Medicine and Health Sciences Commons^™

Anesthesia "Hand Off" Process For Patients At High Risk For Obstructive Sleep Apnea, Terry Yeager

Student Scholar Showcase

No abstract provided.

Association Between Smoking And Functional Outcome In Acute Ischemic Stroke Population Treated With Tissue Plasminogen Activator, Iretioluwa Ajani, Oluyemi R. Rotimi, Olubunmi Kuku, Ndukwe Kalu, Olakunle Oni, Christian Nwabueze, Thomas Nathaniel, Shimin Zheng

Appalachian Student Research Forum

Association between Smoking and Functional Outcome in Acute Ischemic Stroke Population Treated with Tissue Plasminogen Activator

Iretioluwa Ajani¹, Oluyemi Rotimi¹, Olubunmi Kuku¹, Ndukwe Kalu¹, Olakunle Oni¹, Nwabueze Christian¹,Thomas Nathaniel², Shimin Zheng^1*

¹Department of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, TN 37614

²Department of Neurology, Department of Pharmacology, Physiology & Neuroscience, University of South Carolina School of Medicine, Columbia, SC 29208

*Sponsoring faculty

Background

The effect of smoking on outcome in acute ischemic stroke patients treated with …

The Use Of Functional Movement Screening Tests To Determine Injury Risks In Collegiate Soccer Athletes, Hannah Olds

Student Scholar Showcase

The Functional Movement Screening (FMS) was designed as a tool to identify compensatory movement patterns, often used with athletes. The purpose of this study was to find the relationship between FMS scores and injuries throughout the course of a Division III men’s and women’s Varsity soccer season. The effect of intervention with corrective exercises in improving total composite scores was also assessed. A pretest-posttest randomized control group design was used in which subjects (n=28, 50% male) completed the FMS Tests. FMS testing was performed 8 weeks apart. During the 8 weeks, subjects tracked injury occurrences and treatment subjects completed exercises …

Increasing Fruits And Vegetable Consumption Among Snap Recipients Through An Innovative Prescription Program: Appalachian Farmacy, Kiriinya Mwirigi, Beenish Kamran

Appalachian Student Research Forum

Introduction:

Food insecurity prevalence in Washington County, TN is 14.3% yet 61% of SNAP eligible residents are food insecure. Food insecurity is associated with inadequate consumption of fruits and vegetables, as well as increased risk of chronic disease. Tennessee ranks 47^th in the Nation with only 6.7% consuming the recommended fruits and vegetable intake. The Farmacy Pilot Program was developed to encourage increased consumption of produce and to reduce food insecurity among SNAP recipients.

Methods:

This program provided vouchers to SNAP recipients and their families to buy fresh fruits and vegetables at the farmers market and in the grocery …

Factors That Affect Early Sexual Initiation In A Sample Of College Students In North-East Tennessee: The Role Of Adverse Childhood Experiences, Economic Hardship, Family Structure And Religiosity., Oluyemi R. Rotimi, Hima Bindu Dubasi, Ruby Yadav, Mildred Maisonet

Appalachian Student Research Forum

Background

Normal adolescent development often involves sexual activity. Early sexual initiation poses a challenge to health and well-being. In 2015, Tennessee had the 9^th highest teen birth rate in the country. The structural, social and economic environments of growth define sexual risk taking, with poverty, Adverse Childhood Experiences (ACEs) religiosity and family structure known to affect adolescent and adult health. This study seeks to explore the effect of these factors on early sexual initiation.

Methods

A sample of college students taking the introductory psychology course participated in the study through the ETSU SONA system. They completed a self-reported web-based …

Physical Therapy Service-Learning In A Second World Country: What Are The Benefits?, Molly L. Koeneman, Katie B. Palmer, Jessie Bass

Student Scholar Showcase

Social responsibility and service are key initiatives within the physical therapy profession and within the Lynchburg College Doctor of Physical Therapy (DPT) program. Service-learning opportunities are offered in the DPT program within the country of St. Lucia on a yearly basis. The primary focus of this presentation is to evaluate the impact of this type of experiential learning on both students and the local community. During the 2018 service trip, the Minister of Special Education of St. Lucia provided special insight to our contribution to the special education schools in St. Lucia, which indicates the trip provides beneficial and sustaining …

Behavioral Correlates For Quitting Opioids Among Opioid-Dependent Pregnant And Non-Pregnant Women Of Childbearing Age In Rural Appalachia, Sindura Kompella, Sylvester Olubolu Orimaye, Nigel Dsouza, Karl Goodkin, Steven Kendell, Susan Wallace, Tracy Willson

Appalachian Student Research Forum

Background: The opioid epidemic is particularly worrisome in the pregnant population, wherein concerns are raised about the health of a mother and her child, resulting in an alarming incidence and prevalence of Neonatal Abstinence Syndrome (NAS). The 2016 National Survey on Drug Use and Health (NSDUH) show the rate of illicit psychoactive substance use among the females aged 12 or older was 15.5% in the past year. Among pregnant women aged 15 to 44, 6.3% were illicit psychoactive substance users. In Tennessee, the number of hospital discharged NAS cases from 2002 to 2013 increased from 1.50 to 16.6 cases per …

Lc Dpt Service Trip To St. Lucia: Following The Progress Of A 7 Y/O Boy Over 3 Years From Non-Ambulatory To Running With Peers, Brooke Panfil, Ainsley Reed

Student Scholar Showcase

In January of 2016, the Lynchburg College Doctor of Physical Therapy program formed the first group of 10 students and 2 professors that traveled to the island of St. Lucia to provide much-needed physical therapy services to the children in special education schools. During the initial visit, several students had the opportunity to work with a 5-year-old boy named Mark who had just learned to stand and presented with behavioral issues and lacked fine-motor skills. After spending only a couple hours with Mark, the students came up with a plan and some recommendations for Mark’s teachers with hopes to improve …

Being Observant: How Studying Michelangelo Can Improve Pt Practice, Andrew Lloyd, Erica Zachrich

Student Scholar Showcase

The field of physical therapy is swiftly transitioning from a formulaic biomedical model to a patient-centered biopsychosocial model, requiring clinicians to view their patients as a whole instead of as a sum of their parts. Integration of this concept into graduate health science education is variable across professions and amongst the same professional programs. Lynchburg College’s Doctor of Physical Therapy Program is pioneering an experiential learning course for graduate-level PT programs. “The Art of Anatomical Dissection: From Ancient Rome to the Renaissance” will transport students to the land of Da Vinci and Michelangelo, to study how the innovations of these …

Implementation Of The Banner Mobility Assessment Tool For Bariatric Patients, Nicole Benkert

Scholars Week

Abstract

The prevalence of morbidly obese patient within the United States is on a rapid incline. Evidence correlates an increase in patient falls, comorbidities, and hospital admission among this specific patient group. As a result, there is an increase in workload and injuries to staff as they tend to these patients. Healthcare facilities need to continuously update current patient handling programs and create specific policies for safely handling obese patients. Research suggests that Safe Patient Handling and Mobility Programs, as well as the Banner Mobility Assessment Tool (BMAT), have substantially decreased nurse injuries through a wide range of nursing specialties. …

The Effects Of Core Stabilization Training On The Performance Of Functional Tasks In Firefighters, Emily Maxwell

Student Scholar Showcase

The purpose of this study was to observe if core stabilization training plays a significant role in firefighter time-to-completion during a functional performance test. A within subjects study design was used in which subjects (n=13, mean ± SD age and body fat 33.7 ± 7.4 years, 25.79 ± 6.55 percent, respectively) completed two performance tests (pre and post core training), comprised of 7 firefighter-specific exercises performed while wearing a 22.68 kg weight vest to mimic typical firefighter equipment. Between testing sessions, subjects were prescribed specific core stabilization exercises to perform on their own 3+ days a week for a total …

Defining Relationships Between Medication Adherence, Medical Mistrust, And Self-Medication, Mikayla Carlton

Student Scholar Showcase

The purpose of this research is to delve into the topics of medication adherence, medical mistrust, and resulting or concomitant self-medication in order to define relationships and suggest solutions. There seems to be a relationship between greater medical mistrust and lower levels of medication adherence, as well as patients’ likelihood to self-medicate. Lack of medication adherence contributes to chronic disease and an increase in spending toward treatment both by the patient and the health-care industry over time. Medical mistrust has the potential to negatively influence medication adherence as it may prevent people from even seeking treatment. Self-medication may result from …

Sensory Integration In Saint Lucian Schools: A Case Study, Megan Lively Spt, Ashley Danielsen Spt, Leigha Schimmoeller Spt

Student Scholar Showcase

In January 2018, the Lynchburg College Doctor of Physical Therapy program sent a group of ten first- and second-year students to St. Lucia to provide therapy services to children in need across the island in five different special education schools. The group has been able to work hand-in-hand with the Ministry of Education in St. Lucia for the past three years in order to make a positive impact on the special education students and teachers. As the group did their evaluations this year, we noticed a trend that most of the students we worked presented with sensory integration dysfunctions and …

Football Concussions: Effects, Evaluation And Prevention, Karandeep Chera

D.U.Quark

Football related concussions are a growing concern in society. Concussions can lead to a major brain disease called chronic traumatic encephalopathy. This disease leads to many degenerative qualities that affect physical, cognitive, and emotional aspects in football players. In this review, the effects, evaluation, and prevention of concussions in football are discussed. Concussion rates and brain damage can both be decreased through improving equipment such as helmet design as well as better head-on collision rules being developed, and better evaluation techniques for taking concussed players out of games. In the future, with the combination of advancements in evaluation and prevention, …

Exome Sequencing Identifies Genetic Variants Associated With Circulating Lipid Levels In Mexican Americans: The Insulin Resistance Atherosclerosis Family Study (Irasfs), Chuan Gao, Keri L. Tabb, Latchezar Dimitrov, Kent D. Taylor, Nan Wang, Xiuqing Guo, Jirong Long, Jerome I. Rotter, Richard M. Watanabe, Joanne E. Curran, John Blangero

School of Medicine Publications

Genome-wide association studies have identified numerous variants associated with lipid levels; yet, the majority are located in non-coding regions with unclear mechanisms. In the Insulin Resistance Atherosclerosis Family Study (IRASFS), heritability estimates suggest a strong genetic basis: low-density lipoprotein (LDL, h2 = 0.50), high-density lipoprotein (HDL, h2 = 0.57), total cholesterol (TC, h2 = 0.53), and triglyceride (TG, h2 = 0.42) levels. Exome sequencing of 1,205 Mexican Americans (90 pedigrees) from the IRASFS identified 548,889 variants and association and linkage analyses with lipid levels were performed. One genome-wide significant signal was detected in APOA5 with TG (rs651821, PTG = 3.67 …

The Sensory And Textural Evaluation Of A St. Louis Style Butter Cake Made With Greek Yogurt As A Fat Replacer, Caprisse Johnson

Scholars Week

In modern America, many nutrition-related health issues are on the rise, including diabetes, obesity, and heart disease. Many nutrition professionals link the rise in these three diseases to the Western Diet, which includes a high fat and sugar content within its foods. Due to the increased consumption of this diet high in sugar and fat, obesity, heart disease, and diabetes rates seem to be rising. However, many people who eat this diet and are at risk for these complications, hesitate to change their diet because they feel that healthier alternatives bland in flavor or have a repugnant taste when compared …

Vte Prevention: A Risk Assessment Tool, Mary Gilkey

Scholars Week

VTEs are a leading cause of hospital deaths and cost healthcare systems billions. A risk assessment tool that correctly identifies at risk patients and provides appropriate prophylactic measures can decrease the rate of hospital acquired VTE.

Nursing Interventions For Neonatal Abstinence Syndrome, Sierra Harris

Scholars Week

This project serves to explore evidence for three nursing interventions aimed at neonatal abstinence syndrome including: breastfeeding, kangaroo care, and rooming-in. Many nursing interventions and policies are aimed at treating the symptoms despite limited research supporting their effectiveness. Further investigation into these interventions and policies regarding neonatal abstinence syndrome needs to be addressed in order to improve the quality of care for affected neonates and decrease the stigma surrounding neonatal abstinence syndrome.

The Effectiveness Of A "Patient Discharge Information" Booklet In Patient Education Program In Saudi Arabia, Amani Al Rebeh

Annual Graduate Student Symposium

The purpose of this research was to investigate the effectiveness of the Patient Discharge Information (PDI) booklet on the knowledge, attitude, and behaviors of participants who were cesarean patients in local hospitals in Saudi Arabia. This study investigated the following two research questions: (1) does the participant have information, resources, and understand basic personal health information regarding her health conditions including diagnosis, treatment, self-care management, medication instructions, normal expected symptoms, dangerous signs and what to do, as well as lifestyle changes?; and (2) how does patient discharge information provided by the hospital make a difference in participants’ knowledge, attitude, and …

Characterization Of Sex-Based Dna Methylation Signatures In The Airways During Early Life., Cesar L Nino, Geovanny F Perez, Natalia Isaza, Maria J Gutierrez, Jose L Gomez, Gustavo Nino

Pediatrics Faculty Publications

Human respiratory conditions are largely influenced by the individual's sex resulting in overall higher risk for males. Sex-based respiratory differences are present at birth suggesting a strong genetic component. Our objective was to characterize early life sex-based genomic signatures determined by variable X-chromosome methylation in the airways. We compared male versus female genome-wide DNA methylation in nasal airway samples from newborns and infants aged 1-6 months (N = 12). We analyzed methylation signals across CpG sites mapped to each X-linked gene using an unsupervised classifier (principal components) followed by an internal evaluation and an exhaustive cross-validation. Results were validated in …

2018 April 3 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Global Health Navigators: A New Component In A Refugee-Centered Medical Home Model Of Care, Ruth M. Carrico

Journal of Refugee & Global Health

In this video, Dr. Ruth Carrico, Director of the Global Health Center Travel Clinic and Refugee Health Programs:

• Describes the University of Louisville refugee-centered medical home care model
• Introduces a novel element, the Global Health Navigator, and their roles and responsibilities in the care of the refugee population
• Reviews the competencies and training components important for this new role
• Uses case scenarios to demonstrate the value of Global Health Navigators in refugee care

Driver Fusions And Their Implications In The Development And Treatment Of Human Cancers., Qingsong Gao, Wen-Wei Liang, Steven M Foltz, Gnanavel Mutharasu, Reyka G Jayasinghe, Song Cao, Wen-Wei Liao, Sheila M Reynolds, Matthew A Wyczalkowski, Lijun Yao, Lihua Yu, Sam Q Sun, Ken Chen, Alexander J Lazar, Ryan C Fields, Michael C Wendl, Brian A Van Tine, Ravi Vij, Feng Chen, Matti Nykter, Ilya Shmulevich, Li Ding

Articles, Abstracts, and Reports

Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% validation rate. Integration of gene expression, copy number, and fusion annotation data revealed that fusions involving oncogenes tend to exhibit increased expression, whereas fusions involving tumor suppressors have the opposite effect. For fusions involving kinases, we found 1,275 with an intact kinase domain, the proportion of which varied significantly across cancer types. Our study suggests that fusions drive the development of 16.5% of …

Genomic And Molecular Landscape Of Dna Damage Repair Deficiency Across The Cancer Genome Atlas., Theo A Knijnenburg, Linghua Wang, Michael T Zimmermann, Nyasha Chambwe, Galen F Gao, Andrew D Cherniack, Huihui Fan, Hui Shen, Gregory P Way, Casey S Greene, Yuexin Liu, Rehan Akbani, Bin Feng, Lawrence A Donehower, Chase Miller, Yang Shen, Mostafa Karimi, Haoran Chen, Pora Kim, Peilin Jia, Eve Shinbrot, Shaojun Zhang, Jianfang Liu, Hai Hu, Matthew H Bailey, Christina Yau, Denise Wolf, Zhongming Zhao, John N Weinstein, Lei Li, Li Ding, Gordon B Mills, Peter W Laird, David A Wheeler, Ilya Shmulevich, Raymond J Monnat, Yonghong Xiao, Chen Wang

Articles, Abstracts, and Reports

DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide a comprehensive view of DDR deficiency across 33 cancer types. Mutations with accompanying loss of heterozygosity were observed in over 1/3 of DDR genes, including TP53 and BRCA1/2. Other prevalent alterations included epigenetic silencing of the direct repair genes EXO5, MGMT, and ALKBH3 in ∼20% of samples. Homologous recombination deficiency (HRD) was present at varying frequency in many cancer types, most notably ovarian cancer. However, in contrast to ovarian cancer, HRD was associated with worse outcomes in several other cancers. Protein …

Systematic Analysis Of Splice-Site-Creating Mutations In Cancer., Reyka G Jayasinghe, Song Cao, Qingsong Gao, Michael C Wendl, Nam Sy Vo, Sheila M Reynolds, Yanyan Zhao, Héctor Climente-González, Shengjie Chai, Fang Wang, Rajees Varghese, Mo Huang, Wen-Wei Liang, Matthew A Wyczalkowski, Sohini Sengupta, Zhi Li, Samuel H Payne, David Fenyö, Jeffrey H Miner, Matthew J Walter, Benjamin Vincent, Eduardo Eyras, Ken Chen, Ilya Shmulevich, Feng Chen, Li Ding

Articles, Abstracts, and Reports

For the past decade, cancer genomic studies have focused on mutations leading to splice-site disruption, overlooking those having splice-creating potential. Here, we applied a bioinformatic tool, MiSplice, for the large-scale discovery of splice-site-creating mutations (SCMs) across 8,656 TCGA tumors. We report 1,964 originally mis-annotated mutations having clear evidence of creating alternative splice junctions. TP53 and GATA3 have 26 and 18 SCMs, respectively, and ATRX has 5 from lower-grade gliomas. Mutations in 11 genes, including PARP1, BRCA1, and BAP1, were experimentally validated for splice-site-creating function. Notably, we found that neoantigens induced by SCMs are likely several folds more immunogenic compared to …

Ef-P Post-Translational Modification Has Variable Impact On Polyproline Translation In Bacillus Subtilis, Anne Witzky, Katherine R. Hummels, Rodney Tollerson Ii, Andrei Rajkovic, Lisa A. Jones, Daniel B. Kearns, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Elongation factor P (EF-P) is a ubiquitous translation factor that facilitates translation of polyproline motifs. In order to perform this function, EF-P generally requires posttranslational modification (PTM) on a conserved residue. Although the position of the modification is highly conserved, the structure can vary widely between organisms. In Bacillus subtilis, EF-P is modified at Lys³² with a 5-aminopentanol moiety. Here, we use a forward genetic screen to identify genes involved in 5-aminopentanolylation. Tandem mass spectrometry analysis of the PTM mutant strains indicated that ynbB, gsaB, and ymfI are required for modification and that yaaO, yfkA, and …

Critères D’Aménagement Sécuritaire Et Ergonomique Des Postes De Haleur Et De Support À Casiers Des Homardiers Du Québec, Francis Coulombe, Sylvie Montreuil, Jean-Guy Richard, Michel Tremblay

Rapports de recherche scientifique

La pratique de la pêche commerciale est reconnue comme l’un des métiers les plus dangereux à l’échelle mondiale. Entre 2012 et 2014, elle a fait l’objet de deux projets de recherche qui ont été réalisés en Gaspésie et aux Îles-de-la-Madeleine. Le premier visait à analyser les activités de travail et les risques de chute par-dessus bord des homardiers ainsi que leurs déterminants, tandis que le deuxième consistait en l’étude des aménagements aux postes de travail « haleur et support à casiers ». La présente recherche découle de ces projets et porte sur l’amélioration de l’ergonomie et de la sécurité de …

Pro-Inflammatory Cytokines And Depression, Amy Roesch

Nursing Capstones

No abstract provided.

Cardiovascular Risk Management For Patients With Rheumatoid Arthritis: A Case Report, Rachel Bethke

Nursing Capstones

No abstract provided.

"My Bitterness Is Deeper Than The Ocean": Understanding Internalized Stigma From The Perspectives Of Persons With Schizophrenia And Their Family Caregivers., Yin-Ling Irene Wong, Dexia Kong, Lufei Tu, Rosemary Frasso Phd, Msc, Cph

College of Population Health Faculty Papers

Background: It is estimated that 8 million of the Chinese adult population had a diagnosis of schizophrenia. Stigma associated with mental illness, which is pervasive in the Chinese cultural context, impacts both persons with schizophrenia and their family caregivers. However, a review of the literature found a dearth of research that explored internalized stigma from the perspectives of both patients and their caregivers.

Methods: We integrated data from standardized scales and narratives from semi-structured interviews obtained from eight family-dyads. Interview narratives about stigma were analyzed using directed content analysis and compared with responses from Chinese versions of the Internalized Stigma …