Medicine and Health Sciences Commons^™

Hiv Clustering In Mississippi: Spatial Epidemiological Study To Inform Implementation Science In The Deep South, Thomas J. Stopka, Lauren Brinkley-Rubinstein, Kendra Johnson, Philip A. Chan, Marga Hutcheson, Richard A. Crosby, Deirdre Burke, Leandro Mena, Amy Nunn

Health, Behavior & Society Faculty Publications

Background: In recent years, more than half of new HIV infections in the United States occur among African Americans in the Southeastern United States. Spatial epidemiological analyses can inform public health responses in the Deep South by identifying HIV hotspots and community-level factors associated with clustering.

Objective: The goal of this study was to identify and characterize HIV clusters in Mississippi through analysis of state-level HIV surveillance data.

Methods: We used a combination of spatial epidemiology and statistical modeling to identify and characterize HIV hotspots in Mississippi census tracts (n=658) from 2008 to 2014. We conducted spatial analyses of all …

Ovarian Reserve Testing: A Promising Tool For Family Planning And Fertility Preservation In The 21st Century, Heather Badger

Nursing Capstones

No abstract provided.

Spatial Organization And Molecular Correlation Of Tumor-Infiltrating Lymphocytes Using Deep Learning On Pathology Images., Joel Saltz, Rajarsi Gupta, Le Hou, Tahsin Kurc, Pankaj Singh, Vu Nguyen, Dimitris Samaras, Kenneth R Shroyer, Tianhao Zhao, Rebecca Batiste, John Van Arnam, Ilya Shmulevich, Arvind U K Rao, Alexander J Lazar, Ashish Sharma, Vésteinn Thorsson

Articles, Abstracts, and Reports

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumor-infiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched …

Stochastic Modeling Of Radiation-Induced Dendritic Damage On In Silico Mouse Hippocampal Neurons, Eliedonna Cacao, Vipan K. Parihar, Charles L. Limoli, Francis A. Cucinotta

Health Physics and Diagnostic Sciences Faculty Research

Cognitive dysfunction associated with radiotherapy for cancer treatment has been correlated to several factors, one of which is changes to the dendritic morphology of neuronal cells. Alterations in dendritic geometry and branching patterns are often accompanied by deficits that impact learning and memory. The purpose of this study is to develop a novel predictive model of neuronal dendritic damages caused by exposure to low linear energy transfer (LET) radiation, such as X-rays, gamma-rays and high-energy protons. We established in silico representations of mouse hippocampal dentate granule cell layer (GCL) and CA1 pyramidal neurons, which are frequently examined in radiation-induced cognitive …

Systemic Exercise-Induced Hypoalgesia Following Isometric Exercise Reduces Conditioned Pain Modulation, Ali Alsouhibani, Henrik Bjarke Vaegter, Marie K. Hoeger Bement

Physical Therapy Faculty Research and Publications

Objective

Physically active individuals show greater conditioned pain modulation (CPM) compared with less active individuals. Understanding the effects of acute exercise on CPM may allow for a more targeted use of exercise in the management of pain. This study investigated the effects of acute isometric exercise on CPM. In addition, the between-session and within-session reliability of CPM was investigated.

Design

Experimental, randomized crossover study.

Setting

Laboratory at Marquette University.

Subjects

Thirty healthy adults (19.3±1.5 years, 15 males).

Methods

Subjects underwent CPM testing before and after isometric exercise (knee extension, 30% maximum voluntary contraction for three minutes) and quiet rest in …

Factors Associated With College Students' Willingness And Readiness To Act In A Food Allergic Emergency, Olga Kagan

Theses & Dissertations

Problem/Significance: Food allergy is a growing public health concern in the United States affecting nearly 15 million Americans. According to FAIR Health (Gelburd, 2017), diagnoses of anaphylactic food reactions increased by 377% nationwide from 2007 to 2016, with 66% among patients 18 years or younger, and 34% in those over 18 years old. Several tragic incidents and lawsuits have occurred on college campuses in recent years raising concerns over the safety of college students experiencing a food allergic emergency. Purpose: The purpose of this quantitative descriptive correlational study is to identify factors associated with college students’ willingness and readiness to …

Examining The Use Of Rapid Polymerase Chain Reaction Assay In Optimizing Antimicrobial Usage In Respiratory Viral Infections, Deandra Romero, Ana Lopez-Samblas, Maria Rojo-Carlo

All Publications

Abstract Category: Research

Purpose: Historically, respiratory pathogen testing has included the use of cultures and antigen-testing. Introduction of rapid polymerase chain reaction (PCR) assay has resulted in fast, effective identification of viral pathogens. However, studies show conflicting findings in the usefulness of PCR technology in the management of respiratory infections. The objective of this study is to examine the use of viral PCR assays in the management of respiratory viral infections in a community hospital. The study will describe viral PCR use in identifying viral pathogens, evaluating appropriate treatment, and de-escalating of antimicrobial therapy when indicated.

Methods: Patients will be …

Hippocampal Protein Kinase D1 Is Necessary For Dhpg-Induced Learning And Memory Impairments In Rats, Wei Wang, Florian Duclot, Bradley R. Groveman, Nicole Carrier, Haifa Qiao, Xiao-Qian Fang, Hui Wang, Wenkuan Xin, Michael W. Salter, Xin-Sheng Ding

School of Medicine Publications

Background

Understanding molecular mechanisms underlying the induction of learning and memory impairments remains a challenge. Recent investigations have shown that the activation of group I mGluRs (mGluR1 and mGluR5) in cultured hippocampal neurons by application of (S)-3,5-Dihydroxyphenylglycine (DHPG) causes the regulated internalization of N-methyl-D-aspartate receptors (NMDARs), which subsequently activates protein kinase D1 (PKD1). Through phosphorylating the C-terminals of the NMDAR GluN2 subunits, PKD1 down-regulates the activity of remaining (non-internalized) surface NMDARs. The knockdown of PKD1 does not affect the DHPG-induced inhibition of AMPA receptor-mediated miniature excitatory post-synaptic currents (mEPSCs) but prevents the DHPG-induced inhibition of NMDAR-mediated mEPSCs in …

Projection Of Potential Reimbursement Of A Post-Hospital Discharge Pharmacist Operated Medication Management Service, Patricia Gonzalez-Abreu, Maria Perez Arias, Ana Lopez-Samblas

All Publications

Abstract Category: Practice Innovation / Performance Improvement (PI)

Purpose: It is well established in the literature that pharmacists providing medication therapy management services (MTM) post-hospital discharge can improve medication adherence and safety, as well as decrease Emergency Department visits and readmissions. Although the evidence supports these programs, the number of patients receiving such services is very limited, mainly due to cost. The purpose of this study is to determine if enough revenue can be generated to sustain a post-discharge pharmacist driven medication therapy management program.

Methods: A prospective review of patients discharged from medical/surgical units for an 11 months period …

Gastric Calcifying Fibrous Tumor Mimicking Gi Stromal Tumor, Nneoma Okoronkwo, Shima Ghavimi, Ravi Chokshi, Stephen Peters, Sushil Ahlawat

Internal Medicine

A 27-year-old female with no significant medical history was referred for an EUS to evaluate a large, firm, gastric mass, which was detected during esophagastroduodenoscopy done for persistent reflux symptoms and intermittent epigastric pain. EUS revealed a polypoid, broad-based, solid intramural mass, 2 cm x 4 cm in size, heterogeneous in echo-texture with calcifications and post-acoustic shadowing. The polypoid gastric mass appeared to arise from the muscularis propria.

Ada News - 04/02/2018, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

What's Happening: April 2, 2018, Maine Medical Center

What's Happening

No abstract provided.

The Effects Of An Occupation-Based Home Exercise Program For Stroke Survivors, Shannon King

MOT Student Capstones

Stroke survivors seldom regain their full functionality following hospital or inpatient rehabilitation, it is therefore pertinent to have an intervention that can aid their recovery back at home. Functional impairments often lead to other complications if not properly managed including decreased participation in activities of daily living, decreased social activities, and increased depression. This project introduces a consistent, daily exercise for their recovery that is essential, described as occupation-based home exercise program (HEP). The purpose of the study is to administer this occupation-based home exercise program to assist stroke survivors to continue recovery at home to improve their functional ability, …

Jefferson Digital Commons Quarterly Report: January-March 2018, Kelsey Duinkerken, Msi, James Copeland, Libt

Jefferson Digital Commons Reports

This quarterly report includes:

• Articles
• Conference materials
• From the Archives - Yearbooks
• Grand Rounds
• Journals
• MPH Capstones
• Newsletters
• Podcasts
• Posters
• Reports
• Symposiums
• What People are Saying About the Jefferson Digital Commons

Rhythmic Movements And Feeling States, Melanie Johnson

Expressive Therapies Dissertations

This study was conducted to test the validity of a theoretical framework in developmental psychology of body movement analysis, the Kestenberg Movement Profile (KMP). Motor patterns associated with needs and foundations for affect expression, the tension flow rhythms (TFRs), were examined. Recent research examined the validity of the TFRs in nonclinical adults and found preliminary support for some of the KMP’s assumptions associating smooth (indulging) rhythms with indulgent affects and sharp (fighting) movements with assertive or aggressive affects. This study aimed to test the TFRs associated with the first two years of development—the sucking, biting, twisting, and strain/release rhythms. The …

Prevention Of Central Line-Associated Bloodstream Infection (Clabsi) In Adult Oncology Patients, Christina Winkelman

Doctoral Projects

Central Line-Associated Bloodstream Infection (CLABSI) is a preventable issue in healthcare. CLABSI contributes to negative patient outcomes and increased healthcare cost. Research demonstrates that many interventions are effective in reducing the rate of CLABSI. The implementation of CLABSI bundles can significantly reduce the occurrence of CLABSI. This quality improvement project implemented a CLABSI bundle that specifically targeted identified areas of weakness in CLABSI prevention at an organization with a focus on adult oncology care. The three part CLABSI prevention bundle focused on: (a) registered nurses (RN) changing and documenting endcaps in the electronic health record after blood administration, (b) RNs …

Involuntary Sterilization Among Hiv-Positive Garifuna Women From Honduras Seeking Asylum In The United States: Two Case Reports, Holly G. Atkinson, Deborah Ottenheimer

Publications and Research

Voluntary sterilization is one of the most widely used forms of contraception by women worldwide; however, involuntary sterilization is considered a violation of multiple human rights and grounds for asylum in the United States. Women have been disproportionately affected by this practice. We report two cases of involuntary sterilization in HIV-positive Garifuna women from Honduras who sought asylum in America and were medically evaluated at the request of their attorneys. Key lessons can be drawn from these cases with regard to the importance of medical evaluations in establishing persecution. These include the need for a detailed account of the events …

Bystander Program Effectiveness To Reduce Violence Acceptance: Rct In High Schools, Ann L. Coker, Heather M. Bush, Candace J. Brancato, Emily R. Clear, Eileen A. Recktenwald

Obstetrics and Gynecology Faculty Publications

Bystander-based violence prevention interventions have shown efficacy to reduce dating violence and sexual violence acceptance at the individual level yet no large randomized controlled trial (RCT) has evaluated this effect at the high-school level and over time. This rigorous cluster-randomized controlled trial addresses this gap by evaluating intervention effectiveness at both school and individual levels. Kentucky high schools were randomized to intervention or control conditions. In intervention schools educators provided school-wide ‘Green Dot’ presentations and bystander training with student popular opinion leaders. Each spring from 2010 to 2014; 73,044 students completed anonymous surveys with no missing data on relevant outcomes. …

Comparing The Cost Effectiveness Of A Celiac Disease Panel To A Testing Cascade, Caleb Bazyler, Kevin Breuel

ETSU Faculty Works

Recent reductions in healthcare funding in the United States has pressured clinical laboratories to provide the same quality of diagnostic testing with fewer resources. Testing cascades have been developed to assist in the diagnosis of various illnesses, which use fewer tests and subsequently reduce costs. However, the cost effectiveness of a celiac disease (CD) testing cascade compared to a panel is currently unknown. Therefore, the purpose of this study was to determine if a CD testing cascade was equivalent to a panel in identifying patients deemed likely for CD, and to compare their cost effectiveness in a sample of symptomatic …

Abstracts From The 24th Annual Health Care Systems Research Network Conference, April 11–13, 2018, Minneapolis, Minnesota

Journal of Patient-Centered Research and Reviews

Founded in 1994, the Health Care Systems Research Network (HCSRN) is a consortium of 18 research centers that are housed in community-based health systems. The organization's annual conference serves as a venue for research teams to disseminate scientific findings, stimulate new collaborations, and share insights about conducting research in real-world care-delivery settings. Abstracts accepted for presentation at HCSRN 2018 are published within this supplement of the Journal of Patient-Centered Research and Reviews.

Diversity Unsupported Is Diversity Derailed, Kauser Jabeen, Kulsoom Ghias

Department of Pathology and Laboratory Medicine

In this view point challenges of a diverse student body and its impact on quality of education and student’ social interactions are discussed. Enhanced institutional responsibility and ownership of all institutional members to provide adequate support for all individuals that make up the student body has been discussed as a major strategy to overcome these challenges.

Articulatory Kinematics During Stop Closure In Speakers With Parkinson’S Disease, Austin Ross Thompson

LSU Master's Theses

Purpose: The goal of this exploratory study was (a) to investigate the differences in articulatory movements during the closure phase of bilabial stop consonants with respect to distance, displacement, and timing of motion between individuals with Parkinson’s Disease (PD) and healthy controls; and (b) to investigate changes in articulatory movements of speakers with PD when they voluntarily vary the degree of speech intelligibility.

Methods: Six participants, 4 PD and 2 healthy control (HC) speakers, participated in this study. The stimulus was a sentence containing several bilabial stop consonants (i.e., “Buy Bobby a puppy”). Movement data were collected using …

Disart: Redefining The Construct Of Participation, Jennifer Fortuna

The Open Journal of Occupational Therapy

DisArt, an arts and culture organization based in Grand Rapids, MI, provided the cover art for the Spring 2018 issue of the Open Journal of Occupational Therapy (OJOT). The piece, a somatic sculpture by Petra Kuppers, was featured at the 2015 DisArt Festival in Grand Rapids. Kuppers is a disability culture activist and community performance artist who connects people, both disabled and nondisabled, in public spaces. DisArt’s mission is to increase the participation of disabled people in our communities through disability art exhibitions, cutting edge public events, and consultation. In a recent interview, DisArt co-founders and executive directors, Dr. Christopher …

Occupational Therapy Adjunct Faculty Self-Perceptions Of Readiness To Teach, Laronda Lockhart-Keene, Marie-Christine Potvin

The Open Journal of Occupational Therapy

To meet the demands of a growing profession, occupational therapy (OT) education programs rely on adjunct faculty to augment their faculty pool. Clinicians transitioning into faculty roles frequently do not have formal training in teaching and learning practices. This problem is compounded with adjunct faculty, as they are not using best teaching practices in OT education programs and do not have easy access to university resources. A qualitative study was conducted to describe the perceptions of new OT adjunct faculty on their degree of preparedness to teach, the supports needed to be successful in transitioning from clinician to academician, and …

Screens Or Mp4s: Acquiring Clinical Competencies Through The Use Of E-Ospes In Occupational Therapy, Lizahn Gracia Cloete, Lee-Ann Juliana Jacobs-Nzuzi Khuabi, Lana Van Niekerk

The Open Journal of Occupational Therapy

The assessment of clinical competence of undergraduate students is a crucial part of higher education training in occupational therapy. The use of online objective standardized practical examinations (e-OSPEs) was piloted as a technological innovation to determine student learning needs. An action research framework with four phases was used. Descriptive statistics in the form of frequency tables and percentages were used to report survey results. The students had multiple practice opportunities before uploading their best attempt. Thirty participants completed a 12-item survey. The results were analyzed using descriptive analysis and presented by means of statistical graphs. Peer assessment facilitated experiential learning. …

Exposure To, Knowledge Of, And Interest In Occupational Therapy And Physical Therapy As Career Options, Prisca M. Collins, Cynthia Carr

The Open Journal of Occupational Therapy

Lack of awareness and knowledge of the occupational therapy (OT) and physical therapy (PT) professions has been cited as a barrier to consideration of these professions as career options. This study examined the types of exposure to, knowledge of, and career interest in OT and PT of students from underrepresented minority (URM) and non-Hispanic White and Asian American (NHW-AA) populations. A questionnaire was administered to a convenience sample of 150 high school and undergraduate college students. Demographic data and student responses to questions regarding exposure to, knowledge of, and career interest in OT and PT were collected. Descriptive statistics and …

Pinch Testing Positions Among Certified Hand Therapists: A Cross-Sectional Survey, Sueann R. Woods, Christa Lilly

The Open Journal of Occupational Therapy

Background: Pinch strength is indicative of later functional hand use following injury to hand. However, we believe clinicians (and more specifically CHTs) currently do not use a consistent measurement of pinch grip, despite availability of a “gold standard” of current (2015) ASHT standards for measuring pinch grip.

Methods: This cross-sectional survey (N = 175, 35% response) was designed to determine whether CHTs adhere to the standardized testing position for palmar pinch strength as recommended by the ASHT.

Results: Results determined that only 5.7% (n = 10) of the CHTs surveyed complete the entire ASHT standardized testing …

Reliability Of The Bulb Dynamometer For Assessing Grip Strength, Colleen Maher, Seoyoung Yoon, Shannon Donovan, Rochelle J. Mendonca

The Open Journal of Occupational Therapy

Background: Hand function is an overall indicator of health and is often measured using grip strength. Hand-held dynamometry is the most common method of measuring grip strength. The purpose of this study was to determine the inter-rater and test-retest reliability, the reliability of one trial versus three trials, and the preliminary norms for a young adult population using the Baseline^® Pneumatic Squeeze Bulb Dynamometer (30 psi).

Methods: This study used a one-group methodological design. One hundred and three healthy adults (30 males and 73 females) were recruited. Six measurements were collected for each hand per participant. The …

The Distinct Value Of Occupational Therapy In Supported Employment Of Adults With Intellectual Disabilities, Katie Coakley, Kimberly Bryze

The Open Journal of Occupational Therapy

Background: Supported employment provides individuals with intellectual disabilities (ID) the support needed for community work. ID work is an integral occupation of adult life, facilitates social interaction, and fosters a sense of accomplishment and independence. The purpose of this study was to explore the unique contribution of occupational therapy to supported employment of adults with ID.

Methods: Case study methodology incorporating qualitative and quantitative data were used to examine two supported employees. Qualitative data were collected from interviews and administration of the Occupational Self-Assessment (OSA) and Work Environment Impact Scale (WEIS). The Assessment of Motor and Process Skills …

Informal Leadership In The Clinical Setting: Occupational Therapist Perspectives, Clark Patrick Heard, Jared Scott, Tanisha Mcginn, Emily Van Der Kamp, Amjad Yahia

The Open Journal of Occupational Therapy

Background: Leadership is vital to clinical, organizational, and professional success. This has compelled a high volume of research primarily related to formal leadership concepts. However, as organizations flatten, eliminate departmental structures, or decentralize leadership structures the relevance of informal leaders has markedly enhanced.

Methods: Using a qualitative phenomenological methodology consistent with interpretative phenomenological analysis, this study examines the impact of informal leadership in the clinical setting for occupational therapists. Data was collected through the completion of semi-structured interviews with 10 peer-identified informal occupational therapy leaders in Ontario, Canada. Collected data was transcribed verbatim and coded for themes by …