Medicine and Health Sciences Commons^™

Favorable Response Of Advanced Superior Sulcus Non-Small Cell Lung Carcinoma To Gefitinib For 11 Years Complicated By Interval Development Of Small Cell Carcinoma Of The Lung., Mark H. Cooper

Marshall Journal of Medicine

Gefitinib is a medication that was originally developed as an epidermal growth factor receptor (EGFR) blocker. It has been used to treat non-small cell lung cancer with varying success. We describe a patient who presented with Pancoasts syndrome and after being deemed surgically unresectable had limited success with chemotherapy and radiation but had an excellent response to the medication Gefitinib. The patient was disease free for several years and after 11 years of follow up with CT scans, a PET CT showed an isolated area of FDG avidity which on biopsy was small cell carcinoma of the lung. The patient …

A Rare Case Of Asystole During A Laparoscopic Appendectomy In A Young Patient, Rachit Gupta, George Yousef, Melissa Lester

Marshall Journal of Medicine

Laparoscopic surgery has become the mainstay of treatment for uncomplicated appendicitis cases. We describe a case of a 29 year old male with a pertinent past medical history of poorly controlled hypertension who was undergoing a routine laparoscopic appendectomy for confirmed appendicitis and developed bradycardia and subsequent asystolic cardiac arrest approximately one hour into the operation. Urgent cardiopulmonary resuscitation and intravenous (IV) atropine were required to reinitiate sinus cardiac rhythm. While the patient was admitted to the intensive care unit for close monitoring following his operation, he ultimately had an uncomplicated postoperative period and an unremarkable cardiac work up and …

Hemimegalencephaly With Prominent Ipsilateral Facial Hypertrophy, Seraj Saleh Ajaj, Faisal Bentaleb, Jamal Elasfer, Khawla Shlaibek

Marshall Journal of Medicine

Hemimegalencephaly is uncommon congenital malformation with unilateral enlargement of the hemicerebrum. Here we report a 1 month-old male child presented at our neurosurgery outpatient’s clinic with recurrent seizures and facial asymmetry. CT and MRI of the brain revealed diagnostic characteristic features of Hemimegalencephaly associated with ipsilateral Facial Congenital Infiltrating Lipomatosis.

Effect Of A Brief Patient Communication Teaching On Both Attendee And Non-Attendee Family Medicine Residents., Dilip Nair, Adrienne Mays, Mohit Harsh

Marshall Journal of Medicine

Physician-patient communication skills are important for physicians to acquire. Teaching skills is thought to require attendance by learners but this is difficult in graduate medical education settings. We asked if an educational intervention on physician-patient communication was associated with a "spill-over" effect to non-attendees in the same family medicine residency program.

We surveyed residents regarding communicating instructions to patients before the intervention and one month later, regardless of their attendance. Residents’ assessment of their patients’ understanding increased significantly post-intervention only if non-attendees were included.

This pilot study suggests a beneficial “spill-over” effect to non-attendee residents that warrants further study.

Review Of Kawasaki Disease, Rani Shah, Hisham Hirzallah, Munes Fares, Ashwini Mallad, Gudjon Karlsson, Mehiar El-Hamdani

Marshall Journal of Medicine

Abstract

Background: Kawasaki disease is one of the leading causes of acquired heart disease in children. It is an acute self-limited vasculitis that predominantly affects infants and children younger than 5 years of age. These patients present with nonspecific symptoms, such as fever and lymphadenopathy, making the diagnosis challenging. This disease can have serious and potentially fatal outcomes, and prompt recognition of this disease is vital to the patient’s outcome. We present a complete review of the disease, including the epidemiology, pathophysiology, diagnosis and management of acute Kawasaki disease, the natural history of this disease, and follow up of …

Chasing The Dragon, Daniel Young Cho, Hani Nazha, Kalin Fisher

Marshall Journal of Medicine

Abstract: Although rare, toxic leukoencephalopathy (TLE) associated with heroin inhalation have been reported. ‘Chasing the dragon’ may lead to progressive spongiform degeneration of the brain and presents with a large range of neuropsychological sequelae. A thorough social history and clinical suspicion are paramount in recognizing the diagnosis. This case is an example of TLE in a middle-aged white male with a history of polysubstance abuse. He presented with a three week history of progressive neuropsychological symptoms, including abulia, bradyphrenia, hyperreflexia, and visual hallucinations. He was initially suspected to have progressive multifocal leukoencephalopathy, however, JCV PCR was negative. MRI showed diffuse …

Overcoming America’S Opioid Epidemic Will Need Action Not Words, Rahul Gupta

Marshall Journal of Medicine

Opioids kill thousands of Americans each year. The opioid epidemic is the worst public health disaster in our nation’s history. The crisis touches countless communities, is a pivotal driver of the diminishing labor force and costs the country billions of dollars each year. West Virginia has the highest death rate due to drug overdose. It is important to identify the risk factors that can lead to overdose and seek science based and practical recommendations to tackle the problem.

Training 21st-Century Physicians And Scientists In Team Science, Darshana T. Shah

Marshall Journal of Medicine

No abstract provided.

A Practicality Analysis Pertaining To Minimally Invasive Robot-Assisted Urologic Surgery, Chase Cavayero

The Pegasus Review: UCF Undergraduate Research Journal

Minimally invasive robot-assisted surgery is a technological development that has changed the field of medicine in the past decade. The introduction of the da Vinci® by Intuitive Surgical Inc. has opened up many interesting options in several different fields. Specifically, the field of urology has seen increased utilization of the robotic technique due to the precision allowed by the technology. Although many perioperative and postoperative benefits have been documented within the literature pertaining to robotic surgery, some surgeons contend that the extra cost associated with the procedures is not practical. To this point the extra cost has not been prohibitive, …

Understanding Older Women's Experience Of Being Diagnosed With Breast Cancer, Molly Wilhelm

The Pegasus Review: UCF Undergraduate Research Journal

This study describes the experience of being diagnosed with early stage breast cancer for women age 65 and older. This qualitative study used content analysis to analyze twenty interviews of older women with early stage breast cancer. A variety of positive and negative factors influence the experience of being diagnosed with breast cancer. These factors include: their initial reactions, interactions with their respective medical teams, family support, religion, education, and misinformation. Nurses can use the information from this study to help make diagnosis more positive by educating older women about breast cancer and treatment, encouraging them to develop an optimistic …

Early Adolescent Latinas And Non-Coital Sexual Behavior: Individual, Social, And Parental Variables, Ellita Williams

The Pegasus Review: UCF Undergraduate Research Journal

Unplanned pregnancies and sexually transmitted infections (STI) are increasing at a faster rate among young, low income Latinas as compared to other low income groups of girls. However, little is known about the non-coital behavior that early adolescent girls may engage in, which puts them at risk for initiation of intercourse. This study examines the frequency of a particular non-coital behavior, being touched below the waist on top of clothes, and investigates how girls who engage in this behavior differ from those who do not with respect to individual (biologic and cognitive), social (peer norms and acculturation), and parental (single …

Direct And Indirect Influences Of Defendant Mental Illness On Jury Decision Making, Marie Sabbagh

The Pegasus Review: UCF Undergraduate Research Journal

It is a common misconception that individuals with schizophrenia are significantly more dangerous and violent than individuals free of mental illness. This stigmatization may lead to harsher sentences when people with schizophrenia are involved in criminal activities and sentenced by a jury. This study presented four conditions to which participants were randomly assigned, alone or in a group of three, and were asked to sentence a defendant, either with or without schizophrenia. It was hypothesized that group deliberations would result in more lenient sentences for defendants with schizophrenia as compared to individual deliberations. Furthermore, it was predicted that both group …

The Backward Masking Red Light Effect And Schizotypy: The Influence Of Sex, Diana C. Hernandez, Andrea Y. Ranieri

The Pegasus Review: UCF Undergraduate Research Journal

Previous research has shown a unique effect of red light on visual processing related to both schizophrenia and positive schizotypy. The current study examines whether this effect is influenced by sex in a more broadly-defined schizotypy sample. A location backward masking (BM) task with three color background conditions (red, green, and gray) was administered to 34 undergraduate students (59% female) with a high score on the Schizotypal Personality Questionnaire (SPQ) and 39 students (51% female) with a low score. Results revealed that the group by color interaction was significant for the male participants, while it did not approach significance in …

Mirror, William Ciurylo

Akesis

No abstract provided.

Drowning & Undrowning, Jenna Wozer

Akesis

No abstract provided.

Crazy Carry Cash Only, Breanna M. Glynn

Akesis

Taken in the Back Bay of Boston on a sunny early spring morning. I wanted to remember the moment that this photo was taken. I remember I was so sick of winter (as I usually am), and it was a gorgeous sunny morning. I can still feel the sun on my back, making me almost (almost) warm enough to want to take off my fuzzy coat. The sun was shining on my partner and me as we walked hand and hand down the street. We stopped by an antique shop, as my partner is apt to do, and we happened …

Mistakes, Kristina Carlson

Akesis

And I see myself reflected in all my mistakes.

Untitled, Laura Morin

Akesis

No abstract provided.

Examine Yourself 5, Jordan Morrison-Nozik

Akesis

Reflection on the self, the career decision, the education process, and the appearance that comes with becoming a physician

Examine Yourself 4, Jordan Morrison-Nozik

Akesis

No abstract provided.

Examine Yourself 3, Jordan Morrison-Nozik

Akesis

No abstract provided.

Examine Yourself 2, Jordan Morrison-Nozik

Akesis

No abstract provided.

Examine Yourself 1, Jordan Morrison-Nozik

Akesis

No abstract provided.

Etiology Of Community Acquired Clostridium Difficile-Associated Disease, Shannan Sherman, Dr. Pamela Ark

The Pegasus Review: UCF Undergraduate Research Journal

A review of literature related to community acquired Clostridium difficile -associated disease (CA-CDAD) was conducted. Nine relevant studies were identified using the Cumulative Index to Nursing and Allied Health (CINAHL) and MEDLINE-EBSCOhost databases. Clinical practice recommendations were obtained from the Centers for Disease Control and Prevention. The studies provided information about epidemiology of infection due to C. difficile in the community and interventions to reduce transmission. Multiple studies found underlying gastrointestinal disorders and use of cephalosporin antibiotics to be a risk factor. Another risk factor was administration of gastric acid suppressive drugs. No particular C. difficile strain was more likely …

Transcriptional Regulatory Control Of Mammalian Nephron Progenitors Revealed By Multi-Factor Cistromic Analysis And Genetic Studies., Lori L O'Brien, Qiuyu Guo, Emad Bahrami-Samani, Joo-Seop Park, Sean M Hasso, Young-Jin Lee, Alan Fang, Albert D Kim, Jinjin Guo, Trudy M Hong, Kevin A Peterson, Scott Lozanoff, Ramya Raviram, Bing Ren, Ben Fogelgren, Andrew D Smith, Anton Valouev, Andrew P Mcmahon

Faculty Research 2018

Nephron progenitor number determines nephron endowment; a reduced nephron count is linked to the onset of kidney disease. Several transcriptional regulators including Six2, Wt1, Osr1, Sall1, Eya1, Pax2, and Hox11 paralogues are required for specification and/or maintenance of nephron progenitors. However, little is known about the regulatory intersection of these players. Here, we have mapped nephron progenitor-specific transcriptional networks of Six2, Hoxd11, Osr1, and Wt1. We identified 373 multi-factor associated 'regulatory hotspots' around genes closely associated with progenitor programs. To examine their functional significance, we deleted 'hotspot' enhancer elements for Six2 and Wnt4. Removal of the distal enhancer for Six2 …

The Challenged Brain Bps 205g, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Teenage Exercise Is Associated With Earlier Symptom Onset In Dysferlinopathy: A Retrospective Cohort Study., Ursula R Moore, Marni Jacobs, Roberto Fernandez-Torron, Jiji Jang, Meredith K James, Diana X Bharucha-Goebel, +Several Additional Authors

Pediatrics Faculty Publications

No abstract provided.

What's Happening: January 29, 2018, Maine Medical Center

What's Happening

No abstract provided.

Anatomical Study Of The Extreme Lateral Transpsoas Lumbar Interbody Fusion With Application To Minimizing Injury To The Kidney., Joe Iwanaga, Emre Yilmaz, Tamir Tawfik, Amir Abdul-Jabbar, Marc Vetter, Marc Moisi, Koichi Watanabe, Koh-Ichi Yamaki, R Shane Tubbs, Rod J Oskouian

Articles, Abstracts, and Reports

Objective Since the extreme lateral lumbar interbody fusion procedure was first reported by Ozgur in 2006, a large number of clinical studies have been published. Anatomical studies which explore methods to avoid visceral structures, such as the kidney, with this approach have not been examined in detail. We dissected the retroperitoneal space to analyze how the extreme lateral transpsoas approach to the lumbar spine could damage the kidney and related structures. Methods Eight sides from four fresh Caucasian cadavers were used for this study. The latissimus dorsi muscle and the thoracolumbar fascia were dissected to open the retroperitoneum. The fat …

Risks Of Colon Injuries In Extreme Lateral Approaches To The Lumbar Spine: An Anatomical Study., Emre Yilmaz, Joe Iwanaga, Marc Moisi, Ronen Blecher, Amir Abdul-Jabbar, Tamir Tawfik, Rod J Oskouian, R Shane Tubbs

Articles, Abstracts, and Reports

Introduction
 The extreme lateral interbody fusion technique (XLIF) is a modification of the retroperitoneal approach to the lumbar spine. This is a minimally invasive technique allowing direct access to the disc space without peritoneal or posterior paraspinal musculature damage. Nevertheless, the retroperitoneal part of the colon can be injured in this operative technique. To our knowledge, a study analyzing the anatomical considerations of the extreme lateral interbody fusion technique with regards to potential colon injuries has not been previously performed. Therefore, the aim of this study was to evaluate the potential risk of colon injuries during the extreme lateral approach …