Medicine and Health Sciences Commons^™

Speech Naturalness Before And Following Treatment In Adults Who Stutter, Alexis Novelli

Honors Theses

Purpose: The speech of persons who stutter can often sound unnatural. This can be due to a variety of factors including the presence of stuttering itself and/or the unintended consequence of speech-altering treatment. Understanding factors that contribute to speech naturalness within the stuttering population can direct improved management approaches. This study examines associations between speech task, behavioral measures of stuttering, and selected acoustic measures on listener ratings of speech naturalness for a group of adults immediately before and after participation in an intensive fluency-shaping treatment program. A secondary aim of this study is to assess the use of a novel …

Evaluation Of Hepatocellular Carcinoma Transarterial Chemoembolization Using Quantitative Analysis Of 2d And 3d Real-Time Contrast Enhanced Ultrasound., Kibo Nam, Maria Stanczak, Andrej Lyshchik, Priscilla Machado, Yuko Kono, Flemming Forsberg, Colette M. Shaw, John R. Eisenbrey

Department of Radiology Faculty Papers

Quantitative 2D and 3D contrast-enhanced ultrasound (CEUS) was assessed to evaluate early transarterial chemoembolization (TACE) treatment response. Seventeen patients scheduled for TACE for the treatment of hepatocellular carcinoma participated in the study. 2D and 3D CEUS were performed for each patient at three time points: Prior to TACE, 1-2 weeks post TACE, and 1 month post TACE. Peak-intensities of the tumor and surrounding liver tissue were calculated from 2D and 3D data before and after TACE and used to evaluate tumor treatment response. Residual tumor percentages were calculated from 2D and 3D CEUS acquired 1-2 weeks and 1 month post …

Identification Of Novel Hits Against, Ala A. Azhari

USF Tampa Graduate Theses and Dissertations

Leishmaniasis is a disease caused by obligate intracellular parasites of the genus Leishmania, including 20 species that are pathogenic to humans. Female sand fly is the known vector that can transmit the disease. Visceral leishmaniasis is the severe form of the disease that affects internal organs and can be fatal with inappropriate diagnosis or treatment. Leishmania donovani is the causative agent of visceral leishmaniasis. Approximately 350 million in 89 countries are at risk of infection. Around 2 million new cases are reported annually with 500,000 of these are visceral leishmaniasis. Current drug therapies are inadequate due to their toxicity, high …

Interphotoreceptor Retinoid-Binding Protein Implications In Diabetic Retinopathy, Kevin Bermea

School of Medicine Publications

The interphotoreceptor retinoid-binding protein (IRBP) is the most abundant protein in the interphotoreceptor matrix (IPM) and its levels decrease beginning in the early stages of diabetes. IRBP participates in the delivery of retinoids between retinal cells to carry out the visual cycle and also protects those retinoids against degradation in the IPM. IRBP deficiency is related to several conditions such as retinitis pigmentosa, cone-rod dystrophy, increased oxidative stress in the photoreceptors, and myopia. Decreased IRBP levels in diabetes could be due to the secretion of inflammatory cytokines and a direct effect of hyperglycemia on the photoreceptors. It is known that …

Is Therapy Going To The Dogs? Evaluating Animal Assisted Therapy For Early Identified At-Risk Children, Leah Faith Brookner

Dissertations and Theses

This study explores the historical context of human-animal relationships and examines the important ways that humans benefit from various types of interactions with domesticated animals. Therapeutic approaches that incorporate animals have been shown to have multiple benefits, including improved physical and mental health. Although this area of study is still largely overlooked in scientific fields of study, including social work, Animal Assisted Therapy (AAT) has become increasingly prevalent in various mental health settings. Despite its popularity and anecdotal support, research on the benefits of AAT with children is minimal; there are no studies examining the ways in which this approach …

Physical Therapy And Proper Sleep Positions Lead To Improved Hamstring Flexibility, Bailey Miley

Undergraduate Research Conference

Research Question: How effectively can physical therapy and correct sleep positioning improve hamstring flexibility and reduce pain, based on age and everyday activity?

A Study On The Development Of Robotic Prosthesis, Alexandra Knight

Undergraduate Research Conference

This paper is a multi-analysis study of the development of robotic prosthesis. There are many types of robotic prosthesis, some of which are already in circulation. However, true robotic prosthetics which can move in the exact fashion of the original limb are still in the early stages of prototyping. In experimenting there have been problems found in the methods of communicating movement and the manufacturing of sensory recording material. Using a comparison of the failed and successful experiments it is possibly to approximate the material that will be used and the cost of future market ready robotic prosthesis.

Veterans Health Awareness And Promotion, Emilio Villavicencio

Community Engagement Theme

No abstract provided.

Prevention Of Decubitus Ulcers In The Clinical Setting, Stephanie Parker, Carli Burton, Jordan Adkins, Samantha Cunningham, Kasea Thornberry, Shelley Sadler

Celebration of Student Scholarship Poster Sessions Archive

No abstract provided.

2018 April 17 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

The Corticosteroid Compounds Prednisolone And Vamorolone Do Not Alter The Nociception Phenotype And Exacerbate Liver Injury In Sickle Cell Mice., Luis E F Almeida, Jesse M Damsker, Sarah Albani, Nina Afsar, Sayuri Kamimura, Drew Pratt, David E Kleiner, Martha Quezado, Heather Gordish-Dressman, Zenaide M N Quezado

Anesthesiology and Critical Care Medicine Faculty Publications

Clinicians often hesitate prescribing corticosteroids to treat corticosteroid-responsive conditions in sickle cell disease (SCD) patients because their use can be associated with complications (increased hospital readmission, rebound pain, strokes, avascular necrosis, acute chest syndrome). Consequently, SCD patients may receive suboptimal treatment for corticosteroid-responsive conditions. We conducted a preclinical trial of dissociative (vamorolone) and conventional (prednisolone) corticosteroid compounds to evaluate their effects on nociception phenotype, inflammation, and organ dysfunction in SCD mice. Prednisolone and vamorolone had no significant effects on nociception phenotype or anemia in homozygous mice. Conversely, prednisolone and vamorolone significantly decreased white blood cell counts and hepatic inflammation. Interestingly, …

The Relationship Between Nurses' Work Environment And Patient Satisfaction, Carissa Williams

Nursing Masters

Background: Patient satisfaction has become an area of interest among health care organizations since the early 2000s when Crossing the Quality Chasm identified patient-centered care as one of the six areas in need of improvement within the U.S health care system (Institute of Medicine, 2001). As a result of this report, hospitals are reimbursed based on patient satisfaction. Hospitals with low satisfaction scores are at risk of losing $500,000 to $850,000 annually.

Objective: To evaluate the relationship between nurses’ perception of their work environment and patient satisfaction in a sample of nurses in Upstate New York.

Methods: A sample of …

What's Happening: April 17, 2018, Maine Medical Center

What's Happening

No abstract provided.

Swosu Research And Scholarly Activity Fair 2018, Lisa Appeddu, Cj Smith

SWOSU Research and Scholarly Activity Fair Programs

On behalf of the members of the Southwestern Oklahoma State University (SWOSU) University Research and Scholarly Activity Committee (USRAC) - Welcome to the Twenty-Fifth SWOSU Research and Scholarly Activity Fair! There are 130 poster presentations and 10 oral presentations involving 293 student researchers, writers, presenters, artists, collaborators, and faculty sponsors encompassing activities from the SWOSU College of Pharmacy; SWOSU School of Nursing & Allied Health Sciences; and SWOSU Departments of Art, Communication, & Theatre; Biological Sciences; Business & Computer Science; Chemistry and Physics; Education; Engineering Technology; Language & Literature; Music; Psychology; and Social Sciences. This also includes guest presenters from …

Primary Care-Ot For Older African Americans With Diabetes And Mild Cognitive Impairment: Intervention Approaches And Case Stories, Catherine Verrier Piersol, Phd, Otr/L, Faota, Susan Santalucia, Ms, Otr/L, Michele Rifkin, Mhsed, Otr/L, Barry Rovner, Md, Robin Casten, Phd, Neva White, Np, Crnp, Cde

Department of Occupational Therapy Posters and Presentations

Purpose:

To test the efficacy of a collaborative intervention to lower hemoglobin A1c levels (HbA1c) in older African Americans with Type 2 diabetes (DM), Mild Cognitive Impairment (MCI), and suboptimal medication adherence and glycemic control.

Aims:

1. To reduce HbA1c level by 0.5% at 6 and 12 months.
2. To increase MEMS-measured adherence to an oral DM medication at 6 and 12 months.

Hypotheses:

1. Fifty-five percent of intervention participants, compared to 25% of control participants, will have a reduction in HbA1c of 0.5% at 6 months (short term effect) and 12 months (maintenance effect).
2. The Primary Care-Occupational Therapy intervention will increase MEMS-measured …

Gdf-15 As A Biomarker For Glaucoma, Caylee Pattison

Honors Theses

Biomarkers are measurable substances in an organism that are indicative of some phenomenon. Examples of biomarkers in clinical settings are body temperature and blood pressure. Body temperature is indicative of a fever while blood pressure can be used to monitor someone’s risk of a stroke. Previous studies have investigated the possibility of there being a potential biomarker for glaucoma. One possible biomarker identified is growth differentiation factor 15 or GDF15. These studies prompted a study in our lab using a rat glaucoma model. The objective of this study was to show there is a biomarker present for the neurodegenerative disease, …

Adherence Of Collegiate Level, Recreational/Intramural And Non-Athlete College Students To The Mediterranean Diet, Amber E. Ugbo

Honors College Theses

The Mediterranean Diet, which is rich in complex carbohydrates and plant-based foods, may be beneficial to athletic performance. To date, no one has examined adherence of collegiate athletes to a Mediterranean Diet. This study compared how closely collegiate, recreational/intramural, and non-athletes in college followed a Mediterranean Diet. Surveys and validated Mediterranean Diet score questionnaires were completed by 933 undergraduates in HLTH 1520: Healthful Living at Georgia Southern University. Participants self-reported following various diets including decreased or increased carbohydrate, increased protein, and increased water intake. No one specifically reported following a Mediterranean Diet and total calculated Mediterranean Diet scores were low …

Continuous Renal Replacement Therapy: Educating Nurses For Prevention Of Complications, Brittany Stoltman

Nursing Capstones

No abstract provided.

In Vivo Structures Of The Helicobacter Pylori Cag Type Iv Secretion System, Yi-Wei Chang, Carrie L. Shaffer, Lee A. Rettberg, Debnath Ghosal, Grant J. Jensen

Veterinary Science Faculty Publications

The type IV secretion system (T4SS) is a versatile nanomachine that translocates diverse effector molecules between microbes and into eukaryotic cells. Here, using electron cryotomography, we reveal the molecular architecture of the Helicobacter pylori cag T4SS. Although most components are unique to H. pylori, the cag T4SS exhibits remarkable architectural similarity to other T4SSs. Our images revealed that, when H. pylori encounters host cells, the bacterium elaborates membranous tubes perforated by lateral ports. Sub-tomogram averaging of the cag T4SS machinery revealed periplasmic densities associated with the outer membrane, a central stalk, and peripheral wing-like densities. Additionally, we resolved pilus-like …

Zika Virus Can Strongly Infect And Disrupt Secondary Organizers In The Ventricular Zone Of The Embryonic Chicken Brain, Ankita Thawani, Devika Sirohi, Richard J. Kuhn, Donna Fekete

Department of Biological Sciences Faculty Publications

Zika virus (ZIKV) is associated with severe neurodeve- lopmental impairments in human fetuses, including microencephaly. Previous reports examining neural progenitor tropism of ZIKV in organoid and animal models did not address whether the virus infects all neural progenitors uniformly. To explore this, ZIKV was injected into the neural tube of 2-day-old chicken embryos, resulting in nonuniform periventricular infec- tion 3 days later. Recurrent foci of intense infection were present at specific signaling centers that influ- ence neuroepithelial patterning at a distance through secretion of morphogens. ZIKV infection reduced transcript levels for 3 morphogens, SHH, BMP7, and FGF8 expressed at the …

Do Global Diets Affect The Rate Of Type 2 Diabetes?, Demetria Meyer

Honors Theses

The purpose of this study is to determine whether different global diets correlate with the increase in type 2 diabetes rates. Type 2 diabetes is the main diabetes type being looked at due to it being the one that can be maintained primarily by glycemic control, which is controlled by a good diet. Five different countries from different regions will be examined: Brazil, China, Micronesia, Nigeria, and the United States. The diets of these countries will be broken down into smaller pieces, like calories consumed each day and the percentage of macronutrients that make up the calories. Eleven food groups …

Preclinical Comparison Of Proteasome And Ubiquitin E1 Enzyme Inhibitors In Cutaneous Squamous Cell Carcinoma: The Identification Of Mechanisms Of Differential Sensitivity, Angela Mchugh, Kenneth Fernandes, Andrew P. South, Jemima E. Mellerio, Julio C. Salas-Alanis, Charlotte M. Proby, Irene M. Leigh, Mark K. Saville

Department of Dermatology and Cutaneous Biology Faculty Papers

Proteasome inhibitors have distinct properties and the biochemical consequences of suppressing ubiquitin E1 enzymes and the proteasome differ. We compared the effects of the proteasome inhibitors bortezomib, ixazomib and carfilzomib and the ubiquitin E1 enzyme inhibitor MLN7243/TAK-243 on cell viability and cell death in normal keratinocytes and cutaneous squamous cell carcinoma (cSCC) cell lines. The effects of both a pulse of treatment and more extended incubation were investigated. This is relevant to directly-delivered therapy (topical treatment/intratumoral injection) where the time of exposure can be controlled and a short exposure may better reflect systemically-delivered inhibitor pharmacokinetics. These agents can selectively kill …

Effects Of Muscle Activation On Gdnf Protein Content In Skeletal Muscle, Ramsey Potter

Honors Theses

Impairment of neuromuscular function as a result of aging is primarily associated with degeneration of the peripheral nervous system and loss of type II muscle fibers (Lexell et al, 1988). Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor found in skeletal muscle that has been shown to rescue motor neurons from axotomy-induced cell death (Oppenheim et al., 1995) and to induce NMJ plasticity (Keller-Peck et al., 2001). The aim of this study was to examine GDNF protein content following muscle activation in vitro and in vivo models. GDNF protein content was measured in rat gastrocnemius muscles following differing …

Inhibition Of Insulin‐Like Growth Factor 1 Receptor Enhances The Efficacy Of Sorafenib In Inhibiting Hepatocellular Carcinoma Cell Growth And Survival, Fang Wang, Thomas Bank, George Malnassy, Maribel Arteaga, Na Shang, Annika Dalheim, Xianzhong Ding, Scott J. Cotler, Mitchell F. Denning, Michael I. Nishimura, Peter Breslin, Wei Qiu

Biology: Faculty Publications and Other Works

Hepatocellular carcinoma (HCC) is the fifth most common primary cancer and second largest cause of cancer‐related death worldwide. The first‐line oral chemotherapeutic agent sorafenib only increases survival in patients with advanced HCC by less than 3 months. Most patients with advanced HCC have shown limited response rates and survival benefits with sorafenib. Although sorafenib is an inhibitor of multiple kinases, including serine/threonine‐protein kinase c‐Raf, serine/threonine‐protein kinase B‐Raf, vascular endothelial growth factor receptor (VEGFR)‐1, VEGFR‐2, VEGFR‐3, and platelet‐derived growth factor receptor β, HCC cells are able to escape from sorafenib treatment using other pathways that the drug insufficiently inhibits. The aim …

Interpreting Mmse Performance In Highly Proficient Bilingual Spanish-English And Asian Indian-English Speakers: Demographic Adjustments, Item Analyses, And Supplemental Measures, Lisa H. Milman, Yasmeen Faroqi-Shah, Chris D. Corcoran, Deanna M. Damele

Communicative Disorders and Deaf Education Faculty Publications

Purpose: Performance on the Mini-Mental State Examination (MMSE), among the most widely used global screens of adult cognitive status, is affected by demographic variables including age, education, and ethnicity. This study extends prior research by examining the specific effects of bilingualism on MMSE performance.

Method: Sixty independent community-dwelling monolingual and bilingual adults were recruited from Eastern and Western regions of the United States in this cross-sectional group study. Independent sample t-tests were used to compare two bilingual groups (Spanish-English and Asian Indian-English) with matched monolingual speakers on the MMSE, demographically adjusted MMSE scores, MMSE item scores, and a nonverbal cognitive …

An Area Based Fan Beam Projection Model, Richard E. Steele, Jiehua Zhu

Honors College Theses

Area based projection models for computed tomography mitigate raw data errors by treating X-Rays as beams, whereas traditional line based projection models treat an X-Ray like a line, thus generating significant error. In an existing area based fan beam projection model, a rotation matrix, Q, simulates the rotation of the emitter detector pair to reduce computational load, but this introduces approximations by using an approximated rotation matrix. We eliminate approximations by deriving an exact formula for the entries of Q. Using a rotation of axes and by considering the neighboring cells' contributions to the area, the result has formulations for …

Developmental Outcomes Of Pediatric Cancer Survivors After Chemotherapy, Kaley Scanlon

Honors College Theses

PURPOSE: With the increased survival rates in pediatric cancer, these patients are exhibiting new possible long-term side effects, such as delays in cognitive and social-emotional development. The purpose of this research study is to assess the cognitive and social-emotional developmental outcomes of pediatric cancer survivors who currently receive chemotherapy or have received chemotherapy in the past.

DESIGN/METHODS: This pilot study used a quantitative survey to assess cognitive and social-emotional developmental outcomes of pediatric cancer survivors. The inclusion criteria for this study included parents of school aged children (ages 5-18) who received chemotherapy for at least six months, either currently or …

Sorafenib-Induced Tumor Lysis Syndrome In A Patient With Metastatic Hepatocellular Carcinoma., Sardar Zakariya Imam, Mohammad Faizan Zahid, Muhammad Asad Maqbool

Medical College Documents

Tumor lysis syndrome is a potentially lethal complication of chemotherapy, usually associated with aggressive hematologic malignancies. We describe the case of a young patient with meta-static hepatocellular cancer who developed rapid and fatal tumor lysis syndrome following ini-tiation of sorafenib therapy. Although rare with sorafenib therapy for hepatocellular carcinoma, tumor lysis syndrome is serious complication. Patients with a high burden of disease at therapy initiation should have their metabolic parameters measured prior to starting therapy and closely followed for the first 1–2 weeks while being treated

Event Agenda, Lehigh Valley Health Network

Faculty Development

No abstract provided.

Volume 4, Full Contents

Butler Journal of Undergraduate Research

No abstract provided.