Medicine and Health Sciences Commons^™

Abnormal Involuntary Movement Scale In Tardive Dyskinesia: Minimal Clinically Important Difference, Martha Sajatovic

Faculty Scholarship

Background: A minimal clinically important difference has not been established for the Abnormal Involuntary Movement Scale in patients with tardive dyskinesia. Valbenazine is a vesicular monoamine transporter 2 inhibitor approved for the treatment of tardive dyskinesia in adults. Efficacy in randomized, double-blind, placebo-controlled trials was defined as the change from baseline in Abnormal Involuntary Movement Scale total score (sum of items 1-7). Objectives: To estimate an minimal clinically important difference for the Abnormal Involuntary Movement Scale using valbenazine trial data and an anchor-based method. Methods: Data were pooled from three 6-week double-blind, placebo-controlled trials: KINECT (NCT01688037), KINECT 2 (NCT01733121), and …

Generalized Anxiety Disorder: Management Practices Among Primary Care Providers In Northern Mississippi, Jennifer Bolen, Grace Henson, Sabrina Mcclain, Al Rayburn, Benjamin Spencer

MSN Research Projects

The purpose of this research was twofold. First, the research revealed the practices among primary care providers in northern Mississippi for treating GAD whether psychotherapy, pharmacological, or a combination. The specific modalities of psychotherapy and pharmacotherapy were listed. Second, the research revealed that these management practices are consistent with contemporary evidence-based research.

Are Health Care Providers Educating 1 Heir Patients On Proper Storage And Disposal Of Electronic Nicotine Devices?, Larisa Bell, Shada Breeze Chunn, Kaitlyn Smith, Tammy Steele

MSN Research Projects

The purpose of our research is to determine if healthcare providers are educating patients on the proper storage and disposal of electronic nicotine devices and the associated liquids.

Recombinant Zoster Vaccine (Shingrix) Knowledge And Practices Of Primary Care Providers In Mississippi, Leigh Gault, Casie Brown, Mackinzie Lee, Kimberly Word

MSN Research Projects

The purpose of this study was to determine Mississippi primary care providers' (PCP) knowledge and practices of the Centers for Disease Control and Prevention's (CDC) Advisory Committee on Immunization Practices (ACIP) recommendations for administering the Shingrix vaccine to immunocompetent adults aged 50 years and older.

Investigation Of Microbiota In Health And Disease Of Poultry, Bishnu Adhikari

Graduate Theses and Dissertations

The microbiotas play vital roles in health and diseases of both humans and animals. 16S rRNA genes sequence analysis is one of the most popular and commonly used methods in the analysis of microbiotas associated with hosts. In this dissertation, the microbiotas of chickens (broilers, breeders, and layers) and turkeys were evaluated by 16S rRNA gene sequencing. Characterization of the culturable subpopulations of Lactobacillus in the chicken gut can serve as a valuable resource for probiotic development. In Chapter 2, Lactobacillus subpopulations recovered on MRS from chicken gut were defined comprehensively for the first time using 16S rRNA gene profiling, …

Prediction And Evaluation Of Breast Myopathy, Barbara De Almeida Mallmann

Graduate Theses and Dissertations

Broiler breast myopathies, including woody breast, white striping, and spaghetti breast, negatively impact the industry. Therefore, evaluation, prediction, and frequency of these muscle abnormalities on modern birds are important for decision making. Modern broilers are not highly active and often sit with the breast of the bird resting on the floor. Therefore, the first experiment was to promote bird movement and explore the impact on the breast myopathies. The movement was stimulated by human interaction (walking through pen) and higher light intensity so that birds walked around the pen more often throughout the day. The control group had normal low …

Barriers Of African American Football Student-Athletes In Seeking Mental Health Services, Todd Andrew Wilkerson

Graduate Theses and Dissertations

Nearly half (48%) of collegiate football student-athletes are African American (NCAA, 2018). African American student-athletes face adversity at their respective institutions in the forms of racism and unfair treatment (Hill, Hall & Appleton, 2010). African American male student-athletes face educational stressors, campus stressors and athletic stressors. These stressors consist of academics, family, athletics and social relationships (Miller & Hoffman, 2009). Many African American student-athletes do not seek mental health treatment due to their status on campus (Watson, 2006). However, few studies have examined mental health and barriers for African American male student-athletes when seeking mental health services. As such, the …

Potential Antimicrobials For Controlling Listeria Monocytogenes In Frankfurters, Aaron Rashad Bodie

Graduate Theses and Dissertations

Listeria monocytogenes is a pathogenic microorganism that causes Listeriosis. Listeriosis is a highly mortal disease with approximately 20% mortality rate. Listeria is psychrophilic, therefore it is able to survive in the refrigerator. This affects foods at cool storage such as fresh produce and RTE meats. To ensure the safety of RTE meat, post processing treatments are used such as vacuum packing, edible films, dip and treatment. One-way RTE can be treated is with the use of antimicrobials. However, in the past chemical substances were used. Currently, consumers want more natural and organic preservatives to combat health problems from toxic components …

Influence Of Heating And Biological Sex On Vascular Dysfunction Associated With Long-Duration Sitting And Standing, Aaron Richard Caldwell

Graduate Theses and Dissertations

Purpose: The purpose of these studies was to determine if arterial angulations (through sitting or standing), shear stress (through local heating), or a combination of these factors affected vascular function. Moreover, this studied estimated the magnitude of the effect that biological sex has on these vascular responses. Methods: Twenty-six healthy, young (18-40 years old) males (n=13) and females (n=13) completed two experimental trials (2-h sitting and 2-h standing). In a randomized fashion, one leg was passively heated in order to increase shear rate. Following a 48-h washout, participants returned to the laboratory to complete the other trial. Flow-mediated dilation (FMD) …

Implicit Bias And The Boundaries Of Belief: A Single-Representational Dual-Attitude Account Of Implicit Attitudes, Austin Dakota Synoground

Graduate Theses and Dissertations

Since their inception, implicit attitudes have been defined as associative mental states, separate from beliefs, which are considered to be propositional in nature. Recently, several philosophers have challenged this distinction, arguing that implicit attitudes are actually unconscious beliefs. In turn, I argue that the attitudes detected by current experimental paradigms are blind to distinctions between implicit attitudes, which I define as the products of an associative learning mechanism, and unconscious beliefs, which are the products of a propositional learning mechanism. Specifically, I argue for a single-representational dual-attitude account of implicit bias.

Characterization Of The Swine Gut Microbiome Dynamics, Culturomics And Probiotics, Xiaofan Wang

Graduate Theses and Dissertations

The gastrointestinal tract is a critical place where the immune system concentrates many of its protective functions. It exerts both physical and biochemical defenses against invading foodborne pathogens and other hazards. In pigs, the gut microbiota community assembled postnatal plays a very important role in the development of multiple physiologic aspects, such as development of the gastrointestinal tract, nutrient exchange, immune defense against foreign pathogens and growth performance. Microbiome-host communication changes with age. Despite recent advances in understanding the swine gut microbiome at different growth stages, a comprehensive longitudinal study of the lifelong dynamics of the swine gut microbiome is …

Selectivity Of Infrared Heat Treatment On Inactivation Of Mycotoxigenic Fungi On Stored Grain, Shantae A. Wilson

Graduate Theses and Dissertations

Selective Infrared (IR) heating holds great potential to decontaminate spores of unsafe fungi in corn. The objectives for this study were to investigate the impact of exposing corn to infrared energy at selected peak wavelengths (λ), infrared intensities and treatment durations, followed by tempering for further inactivation of microbes on the grain and explore a method for decontaminating Aspergillus flavus (A. flavus) spores on corn. Freshly harvested corn with initial moisture contents (IMCs) of 16%, 20%, and 24% wet basis (w.b.) were used. The corn samples were treated at different infrared wavelengths (3.2, 4.5, and 5.8 μm) for 20, 40 …

Older Adults’ Expectations, And Knowledge Of Oral Health Issues: A Study Of Arkansas Seniors, Virginia Marie Hardgraves

Graduate Theses and Dissertations

The life expectancy of the U. S. population is increasing. The advantages of fluoridated water, dental insurance, greater awareness of preventive oral healthcare measures, and more restorative dental services, have helped this generation of adults maintain their teeth into their advanced years. The demand for oral health care services will be greater and more complex that of previous generations. Challenges for the older adult, and the healthcare system providing for them, are complex. Increasing evidence of a link between oral health and overall health underscores the need to promote public health awareness of the need for dental care to be …

Comprehensive Staff Education And Implementation Of A Checklist Tool To Increase Staff Adherence To Pitocin Titration Protocols, Tara N. Cassell

Electronic Theses and Dissertations

This quality improvement project was designed to increase staff adherence to an existing Pitocin titration protocol used in a labor and delivery unit at a community hospital. In the current U.S. health care climate, safe patient care is paramount and the Institute for Safe Medication Practices identified Pitocin as a high-alert medication. Evidence-based practice recommends the use of a titration protocol to guide proper use of Pitocin. Prior research has shown improvements in patient outcomes when facilities implement Pitocin titration protocols, with staff adherence key to the successful implementation of evidence-based titration protocols, which may be improved with the use …

Unimóvil: A Mobile Health Clinic Providing Primary Care To The Colonias Of The Rio Grande Valley, South Texas, Eron G. Manuosv, Vincent P. Diego, Jacob Smith, Jesus R. Garza Ii, John Lowdermilk, John Blangero, Sarah Williams-Blangero, Francisco Fernandez

School of Medicine Publications

Background: We describe a mobile unit (UniMóvil) designed to improve poor healthcare access delivery to residents in two South Texas underserved Colonias. The interprofessional team measured seven clinical outcomes [obesity, diabetes, hypertension, hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-C) levels, and depression], and using the Duke Health Profile, assessed the health-related quality of life (HrQoL).

Methods: The investigators used previously reported disease prevalence, an implementation model, and community needs-assessments to design an outreach healthcare delivery model. A retrospective review of the cohort provides data used to determine potential predictors of clinical variables, 11 domains of HrQOL, and inter/intra Colonia …

A Phenomenological Investigation Of Women’S Infertility And Miscarriage Grief Experiences, Tristan Mcbain

Dissertations

Infertility and miscarriage are reproductive losses that often produce grief reactions in affected women. This phenomenological study investigated the grief experiences of infertility and miscarriage through the ambiguous loss and disenfranchised grief frameworks in order to better understand both the obscurity of reproductive loss and how the resulting grief may be invalidated.

Sixteen women volunteered to participate in this study and each fell into one of the following three categories: women affected by infertility without miscarriage (4); women affected by miscarriage without infertility (4); and women affected by infertility and miscarriage (8). A phenomenological hermeneutic approach was utilized to uncover …

The Effectiveness Of Selective Serotonin Reuptake Inhibitors For Treatment Of Obsessive-Compulsive Disorder In Adolescents And Children: A Systematic Review And Meta-Analysis, Vijaya P. Kotapati, Ali M. Khan, Sara Dar, Gulshan Begum, Ramya Bachu, Mahwish Adnan, Aarij Zubair, Rizwan A. Ahmed

School of Medicine Publications

Background: Obsessive-compulsive disorder (OCD) is a common behavioral disorder among adolescents and children. The selective serotonin reuptake inhibitors (SSRIs) are the first pharmacological choice for this condition due to mild adverse effect profile.

Objective: This systematic review was performed to evaluate the efficacy of SSRI for OCD in adolescents and children.

Methods: Search terms were entered into PubMed, PsycINFO, Scopus, CINAHL, and Google Scholar. The included studies were randomized, placebo-controlled trials of SSRIs conducted in populations of children and adolescents younger than 18 years. Change from baseline Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS), end-treatment CY-BOCS with respective SD, and response and …

Acute Cardiovascular Response To Low-Load Unilateral, Bilateral, And Alternating Resistance Exercise With Blood Flow Restriction In The Lower Body, Daphney Stanford

Master's Theses

Resistance exercise with blood flow restriction (BFR) has been suggested to exaggerate the exercise pressor response over traditional non-BFR exercise. While applying BFR relative to an individual’s arterial occlusion pressure (AOP) and exercising at low-loads seems to produce a comparable cardiovascular response to traditional moderate or high-load training, it is beneficial to identify modifications for reducing the cardiovascular response to BFR exercise. PURPOSE: To determine if unilateral (UNI), bilateral (BI), or alternating (ALT) exercise modalities elicit different cardiovascular responses during BFR exercise. METHODS: 18 participants (13 male and 5 female) performed four sets of UNI, BI, and ALT knee-extensions at …

The Effect Of Prescribed Burning On Wood-Decay Fungi In The Forests Of Northwest Arkansas, Nawaf Ibrahim Alshammari

Graduate Theses and Dissertations

Prescribed burning is defined as the process of the planned application of fire to a predetermined area under specific environmental conditions in order to achieve a desired outcome such as land management. This project used both morphological and molecular methods to identify and characterize the wood-decay fungi associated with the forests of northwest Arkansas—Pea Ridge National Military Park, Devil’s Den State Park, and the Buffalo National River—through frequent visits made between February 2018 and February 2019. In addition, in order to assess the effects of prescribed burning, incubation chambers were used to compare the growth of fungi from both unburned …

The Impact Of Mother And Adolescent Offspring Distress Reduction Training On Maternal Anxiety And Alcohol Related Behaviors Following Conflict, Sarah Ann Bilsky

Graduate Theses and Dissertations

Nearly half of people suffering from psychopathology meet criteria for more than one disorder. Scholars have focused on understanding factors that may simultaneously maintain multiple psychiatric problems. Elevated distress during interpersonal conflict is likely to maintain both alcohol use and anxiety psychopathology. Reducing distress elicited by normative mother-adolescent conflict holds particular promise. Conflict is common in families with problematic drinking and anxiety disorders and the affective impact of parent-offspring conflict is malleable. Distress reduction skills, such as cognitive reappraisal, are effective in reducing distress during conflict. The current study examined the unique and combined effects of training mothers and adolescents …

How Does Alcohol Intoxication Impair Risk Detection Of Sexual Assault? Testing An Integration Of Alcohol Myopia And Social Information Processing Theories, Alexander James Melkonian

Graduate Theses and Dissertations

Sexual assault among young adults is a highly prevalent public health concern. Alcohol is often implicated as a risk factor for sexual assault through its impairing effects on an individual’s ability to process and respond to social cues in the environment. The effect of alcohol myopia can result in greater focus of attention on salient environmental cues. The relationship between alcohol intoxication and resulting behavior may depend on what type of information is most salient. The current study examined the effects of alcohol on social information processing as it relates to sexual assault risk detection. Method: Participants were 48 young …

Preliminary Outcomes, Acceptability, And Feasibility Of A Brief Crisis Response Planning Intervention For Reducing Suicide Risk In Primary Care Behavioral Health Patients, Aubrey R. Dueweke

Graduate Theses and Dissertations

Primary care is an important setting for improving identification and treatment of people at risk for suicide. However, there are few developed protocols for management of suicide risk in this setting. This study aimed to evaluate the preliminary outcomes, acceptability, and feasibility of a brief crisis response planning intervention for patients at a moderate risk for suicide in a primary care behavioral health (PCBH) setting. The outcomes examined included change in suicidal cognitions, suicidal intent, hope, and coping efficacy. Twenty-two adult primary care patients at moderate risk for suicide participated in this study, which involved filling out self-report measures before …

Dynamics Of Momentary Perceived Self-Regulation Abilities As Novel Predictors Of Overeating In Daily Life, Kayla Dawn Skinner

Graduate Theses and Dissertations

Despite an increase of research in the realm of overeating - a well-known contributor to obesity - the psychological mechanisms that maintain overeating behaviors across time and context are still poorly understood. It may be that people’s perceptions of their self-regulation abilities fluctuate over time, and overeating results from momentary increases in negative mood eliciting negative perceptions of their self-efficacy and current willpower, stronger beliefs that cravings can be controlled and a greater ability to tolerate distress. The current study examined the dynamics of and momentary predictors of overeating using a 7-day EMA protocol to study unsuccessful restrained eaters (n …

Effects Of Multivitamin-Mineral Supplementation On Mental Health Among Young Adults, Ya-Hsuan Chang

Graduate Theses and Dissertations

The percentage of young adults who had mental illnesses has increased from 2008 to 2015. However, few existing studies investigating the potential benefits of multivitamin-mineral (MVM) supplementation on mental health focused on young adults (18-24 years of age), whose eating behaviors are often unhealthy. The purpose of this study was to examine the effects of a MVM supplement on mental health in young adults. One hundred and thirty-three college students (Mage=20.59, SD=1.77; 80.15% female) participated in this randomized, double-blind, placebo-controlled trial. Participants consumed either a MVM supplement or a placebo for 30 days. The supplement contained B Vitamins, Vitamin C, …

The Effects Of Hand Holding On Cancer Patients Level Of Anxiety: A Single-Case Study, West Loveland

Graduate Theses and Dissertations

The purpose of this dissertation was to explore how the anxiety levels of non-Hodgkin’s lymphoma patients receiving chemotherapy are affected while holding hands with a secure attachment. This study utilized three experimental single-case designs: participant one measured under a B-design, participant two measured under a B-A design, and participant three measured under an A-B design. Each participant’s anxiety was assessed during six chemotherapy treatments and one meeting with their primary oncologist to discuss the prognosis of their cancerous disease. Results visually indicate a greater effect on anxiety reduction during treatment when the intervention is utilized compared to only having a …

Tattoo Narratives And Counseling, Danny Lane Mccarty

Graduate Theses and Dissertations

Much research has been done on tattoos and on those who acquire them, but most of the research has focused on negative correlations that might exist with people who have tattoos. This current research, however, showed that people’s tattoo narratives can relate to how they view self, others, and the world, and to how they approach life. A narrative approach to qualitative research was used, and ten people participated in the study. Participants’ views of self, others, and the world were discussed as these views emerged from the narratives. Their possible approaches to life were also addressed. Themes that emerged …

From The Boots On The Ground: A Comparison Of The Attitudes And Beliefs Of Military Members And Mental Health Professionals Regarding The Moral Injury Construct, Karis L. Callaway

Dissertations

An increasing amount of research conducted in recent years indicates that, in addition to Posttraumatic Stress Disorder, moral injury is a key concept to recognize when considering the deployment experiences of service members. Although related to Posttraumatic Stress Disorder, which is a fear-based mental health diagnosis, moral injury is a distinct concept. It acknowledges the possible prolonged negative psychological, social, and spiritual consequences that may occur after experiences that challenge and transgress one’s deeply held moral beliefs. Events such as perpetration of harm, failing to protect or prevent harm, and witnessing or learning about distressing acts committed by influential others …

Association Of Office And Ambulatory Blood Pressure With Mortality And Cardiovascular Outcomes, Wen-Yi Yang, Jesus D. Melgarejo, Lutgarde Thijs, Zhen-Yu Zhang, José Boggia, Fang-Fei Wei, Tine W. Hansen, Kei Asayama, Gladys E. Maestre, Takayoshi Ohkubo

School of Medicine Publications

Importance Blood pressure (BP) is a known risk factor for overall mortality and cardiovascular (CV)-specific fatal and nonfatal outcomes. It is uncertain which BP index is most strongly associated with these outcomes.

Objective To evaluate the association of BP indexes with death and a composite CV event.

Design, Setting, and Participants Longitudinal population-based cohort study of 11 135 adults from Europe, Asia, and South America with baseline observations collected from May 1988 to May 2010 (last follow-ups, August 2006-October 2016).

Exposures Blood pressure measured by an observer or an automated office machine; measured for 24 hours, during the day or …

Periodontal Pathogens Are A Risk Factor Of Oral Cavity Squamous Cell Carcinoma, Independent Of Tobacco And Alcohol And Human Papillomavirus, Ian Ganly, Liying Yang, Rachel Giese, Yuhan Hao, Carlos W. Nossa, Luc G. T. Morris, Matthew Rosenthal, Jocelyn Migliacci, Dervla Kelly, Wenzhi Tseng

School of Medicine Publications

Over the past decade, there has been a change in the epidemiology of oral cavity squamous cell cancer (OC-SCC). Many new cases of OC-SCC lack the recognized risk factors of smoking, alcohol and human papilloma virus. The aim of this study was to determine if the oral microbiome may be associated with OC-SCC in nonsmoking HPV negative patients. We compared the oral microbiome of HPV-negative nonsmoker OC-SCC(n = 18), premalignant lesions(PML) (n = 8) and normal control patients (n = 12). Their oral microbiome was sampled by oral wash and defined by 16S rRNA gene sequencing. We report that the …

Computed Tomography Imaging Findings Of Acute Aortic Pathologies, Elif S. Duran, Farhan Ahmad, Mohamed Elshikh, Irfan Masood, Cihan Duran

School of Medicine Publications

Acute aortic syndromes (AAS) encompass a spectrum of life-threatening conditions characterized by acute aortic pain. AAS include acute aortic dissection, intramural hematoma, penetrating atherosclerotic ulcer, and aneurysm rupture. The prognosis of AAS is clearly related to prompt diagnosis and appropriate management. The different types of AAS cannot be reliably differentiated solely based on clinical presentation since the clinical features are indistinguishable. Multidetector-row computed tomography (MDCT) with electrocardiographic gating (ECG-gated MDCT) has been used in the acute emergency setting as a powerful clinical tool, which enables rapid and specific diagnosis of aortic pathologies. ECG-gated MDCT significantly reduces motion artifact and avoids …