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Himmelfarb Headlines - September/October 2019, George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Headlines (2009 - present)

News and information about Himmelfarb Health Sciences Library of interest to users.

Aca And Medicaid Expansion Associated With Increased Insurance Coverage For Rural Americans With Disabilities, Rtc: Rural, University Of Montana Rural Institute

Health and Wellness

This fact sheet explores insurance rate changes associated with the Affordable Care Act (ACA) and Medicaid expansion on insurance coverage for rural and urban people with and without disabilities. Following the implementation of the ACA, rural people with disabilities had the greatest gains in insurance coverage. Rural people with disabilities in Medicaid expansion states saw a 10.7% increase in insurance coverage, compared to a 5.3% increase for those in non-expansion states. The loss of the ACA and Medicaid expansion could hurt rural people with disabilities more than their urban counterparts, or those without disabilities.

Body Mass Index (Bmi) And Healthcare Utilization Among Us Adults With Asthma In 2016, Saleh Khateeb

Annual SHSP Student Research and Scholarship Day

No abstract provided.

Δ9-Tetrahydrocannabinol Derivative-Loaded Nanoformulation Lowers Intraocular Pressure In Normotensive Rabbits, Pranjal S. Taskar, Akash Patil, Prit Lakhani, Eman Ashour, Waseem Gul, Mahmoud A. Elsohly, Brian Murphy, Soumyajit Majumdar

Faculty and Student Publications

No abstract provided.

College Of Health Sciences E-Newsletter, September 2019, Irvin B. Harrell (Editor)

Ellmer College of Health Sciences Newsletters

September 2019 issue of Old Dominion University's College of Health Sciences Newsletter.

Adaptation Of The Systematic Review Framework To The Assessment Of Toxicological Test Methods: Challenges And Lessons Learned With The Zebrafish Embryotoxicity Test, Martin L. Stephens, Sevcan Gül Akgün-Ölmez, Sebastian Hoffman, Rob De Vries, Burkhard Flick, Thomas Hartung, Manoj Lalu, Alexandra Maertens, Hilda Witters, Robert Wright, Katya Tsaioun

Toxicology and Animal Models in Research Collection

Systematic review methodology is a means of addressing specific questions through structured, consistent, and transparent examinations of the relevant scientific evidence. This methodology has been used to advantage in clinical medicine, and is being adapted for use in other disciplines. Although some applications to toxicology have been explored, especially for hazard identification, the present preparatory study is, to our knowledge, the first attempt to adapt it to the assessment of toxicological test methods. As our test case, we chose the zebrafish embryotoxicity test (ZET) for developmental toxicity and its mammalian counterpart, the standard mammalian prenatal development toxicity study, focusing the …

Breast Cancer Detection Using Photoacoustic Imaging, Luma W. Jameel

Al-Nisour Journal for Medical Sciences

This work is about a tumor detection using photoacoustic technique, the photoacoustic waves generation and detection in tissue phantom (liver in chicken breast) which used to representing the real tissue. The one dimensional photoacoustic signal was generated using Nd:YAG laser, detected using piezoelectric detector and displayed on a storage oscilloscope, the experimental work is done at Different depth, thickness and the distance to the detector for several phantoms and different laser energy 250,400 and 500 mJ.

Evaluation The Effect Of Different Thicknesses Core On The Micro-Hardness Of Zirconia Ceramic Material, Nawras Adnan Mohammed, Ihab Naffea Yasse

Al-Nisour Journal for Medical Sciences

All-ceramics have been increasingly used in prosthetic dentistry to fabricate a wide variety of restorations]1[ The most recently core materials are the yttrium oxide partially stabilized zirconia (Y-TZP), were found as a new material for all dental ceramic restorations Partially stabilized yttria tetragonal zirconia polycrystalline (Y-TZP) ceramics are a relatively new class of dental ceramics introduced to the market. that are made into blanks and milled to the favorite dimensions using the CAD/CAM (Computer Aided Design/Computer Aided Manufacturing) technology. Objective: To evaluate the effect of different thicknesses on the hardness of disks fabricated by the yttrium oxide partially stabilized zirconia …

Phenotype And Genotype Of Virulence Factors In Escherichia Coli Isolated From Different Clinical Samples, Nihad Khalawe Tektook, Mohammed Flayyih Tareef, Eptissam Younan Pirko

Al-Nisour Journal for Medical Sciences

Escherichia coli is the principal causative agent of most infection of bacterial origin, and extraintestinal pathogenic E. coli (ExPEC) is responsible for 80% of infections of urinary tract in human bieng. The aim of this work was to study the distribution of some virulence factors of Escherichia coli in different type of human samples. This study was carried out in Baghdad cityIraq from January to June 2019, included 70 clinical samples (Blood, Urine and Wound samples) with positive culture for E. coli. Each sample was managed bacteriologically to isolate causative bacteria as mentioned in standard systems of bacteriology Lab. The …

Reliability And Validity Measurement Issues: Nothing New To Clinical Nurse Specialists; But Liability Issues Too?, Ann Mayo Rn, Dnsc, Faan

School of Nursing and Health Science: Faculty Scholarship

Reliability and validity measurement issues are nothing new to clinical nurse specialists (CNS). Over the years, this journal has published a plethora of articles addressing measurement, and as students, CNSs were educated programs about the importance of reliability and validity as applied to instrument selection, usage and interpretation of scores. As a result, healthcare organizations know that their CNSs are the go-to professionals when a process or outcome needs to be measured. A recent announcement from the Montreal Cognitive Assessment (MoCA) Clinic and Institute demonstrated the importance of liability as a third element to be considered when selecting and using …

Using The General Social Survey - National Death Index Cohort To Study The Relationship Between Neighbourhood Fear And Mortality In The Usa, Erin Grinshteyn, Peter Muennig, Roman Pabayo

Nursing and Health Professions Faculty Research and Publications

Objectives Fear of crime is associated with adverse mental health outcomes and reduced social interaction independent of crime. Because mental health and social interactions are associated with poor physical health, fear of crime may also be associated with death. The main objective is to determine whether neighbourhood fear is associated with time to death. Setting and participants Data from the 1978–2008 General Social Survey were linked to mortality data using the National Death Index (GSS-NDI) (n=20 297). Methods GSS-NDI data were analysed to assess the relationship between fear of crime at baseline and time to death among adults after removing …

Territorial And Trans-Territorial Community-Institutional Partnerships To Build Healthier Communities In Developing Countries: Lessons Learned From A Dominican Republic Low-Resource Community, Arelis Moore De Peralta, Emily Schultz, Katherine Brown, N. Suzanne Falconer

Publications

This descriptive case study examines the value of multi-level partnerships to foster a Building a Healthier Community (BHC) process in a low-resource community in the Dominican Republic. Partnerships developed for this BHC project were categorized under the Global Health Education Framework. Partners included a U.S-based university (trans-territorial partnership), a Dominican university, and various governmental, non-governmental, and community organizations in the Dominican Republic (territorial partnerships). Las Malvinas BHC project is an interdisciplinary and holistic approach to community health and well-being improvement that supports community members’ efforts and at the same time promotes participating students’ global health competence. Strategies, methods, the value …

Novel Targeting Approaches Of Nanoparticles For Anticancers Drug Delivery: A Focused Review, Yatri S. Patel, Nandita Das, Sudip Das

Scholarship and Professional Work – COPHS

Nanoparticles have presented a new paradigm in anticancer drug delivery to reduce adverse effects and improve therapeutic outcomes. Nanoparticle surface properties and morphology significantly affect the drug delivery to tumors while passive targeting. Conjugations with hyaluronic acid, transferrin and aptamers have shown to be effective in active targeting of anticancer drugs to tumor tissues. This review presents an overview of some credible techniques of passive and active drug delivery to tumors.

Asthma Exacerbation Trajectories And Their Predictors In Children With Incident Asthma., Sharifa Nasreen, Piotr Wilk, Tara Mullowney, Igor Karp

Paediatrics Publications

BACKGROUND:
Asthma exacerbation trajectories in children after incident asthma diagnosis are understudied.

OBJECTIVE:
To identify trajectories of asthma exacerbation and predictors of these trajectories in children with incident asthma.

METHODS:
Children from the National Longitudinal Survey of Children and Youth, Canada, with incident asthma were followed-up for up to 12 years during childhood. Latent class growth modeling was used to identify distinct asthma exacerbation trajectory groups. Multinomial logistic regression was performed to identify predictors of trajectory group membership.

RESULTS:
The mean age at asthma diagnosis among 403 children was 5.9 years. Three distinct trajectories were identified: low increasing (21.3% of …

Eliminating The Effects Of Motion During Radiofrequency Lesion Delivery Using A Novel Contact-Force Controller., Daniel Gelman, Allan C Skanes, Douglas L Jones, Michael Timofeyev, Tal Bar-On, Maria Drangova

Medical Biophysics Publications

INTRODUCTION: Catheter-tissue contact force is a determinant of radiofrequency (RF) ablation lesion effectiveness. However, ablation on a beating heart is subject to force variability, making it difficult to optimally deliver consistently durable and transmural lesions. This work evaluates improvements in contact force stability and lesion reproducibility by using a catheter contact-force controller (CFC) during lesion delivery in vitro and in vivo.

METHODS AND RESULTS: Using a sheath and force-sensing catheter, an experienced operator attempted to maintain a constant force of 20 g at targets within the atria and left ventricle of a pig manually and using the CFC; the average …

Development Of A Stand-Alone Dcs System For Monitoring Absolute Cerebral Blood Flow, Mahro Khalid, Daniel Milej, Ajay Rajaram, Androu Abdalmalak, Laura Morrison, Mamadou Diop, Keith S.T. Lawrence

Medical Biophysics Publications

© 2019 Optical Society of America. Diffuse correlation spectroscopy (DCS) is a noninvasive optical technique for monitoring cerebral blood flow (CBF). This work presents a stand-alone DCS system capable of monitoring absolute CBF by incorporating a quantitative dynamic contrast-enhanced (DCE) technique. Multi-distance data were acquired to measure the tissue optical properties and to perform DCE experiments. Feasibility of the technique was assessed in piglets in which the optical properties were measured independently by time-resolved near-infrared spectroscopy. A strong linear correlation was observed between CBF values derived using the two sets of optical properties, demonstrating that this hybrid DCS approach can …

Evaluation Of Hyperspectral Nirs For Quantitative Measurements Of Tissue Oxygen Saturation By Comparison To Time-Resolved Nirs, Matthew Kewin, Ajay Rajaram, Daniel Milej, Androu Abdalmalak, Laura Morrison, Mamadou Diop, Keith St Lawrence

Medical Biophysics Publications

© 2019 Optical Society of America. Near-infrared spectroscopy (NIRS) is considered ideal for brain monitoring during preterm infancy because it is non-invasive and provides a continuous measure of tissue oxygen saturation (StO2). Hyperspectral NIRS (HS NIRS) is an inexpensive, quantitative modality that can measure tissue optical properties and oxygen saturation (StO2) by differential spectroscopy. In this study, experiments were conducted using newborn piglets to measure StO2 across a range of oxygenation levels from hyperoxia to hypoxia by HS and time-resolved (TR) NIRS for validation. A strong correlation between StO2 measurements from the two techniques was observed (R2 = 0.98, average …

Performance Of Qct-Derived Scapula Finite Element Models In Predicting Local Displacements Using Digital Volume Correlation, Jonathan Kusins, Nikolas Knowles, Melissa Ryan, Enrico Dall'ara, Louis Ferreira

Bone and Joint Institute

© 2019 Subject-specific finite element models (FEMs)of the shoulder complex are commonly used to predict differences in internal load distribution due to injury, treatment or disease. However, these models rely on various underlying assumptions, and although experimental validation is warranted, it is difficult to obtain and often not performed. The goal of the current study was to quantify the accuracy of local displacements predicted by subject-specific QCT-based FEMs of the scapula, compared to experimental measurements obtained by combining digital volume correlation (DVC)and mechanical loading of cadaveric specimens within a microCT scanner. Four cadaveric specimens were loaded within a microCT scanner …

Stimulus-Locked Responses On Human Upper Limb Muscles And Corrective Reaches Are Preferentially Evoked By Low Spatial Frequencies, Rebecca A. Kozak, Philipp Kreyenmeier, Chao Gu, Kevin Johnston, Brian D. Corneil

Brain and Mind Institute Researchers' Publications

© 2019 Kozak et al. In situations requiring immediate action, humans can generate visually-guided responses at remarkably short latencies. Here, to better understand the visual attributes that best evoke such rapid responses, we recorded upper limb muscle activity while participants performed visually-guided reaches towards Gabor patches composed of differing spatial frequencies (SFs). We studied reaches initiated from a stable posture (experiment 1, a static condition), or during on-line reach corrections to an abruptly displaced target (experiment 2, a dynamic condition). In both experiments, we detail the latency and prevalence of stimulus-locked responses (SLRs), which are brief bursts of EMG activity …

Thirty-Five Years Of Computerized Cognitive Assessment Of Aging — Where Are We Now?, Avital Sternin, Alistair Burns, Adrian M. Owen

Brain and Mind Institute Researchers' Publications

Over the past 35 years, the proliferation of technology and the advent of the internet have resulted in many reliable and easy to administer batteries for assessing cognitive function. These approaches have great potential for affecting how the health care system monitors and screens for cognitive changes in the aging population. Here, we review these new technologies with a specific emphasis on what they offer over and above traditional ‘paper-and-pencil’ approaches to assessing cognitive function. Key advantages include fully automated administration and scoring, the interpretation of individual scores within the context of thousands of normative data points, the inclusion of …

Walking For Health During Pregnancy: A Literature Review And Considerations For Future Research, Christopher P. Connelly, Scott A. Conger, Alexander H.K. Montoye, Mallory R. Marshall, Rebecca A. Schlaff, Sylvia E. Badon, James M. Pivarnik

Kinesiology Faculty Publications and Presentations

Walking is the most commonly chosen type of physical activity (PA) during pregnancy and provides several health benefits to both mother and child. National initiatives have promoted the importance of walking in general, but little emphasis is directed toward pregnant women, the majority of whom are insufficiently active. Pregnant women face a variety of dynamic barriers to a physically active lifestyle, some of which are more commonly experienced during specific times throughout the pregnancy experience. Walking is unique in that it appears resistant to a number of these barriers that limit other types of PA participation, and it can be …

Himmelfarb Library Liaison Letter - September 2019, The George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Library Liaison Letters

No abstract provided.

Bourbon Virus In Wild And Domestic Animals, Missouri, Usa, 2012–2013, Katelin C. Jackson, Thomas Gidlewski, J. Jeffrey Root, Angela M. Bosco-Lauth, R. Ryan Lash, Jessica R. Harmon, Aaron C. Brault, Nicholas A. Panella, William L. Nicholson, Nicholas Komar

United States Department of Agriculture Wildlife Services: Staff Publications

Bourbon virus (BRBV) was first isolated from a febrile patient with a history of tick bites in Bourbon County, Kansas, USA; the patient later died from severe illness in 2014 (1). Several additional human BRBV infections were reported subsequently from the midwestern and southern United States (2). BRBV belongs to the family Orthomyxoviridae, genus Thogotovirus, which is distributed worldwide and includes Araguari, Aransas Bay, Dhori, Jos, Thogoto, and Upolu viruses (1,3). Thogoto and Dhori viruses have been associated with human disease (4–6). Viruses within the genus Thogotovirus have been associated with hard or soft ticks (7). Recent studies suggest that …

Using Community-Engaged Research To Explore Social Determinants Of Health In A Low-Resource Community In The Dominican Republic: A Community Health Assessment, Arelis Moore De Peralta, Lauren Davis, Katherine Brown, Michelle Fuentes, Suzanne Falconer, Jenneil Charles, Michelle Eichinger

Publications

Introduction:

Previously published community health assessments (CHA) have explored social determinants of health in low-resource, Haitian-majority Dominican communities. The present CHA was conducted in Las Malvinas II, a Dominican-majority low-resource community, and represented a first step for developing a building a healthier community process.

Method:

A binational community–academic partnership adapted the Centers for Disease Control and Prevention’s CHANGE (Community Health Assessment and Group Evaluation) guide to conduct a CHA through community-engaged, mixed-methods research. Data were collected on five community selected public health priorities (i.e., education, sanitation, unwanted pregnancies, chronic disease management, and vaccine-preventable diseases) and community assets through focus groups, …

Knowledge Of Cytomegalic Inclusion Disease Among A Sample Of Pregnant Women In Baghdad City/Iraq, Ishraq Ahmed Chiad, Adel Amen Hama

Al-Nisour Journal for Medical Sciences

Background: Cytomegalovirus is a common virus that can cause disease in infant's whose mothers are infected with Cytomegalovirus during pregnancy. Objective: To determine knowledge of pregnant women regarding Cytomegalic inclusion disease. Subjects and methods: A cross sectional study was carried out in Baghdad City / Iraq, during the period started from the November 2017 to November 2018. Four primary health care centers randomly selected, and data were obtained by direct interview with the pregnant women by using detailed self- reporting questionnaire. Results: The demographic data was conducted on 360 pregnant women with the age group ranging from 16 to 46 …

Association Between The Infection By Cytomegalovirus (Cmv) With Acute And Chronic Toxoplasmosis Among Random Sample Of Aborted Women At Baghdad Province, Salah Mehdi Hassan, Amany M. Al-Kaysi, Amal Kamel

Al-Nisour Journal for Medical Sciences

This study was carried out during the periods from September 2017 to march 2018 in laboratories Department of different hospitals /Baghdad Teaching Hospital, and Abn-Abalady hospital in 70 women ages ranged from 20 year to 33 years .Bio-ELISA immuno-enzymatic assay was used for Cytomegalovirus Ab sera Immunoassay for the detection of Toxoplasma antibodies IgG and IgM also were carried out to all samples included.The results showed No significant differences between age group studied in pregnant and non-pregnant women in all sample studied and recoded that 25(46.3%) out of 34(63%) of pregnant women studied had Toxo-IgG antibodies and pregnant women who …

Surgical Configurations Of The Pectoralis Major Flap For Reconstruction Of Sternoclavicular Defects: A Systematic Review And New Classification Of Described Techniques, Jude Opoku-Agyeman, David Matera, Jamee Simone

Plastic Surgery Resident Research

The pectoralis major flap has been considered the workhorse flap for chest and sternoclavicular defect reconstruction. There have been many configurations of the pectoralis major flap reported in the literature for use in reconstruction sternoclavicular defects either involving bone, soft tissue elements, or both. This study reviews the different configurations of the pectoralis major flap for sternoclavicular defect reconstruction and provides the first ever classification for these techniques. We also provide an algorithm for the selection of these flap variants for sternoclavicular defect reconstruction.

METHODS:

EMBASE, Cochrane library, Ovid medicine and PubMed databases were searched from its inception to August …

Trends In Well-Being In Nonmetropolitan Nebraska: Nebraska Rural Poll Research Report 19-3, Rebecca Vogt, Cheryl Burkhart-Kriesel, Randolph Cantrell, Bradley Lubben, Timothy Meyer, Jason L. Weigle

Rural Futures Institute: Publications

Nebraska’s economy remained strong in the beginning of 2019. However, the continued weakness of the agriculture sector had the possibility of hampering the state’s economic growth. In addition, the March flooding had the potential for negative economic effects. Given these challenges, how do rural Nebraskans feel about their community? Are they satisfied with the services provided by their community? How do rural Nebraskans believe they are doing and how do they view their future? How satisfied are they with various items that influence their well-being? Have these views changed over the past 24 years? This paper provides a detailed analysis …

Phase 1 Trial Of Fruquintinib In Patients With Advanced Solid Tumors: Results Of The Dose Escalation Phase., A Wang-Gillam, H Park, H Yeckes-Rodin, Thomas Stanton, M Kosmo, S Fan, N Sauter, M Kanie

Articles, Abstracts, and Reports

Background: Fruquintinib (Fruq) is a potent, highly selective, novel vascular endothelial growth factor receptor (VEGFR) -1, -2, and -3 tyrosine kinase inhibitor. In the Phase III FRESCO trial¹ that led to the drug approval in China, Fruq improved the median overall survival in patients with metastatic colorectal cancer (mCRC) in the third line or later setting when compared to placebo (9.3 vs 6.6 months); hazard ratio 0.65 (95% CI, 0.51-0.83; P < .001),

Methods: This is a Phase 1 open-label, dose escalation/dose expansion study conducted in the US (NCT03251378). The primary objectives are to evaluate the safety and tolerability of Fruq …

Gbs With Non-Hodgkin Lymphoma, A Rarity, Javaria Munir, Umer Aziz Qazi

Pakistan Journal of Neurological Sciences (PJNS)

Patients of Non-Hodgkin’s lymphomas may develop neurological signs and symptoms. This case is of a 76 year old male recently diagnosed with Non-Hodgkin’s lymphoma and on chemotherapy who presented with sudden bilateral leg weakness and inability to walk. The signs and symptoms, neurological examinations and Nerve conduction studies revealed a polyneuropathy which was consistent with Guillain-Barré syndrome (GBS). This has been seen in patients with Hodgkin's lymphoma but is rare in NHL.