Medicine and Health Sciences Commons^™

Impact Of Telehealth Education Versus Standard Care On Increasing Self-Efficacy Scores And Diabetes Knowledge In Adult Diabetics, Glenda A. Tisdale Msn Rn

Doctor of Nursing Practice Projects

Background: Evidence supports the use of telehealth as an effective method to support the increase in self-efficacy and knowledge among patients with Diabetes Mellitus.

Objectives: This study was to determine whether using telehealth education in conjunction with standard care compared to standard care only, could increase self-efficacy scores and knowledge for adults with diabetes.

Methodology: A randomized, pre-posttest design is used. A convenient sample of 58 adults with self-reported type 2 diabetes were recruited from a faith-based environment. The control group received two 45-minutes standard education sessions about diabetes and diabetes care. The intervention group received weekly smart-phone messaging for …

Cooking And Meal Planning As Predictors Of Fruit And Vegetable Intake And Bmi In First-Year College Students, Andrea Hanson, Kendra K. Kattelmann, Lacey A. Mccormack, Wenjun Zhou, Onika N. Brown, Tanya M. Horacek, Karla P. Shelnutt, Tandalayo Kidd, Audrey Opoku-Acheampong, Lisa Franzen-Castle, Melissa D. Olfert, Sarah E. Colby

Health and Nutritional Sciences Faculty Publications

The objective was to determine if cooking skills and meal planning behaviors are associated with greater fruit and vegetable intake and lower body mass index (BMI) in first-year college students who are at risk for excessive weight gain. A cross-sectional analysis was conducted using baseline data from a multi-state research project aimed at preventing weight gain in first-year college students. Cooking type, frequency and confidence, self-instruction for healthful mealtime behavior intention, self-regulation of healthful mealtime behavior, and cup equivalents of fruits and vegetables (FV) were measured using validated surveys. BMI was calculated from measured height and weight. First-year students (n …

Position Statement:Emerging Genetic Therapies For Rare Disorders, Pauline Samia, Adam Kirton, Russell Dale, Silvia Tenembaum, Chahnez Charfi Triki, Anaita Hegde, Richard Idro, Jo M. Wilmshurst, Ingrid Tein, Haluk Topaloğlu

Paediatrics and Child Health, East Africa

Emerging genetic therapies for rare disorders at high cost, cannot realistically address the global burden of disease. Stakeholders must develop new pathways to ensure safe, fair and sustainable provision of such therapies.

Effect Of Heat-Treatment Time On Bending Properties Of Cobolt-Chromium Orthodontic Wires, Melanie Hammerbeck

Master's Theses (2009 -)

Different protocols appear in the literature with respect to heat-treating cobalt-chromium orthodontic wires. The objective was to determine the effect of variable heat-treatment time and method on the bending properties of CoCr wires. Two tempers of CoCr ‘Elgiloy’ wires (Rocky Mountain Orthodontics), blue (B) and yellow (Y), were heat-treated for different durations. The groups (n=20/group/temper) included: 1) as-received (control); 2) brush-flame; 3) 480oC for 5sec; 4) 480oC for 10min; 5) 480oC for 2hr; and 6) 480oC for 5hr. Wire segments were tested by a three-point bend test. Stiffness/flexural modulus, percent recovery, and force values at select deflections were statistically compared …

A Technique For Approximating Transition Rates From Published Survival Analyses, Markian A. Pahuta, Joel Werier, Eugene K. Wai, Roy A. Patchell, Doug Coyle

Neurology Faculty Publications

Background: Quality-adjusted-life-years (QALYs) are used to concurrently quantify morbidity and mortality within a single parameter. For this reason, QALYs can facilitate the discussion of risks and benefits during patient counseling regarding treatment options. QALYs are often calculated using partitioned-survival modelling. Alternatively, QALYs can be calculated using more flexible and informative state-transition models populated with transition rates estimated using multistate modelling (MSM) techniques. Unfortunately the latter approach is considered not possible when only progression-free survival (PFS) and overall survival (OS) analyses are reported.

Methods: We have developed a method that can be used to estimate approximate transition rates from published PFS …

Marking The 102nd Anniversary Of Chulalongkorn University, Sittisak Honsawek

Chulalongkorn Medical Journal

Chulalongkorn University, as the country’s first university, continues to uphold the royal intent of HMKing Chulalongkorn (RAMA V) and HM King Vajiravudh (RAMA VI) to be the “cornerstone of the capital city,” while aspiring towards sustainably becoming a world-class university. The university was originally founded during King Chulalongkorn’s reign as a school for training royal pages and civil servants in 1899 (B.E. 2442) at the Grand Palace of Thailand. It was later established as a national university in 1917, making it the oldest institute of higher education in Thailand. During the reign of Chulalongkorn’s son, King Vajiravudh, the Royal Pages …

Correlation Between Trans Rectal Ultrasound Guided Prostate Biopsy And Radical Prostatectomy Specimen And Risk Factors For Upgraded Gleason Score In Prostate Cancer, Aekgarin Palakho, Apirak Santi-Ngamkun, Julin Opanuraks, Kavirach Tantiwongse, Supoj Ratchanon, Kamol Panumatrassamee

Chulalongkorn Medical Journal

Background: Gleason score is an important pathologic factor for risk stratification in prostate cancer. Upgraded Gleason score is not uncommon after radical prostatectomyObjectives: This study aimed to investigate the prevalence of upgraded Gleason scores between trans rectalultrasound guided prostate biopsy (TRUS-biopsy) and radical prostatectomy (RP) specimen and to determinethe predictive factors for increased Gleason scores.Methods: We retrospectively reviewed the medical records of prostate cancer patients who underwent RP from June 2006 – June 2016 at King Chulalongkorn Memorial Hospital (KCMH). Gleason scores from TRUS-biopsy and RP were compared. Pre-operative clinical parameters were analyzed to determine the risk factors of upgraded …

Ct Appearance Of Acute Pancreatitis Using Multiphase Multidetector Computed Tomography And Correlation Between Ct Severity Index And Clinical Outcomes, Busaba Jiruppabha

Chulalongkorn Medical Journal

Background: Pancreatitis is one of the most complicated and clinically challenging of all abdominal disorders.Computed tomography (CT) is highly accurate and sensitive in both diagnosing and demonstrating its extent.In Thailand, in spite of the importance of the disease, there are a few studies of acute pancreatitis (AP),which mainly focus on its management. Currently, the 2012 revision of the Atlanta classification includingnew terminology and clinical assessment of the severity of AP is used.Objective: To describe CT findings of AP using the 2012 revision of the Atlanta classification and associationbetween CT severity index (CTSI) with clinical outcomes.Methods: The multiphase multidetector computed tomography …

Reduction Of Leukocyte Mitochondrial Dna Copy Number In Knee Osteoarthritis, Dong Zhan, Sittisak Honsawek

Chulalongkorn Medical Journal

This case-control study included 215 knee OA patients (mean age 64.32 gif.latex?\pm 7.22 years), diagnosed following the criteria of the American College of Rheumatology, and 218 healthy age-matched volunteers (mean age 64.05 gif.latex?\pm 6.08 years). This research has been approved by the Institution Review Board (IRB) of the Faculty of Medicine, Chulalongkorn University. A total of 5 mL of peripheral blood was drawn from each participant, andtransferred into coded sodium citrate anticoagulant tubes.

Change Agent Impact On Pain Management Experience Through Lavender Aromatherapy: Evidence-Based Practice Project, Karen Mack Ms, Mba, Aprn, Rn-Bc, Ccns, Acnpc

Doctor of Nursing Practice Projects

Inadequately controlled acute pain is a problem for hospitalized patients. Non-pharmacological pain management interventions (NPPMIs) are recommended but underutilized. Nurse-directed lavender aromatherapy is a feasible and effective NPPMI. Patients at a community hospital, including its surgical-orthopedic unit, reported lower patient pain management experience scores than the average score of Magnet Recognition status hospitals. The community hospital planned to improve pain management by implementing nurse-directed lavender aromatherapy. The purpose of this evidence-based practice project was to fortify the hospital’s nurse-directed lavender aromatherapy implementation with change agents. A logic model guided implementation. Project aims were to increase the surgical-orthopedic unit’s pain management …

Evidence-Based Practice Initiative For Staff Training To Reduce Adult Psychiatric Inpatient Restraints & Injuries, Mary Leveillee Phd, Rn, Pmhcns-Bc

Doctor of Nursing Practice Projects

Background: Violence against healthcare professionals is a growing phenomenon, and mental health care has the highest risk (Phillips, 2016). The experience of workplace violence is demoralizing, resulting in low job satisfaction, decrease productivity, physical injury, and potential Post-Traumatic Stress Disorder (Phillips, 2016; Howerton & Mentes, 2010). The Joint Commission and The Centers for Medicare and Medicaid identify patient perpetrated violence as a significant workplace risk, and they endorse education and training for risk reduction and safe intervention (The Joint Commission, 2018, 2019).

Objective: The purpose of this evidence-based practice initiative was to evaluate the impact of staff training with the …

Topography Study Of Fixa: Generation Of A Lipid Anchored Molecular Ruler With Attached Inhibitor, Nickolas P. Buchanan

PCOM Biomedical Studies Student Scholarship

Blood coagulation, an important hemostatic property, is directed through activation of proteolytic enzymes known as serine proteases to generate a fibrin plug. Using multiple proteases allows for localized and precise regulation of blood coagulation within the circulatory system. Factor IX, a serine protease, is a key activator in the coagulation cascade by activating Factor X. For activation of FX to occur, FIXa must be in proper conformation on the platelet surface with cofactor FVIIIa to increase enzymatic abilities of FIXa a billion-fold. Current research looks at structure and function of FIXa yet neglects structural plasticity on the membrane, with function …

Optimizing Intraprofessional Communication At Patient Handover, Allison Crabtree

Doctor of Nursing Practice Projects

This performance improvement project aimed to increase the communication competency of nurses during intraprofessional interactions at patient handover. An educational program focused on optimizing communication among nurses was implemented in a community-based, not-for-profit, rural hospital. The course was designed to incorporate a variety of instructional strategies to meet learner needs. Consistency and standardization of the patient handover process was a central theme. Topics of the course focused on the use of a standardized communication tool, the relationship of communication on patient safety, the importance of clear and effective communication, the role of the nurse as gatekeeper and facilitator of patient-specific …

Nivolumab Plus Ipilimumab Versus Chemotherapy As First-Line Treatment In Advanced Non-Small-Cell Lung Cancer With High Tumour Mutational Burden: Patient-Reported Outcomes Results From The Randomised, Open-Label, Phase Iii Checkmate 227 Trial, Martin Reck, Michael Schenker, Ki Hyeong Lee, Mariano Provencio, Makoto Nishio, Krzysztof Lesniewski-Kmak, Randeep Sangha, Samreen Ahmed, Judith Raimbourg, Kynan Feeney, Romain Corre, Fabio Andre Franke, Eduardo Richardet, John R. Penrod, Yong Yuan, Faith E. Nathan, Prabhu Bhagavatheeswaran, Michael Derosa, Fiona Taylor, Rachael Lawrance, Julie Brahmer

Research outputs 2014 to 2021

BACKGROUND: In the phase III CheckMate 227 study, first-line nivolumab + ipilimumab significantly prolonged progression-free survival (co-primary end-point) versus chemotherapy in patients with advanced non-small-cell lung cancer (NSCLC) and high tumour mutational burden (TMB; ≥10 mutations/megabase).

AIM: To evaluate patient-reported outcomes (PROs) in this population.

METHODS: Disease-related symptoms and general health status were assessed using the validated PRO questionnaires Lung Cancer Symptom Scale (LCSS) and EQ-5D, respectively. LCSS average symptom burden index (ASBI) and three-item global index (3-IGI) and EQ-5D visual analogue scale (VAS) and utility index (UI) scores and changes from baseline were analysed descriptively. Longitudinal changes were assessed …

New Graduate Nurses' Understanding And Attitudes About Patient Safety Upon Transition To Practice, Melanie Murray, Deborah Sundin, Vicki Cope

Research outputs 2014 to 2021

AIMS: To explore the transition experiences of newly graduated registered nurses with particular attention to patient safety.

BACKGROUND: New graduate registered nurses' transition is accompanied by a degree of shock which may be in tune with the described theory-practice gap. The limited exposure to clinical settings and experiences leaves these nurses at risk of making errors and not recognising deterioration, prioritising time management and task completion over patient safety and care.

DESIGN: Qualitative descriptive approach using semi-structured interviews.

METHODS: Data were collected during 2017-18 from 11 participants consenting to face-to-face or telephone semi-structured interviews. Interviews were transcribed verbatim, and data …

Reducing Aerodynamic Drag By Adopting A Novel Road-Cycling Sprint Position, Paul F. J. Merkes, Paolo Menaspa, Chris R. Abbiss

Research outputs 2014 to 2021

Purpose:

To assess the influence of seated, standing, and forward-standing cycling sprint positions on aerodynamic drag (CdA) and the reproducibility of a field test of CdA calculated in these different positions.

Methods:

A total of 11 recreational male road cyclists rode 250 m in 2 directions at around 25, 32, and 40 km·h.

Results:

A main effect of position showed that the average CdA of the 2 d was lower for the forward-standing position (0.295 [0.059]) compared with both the seated (0.363 [0.071], P = .018) and standing positions (0.372 [0.077], P = .037). Seated and standing positions did …

The Write Stuff - Summer 2019 (Vol. 16, No. 3), Research Medical Library

Write Stuff 2019

• Using Research Resource Identifiers (RRIDs) to enhance rigor and reproducibility
• Court ruling sheds light on publishing giant OMICS International
• Manuscript presentation tips to improve the peer review process
• How to insert Greek letters, symbols, and other special characters in Word documents
• Changes to Plan S give researchers and publishers time to adapt
• Unusual terms used in scientific writing and publishing: Hanging indent

Long-Dose Intensive Therapy Is Necessary For Strong, Clinically Significant, Upper Limb Functional Gains And Retained Gains In Severe/Moderate Chronic Stroke, Janis J. Daly, Jessica P. Mccabe, John P. Holcomb, Michelle Monkiewicz, Jennifer Gansen, Svetlana Pundik

Mathematics and Statistics Faculty Publications

Background. Effective treatment methods are needed for moderate/severely impairment chronic stroke. Objective. The questions were the following: (1) Is there need for long-dose therapy or is there a mid-treatment plateau? (2) Are the observed gains from the prior-studied protocol retained after treatment? Methods. Single-blind, stratified/randomized design, with 3 applied technology treatment groups, combined with motor learning, for long-duration treatment (300 hours of treatment). Measures were Arm Motor Ability Test time and coordination-function (AMAT-T, AMAT-F, respectively), acquired pre-/posttreatment and 3-month follow-up (3moF/U); Fugl-Meyer (FM), acquired similarly with addition of mid-treatment. Findings. There was no group difference in …

Role Of Epigenome And Microbiome In Cannabinoid And Aryl Hydrocarbon Receptor-Mediated Regulation Of Inflammatory And Autoimmune Diseases, Zinah Zamil Al-Ghezi

Theses and Dissertations

Inflammation is considered to be the underlying cause of a majority of clinical disorders. Thus, studies aimed at understanding the signaling pathways that trigger inflammation could have significant translational impact. In the current study, we investigated the effect of activation of cannabinoid (CB) and Aryl hydrocarbon hydroxylase (AhR) receptors on the inflammatory response. To that end, we used cannabinoids such as Δ (9)-Tetrahydrocannabinol (THC) and cannabidiol (CBD), and a well-established AhR agonist namely 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD). These were tested against two inflammatory disease models: 1) Experimental autoimmune encephalomyelitis (EAE), an animal model for human multiple sclerosis (MS), and 2) Exposure to …

Effects Of Human Dopamine Transporter (Dat) Mutations And Novel Allosteric Modulatory Compounds In Disrupting Hiv-1 Tat-Dat Protein Interaction, Pamela Marie P. Quizon

Theses and Dissertations

More than 37 million people are living with HIV worldwide. Despite the widespread use of antiretroviral therapy (ART), up to 70% of HIV-positive individuals suffer from cognitive and behavioral deficits collectively known as HIV-associated neurocognitive disorders (HAND). HIV-mediated damage to the dopaminergic system is a mediating factor in HAND. Dopamine (DA) transporter (DAT)-mediated reuptake is essential for maintaining DA homeostasis. Because most ART cannot efficiently cross the blood-brain barrier (BBB), the brain serves as a viral reservoir that facilitates the spread of infection to microglia and astrocytes. Infected cells shed viral proteins such as Tat, which plays a critical role …

Behavioral And Neural Correlates Of Aging Effects On Temporal Predictive Mechanisms During Speech Production And Limb Movement, Karim Joharikhatoonabad

Theses and Dissertations

Existing evidence suggests that the brain facilitates motor responses to temporally predictable sensory inputs by generating more robust predictions about the timing of incoming stimuli to better estimate the next state of movement. In this context, previous studies have shown that motor responses are generated with faster reaction time in response to sensory stimuli with predictable compared to those with unpredictable temporal dynamics. However, our understanding of the underlying behavioral and neural mechanisms of temporal predictive mechanisms during movement production has remained limited by several factors. First, studies regarding temporal predictive mechanisms have mainly examined limb movement as a target …

Association Between Snps In The Vitamin D Binding Protein, Vitamin D Status, And Aggressive Prostate Cancer By Race, Diana Diaz

Theses and Dissertations

Prostate cancer incidence and mortality have been decreasing in recent years, but it remains the most commonly diagnosed cancer among men. Racial disparities exist in prostate cancer with African Americans (AAs) having notably higher rates of incidence and mortality, lower survival rates, and are more likely to be diagnosed with a highergrade cancer compared to European Americans (EAs). Genome-wide association studies have revealed several single nucleotide polymorphisms (SNPs) within the vitamin Drelated GC gene that may be associated with prostate cancer aggressiveness. In addition to SNPs, previous research has suggested that low levels of 25-hydroxyvitamin D (25(OH)D) may be related …

Pre-Exposure Prophylaxis (Prep) For Hiv Prevention: A Mixed-Methods Study Of Sexual Risks And Knowledge, Perceptions, And Willingness Of Prep Use Among African American Women In The South, Jamie Troutman

Theses and Dissertations

There are approximately 1.1 million people living with HIV in United States, with nearly 40,000 new diagnoses annually. Significant regional and racial disparities are associated with HIV diagnoses — with the South experiencing the greatest burden of HIV and African American women accounting for 60% of new diagnoses among women. Pre-exposure prophylaxis (PrEP) has been designated as an effective tool to prevent HIV transmission among individuals who may be at risk of HIV infection. Earlier PrEP research has focused mainly on at-risk groups such as men who have sex with men (MSM). Previous PrEP research involving African American women included …

Astrocyte Sensitivity To Dopamine In Culture And Ex Vivo, Ashley L. Galloway

Theses and Dissertations

Dopamine is critical for processing of reward and etiology of drug addiction. Astrocytes throughout the brain express dopamine receptors, but consequences of astrocytic dopamine receptor signaling are not well established. This thesis illustrates effects of dopamine on cultured astrocytes and astrocytes in brain slices (ex vivo). In striatal cultures, extracellular dopamine triggered changes in astrocytic Ca²⁺ signaling and rapid concentration-dependent stellation of astrocytic processes that was not a result of dopamine oxidation, but instead relied on both cAMP-dependent and cAMP-independent dopamine receptor signaling. To isolate possible mechanisms underlying these structural and functional changes, whole-genome RNA sequencing was …

Racial And Ethnic Disparities In Stroke Outcomes: A Scoping Review Of Post-Stroke Disability Assessment Tools, Suzanne Perea Burns, Brandi M. White, Gayenell Magwood, Charles Ellis, Ayaba Logan, Joy N. Jones Buie, Robert J. Adams

Health and Clinical Sciences Faculty Publications

Purpose: To identify how post-stroke disability outcomes are assessed in studies that examine racial/ethnic disparities and to map the identified assessment content to the International Classification of Functioning, Disability, and Health (ICF) across the time course of stroke recovery.

Methods: We conducted a scoping review of the literature. Articles published between January 2001 and July 2017 were identified through Scopus, PubMed, CINAHL, and PsycINFO according to predefined inclusion and exclusion criteria.

Results: We identified 1791 articles through database and hand-searching strategies. Of the articles, 194 met inclusion criteria for full-text review, and 41 met inclusion criteria for study inclusion. The …

Pre-Discharge Bnp: A Policy Change To Reduce Hospital Readmission, Melissa Duckett

Doctor of Nursing Practice Projects

Heart Failure (HF) is the leading cause of hospital readmission for patients 65 years of age and older. A pre-discharge B-type natriuretic peptide is a strong predictor of hospital readmission and mortality. The annual cost for admission of patients with HF is greater than $17 billion. Diagnosed heart failure patients continue to be discharged without the physician knowing their current BNP levels. The Affordable Care Act established the Hospital Readmissions Reduction Program (HRRP) requiring the Center for Medicare and Medicaid Services (CMS) to reduce reimbursement to hospitals with high readmission rates. A change in policy should be initiated to include …

Cultivating Self-Confidence: Integrating Simulation Into Hospital Nursing Orientation, Martha Richey

Doctor of Nursing Practice Projects

Background: Simulation provides a safe environment for newly hired nurses at all levels to learn and practice new skills in a safe and structured approach. Simulation allows nurses the opportunity to increase self-confidence at the bedside without placing a patient at risk for harm.

Purpose: The purpose of this Doctor of Nursing Practice (DNP) project is to evaluate the effectiveness of implementing a simulation program during hospital orientation to increase self-confidence with newly hired nurses.

Design Method: A quasi-experimental design using a pre-test-post-test data collection method.

Conclusion: The rapidly changing healthcare environment requires that nurses are prepared to provide patient …

Improving Sepsis Bundle Compliance Through Comprehensive Education, Stacy Mikel

Doctor of Nursing Practice Projects

Purpose: The purpose of this project was to improve emergency department compliance with sepsis bundles by educating registered nurses and licensed practical nurses on the proper use of sepsis screening tools, make changes to screening tools identified through chart reviews, and finally to evaluate the impact of these changes once initiated. This project sought to increase staff knowledge using an educational module.

Methods: This project began with the delivery of a pre-test questionnaire. The facility's target audience was asked to complete this to determine their current knowledge level regarding sepsis. Once these questionnaires were completed, they were reviewed, and information …

Dean's Research Newsletter, Summer 2019, Jerry L. Nadler

SOM Dean's Research Newsletter

No abstract provided.

Expression Of Integrin And Tgfbi In Human Retinal Pericytes, Andrew T C Tsin, Brenda Su, Laura Valdez, Edgar Serrato

School of Medicine Publications

Purpose: The aim for this study is to investigate the expression of integrin α3, β1 and TGF-β induced protein (TGFBI) and the secretion of TGFBI by primary culture of human retinal pericytes (pHRP). Evidence suggests that chronic diabetes associate with HRP apoptosis leading to the development of diabetic retinopathy.

Methods: pHRP (Cell Systems) were cultured in complete media (15mM glucose) in a humidified, 5% CO2, 37°C condition. Cells were seeded at passage 6 to 8 into a 24 well-plate with coverslips or P10 dishes. Cells (85% confluence) media were then replaced by DMEM media with euglycemic glucose (5.5mM) or hyperglycemic …