Medicine and Health Sciences Commons^™

Perceptions Of Nursing Students Of Educational Environment At A Private Undergraduate School Of Nursing In Karachi, Salima Farooq, Rehana Rehman, Jacqueline Maria Dias, Mehwish Hussain

School of Nursing & Midwifery

Ojective: To assess educational environment at a nursing school..
Methods: The cross-sectional survey was carried out from May to October 2016 at Aga Khan University School of Nursing and Midwifery, Karachi, using the Dundee Ready Educational Environment Measure tool. The scores were obtained by merging five sub-scales of the inventory. The average scores of the scale and sub-scales were compared in terms of age, year of study, and living status using Mann-Whitney U test, and among years of study by Kruskal Wallis test..
Results: Of the 442 students, 228(51.6%) had age below 20 years. Overall, 131(29.1%) subjects were in the …

Randomized Controlled Trials Evaluating Patient-Reported Outcomes After Cholecystectomy: A Systematic Review, Krislynn M Mueck, Deepa V Cherla, Amy Taylor, Tien C Ko, Mike K Liang, Lillian S Kao

Library Staff Publications

No abstract provided.

Hepatic, Periportal, Retroperitoneal, And Mesenteric Neurofibromatosis In Von Recklinghausen's Disease, Kumail Khandwala, Zafar Sajjad, Summar-Un-Nisa Abbasi, Muhammad Usman Tariq

Department of Radiology

We present a rare case of histologically proven neurofibromatosis of the liver, hepatic hilum, retroperitoneum, and mesentery. An adult male who had been diagnosed with neurofibromatosis (NF) type 1 underwent a computed tomography (CT) scan for abdominal pain and vomiting. The CT scan showed a large low-attenuating lesion in the region of porta hepatis which was infiltrating along portal tracts into the liver, encasing the major vessels, and extending into the retroperitoneum and mesentery. Based on the radiological findings, a differential diagnosis of plexiform neurofibroma was given, although sarcomatous transformation could not have been entirely excluded from imaging alone. The …

Effectiveness Of Influenza Vaccine In Preventing Medically-Attended Influenza Virus Infection In Primary Care, Israel, Influenza Seasons 2014/15 And 2015/16, Hamutal Yaron-Yakoby, Hanna Sefty, Rakefet Pando, Rita Dichtiar, Mark A. Katz, Aharona Glatman-Freedman, The Israeli Influenza Surveillance Network (Iisn)

NYMC Faculty Publications

IntroductionInfluenza vaccine is recommended for the entire population in Israel. We assessed influenza vaccine effectiveness (VE) for the 2014/15 and 2015/16 seasons in Israel, for the first time. Methods: Combined nose and throat swab specimens were collected from patients with influenza-like illness (ILI) presenting to sentinel primary care clinics and tested for influenza virus by RT-PCR. VE of the trivalent inactivated vaccine (TIV) was assessed using test-negative case-control design. Results: During the 2014/15 season 1,142 samples were collected; 327 (28.6%) were positive for influenza, 83.8% A(H3N2), 5.8% A(H1N1)pdm09, 9.2% B and 1.2% A un-subtyped. Adjusted VE against all influenza viruses …

Acute Myeloid Leukemia In A Father And Son With A Germline Mutation Of Asxl1, Karen Seiter, Kyaw Htun, Paul Baskind, Zach Liu

NYMC Faculty Publications

Background: Myelodysplastic syndromes and acute myeloid leukemia usually occur sporadically in older adults. More recently cases of familial acute myeloid leukemia and/or myelodysplastic syndrome have been reported. Case presentation: Currently we report a father and son who both developed myelodysplastic syndrome that progressed to acute myeloid leukemia. Both patients were found to have the identical mutation of ASXL1 on nextgen sequencing of both hematologic and nonhematologic tissues. Conclusions: These cases support the diagnosis of a germline mutation of ASXL1.

Gastrointestinal Tuberculosis Presenting As Malnutrition And Distal Colonic Bowel Obstruction, Raja C. Chakinala, Zahava Farkas, Benjamin Barbash, Khwaja Haq, Shantanu Solanki, Taliya Farooq, Brad Dworkin

NYMC Faculty Publications

Gastrointestinal (GI) tuberculosis (TB) is rare and can occur in the context of active pulmonary disease or as a primary infection with no pulmonary symptoms. It typically presents with vague abdominal symptoms, making it difficult to discern from alternative disease processes. Although the ileocecal region is the most commonly affected site, tuberculous enteritis can involve any aspect of the GI tract. To demonstrate the importance of maintaining a high clinical suspicion for the disease, we present a case of GI TB presenting as severe malnutrition and segmental colitis of the left colon.

Giant Pilomatrix Carcinoma Of The Face, Sapna Lohiya, Yeshwant B. Rawal, Jasjit K. Dillon

School of Dentistry Faculty Research and Publications

This case report describes an unusually large facial pilomatrix carcinoma (PC) in a 60-year-old man. This PC had been growing slowly for 11 months and had recently ulcerated. It measured 9 cm × 7 cm × 5 cm. Initial punch biopsy findings were inconclusive. The tumor was excised in total with 5-mm margins in a supra-superficial musculoaponeurotic system plane. The defect was reconstructed with a cervicofacial bilobed rotational advancement flap. Histopathologic findings confirmed the diagnosis of PC. There was no lymph node spread or distant metastasis. The patient recovered with a good esthetic result. This case represents one of the …

Preoperative Low Dose Aspirin Therapy, Alicia Erickson

Nursing Capstones

No abstract provided.

Nutrinews, Volume 37, February, 2018, Department Of Nutrition And Dietetics, University Of North Florida

NutriNews

This issue features Social Influences maybe holding you back from your goals, Nutri Recipes featuring recipes that follow the Mediterranean Diet

Association Between Environmental Tobacco Smoke And Dental Caries Amongst 5-14 Years Old Children In Karachi, Pakistan., Anna Ali Nayani, Romaina Iqbal, Syed Iqbal Azam, Farhan Raza Khan, Aysha Habib Khan, Naveed Janjua, Azmina Hussain

Community Health Sciences

Objective:To determine the association between environmental tobacco smoke and dental caries.
Methods:This cross-sectional study was conducted in peri-urban and urban areas of Karachi, from February to August 2014, and comprised children aged 5-14 years. A pre-coded questionnaire for environmental tobacco smoke and food frequency questionnaire for dietary habits were used. Dental examination of children was done to detect caries. Cox-proportional hazard algorithm was used to measure the association of environmental tobacco smoke with dental caries at multivariable level. STATA version 12.0 was used for statistical analysis.
Result:Of the 500 children, 250(50%) each were from peri-urban and urban …

Consensus Guidelines For Newborn Screening, Diagnosis And Treatment Of Infantile Krabbe Disease., Jennifer M. Kwon, Dietrich Matern, Joanne Kurtzberg, Lawrence Wrabetz, Michael H. Gelb, David A. Wenger, Can Ficicioglu, Amy T. Waldman, Barbara K. Burton, Patrick V. Hopkins, Joseph J. Orsini

Department of Neurology Faculty Papers

BACKGROUND: Krabbe disease is a rare neurodegenerative genetic disorder caused by deficiency of galactocerebrosidase. Patients with the infantile form of Krabbe disease can be treated at a presymptomatic stage with human stem cell transplantation which improves survival and clinical outcomes. However, without a family history, most cases of infantile Krabbe disease present after onset of symptoms and are ineligible for transplantation. In 2006, New York began screening newborns for Krabbe disease to identify presymptomatic cases. To ensure that those identified with infantile disease received timely treatment, New York public health and medical systems took steps to accurately diagnose and rapidly …

Parp Pet Imaging Agents, Brandon Carney

Dissertations, Theses, and Capstone Projects

The poly (adenosine-diphosphate (ADP) ribose) polymerase (PARP) family of enzymes has been of interest to researchers and clinicians for over fifty years, especially the first member of the family, PARP1. This enzyme has become a target for cancer therapeutics due the reliance of highly proliferating cells on PARP1 for genomic maintenance. In the coming age of individualized medicine, however, highly specific therapeutic agents like PARP inhibitors are in need of similarly highly specific companion diagnostic agents. These kind of agents have been made possible with the quickly progressing field of molecular imaging. Specifically, positron emission tomography (PET) has enabled the …

Lexical Access In Individuals With Cerebral Palsy And Severe Speech And Physical Impairment, Iris Fishman

Dissertations, Theses, and Capstone Projects

This study examined lexical access in adolescents and adults with cerebral palsy and severe speech and physical impairment (CP/SSPI) who have limited language production due to severe dysarthria or anarthria. To date, the impact of a severe speech production deficit on lexical activation and the organization of the mental lexicon has not been investigated. Such an investigation may support or refute these views of an articulatory basis of speech perception and lexical development and access. The hypothesis of this study is that spoken word recognition will be severely reduced or absent in this population although individual differences may result in …

Managing Ambiguity: Nurses Caring For The Mother Of A Stillborn Baby, Natasha J. Nurse

Dissertations, Theses, and Capstone Projects

Abstract

Purpose: The aim of this study was to describe and conceptualize the experiences and processes involved when labor and delivery nurses provide care to women experiencing a stillbirth.

Background: The care of a woman experiencing a stillbirth is an important topic that requires attention, however, there is a paucity of literature on the specifics of a nurse’s experience as she or he cares for a grieving mother. These experiences may shed light on gaps in care that may exist as well as gaps in the resources, education and support needed to appropriately prepare nurses for providing care …

Microrna 1207-3p In Prostate Cancer, Dibash Das

Dissertations, Theses, and Capstone Projects

Prostate cancer (PCa) is the most commonly diagnosed male cancer and the second leading cause of cancer-related death for men in the United States. Understanding the molecular mechanisms involved in progression from the asymptomatic androgen-dependent PCa to the lethal castration resistant prostate cancer (CRPC) is a major challenge. MicroRNAs (miRNAs), are known to be dysregulated in PCa. MicroRNA-1207-3p (miR-1207-3p) is encoded by the non-protein coding gene locus PVT1 on the 8q24 human chromosomal region, an established PCa susceptibility locus. However, the role of miR-1207-3p in PCa is unclear. We have discovered that miR-1207-3p is significantly underexpressed in PCa cell lines …

New Dyes For Cancer Theranostics, Waqar Rizvi

Dissertations, Theses, and Capstone Projects

Porphyrinoids are robust heterocyclic dyes studied extensively for applications in medicine and as photonic materials because of their tunable photophysical properties, diverse means of modifying the periphery, and the ability to chelate most transition metals. Commercial applications include phthalocyanine dyes in optical discs, porphyrins in photodynamic therapy, and as oxygen sensors. Most applications of these dyes require exocyclic moieties to improve solubility, target disease, modulate photophysical properties, or direct self-organization into architectures with desired photonic properties. The synthesis of the porphyrinoid depends on the desired application, but the de novo synthesis often involves several steps, is time consuming, and results …

Validity Testing Of The Genetics And Genomics In Nursing Practice Survey (Ggnps), Alexandra Plavskin

Dissertations, Theses, and Capstone Projects

Genetics and genomics have the potential to change how health care providers screen for, diagnose, and treat diseases; as well as how they intervene to reduce disease risk. Because genetics/genomics play a role in disease prevention and health promotion, screening, diagnosis, treatment selection, and patient-education, all nurses must adopt genetics and genomics into clinical practice to provide competent care.

The purpose of this study was to evaluate the face, content, and construct validity of the Genetics and Genomics Nursing Practice Survey (GGNPS). The GGNPS is an instrument designed to measure Registered Nurses’ (RNs) competency/knowledge, confidence, attitudes/receptivity and decision/adoption of genetics …

Nurses' Knowledge, Attitudes, And Perceived Self-Competency Regarding Individualized Developmental Care In The Neonatal Intensive Care Unit, Patricia Macho

Dissertations, Theses, and Capstone Projects

Infants born prematurely are at a greater risk for developing both cognitive and motor development delays related to continuing their development outside the normal uterine environment. Because of the potential adverse effects of the Neonatal Intensive Care Unit (NICU) environment on the quality of life of premature infants and their families, researchers have investigated, developed, and tested different developmentally supportive interventions to improve outcomes and decrease the negative effects of the NICU. The majority of successful interventions are based on the Synactive Theory of Individualized Developmental Care (IDC)-a form of patient/family- centered care for the neonate.

The majority of published …

Bacterial Lps At The Immune Modulating Component In Juzen-Taiho-To, Diego Montenegro

Dissertations, Theses, and Capstone Projects

Juzen-taiho-to (JTT) is an immune-boosting herbal formulation with an ideal balance of safety and efficacy. For example, JTT is clinically used in Japan to stimulate the immunological functions of cancer patients undergoing chemotherapy and radiation. Although the clinical effects of JTT are recognized, the active compounds and mechanism of action are unknown. The studies conducted previously in our laboratory associated several phytosterols and plant glycolipids with the potent immunostimulatory activity of JTT: namely, β-sitosteryl β-D-glucoside (BSSG), glucocerebroside (GluCer), digalactosyldiacylglycerol (DGDG) and monogalactosyldiacylglycerol (MGDG). However, these compounds, when further purified, exhibited little or no immunostimulatory activity. This suggested that the immunostimulatory …

Nursing Students At The Helm: A Study Of The Effect Of A Health Literacy Module (Helm) On The Health Literacy Knowledge, Skills And Attitudes Of Pre-Licensure Baccalaureate Nursing Students, Joy G. Borrero

Dissertations, Theses, and Capstone Projects

Background: Effective communication is a foundation of high-quality, patient-centered health care. Understanding health literacy is an essential attribute that health care professionals need to possess in order to promote effective partnerships with patients and their significant others. Nurses, especially, need to be involved in addressing the epidemic problem of low health literacy in the United States because they are responsible for the majority of patient, caregiver and community health education and communication. Nurses play a key role in providing health care information to individuals, families and groups in a variety of settings and therefore should be educated about the essentials …

Prognostic Significance Of Optic Nerve Sheath Diameter On Computed Tomography Scan With Severity Of Blunt Traumatic Brain Injury In The Emergency Department., Shahan Waheed, Muhamamd Akbar Baig, Emaduddin Siddiqui, Danyal Jamil, Asher Feroze

Department of Emergency Medicine

Optic nerve sheath diameter measurement (ONSD) has been associated with identifying the prognosis of traumatic brain injury (TBI) patients. The study was planned to evaluate the prognostic value of ONSD measured on the initial brain computed tomography (CT) scan performed on patients with blunt TBI in the emergency department(ED). This retrospective cross-sectional study was conducted at the Aga Khan University Hospital, Karachi, and comprised data of moderate and severe TBI patients from January to December 2014. ONSD for each eye on the initial CT scan and Glasgow Coma Scale (GCS) was measured upon patient presentation. Correlation between presentation GCS and …

Mr And Diffusion Tensor Imaging Of Isolated Tentorial Hypoplasia, Yankai Sun, Shalabh Bobra, Christeena Kurian, Brij Ahluwalia-Singh, Anila Thomas, Hasit Mehta

NYMC Faculty Publications

No abstract provided.

Improving Pneumococcal Vaccine Uptake In Veterans With Chronic Lymphocytic Leukemia Through A Virtual Clinic, Brigid M. Wilson, L. Arfons, Federico Perez, Robin L.P. Jump

Faculty Scholarship

Through a “virtual clinic,” we used the electronic medical record to identify and intervene upon patients with chronic lymphocytic leukemia (CLL) who were not current for pneumococcal vaccines. Within 180 days, 100/160 patients (62%) received the recommended pneumococcal vaccine. A virtual clinic may improve vaccination rates among high-risk patient populations.

Adropin: An Endocrine Link Between The Biological Clock And Cholesterol Homeostasis, Sarbani Ghoshal, Joseph R. Stevens, Cyrielle Billon, Clemence Girardet, Sadichha Sitaula, Arthur S. Leon, D.C. Rao, James S. Skinner, Tuomo Rankinen, Claude Bouchard, Marinelle V. Nuñez, Kimber L. Stanhope, Deborah A. Howatt, Alan Daugherty, Jinsong Zhang, Matthew Schuelke, Edward P. Weiss, Alisha R. Coffey, Brian J. Bennett, Praveen Sethupathy, Thomas P. Burris, Peter J. Havel, Andrew A. Butler

Physiology Faculty Publications

Objective

Identify determinants of plasma adropin concentrations, a secreted peptide translated from the Energy Homeostasis Associated (ENHO) gene linked to metabolic control and vascular function.

Methods

Associations between plasma adropin concentrations, demographics (sex, age, BMI) and circulating biomarkers of lipid and glucose metabolism were assessed in plasma obtained after an overnight fast in humans. The regulation of adropin expression was then assessed in silico, in cultured human cells, and in animal models.

Results

In humans, plasma adropin concentrations are inversely related to atherogenic LDL-cholesterol (LDL-C) levels in men (n = 349), but not in women (n = …

Rad Gtpase Deletion Atenuates Post-Ischemic Cardiac Dysfunction And Remodeling, Janet R. Manning, Lakshman Chelvarajan, Bryana R. Levitan, Catherine Nicole Kaminski Withers, Prabhakara R. Nagareddy, Christopher M. Haggerty, Brandon K. Fornwalt, Erhe Gao, Himi Tripathi, Ahmed Abdel-Latif, Douglas A. Andres, Jonathan Satin

Physiology Faculty Publications

The protein Rad interacts with the L-type calcium channel complex to modulate trigger Ca²⁺ and hence to govern contractility. Reducing Rad levels increases cardiac output. Ablation of Rad also attenuated the inflammatory response following acute myocardial infarction. Future studies to target deletion of Rad in the heart could be conducted to establish a novel treatment paradigm whereby pathologically stressed hearts would be given safe, stable positive inotropic support without arrhythmias and without pathological structural remodeling. Future investigations will also focus on establishing inhibitors of Rad and testing the efficacy of Rad deletion in cardioprotection relative to the time of …

Chronic Voluntary Oral Methamphetamine Induces Deficits In Spatial Learning And Hippocampal Protein Kinase Mzeta With Enhanced Astrogliosis And Cyclooxygenase-2 Levels, Jorge A. Avila, Roseanna M. Zanca, Denis Shor, Nicholas Paleologos, Amber A. Alliger, Maria E. Figueiredo-Pereira, Peter A. Serrano

Publications and Research

Methamphetamine (MA) is an addictive drug with neurotoxic effects on the brain producing cognitive impairment and increasing the risk for neurodegenerative disease. Research has focused largely on examining the neurochemical and behavioral deficits induced by injecting relatively high doses of MA [30 mg/kg of body weight (bw)] identifying the upper limits of MA-induced neurotoxicity. Accordingly, we have developed an appetitive mouse model of voluntary oral MA administration (VOMA) based on the consumption of a palatable sweetened oatmeal mash containing a known amount of MA. This VOMA model is useful for determining the lower limits necessary to produce neurotoxicity in the …

The World Database For Pediatric And Congenital Heart Surgery: Use Of An International Congenital Database In South Korea., James D. St Louis, Cheul Lee, Hiromi Kurosawa, Richard A. Jonas, Sakamoto Kisaburo, Christo I. Tchervenkov, Jeffery P. Jacobs, James K. Kirklin

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.

Comparing Men Who Have Sex With Men And Transgender Women Who Use Grindr, Other Similar Social And Sexual Networking Apps, Or No Social And Sexual Networking Apps: Implications For Recruitment And Health Promotion, Christina J. Sun, Erin L. Sutfin, Laura H. Bachmann, Jason Stowers, Scott D. Rhodes

OHSU-PSU School of Public Health Faculty Publications and Presentations

Objective: Researchers and public health professionals have increased their attention to GPS-based social and sexual networking applications (apps) tailored to gay, bisexual, and other men who have sex with men (MSM) and transgender women. These populations continue to be disproportionately affected by HIV in the United States; therefore, these apps, in particular Grindr, have become an important sampling venue for the recruitment of HIV-related research participants. As such, it is essential to identify differences among app users to avoid potential sampling bias. This paper seeks to identify differences in MSM and transgender women who use Grindr and those who …

Community Engagement In Academic Health Centers: A Model For Capturing And Advancing Our Successes, Karen Vitale, Gail L. Newton, Ana Abraido-Lanza, Alejandra N. Aguirre, Syed Ahmed, Sarah Esmond, Jill Evans, Sherril Gelmon, Multiple Additional Authors

OHSU-PSU School of Public Health Faculty Publications and Presentations

Academic health centers (AHCs) are under increased pressure to demonstrate the effectiveness of their community-engaged activities, but there are no common metrics for evaluating community engagement in AHCs. Eight AHCs piloted the Institutional Community Engagement Self-Assessment (ICESA), a two-phase project to assess community-engagement efforts. The first phase uses a framework developed by the University of Rochester Medical Center, which utilizes structure, process, and outcome criteria to map CE activities. The second phase uses the Community-Campus Partnerships for Health (CCPH) Self-Assessment to identify institutional resources for community engagement, and potential gaps, to inform community engagement goal-setting. The authors conducted a structured, …

Help-Seeking On Facebook Versus More Traditional Sources Of Help: Cross-Sectional Survey Of Military Veterans, Alan R. Teo, Heather E. Marsh, Samuel B.L. Liebow, Jason I. Chen, Christopher W. Forsberg, Christina Nicolaidis, Somnath Saha, Steven K. Dobscha

School of Social Work Faculty Publications and Presentations

Background: The media has devoted significant attention to anecdotes of individuals who post messages on Facebook prior to suicide. However, it is unclear to what extent social media is perceived as a source of help or how it compares to other sources of potential support for mental health problems.

Objective: This study aimed to evaluate the degree to which military veterans with depression use social media for help-seeking in comparison to other more traditional sources of help.

Methods: Cross-sectional self-report survey of 270 adult military veterans with probable major depression. Help-seeking intentions were measured with a modified General Help-Seeking Questionnaire. …