Medicine and Health Sciences Commons^™

Global Higher Education: Challenges And Opportunities, Simon Marginson

HUCBMS: Heads of University Centres of Biomedical Sciences

No abstract provided.

Tu Dublin- Ireland's First Technological University: A New Approach To Higher Education, David Fitzpatrick

HUCBMS: Heads of University Centres of Biomedical Sciences

No abstract provided.

Chemical Epitope Targeting: Review Of A Novel Screening Technology, Qurrat Ul-Ain, Rene Kandler, Dylan Gillespie, Arundhati Nag

Scholarly Undergraduate Research Journal at Clark (SURJ)

Chemical Epitope Targeting is a novel technology developed for designing peptide ligands with high affinity and specificity against specific regions of a protein that may be inaccessible to small molecules or antibodies. In this review, we summarize the key steps and significant applications of this technology. Operating on the same principles as antibody-antigen interactions, this technique involves chemically synthesizing the region of interest on the protein, called the epitope, as a polypeptide with a biotin detection tag and a strategically placed alkyne or azide presenting amino acid. The constructed epitope is screened against a comprehensive linear or cyclic One Bead …

Geriatric Hepatology: The Hepatic Diseases Of The Elderly And Liver Transplant, Shima Ghavimi, Hamed Azimi, Neel Patel, Oleg Shulik

Internal Medicine

Introduction: With the aging US population, chronic liver diseases are becoming more commonly diagnosed in the geriatric population. Advanced age leads to changes in liver blood flow, volume, morphology and normal physiology. This predisposes elderly patients to develop certain chronic liver diseases. Also, the clinical course and management differ in an older patient when compared to a younger patient. Some causes of chronic liver disease in the geriatric population include Hepatitis A, B, C, Non-Alcoholic Fatty liver disease, prolonged alcohol use and inflammation. Many chronic liver diseases are characterized by a slow, indolent course of progression with non-specific symptoms and …

Effect Of Aquatic Exercise On Fatigue, Fitness, Arm Edema, Levels Of Distress, And Quality Of Life Among Breast Cancer Survivors, Ellen Broach, Phillip Norrell

International Journal of Aquatic Research and Education

The purpose of this study was to evaluate the effect of a recreational therapy aquatic intervention on physical and psychosocial performance of breast cancer survivors. Eligible participants were assigned to either a water exercise group or a control group who received standard care treatment for breast cancer. The intervention group attended aquatic exercise sessions three times per week for eight weeks in a heated outdoor pool. Sessions lasted 50 minutes in duration. The aquatic exercise group significantly improved their endurance, body mass, level of distress, and total score for fatigue. No significant differences occurred in the control group. Social validity …

Effects Of 6 Months Of Exercise-Based Cardiac Rehabilitation On Autonomic Function And Neuro-Cardiovascular Stress Reactivity In Coronary Artery Disease Patients, Mark B. Badrov, Katelyn N. Wood, Sophie Lalande, Carolyn P. Sawicki, Lindsay J. Borrell, Carly C. Barron, Jennifer L. Vording, Arlene Fleischhauer, Neville Suskin, Cheri L. Mcgowan, J. Kevin Shoemaker

Bone and Joint Institute

Background Autonomic dysregulation represents a hallmark of coronary artery disease (CAD). Therefore, we investigated the effects of exercise-based cardiac rehabilitation (CR) on autonomic function and neuro-cardiovascular stress reactivity in CAD patients. Methods and Results Twenty-two CAD patients (4 women; 62±8 years) were studied before and following 6 months of aerobic- and resistance-training-based CR. Twenty-two similarly aged, healthy individuals (CTRL; 7 women; 62±11 years) served as controls. We measured blood pressure, muscle sympathetic nerve activity, heart rate, heart rate variability (linear and nonlinear), and cardiovagal (sequence method) and sympathetic (linear relationship between burst incidence and diastolic blood pressure) baroreflex sensitivity during …

Management And Outcomes Of Gastrointestinal Congenital Anomalies In Low, Middle And High Income Countries: Protocol For A Multicentre, International, Prospective Cohort Study, Naomi Jane Wright, Andrew Leather, Nick Sevdalis, Niyi Ade-Ajayi, Adesoji O. Ademuyiwa, Emmanuel A. Ameh, Justine Davies, Kokila Lakhoo, Samuel Parker, Muhammad Arshad

Section of Paediatric Surgery

Introduction: Congenital anomalies are the fifth leading cause of death in children globally, contributing an estimated half a million deaths per year. Very limited literature exists from low and middle income countries (LMICs) where most of these deaths occur. The Global PaedSurg Research Collaboration aims to undertake the first multicentre, international, prospective cohort study of a selection of common congenital anomalies comparing management and outcomes between low, middle and high income countries (HICs) globally.
Methods and Analysis: The Global PaedSurg Research Collaboration consists of surgeons, paediatricians, anaesthetists and allied healthcare professionals involved in the surgical care of children globally. Collaborators …

Preliminary Observations On Soluble Programmed Cell Death Protein-1 As A Prognostic And Predictive Biomarker In Patients With Metastatic Melanoma Treated With Patient-Specific Autologous Vaccines., Robert O Dillman, Gabriel I Nistor, Bryce T Mclelland, Candace Hsieh, Aleksandra J Poole, Andrew N Cornforth, Hans S Keirstead

Articles, Abstracts, and Reports

Because of its role as an immune checkpoint, levels of soluble programmed cell death protein-1 (sPD-1) could be useful as a prognostic biomarker or predictive biomarker in cancer patients treated with vaccines. Very low levels of sPD-1 may indicate lack of an existing anti-cancer immune response; very high levels may indicate an active immune response that is suppressed. In between these extremes, a decrease in PD-1 following injections of an anti-cancer vaccine may indicate an enhanced immune response that has not been suppressed. Blood samples obtained during a randomized trial in patients with metastatic melanoma were tested from 22 patients …

Fatty Acid Metabolites Combine With Reduced Β Oxidation To Activate Th17 Inflammation In Human Type 2 Diabetes, Dequina A. Nicholas, Elizabeth A. Proctor, Madhur Agrawal, Anna C. Belkina, James M. Van Nostrand, Leena Panneerseelan-Bharath, Albert R. Jones Iv, Forum Raval, Blanche C. Ip, Min Zhu, Jose M. Cacicedo, Chloe Habib, Nestor Sanez-Rueda, Leah Persky, Patrick G. Sullivan, Barbara E. Corkey, Caroline M. Apovian, Philip A. Kern, Douglas A. Lauffenburger, Barbara S. Nikolajczyk

Clinical and Translational Science Faculty Publications

Mechanisms that regulate metabolites and downstream energy generation are key determinants of T cell cytokine production, but the processes underlying the Th17 profile that predicts the metabolic status of people with obesity are untested. Th17 function requires fatty acid uptake, and our new data show that blockade of CPT1A inhibits Th17-associated cytokine production by cells from people with type 2 diabetes (T2D). A low CACT:CPT1A ratio in immune cells from T2D subjects indicates altered mitochondrial function and coincides with the preference of these cells to generate ATP through glycolysis rather than fatty acid oxidation. However, glycolysis was not critical for …

Perceptions And Motivation Toward Water Safety And Aquatic Activities In College Students, Jorge Olaves, Ezzeldin R. Aly, Asherah N. B. Allen, Maria Okeke

International Journal of Aquatic Research and Education

As individuals reach adulthood there is a substantial reduction of participation in physical activities. Quality instruction in various physical activities, more specifically aquatics, are beneficial to an individual’s health and career. This current study examined college student’s perceptions and motivations towards the impact of aquatic instruction and water safety skills. Participants included 265 college students between the ages of 19 and 30 years old (n = 147 males, n = 118 females), enrolled in aquatic-related courses at two Historically Black Colleges and Universities (HBCUs). Researchers used a mixed-method approach where the findings indicated that 72% of the participants reported the …

Steenbergen, Joel (Fa 1325), Manuscripts & Folklife Archives

Folklife Archives Finding Aids

Finding aid and full-text scan of paper (Click on “Additional Files” below) for Folklife Archives Project 1325. Student folk studies project titled “Ginseng: The Wonder of the World,” about the history and folklore of ginseng in the United States, its uses, the harvesting process and tools.

Learning Experiences Within Infectious Diseases Pharmacy Residency Programs In The United States: A Cross-Sectional Survey, Jonathan C. Cho, Matthew P. Crotty, Wesley D. Kufel, Elias B. Chahine, Amelia K. Sofjan, Jason C. Gallagher, Sandy J. Estrada

Pharmacy Faculty Publications and Presentations

Background: Pharmacists with residency training in infectious diseases (ID) optimize antimicrobial therapy outcomes in patients and support antimicrobial stewardship (AS) programs. Although most ID residencies are accredited and assessed by certain standards, the degree to which these programs are similar is not known. Methods: A 19-item, cross-sectional, multicentered, electronic survey was distributed via e-mail to pharmacy residency program directors (RPDs) of all 101 second-year postgraduate (PGY-2) ID residency programs in the United States. Results: Survey responses were collected from 71 RPDs (70.3%); 64.8% were associated with an academic medical center and 97.2% focused primarily in adult ID. Rotations in the …

A "Human Knockout" Model To Investigate The Influence Of The Α-Actinin-3 Protein On Exercise-Induced Mitochondrial Adaptations, I. D. Papadimitriou, N. Eynon, X. Yan, F. Munson, M. Jacques, J. Kuang, S. Voisin, K. N. North, David Bishop

Research outputs 2014 to 2021

Research in α-actinin-3 knockout mice suggests a novel role for α-actinin-3 as a mediator of cell signalling. We took advantage of naturally-occurring human "knockouts" (lacking α-actinin-3 protein) to investigate the consequences of α-actinin-3 deficiency on exercise-induced changes in mitochondrial-related genes and proteins, as well as endurance training adaptations. At baseline, we observed a compensatory increase of α-actinin-2 protein in ACTN3 XX (α-actinin-3 deficient; n = 18) vs ACTN3 RR (expressing α-actinin-3; n = 19) participants but no differences between genotypes for markers of aerobic fitness or mitochondrial content and function. There was a main effect of genotype, without an interaction, …

Ormeloxifene Nanotherapy For Cervical Cancer Treatment, Neeraj Chauhan, Diane M. Maher, Bilal B. Hafeez, Hassan Mandil, Man M. Singh, Murali M. Yallapu, Meena Jaggi, Subhash C. Chauhan

School of Medicine Publications

Background: Cervical cancer (CxCa) ranks as the fourth most prevalent women-related cancer worldwide. Therefore, there is a crucial need to develop newer treatment modalities. Ormeloxifene (ORM) is a non-steroidal, selective estrogen receptor modulator (SERM) that is used as an oral contraceptive in humans. Recent investigations suggest that ORM exhibits potent anti-cancer activity against various types of cancers. Nanoparticulates offer targeted delivery of anti-cancer drugs with minimal toxicity and promise newer approaches for cancer diagnosis and treatment. Therefore, the nanotherapy approach is superior compared to traditional chemotherapy, which is not site-specific and is often associated with various side effects.

Methods: Pursuing …

Identification Of Monocyte-Like Precursors Of Granulocytes In Cancer As A Mechanism For Accumulation Of Pmn-Mdscs., Jérôme Mastio, Thomas Condamine, George Dominguez, Andrew V Kossenkov, Laxminarasimha Donthireddy, Filippo Veglia, Cindy Lin, Fang Wang, Shuyu Fu, Jie Zhou, Patrick Viatour, Sergio Lavilla-Alonso, Alexander T. Polo, Evgenii N. Tcyganov, Charles Mulligan, Brian Nam, Joseph Bennett, Gregory Masters, Michael Guarino, Amit Kumar, Yulia Nefedova, Robert H. Vonderheide, Lucia R. Languino, Scott I. Abrams, Dmitry I. Gabrilovich

Department of Cancer Biology Faculty Papers

We have identified a precursor that differentiates into granulocytes in vitro and in vivo yet belongs to the monocytic lineage. We have termed these cells monocyte-like precursors of granulocytes (MLPGs). Under steady state conditions, MLPGs were absent in the spleen and barely detectable in the bone marrow (BM). In contrast, these cells significantly expanded in tumor-bearing mice and differentiated to polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs). Selective depletion of monocytic cells had no effect on the number of granulocytes in naive mice but decreased the population of PMN-MDSCs in tumor-bearing mice by 50%. The expansion of MLPGs was found to be …

Ada News - 09/02/2019, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Parent Supervision Attributes Profile Questionnaire (Psapq) For Young Children: Psychometric Properties Of The Chinese Version, Jun Yang, Shih-Yu Lee, Yuqiu Zhou, Yuxia Cui, Yongkui Han, Hongling Song, Hui Zhang

Nursing Faculty Publications and Presentations

Background: In China, thousands of children die from unintentional injury each year: the incidence rate of injury is from 19.4 to 64.3% which is the leading cause of mortality for children. An important factor to injury may be inadequate supervision. Thus, a linguistic and culturally appropriated, validated instrument to measure the supervision of children in Chinese primary caregiver is important and necessary. The purpose of this study was to translate and test the psychometric properties of the Chinese version of the Parent Supervision Attributes Profile Questionnaire (C-PSAPQ). Methods: This is a two-phase study. In phase I, the C-PSAPQ was produced …

Smoke-Free Policies And Smoking Cessation In The United States, 2003–2015, Andrea R. Titus, Lucie Kalousova, Rafael Meza, David T. Levy, Jim Thrasher, Michael R. Elliott, Paula M. Lantz, Nancy L. Fleischer

Faculty Publications

(1) Background: Smoking restrictions have been shown to be associated with reduced smoking, but there are a number of gaps in the literature surrounding the relationship between smoke-free policies and cessation, including the extent to which this association may be modified by sociodemographic characteristics. (2) Methods: We analyzed data from the Tobacco Use Supplement to the Current Population Survey, 2003–2015, to explore whether multiple measures of smoking restrictions were associated with cessation across population subgroups. We examined area-based measures of exposure to smoke-free laws, as well as self-reported exposure to workplace smoke-free policies. We used age-stratified, fixed effects logistic regression …

Surgical Stress And Cancer Progression: The Twisted Tango., Zhiwei Chen, Peidong Zhang, Ya Xu, Jiahui Yan, Zixuan Liu, Wayne Bond Lau, Bonnie Lau, Ying Li, Xia Zhao, Yuquan Wei, Shengtao Zhou

Department of Emergency Medicine Faculty Papers

Surgical resection is an important avenue for cancer treatment, which, in most cases, can effectively alleviate the patient symptoms. However, accumulating evidence has documented that surgical resection potentially enhances metastatic seeding of tumor cells. In this review, we revisit the literature on surgical stress, and outline the mechanisms by which surgical stress, including ischemia/reperfusion injury, activation of sympathetic nervous system, inflammation, systemically hypercoagulable state, immune suppression and effects of anesthetic agents, promotes tumor metastasis. We also propose preventive strategies or resolution of tumor metastasis caused by surgical stress.

A Case Of Essential Thrombocythemia And Iga Nephropathy With Literature Review Of The Concurrence., Shoja Rahimian, Timothy Johnson, Ronald Herb

Reading Hospital Internal Medicine Residency

Myeloproliferative neoplasms such as essential thrombocythemia (ET) have been associated with glomerular disease on rare instances. A case of ET associated with immunoglobulin A nephropathy (IgAN) is described in a 57-year-old man with a history of hypertension. Progressively worsening renal function was noted in the patient along with unexplained mild thrombocytosis. Pathological review of renal biopsy identified IgAN concurrently with newly diagnosed JAK2-mutated ET. The patient was started on aspirin therapy and closely monitored for his renal function. A literature review of the association of ET and renal disease revealed nine cases of ET associated with IgAN, focal segmental glomerulosclerosis, …

Comparative Genomic Analysis Of Six Glossina Genomes, Vectors Of African Trypanosomes, Geoffrey M. Attardo, Adly M.M. Abd-Alla, Alvaro Acosta-Serrano, James E. Allen, Rosemary Bateta, Joshua B. Benoit, Kostas Bourtzis, Jelle Caers, Guy Caljon, Mikkel B. Christensen, David W. Farrow, Markus Friedrich, Aurélie Hua-Van, Emily C. Jennings, Denis M. Larkin, Daniel Lawson, Michael J. Lehane, Vasileios P. Lenis, Ernesto Lowy-Gallego, Rosaline W. Macharia, Anna R. Malacrida, Heather G. Marco, Daniel Masiga, Gareth L. Maslen, Irina Matetovici, Richard P. Meisel, Irene Meki, Veronika Michalkova

All Peer-Reviewed Publications

Background: Tsetse flies (Glossina sp.) are the vectors of human and animal trypanosomiasis throughout sub-Saharan Africa. Tsetse flies are distinguished from other Diptera by unique adaptations, including lactation and the birthing of live young (obligate viviparity), a vertebrate blood-specific diet by both sexes, and obligate bacterial symbiosis. This work describes the comparative analysis of six Glossina genomes representing three sub-genera: Morsitans (G. morsitans morsitans, G. pallidipes, G. austeni), Palpalis (G. palpalis, G. fuscipes), and Fusca (G. brevipalpis) which represent different habitats, host preferences, and vectorial capacity. Results: Genomic analyses validate established evolutionary relationships and sub-genera. Syntenic analysis of Glossina relative …

Magnetizing: Post Operative Nausea And Vomiting, Andrea Nyquist

Nursing Posters

Purpose:

To guide nursing care in the early recognition and treatment of PONV.

Prevalence:

Postoperative nausea and vomiting (PONV) is the most prevalent postoperative complication occuring within 24 hours of surgery.

Risk Factors:

Adults at a higher risk of PONV include:

• Female
• History of PONV, motion sickness and/or gastroparesis
• Postoperative opioid recipient
• Volatile anesthetic and/or nitrous oxide administration intraoperatively
• Pregnancy
• Use of birth control pills

Implications:

PONV can create a plethora of adverse events for the patient: anxiety and a sense of dread, increased risk for bleeding, dehydration and electrolyte imbalance, risk for aspiration and airway obstruction, …

The Impact Of A Novel Mobile-Friendly Nutrition Education Intervention On Dietary Patterns Among Calfresh Applicants, Kelly Brookshire Condron

Master's Theses

Background: College students experience food insecurity at a rate 3.5 times higher than the U.S. general population, affecting 43% of students. Furthermore, college students consume high amounts of ultra-processed products. NOVA, a food classification system, takes into account food processing and is thought to better fit the modern food environment.

Purpose: The purpose of this research project was to examine the impact of CalFresh enrollment on food security status. This study also evaluated the impact of two different nutrition education interventions (MyPlate and MyPlate+NOVA) on participants’ dietary habits and nutrition knowledge.

Methods: Food security, dietary habits, and nutrition knowledge were …

Magnetic Hyperthermia In Y79 Retinoblastoma And Arpe19 Retinal Epithelial Cells: Tumor Selective Apoptotic Activity Of Iron Oxide Nanoparticle, Ronald Kumon, Hakan Demirc, Naziha Slimani, Mercy Pawar, Prem Vaishnava, Cagri G. Besirli

Natural Sciences Publications

Purpose: To evaluate selective apoptosis of Y79 retinoblastoma versus ARPE-19 retinal pigment epithelial cells by using different doses of dextran-coated iron oxide nanoparticles (DCIONs) in a magnetic hyperthermia paradigm. Methods: Y79 and ARPE-19 cells were exposed to different concentrations of DCIONs, namely, 0.25, 0.5, 0.75, and 1 mg/ml. After 2 hours of incubation, cells were exposed to a magnetic field with a frequency of 250 kHz and an amplitude of 4 kA/m for 30 minutes to raise the cellular temperature between 42 and 46°C. Y79 and ARPE-19 cells incubated with DCION without magnetic field exposure were used as controls. Cell …

Medical School Watercooler Newsletter - September 1, 2019, Lindsey Lyle

Watercooler Newsletter

This is the September 1, 2019 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler.

Contents Include:

USA Health resident receives scholarship to attend national surgery meeting

Menger joins neurosurgery at USA Health

USA College of Medicine programs encourage diversity in physician workforce

Medical student secures more than 2,000 pairs of socks to help vulnerable population

USA Health welcomes new trauma surgeon

Griffin Wright receives Edwin R. Hughes Memorial Award

Practical Pearl: Back To School Readiness - September 2019, John O'Reilly Md, Molly Senn-Mcnally Md

Pediatrics Practical Pearls: Referral Guidelines for Common Problems

No abstract provided.

Safety & Risk Management News - September 2019, Otterbein University

Otterbein Police Department

No abstract provided.

Promising Activity Of Anthemis Austriaca Jacq. On The Endometriosis Rat Model And Isolation Of Its Active Constituents, Mert Ilhan, Zulfiqar Ali, Ikhlas A. Khan, Hakkı Taştan, Esra Küpeli Akkol

Faculty and Student Publications

© 2019, The Author(s). Heparin and heparan sulfate (Hp/HS) are linear complex glycosaminoglycans which are involved in diverse biological processes. The structural complexity brings difficulties in separation, making the study of structure-function relationships challenging. Here we present a separation method for Hp/HS oligosaccharide fractionation with cross-compatible solvent and conditions, combining size exclusion chromatography (SEC), ion-pair reversed phase chromatography (IPRP), and hydrophilic interaction chromatography (HILIC) as three orthogonal separation methods that do not require desalting or extensive sample handling. With this method, the final eluent is suitable for structure-function relationship studies, including tandem mass spectrometry and microarray printing. Our data indicate …

Development Of A Novel Tool For Assessing Coverage Of Implementation Factors In Health Promotion Program Resources, Hannah Calvert, Lindsey Turner

University Author Recognition Bibliography: 2019

Programs for promoting health behaviors have been developed for adoption in various settings such as schools (Hoelscher et al., 2010; Sallis et al., 1997), afterschool programs (Beets et al., 2009), child care centers (Ward et al., 2010), community health and mental health clinics (Aarons et al., 2011), and other settings (Soler et al., 2010). While many of these programs have established efficacy, implementation-related challenges often limit their impact in real-world applications (Glasgow et al., 2003; Glasgow and Emmons, 2007). As a result, an emerging body of literature has pointed to the need to better consider implementation factors related to real-world …

Himmelfarb Headlines - September/October 2019, George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Headlines (2009 - present)

News and information about Himmelfarb Health Sciences Library of interest to users.