Medicine and Health Sciences Commons^™

Security Analysis Of A Large-Scale Concurrent Data Anonymous Batch Verification Scheme For Mobile Healthcare Crowd Sensing, Yinghui Zhang, Jiangang Shu, Ximeng Liu, Jin Li, Dong Zheng

Research Collection School Of Computing and Information Systems

As an important application of the Internet of Things (IoT) technologies, mobile healthcare crowd sensing (MHCS) still has challenging issues, such as privacy protection and efficiency. Quite recently in IEEE Internet of Things Journal (DOI: 10.1109/JIOT.2018.2828463), Liu et al. proposed a large-scale concurrent data anonymous batch verification scheme for mobile healthcare crowd sensing, claiming to provide batch authentication, non-repudiation, and anonymity. However, after a close look at the scheme, we point out that the scheme suffers two types of signature forgery attacks and hence fails to achieve the claimed security properties. In addition, a reasonable and rigorous probability analysis indicates …

Delaying Onset Of Diabetes In Native American Populatons, Seth Tramm

Physician Assistant Scholarly Project Papers

Diabetes is a debilitating disease process caused by the body’s inability to control blood glucose levels. With over 30 million diabetics in the United States, and another 85 million prediabetics, the effects of this disease are wide-spread and far-reaching. Native American/Alaska Native populations have a nearly two-fold increase in incidence of diabetes when compared to non-native populations. Risk factors for diabetes in all populations include modifiable risks such as obesity, diet, physical inactivity as well as non-modifiable factors such as age, family history, and ethnicity. Studies have shown that early identification of symptoms, coupled with proper and intentional treatment can …

Clinical Evaluation Of Exercise Capacity In Adults With Systemic Right Ventricle, Beata Rog, Kinga Salapa, Magdalena Okolska, Natalia Dluzniewska, Piotr Werynski, Piotr Podolec, Lidia Tomkiewicz-Pajak

The Texas Heart Institute Journal

The right ventricle provides systemic circulation in individuals with congenitally corrected transposition of the great arteries (CCTGA) and in those with complete transposition who have had an atrial switch repair (DTGA). The aim of this study was to evaluate how the systemic right ventricle adapts to increased workload and oxygen demand during exercise. From November 2005 through December 2015, 3,358 adult patients with congenital heart disease were treated at our institution; we identified 48 (26 females, 22 males; median age, 25.4 ± 8.1 yr) who met the study criteria; 37 had DTGA and atrial switch repair, and 11 had CCTGA. …

Cardiac Replacement In Our Lifetime, Jack G Copeland

The Texas Heart Institute Journal

No abstract provided.

Preventing A Catastrophe: Increasing Awareness Of Loeys-Dietz Syndrome, Bradley S Kane, Kamran Shamsa

The Texas Heart Institute Journal

Loeys-Dietz syndrome is a genetic disorder that predisposes patients to aortic aneurysms. If left untreated, the natural history of the associated aortopathy often culminates in fatal aortic dissection. We describe the case of a 21-year-old man who was diagnosed with Loeys-Dietz syndrome after 2 family members died of aortic dissection. This case highlights the importance of increased physician awareness of this syndrome, which can play a crucial role in preventing premature sudden cardiac death caused by aortic catastrophe.

The Future Of Tissue Engineering In Heart Transplantation, Doris A Taylor

The Texas Heart Institute Journal

No abstract provided.

Chicken-Fried Steak Changed My Outlook On Medicine, Michael J Lehner

The Texas Heart Institute Journal

No abstract provided.

Waiting For Test Results, Herbert L Fred

The Texas Heart Institute Journal

No abstract provided.

Peer Review/Ethics System: A Guide For Mda Members, Michael G. Maihofer Dds

The Journal of the Michigan Dental Association

Regular column featuring ethical guidance and consideration for practicing dentists.

Penetrating Atherosclerotic Ulcer Of The Ascending Aorta Found Incidentally In A 71-Year-Old Man, Antonino M Grande, Dario Di Perna, Adele Valentini, Eloisa Arbustini

The Texas Heart Institute Journal

No abstract provided.

Role Of Multimodal Cardiac Imaging In Diagnosing A Primary Intimal Sarcoma Of The Left Atrial Appendage, Kara L Raphael, Anthony P Martinez, Stephen D Clements, Ijeoma Isiadinso

The Texas Heart Institute Journal

Primary cardiac tumors are rare, and most are benign. Intimal sarcomas are among the rarest of the malignant cardiac tumors; they are aggressive and associated with a poor prognosis. Whereas transesophageal echocardiography has been instrumental in evaluating cardiac masses, other imaging methods, such as cardiac magnetic resonance, have proved invaluable in accurately characterizing these masses. We present the case of a 49-year-old woman in whom we diagnosed a primary intimal sarcoma of the left atrial appendage, and we discuss the importance of multimodal imaging in the evaluation and diagnosis of cardiac masses.

J Mich Dent Assoc Feb 2019

The Journal of the Michigan Dental Association

Archival issues of the Journal of the Michigan Dental Association may include reports on the activities of the association and its members, clinical articles, information on legal and ethical practice considerations, and perspectives of interest to MDA members and those in the oral health profession.

Calcium Channel Blockade With Nimodipine Reverses Mri Evidence Of Cerebral Oedema Following Acute Hypoxia, Matthew J. Rowland, Martyn Ezra, Anderson M. Winkler, Payashi Garry, Catherine Lamb, Michael Kelly, Thomas W. Okell, Jon Westbrook, Richard G. Wise, Gwenaëlle Douaud

School of Medicine Publications

Acute cerebral hypoxia causes rapid calcium shifts leading to neuronal damage and death. Calcium channel antagonists improve outcomes in some clinical conditions, but mechanisms remain unclear. In 18 healthy participants we: (i) quantified with multiparametric MRI the effect of hypoxia on the thalamus, a region particularly sensitive to hypoxia, and on the whole brain in general; (ii) investigated how calcium channel antagonism with the drug nimodipine affects the brain response to hypoxia. Hypoxia resulted in a significant decrease in apparent diffusion coefficient (ADC), a measure particularly sensitive to cell swelling, in a widespread network of regions across the brain, and …

The Common Rule’S “Reasonable Person” Standard For Informed Consent, Jake Greenblum, Ryan K. Hubbard

School of Medicine Publications

Laura Odwazny and Benjamin Berkman have raised several challenges regarding the new reasonable person standard in the revised Common Rule, which states that informed consent requires potential research subjects be provided with information a reasonable person would want to know to make an informed decision on whether to participate in a study. Our aim is to offer a response to the challenges Odwazny and Berkman raise, which include the need for a reasonable person standard that can be applied consistently across institutional review boards and that does not stigmatize marginal groups. In response, we argue that the standard ought to …

Association Between Periodontal Pathogens And Systemic Disease, Fiona Q. Bui, Cássio Luiz Coutinho Almeida-Da-Silva, Brandon Huynh, Alston Trinh, Jessica Liu, Jacob Woodward, Homer Asadi, David M. Ojcius

All Dugoni School of Dentistry Faculty Articles

A growing body of literature suggests that there is a link between periodontitis and systemic diseases. These diseases include cardiovascular disease, gastrointestinal and colorectal cancer, diabetes and insulin resistance, and Alzheimer's disease, as well as respiratory tract infection and adverse pregnancy outcomes. The presence of periodontal pathogens and their metabolic by-products in the mouth may in fact modulate the immune response beyond the oral cavity, thus promoting the development of systemic conditions. A cause-and-effect relationship has not been established yet for most of the diseases, and the mediators of the association are still being identified. A better understanding of the …

Interprofessional Education For Pre-Service School-Based Professionals: Faculty And Student Collaboration, Julie Strunk, Debi Kipps-Vaughan, Stacey L. Pavelko, Dannette Allen-Bronaugh, Karen Myers, Tammy Gilligan, Michele Kielty, Elizabeth Richardson, Joseph Tacy

Teaching and Learning in Communication Sciences & Disorders

Interprofessional collaboration is necessary for school-based professionals who provide services for students with disabilities. Most pre-service training, however, takes place in separate programs and does not afford students opportunities to learn effective collaborative techniques. This study examined the effects of a one-day interprofessional learning experience for pre-service school-based professionals. The goals were twofold: 1) increase students’ understanding of the core competencies for interprofessional collaborative practice (Interprofessional Education Collaborative, 2016) and 2) provide an opportunity for students to participate in interprofessional collaboration within a simulated school-based context. A mixed method design examined changes in students’ knowledge of the IPEC competencies. Students …

Speech-Language Pathology Students’ Motivation For Learning, Amie M. King, Steffany M. Chleboun

Teaching and Learning in Communication Sciences & Disorders

The primary purpose of this exploratory study was to attempt to gain a better understanding of speech-language pathology students’ motivations for learning. Motivation was assessed in undergraduate and graduate students in two categories of coursework. Results showed statistically significant differences between undergraduate and graduate students in the overall areas of Intrinsic and Extrinsic Motivation, while there were no significant differences in other areas of motivation. These results were situated in potential implications for students, professors, and programs as well as the need for follow-up studies.

What’S In A Question? A Comparison Of Student Questions In Two Learning Spaces, Julie Griffith, Mary Lou Vercellotti, Hannah Folkers

Teaching and Learning in Communication Sciences & Disorders

Active learning pedagogy is thought to allow more opportunities for student interaction. Given that students are more interactive, student questions may reveal how active learning pedagogy may enhance student learning outcomes. The purpose of this research was to investigate the frequency, distribution, and type of questions asked by students during class meetings in two instructional contexts: a traditional lecture classroom and an interactive learning space classroom. A neuroanatomy and neurophysiology for speech, language and hearing course was taught in the two spaces in subsequent semesters. A total of 99 enrolled students gave consent. Six 75-minute class meetings from each classroom …

Training Students Through A Community Outreach Program To Support Families Of Children With Autism Spectrum Disorder, Joann P. Benigno`, John W. Mccarthy, Sarah O. Taylor, Bridget Gornichec Wright, Chao-Yang Lee

Teaching and Learning in Communication Sciences & Disorders

This outreach program involved training eight graduate and 19 undergraduate students to create evidence-based communication supports for families of children with autism spectrum disorder (ASD) within the context of a two-course sequence on ASD. During the training program, ten families in rural Appalachia benefited from our services. Student and family satisfaction data with the outreach program was highly positive. Undergraduate and graduate university students participating in the program met or partially met 97% of their goals set at the beginning of each semester. Undergraduate students’ self-ratings of their own knowledge about material covered in the course were significantly higher than …

Influence Of Supervision And Clinical Experiences On Professional Development Of Graduate Speech Language Pathology Students, Sarah Rapillard, Laura Plexico, Allison M. Plumb

Teaching and Learning in Communication Sciences & Disorders

As with the first companion manuscript, this study used a grounded theory approach to develop and describe a hierarchical model of clinical development of speech-language pathology graduate students. Eight female students attending the speech-language pathology graduate program participated in structured interviews prior to graduate training as well as following each of five subsequent semesters. The interviews were then qualitatively analyzed to create the model of clinical development. This is the second of two companion papers and summarizes three of the five main findings identified. These findings indicate that academic experiences provide foundational skills that students need for clinical development; however, …

Influence Of Graduate Speech Language Pathology Student’S Learning Style And Coping Strategies On Training And Development, Sarah Rapillard, Laura W. Plexico, Allison M. Plumb

Teaching and Learning in Communication Sciences & Disorders

A hierarchical model using grounded theory analysis was used to investigate clinical development of speech-language pathology graduate students. Eight female students attending a graduate speech-language pathology program participated in interviews prior to beginning graduate training and after each of five subsequent semesters. The interviews were then qualitatively analyzed to create the model of clinical development. This is the first of two companion papers and summarizes two of the five main findings identified. These findings indicated that both stress and the coping strategies used by students influenced clinical abilities and the student’s feelings of self-efficacy throughout graduate training. The results support …

Sharing The Gift Of Water: A Hoosier-Haitian Partnership, Lauren Ward

Purdue Journal of Service-Learning and International Engagement

Engagement Methods for International Food Security (YDAE 49100) provided an opportunity for enrolled students to travel abroad to Cap-Haitïen, Haiti. As both a course in agriculture and a service-learning study abroad, the overarching goal was to inspire, engage, and teach Purdue and Haitian students through service learning in agriculture. This was done by developing a project with teammates during the fall semester that was then presented to students in Haiti during the International Agri-Symposium at Université Antenor Firmin over winter break.

Comforting With Mathematics: A Case Study, Michael J. Goldstein

Journal of Humanistic Mathematics

Death by suicide often leaves behind grieving family members with unanswered questions. Of these concerns, fear that their loved one suffered or felt regret is common. When the method of suicide was jumping from height, that answer can easily be determined using basic kinematics. Despite the perception that mathematics is a cold, calculating field, it can provide a clear, definitive answer and comfort those left behind.

A Phewas Study Of A Large Observational Epidemiological Cohort Of African Americans From The Regards Study, Xueyan Zhao, Xin Geng, Vinodh Srinivasasainagendra, Ninad Chaudhary, Suzanne Judd, Virginia Wadley, Orlando M. Gutiérrez, Henry Wang, Ethan M. Lange, Leslie A. Lange, Daniel Woo, Frederick W. Unverzagt, Monika Safford, Mary Cushman, Nita Limdi, Rakale Quarells, Donna K. Arnett, Marguerite R. Irvin, Degui Zhi

Epidemiology and Environmental Health Faculty Publications

Background: Cardiovascular disease, diabetes, and kidney disease are among the leading causes of death and disability worldwide. However, knowledge of genetic determinants of those diseases in African Americans remains limited.

Results: In our study, associations between 4956 GWAS catalog reported SNPs and 67 traits were examined among 7726 African Americans from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, which is focused on identifying factors that increase stroke risk. The prevalent and incident phenotypes studied included inflammation, kidney traits, cardiovascular traits and cognition. Our results validated 29 known associations, of which eight associations were reported for the …

Revised Scientific Review: Minimum Age For Swim Lessons, Stephen J. Langendorfer Ph.D.

International Journal of Aquatic Research and Education

The question addressed in the original scientific review (2009) was rephrased as Does sufficient scientific evidence exist to support setting a minimum age for swimming lessons? for this triennial review. Addressing the research question is significant because strong differences of opinion about the appropriate age(s) for initiating learn-to-swim lessons have existed among the pediatric medical profession, aquatic professionals and agencies, and proprietary programs and swim schools for over four decades. The question has implications for the appropriate purposes, pedagogies, and outcomes associated with swimming experiences for infants and young children that will be addressed in a subsequent review. The revised …

Mitf Has A Central Role In Regulating Starvation-Induced Autophagy In Melanoma., Katrin Möller, Sara Sigurbjornsdottir, Asgeir O Arnthorsson, Vivian Pogenberg, Ramile Dilshat, Valerie Fock, Solveig H Brynjolfsdottir, Christian Bindesboll, Margret Bessadottir, Helga M Ogmundsdottir, Anne Simonsen, Lionel Larue, Matthias Wilmanns, Vesteinn Thorsson, Eirikur Steingrimsson, Margret H Ogmundsdottir

Articles, Abstracts, and Reports

The MITF transcription factor is a master regulator of melanocyte development and a critical factor in melanomagenesis. The related transcription factors TFEB and TFE3 regulate lysosomal activity and autophagy processes known to be important in melanoma. Here we show that MITF binds the CLEAR-box element in the promoters of lysosomal and autophagosomal genes in melanocytes and melanoma cells. The crystal structure of MITF bound to the CLEAR-box reveals how the palindromic nature of this motif induces symmetric MITF homodimer binding. In metastatic melanoma tumors and cell lines, MITF positively correlates with the expression of lysosomal and autophagosomal genes, which, interestingly, …

Guggulsterone Activates Adipocyte Beiging Through Direct Effects On 3t3-L1 Adipocytes And Indirect Effects Mediated Through Raw264.7 Macrophages., Colette N Miller, Janaiya S Samuels, Yusra Azhar, Ashish Parmar, Rangaiah Shashidharamurthy, Srujana Rayalam

PCOM Scholarly Works

Background: Plant-derived phytochemicals have been of emerging interest as anti-obesity compounds due to their apparent effects on promoting reduced lipid accumulation in adipocytes. Despite such promising evidence, little is known about the potential mechanisms behind their anti-obesity effects. The aim of this study is to establish potential anti-obesity effects of the phytochemical guggulsterone (GS). Methods: Mature 3T3-L1 adipocytes were treated with GS, derived from the guggul plant native in northern India, to investigate its effects on mitochondrial biogenesis and adipocyte "beiging." Further, to explore the relationship between macrophages and adipocytes, 3T3-L1s were treated with conditioned media from GS-treated RAW264.7 macrophages. …

The Use Of Aloe Vera In Cancer Radiation: An Updated Comprehensive Review, Carrie-Jo E. Farrugia, Elizabeth Sutton Burke, Mariah E. Haley, Komul T. Bedi, Mona A. Gandhi

Doctoral External Publications

Introduction: Many cancer patients require radiation therapy and often experience adverse effects including erythema, itching, and pain. Aloe vera has been studied for its potential use in the prevention and treatment of radiation related adverse effects as it possesses a variety of properties and is considered an antioxidant and anti-inflammatory agent. Multiple controlled trials have been performed in order to evaluate the efficacy of aloe vera for the prevention and treatment of radiation side effects. Previous systematic reviews have examined the use of aloe vera for radiation-induced skin reactions, however updated literature now includes the use of aloe vera in …

Global Access To Antibiotics Without Prescription In Community Pharmacies: A Systematic Review And Meta-Analysis, Asa Auta, Muhammad A. Hadi, Enoche Oga, Emmanuel O. Adewuyi, Samirah N. Abdu-Aguye, Davies Adeloye, Barry Strickland-Hodge, Daniel J. Morgan

Research outputs 2014 to 2021

Objective To estimate the proportion of over-the-counter antibiotic requests or consultations that resulted in non-prescription supply of antibiotics in community pharmacies globally. Methods We systematically searched EMBASE, Medline and CINAHL databases for studies published from January 2000 to September 2017 reporting the frequency of non-prescription sale and supply of antibiotics in community pharmacies across the world. Additional articles were identified by checking reference lists and a Google Scholar search. A random effects meta-analysis was conducted to calculate pooled estimates of non-prescription supply of antibiotics. Results Of the 3302 articles identified, 38 studies from 24 countries met the inclusion criteria and …

The Insula And Its Epilepsies, Barbara C. Jobst, Jorge Gonzalez-Martinez, Jean Isnard, Philippe Kahane, Nuria Lacuey, Samden D. Lahtoo, Dang K. Nguyen, Chengyuan Wu, Fred Lado

Department of Neurosurgery Faculty Papers

Insular seizures are great mimickers of seizures originating elsewhere in the brain. The insula is a highly connected brain structure. Seizures may only become clinically evident after ictal activity propagates out of the insula with semiology that reflects the propagation pattern. Insular seizures with perisylvian spread, for example, manifest first as throat constriction, followed next by perioral and hemisensory symptoms, and then by unilateral motor symptoms. On the other hand, insular seizures may spread instead to the temporal and frontal lobes and present like seizures originating from these regions. Due to the location of the insula deep in the brain, …