appeared to mimic plasma cell leukemia or severe infection, lymph node biopsy and bone marrow biopsy confirmed a diagnosis of AITL. This case highlights the heterogeneity of …

Shortness Of Breath In A Swimming Athlete, A. Spinelli, A. Getzin

International Journal of Exercise Science: Conference Proceedings

Please click the pdf icon to download the abstract

Unusual Headaches After A Concussion In A Basketball Player, H. Saleemi, A. Getzin

International Journal of Exercise Science: Conference Proceedings

Please click the pdf icon to download the abstract

Foot And Ankle Injury - Soccer, R. Reese, M. Lavallee

International Journal of Exercise Science: Conference Proceedings

Please click the pdf icon to download the abstract

Interesting Case Of Abdominal Pain And Knee Pain In A Soccer Player, E. Reed, R. Davis

International Journal of Exercise Science: Conference Proceedings

Please click the pdf icon to download the abstract

Ankle Pain - Dancer, S. Potteiger, J. Tunis

International Journal of Exercise Science: Conference Proceedings

Please click the pdf icon to download the abstract

More Than Just A Hand Injury In A World Champion, J. Medellin, R. Rompola, M. Lavallee

International Journal of Exercise Science: Conference Proceedings

Please click the pdf icon to download the abstract

Shoulder Injury In A Female Soccer Goalie, U. Hanspal, J. Tom, T. Trojian

International Journal of Exercise Science: Conference Proceedings

Please click the pdf icon to download the abstract

Catching A Déjà Vu? A Repeat Finger Injury In A High School Football Player, E. Daniels, J. Loeffert

International Journal of Exercise Science: Conference Proceedings

Please click the pdf icon to download the abstract

Leg Injury - World Champion Super-Heavyweight Weightlifter, D. Cole, R. Rompola, M. Lavallee

International Journal of Exercise Science: Conference Proceedings

Please click the pdf icon to download the abstract

Left Calf Pain - Runner, T. Chu, T. Trojian

International Journal of Exercise Science: Conference Proceedings

Please click the pdf icon to download the abstract