Medicine and Health Sciences Commons^™

Parkinson's Disease: Promoting Wellbeing Through Creation Health, Rupelin Pichot

DNP Research Projects

There are approximately 1.5 million Americans affected by Parkinson’s disease (PD). In spite of medications and technological advances in managing the disease, patients with PD still live poor quality lives. Therefore, effective natural interventions are essential in promoting wellbeing and quality of life among PD patients. This research study aimed to examine the usefulness and efficacy of a PD brochure designed especially for PD patients and their caregivers by utilizing CREATION Health (CH) principles to promote wellbeing and quality of life in patients with PD. This study employed mixed methods of quantitative and qualitative research designs to evaluate the design, …

Kinetics And Inhibition Studies Of The L205r Mutant Of Camp-Dependent Protein Kinase Involved In Cushing’S Syndrome, Nicole M. Luzi, Charles E. Lyons, Darrell L. Peterson, Keith C. Ellis

Medicinal Chemistry Publications

Overproduction of cortisol by the hypothalamus–pituitary–adrenal hormone system results in the clinical disorder known as Cushing's syndrome. Genomics studies have identified a key mutation (L205R) in the α‐isoform of the catalytic subunit of cAMP‐dependent protein kinase (PKACα) in adrenal adenomas of patients with adrenocorticotropic hormone‐independent Cushing's syndrome. Here, we conducted kinetics and inhibition studies on the L205R‐PKACα mutant. We have found that the L205R mutation affects the kinetics of both Kemptide and ATP as substrates, decreasing the catalytic efficiency (k_cat/K_M) for each substrate by 12‐fold and 4.5‐fold, respectively. We have also determined the IC …

A Chromosomal Deletion And New Frameshift Mutation Cause Arsacs In An African-American, Sean C. Dougherty, Amy Harper, Hind Al Saif, Gregory Vorona, Scott R. Haines

Neurology Publications

Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) is a rare, progressive, neurodegenerative disease characterized by ataxia, spasticity and polyneuropathy. First described in the French-Canadian population of Quebec in 1978, ARSACS has since been identified in multiple patients worldwide. In this clinical case report, we describe the evaluation of an 11-years-old African-American male who presented to neuromuscular clinic for assessment of a gait abnormality. He had a history of gross motor delay since early childhood, frequent falls and a below average IQ. Chromosomal microarray revealed a 1.422 megabase loss in the 13q12.12 region, which includes the SACS gene. Next Generation Sequencing …

Review: Do The Different Sensory Areas Within The Cat Anterior Ectosylvian Sulcal Cortex Collectively Represent A Network Multisensory Hub?, M. Alex Meredith, Mark T. Wallace, H. Ruth Clemo

Anatomy and Neurobiology Publications

Current theory supports that the numerous functional areas of the cerebral cortex are organized and function as a network. Using connectional databases and computational approaches, the cerebral network has been demonstrated to exhibit a hierarchical structure composed of areas, clusters and, ultimately, hubs. Hubs are highly connected, higher-order regions that also facilitate communication between different sensory modalities. One region computationally identified network hub is the visual area of the Anterior Ectosylvian Sulcal cortex (AESc) of the cat. The Anterior Ectosylvian Visual area (AEV) is but one component of the AESc that also includes the auditory (Field of the Anterior Ectosylvian …

Reducing Stigma Among Healthcare Providers To Improve Mental Health Services (Reshape): Protocol For A Pilot Cluster Randomized Controlled Trial Of A Stigma Reduction Intervention For Training Primary Healthcare Workers In Nepal., Brandon A Kohrt, Mark J D Jordans, Elizabeth L Turner, Kathleen J Sikkema, Nagendra P Luitel, Sauharda Rai, Daisy R Singla, Jagannath Lamichhane, Crick Lund, Vikram Patel

Psychiatry and Behavioral Sciences Faculty Publications

Background

Non-specialist healthcare providers, including primary and community healthcare workers, in low- and middle-income countries can effectively treat mental illness. However, scaling-up mental health services within existing health systems has been limited by barriers such as stigma against people with mental illness. Therefore, interventions are needed to address attitudes and behaviors among non-specialists. Aimed at addressing this gap, REducing Stigma among HealthcAre Providers to ImprovE mental health services (RESHAPE) is an intervention in which social contact with mental health service users is added to training for non-specialist healthcare workers integrating mental health services …

Interpersonal Violence And Suicidality Among Former Child Soldiers And War-Exposed Civilian Children In Nepal., Anvita Bhardwaj, Christine Bourey, Sauharda Rai, Ramesh Prasad Adhikari, Carol M Worthman, Brandon A Kohrt

Psychiatry and Behavioral Sciences Faculty Publications

Background: Suicide risk reduction is crucial for 15-29-year-old youth, who account for 46% of suicide deaths in low- and middle-income countries. Suicide predictors in high-resource settings, specifically depression, do not adequately predict suicidality in these settings. We explored if interpersonal violence (IPV) was associated with suicidality, independent of depression, in Nepal.

Methods: A longitudinal cohort of child soldiers and matched civilian children, enrolled in 2007 after the People's War in Nepal, were re-interviewed in 2012. The Depression Self-Rating Scale and Composite International Diagnostic Interview assessed depression and suicidality, respectively. Non-verbal response cards were used to capture experiences of sexual and …

Neural Correlates Of Taste Reactivity In Autism Spectrum Disorder., Jason A Avery, John E Ingeholm, Sophie Wohltjen, Meghan Collins, Cameron D Riddell, Stephen J Gotts, Lauren Kenworthy, Gregory L Wallace, W Kyle Simmons, Alex Martin

Psychiatry and Behavioral Sciences Faculty Publications

Selective or 'picky' eating habits are common among those with autism spectrum disorder (ASD). These behaviors are often related to aberrant sensory experience in individuals with ASD, including heightened reactivity to food taste and texture. However, very little is known about the neural mechanisms that underlie taste reactivity in ASD. In the present study, food-related neural responses were evaluated in 21 young adult and adolescent males diagnosed with ASD without intellectual disability, and 21 typically-developing (TD) controls. Taste reactivity was assessed using the Adolescent/Adult Sensory Profile, a clinical self-report measure. Functional magnetic resonance imaging was used to evaluate hemodynamic responses …

Aloe Vera: A Multipurpose Healer And Bacterial Eradicator, Mary X. Tran, Leira N. Jimenez, Linda K. Blackburn

Dental Hygiene Student Scholarship

The Aloe vera plant is a succulent known for its rich content in vitamins and minerals, thus gaining popularity over the years in healthcare products. With advancements in alternative medicine, it has been recently found useful in dentistry due to properties such as anti-inflammatory, antioxidant and antimicrobial actions that contribute to wound healing. The purpose of this study was to examine and discover how Aloe vera can be used as an alternative therapy in the dental field. The PubMed, Google Scholar and Dentistry & Oral Sciences (DOSS) databases were utilized to find current scientific evidence on the effects of Aloe …

Consideration For Care For Your Patient With Cerebral Palsy, Katlin R. Cannon, Melissa Stowe, Brooke Ryan

Dental Hygiene Student Scholarship

Cerebral palsy (CP) is a common developmental neurological disorder affecting about 2-3 children out of 1,000. CP is the result of infant brain damage or abnormal development resulting in impaired muscle control, coordination, tone, reflex, posture, and balance. These patients are unable to control motor movements of their muscles of mastication and facial expression, causing excessive drooling, clenching, bruxism, and other oral health-related issues. This lack of motor control affects their ability to swallow and often limits these patients to a liquid diet. This can lead to vitamin deficiencies and result in further developmental problems. As an example, a deficiency …

Got Caries? Breast Milk And Early Childhood Caries?, Megan L. Dean, Rebecca Fields, Hannah Fritz

Dental Hygiene Student Scholarship

Objective: To provide an analysis of the association between the longevity of breastfeeding and development of ECC. Determine the optimal time frame in which mothers should cease breastfeeding to reduce ECC development. Methods: Dr. Brickhouse, PubMed, Google Scholar and other scholarly databases were utilized to find current scientific evidence on the effects of breast milk on ECC. Relevant articles were summarized to write a review of literature. 16 articles published from 2015 to the present date were reviewed and cited. Results: From the studies, there is strong evidence to support breastfeeding beyond 12 months of age increases the prevalence …

An Overview Of Perinatal Health And Childhood Development In Honduras, Rose Margaret Carlson, Abigail D. Conrad, Alexandra Nicole Lothe, Caitlin M. O'Donnell, Cameron Svihla

All Electronic Theses and Dissertations

Honduras is a country with great healthcare needs. Within health care, the largest percentage of mortality is due to conditions occurring in the perinatal period, including prenatal and maternal health, delivery and postnatal care (PAHO, 2017a). Additionally, malnutrition continues to affect infants as they growth throughout their childhood (Gray, Cossman, & Powers, 2006). Education is shown to produce positive outcomes in low-income populations (Perkins, et al, 2011). The purpose of this project was to identify Honduran healthcare needs and provide effective and sustainable intervention. A needs assessment with a Honduran-Canadian health organization reiterated evidence found in the literature, illustrating the …

"Epigenetic Silencing Of Socs3 Expression Contributes To Fibrosis In Crohn’S Disease", Emily T. Marshall, Chao Li, John F. Kuemmerle

MD Student Summer Research Fellowship Program Posters

Identified risk polymorphisms affecting the Jak-STAT3 pathway in patients with Crohn’s disease could affect TGF-β1 and collagen I expression and in the pathway’s negative regulator, SOCS3. Genetic factors, however, account for only ~25% of disease. Epigenetic events also shape gene expression. Recent experiments showed that autocrine IL-6 production in mesenchymal cells, subepithelial myofibroblasts (SEMF) and muscle cells, of patients with fibrostenotic Crohn’s disease causes sustained Jak-STAT3 activity, excess TGF-β1 and Collagen I production and fibrosis. SOCS3 paradoxically decreased in these cells. We now identify epigenetic mechanisms that silence SOCS3 expression in SEMF of patients with fibrostenotic Crohn’s disease. In a …

Contraceptive Utilization Among New Exotic Dancers: A Cross-Sectional Study, Mishka Terplan, Caitlin E. Martin, Jennifer Nail, Susan G. Sherman

Obstetrics and Gynecology Publications

Background
Female exotic dancers are a population at high risk of unintended pregnancy. The objective of this study is to describe the reproductive health needs and contraceptive utilization of exotic dancers.

Methods
New exotic dancers (< 6 months dancing) from 26 clubs in Baltimore City/County completed a one-time survey.

Results
Of 117 participants, 96 (82%) had current contraceptive need. The mean age was 24 years, and 55% were black. Sex work (45%), alcohol use disorder (73%), illicit (44%; e.g., heroin, crack, cocaine), and injection drug use (8%) were common. The majority (66%) reported contraception use in the prior 6 months. Condoms were reported by 46% whereas 45% reported non-barrier methods, most commonly hormonal …

Economic Evaluation Of Patient Navigation Programs In Colorectal Cancer Care, A Systematic Review., C Gervès-Pinquié, A Girault, S Phillips, S Raskin, Mandi Pratt-Chapman

GW Cancer Institute

Patient navigation has expanded as a promising approach to improve cancer care coordination and patient adherence. This paper addresses the need to identify the evidence on the economic impact of patient navigation in colorectal cancer, following the Health Economic Evaluation Publication Guidelines. Articles indexed in Medline, Cochrane, CINAHL, and Web of Science between January 2000 and March 2017 were analyzed. We conducted a systematic review of the literature using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The quality assessment of the included studies was based on the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist. Inclusion criteria …

Why West? Comparisons Of Clinical, Genetic And Molecular Features Of Infants With And Without Spasms., Anne T Berg, Samya Chakravorty, Sookyong Koh, Zachary M Grinspan, Renée A Shellhaas, William D Gaillard, +Several Additional Authors

Neurology Faculty Publications

Infantile spasms are the defining seizures of West syndrome, a severe form of early life epilepsy with poorly-understood pathophysiology. We present a novel comparative analysis of infants with spasms versus other seizure-types and identify clinical, etiological, and molecular-genetic factors preferentially predisposing to spasms. We compared ages, clinical etiologies, and associated-genes between spasms and non-spasms groups in a multicenter cohort of 509 infants (

A Randomized Controlled Trial To Evaluate The Impact Of Nurse Navigator Programme (Nnp) On Anxiety, Psychological Distress And Quality Of Life Of Breast Cancer Patients In A Tertiary Care Hospital, Karnataka”, Shejila C H

Manipal College of Nursing, Manipal Theses and Dissertations

No abstract provided.

A Comparative Study To Determine The Effectiveness Of Antepartum Breathing Exercises On Outcome Of Labor Between Primigravid And Multigravid Women In Selected Hospital Of Udupi District, Karnataka, Sushmitha Ramona Karkada

Manipal College of Nursing, Manipal Theses and Dissertations

No abstract provided.

Interpretive Phenomenological Analysis: Exploring The Experiences Of Eye Bank Coordinators When Approaching Families Of Decedents For Eye Donation, Concetta Triglia

Health Sciences Program Student Theses, Dissertations and Capstones

This dissertation was used to addresses a group of individuals who work as eye bank coordinators. These individuals call families and approach them for eye donations from a loved one who has just passed away. An interpretative phenomenological analysis (IPA) was used to explain the lived experience of eye bank coordinators who call families for consent of eye tissue. The focus was to understand the dedication of the coordinators to giving the gift of sight and exploring the positive and negative experiences of eye bank coordinators. IPA is used for a keen understanding of eye bank coordinators, and the investigator …

Nurse-Driven Protocol To Reduce Catheter Associated Urinary Tract Infections, Elva Hamilton

Student Theses, Dissertations and Capstones

Background: Catheter-associated urinary tract infections (CAUTIs) are a major source of avoidable hospital-acquired infections. The scientific evidence supports utilization of nurse-driven protocols to reduce CAUTIs.

Purpose: The purpose of this quality improvement project was to update and implement an evidence-based CAUTI prevention protocol for the nursing staff on a medical-surgical unit in an adult acute care hospital to decrease the utilization of indwelling urinary catheters and CAUTIs.

Theoretical Framework: Donabedian’s structures, processes, and outcomes (SPO) model was utilized as the framework for this project. Donabedian’s SPO model focuses on strong healthcare structures and processes to improve nurse, patient, and organizational …

Lose To Win: Fighting Obesity In The Workplace, Latoya Dotson

Student Theses, Dissertations and Capstones

Background: Obesity is a significant healthcare problem in modern American society. It has led to decreased longevity of employees and decreased productivity in day-to-day duties of healthcare workers. There are more negative attributes to obesity than positive, regardless of the race affected. One of the leading causes of death in 2012 was cardiovascular disease. Due to poor dietary choices, the promotion of sedentary lifestyle has led to complications of obesity such as high blood pressure and diabetes. Major improvements can be made within a community that acknowledges the risks of obesity and seeks to implement preventive programs. Increasing one’s physical …

Implementation Of The Essential Competencies For Evidence-Based Practice In Baccalaureate Nursing Education, Elizabeth Whorley

Student Theses, Dissertations and Capstones

Integrating evidence-based practice into healthcare education has been a recommendation for the past 16 years. Despite this, barriers still exist with the utilization of evidence-based practice. The purpose of this study was to describe the current state of EBP scholarship in the curriculum of baccalaureate pre-licensure nursing programs. Essential Competencies for Evidence-Based Practice in Nursing (Stevens, 2009) was utilized to measure the state of EBP scholarship. The research question stated: how is evidence-based practice scholarship addressed within baccalaureate pre-licensure nursing programs? The research design was guided by Rogers’ diffusion of innovations theoretical framework and the star model of knowledge transformation …

Reducing The Prevalence Of Falls In The Assisted Living Facility Setting, Joan Louis Pierre

Student Theses, Dissertations and Capstones

Background: Falls are an issue of concern among the elderly population; it is not only costly, but their impact can have long-term consequences on the quality of life of the elderly. Fall risk in this population increases with age, and falls are the leading cause of accidental death and disability among older adults (Morris et al., 2016). Fall prevention is needed to help reduce these events. The success of this project required consideration of the unique needs of residents in the assisted living environment. Purpose: The purpose of this project was to reduce the prevalence of falls in the assisted …

Reducing The Prevalence Of Fall In The Assisted Living Facility Setting, Joan Louis Pierre

Student Theses, Dissertations and Capstones

Background: Falls are an issue of concern among the elderly population; it is not only costly, but their impact can have long-term consequences on the quality of life of the elderly. Fall risk in this population increases with age, and falls are the leading cause of accidental death and disability among older adults (Morris et al., 2016). Fall prevention is needed to help reduce these events. The success of this project required consideration of the unique needs of residents in the assisted living environment.

Purpose: The purpose of this project was to reduce the prevalence of falls in the assisted …

Management Of Hypertension Among Haitian Immigrants: Using A Cultural Competency Tool To Improve Practice, Soeurette Bruny

Student Theses, Dissertations and Capstones

Background: The number of Haitian immigrants living in the United States has significantly increased as a result of the catastrophic earthquake in Haiti on January 12, 2010. Hypertension is one of the most significant health concerns among Haitian immigrants, which is one of the fastest growing ethnic groups. A clear understanding of the issues that impact the health practices, beliefs, and attitudes of the Haitianpopulation is essential for positive healthcare outcomes. Purpose: The purpose of this quality improvement project was to improve healthcare practitioners' standard of practice when providing culturally congruent care to Haitian immigrants at a small community clinic …

Com Outlook Winter 2018, College Of Osteopathic Medicine

COM Outlook

No abstract provided.

Evaluation Of Surface Characteristics For Three Milled Cad/Cam Monolithic Ceramic Restorations, Fahad Algahtani

Student Theses, Dissertations and Capstones

Background: Dental ceramics have been chosen as the material of choice by patients and clinicians because of their aesthetics, color stability, and low thermal conductivity. Clinically, almost all restorations need some adjustments to allow adequate occlusion and contacts. However, these adjustments will create rough surfaces. Therefore, different surface treatments have been developed to improve surface smoothness and gloss of dental ceramics. Objective: To evaluate the average surface roughness (Ra) and gloss (GU) of three different monolithic ceramics: Lithium Disilicate (IPS e.max CAD), Leucite reinforced (IPS Empress CAD) and Feldspathic (Vitablocs Mark II) subjected to two different surface treatments (mechanical polishing …

Comparison Of Fracture Resistance And Bond Strength Of E.Max Crowns Restored With Fiber Post And Core With Endo Crowns, Rohit Mathur

Student Theses, Dissertations and Capstones

Objective: This study evaluated the Fracture Resistance and Bond strength of e.max crowns made with CAD/CAM technology on teeth restored with fiber post and core and compare them to Endo crowns. Materials and Methods: 32 extracted premolars were collected from the department of periodontics and oral surgery. These teeth were assigned in 2 groups. 16 teeth were assigned to test compressive load resistance and the other 16 were assigned to test tensile strength. These groups were subdivided into 2 groups. One group with 8 teeth received post and core followed by crown placement and the other group of teeth were …

The Effect Of Osteotomy Preparation Technique And Implant Diameter On Primary Stability And Bone-Implant Interface Of Short Implants (6 Mm), Kanika Bembey

Student Theses, Dissertations and Capstones

Aim: The overall objective of this study is to evaluate the effect of osteotomy preparation technique and implant diameter on primary stability and bone-implant interface of short implants (6mm), when placed in bone with high degree of cancellous content with three osteotomy preparation techniques. Materials and methods: Three groups of different diameter implants were used for this study. The Group SN (Short Narrow), comprised of 30 implants with dimensions 4.2x6mm, the Group SR (Short Regular), comprised of 30 implants with dimensions 4.8x6mm and the Group SW (Short Wide), comprised of 30 implants with dimensions 5. 4x6mm. Each implant group was …

Clinical Performance Of Cad/Cam Versus Conventional Ceramic Restorations On Posterior Teeth: A Retrospective Study, Saleh Almukhlis

Student Theses, Dissertations and Capstones

Brief Background: The utilization of CAD/CAM technology for dental restorations has various benefits over conventional techniques. These benefits incorporate speed, convenience, quality, and eliminate needing a temporary crown. However, failure of dental restorations is a major issue in dental practice, it needs to be quantified and considered against the benefits here stated. Objectives: To evaluate the clinical performance of ceramic conventional and chairside CAD/CAM Onlay/ crowns placed on posterior teeth by postgraduate student in Operative department. Methods: This retrospective study employed patient record data stored in AxiUm. In total, 78 CAD/CAM all ceramic crowns/ onlays and 429 all ceramic conventional …

Evaluation Of Enamel Surface Roughness After Laser Removal Of Clear Aligner Attachments, Nickolaos Z. Kallis

Student Theses, Dissertations and Capstones

Introduction: Following orthodontic appliance removal, the primary objective is to remove all remaining adhesive from the facial surfaces and return the enamel to its pretreatment state. Composite remnant removal must be performed with as little to no damage to the superficial layer of enamel to ensure long-term health and esthetics of the dentition. Numerous studies have investigated the efficacy of multiple composite remnant removal methods with no consensus as to which method should be the standard of care1-7. Traditional methods of composite removal after bracket debonding have included tungsten-carbide burs, white stone burs, green stones, and composite discs; which all …