Medicine and Health Sciences Commons^™

Neurotracker Cognitive Function And Its Relationship To Gpa In College Students, Justin Tran, Caroline Gallagher Poehls

Honors Thesis

Abstract

Introduction: The NeuroTracker system is a training tool used to enhance one’s cognitive abilities. It has been previously tested to improve athletic performance and core cognitive abilities in a variety of populations, but it has yet to be used as a cognitive test to examine its ability to distinguish academic ability in college students. The purpose of this study was to examine the relationships between a student’s grade point average (GPA), major, minutes exercised, and visual tracking speed utilizing the NeuroTracker System.

Methods: Forty-five students volunteered for the study (20 male and 25 female, 20.2±1.09years, ht=170.44±9.48cm, wt=70.98±15.66kg) and were …

The Cancer Immunotherapy Armamentarium: Assessing Applications, Ambitions, And Amplitude, Natisha J. Corum

Essential Studies UNDergraduate Showcase

Given the high, and rapidly increasing, incidence of cancer coupled with the enormous cost burden associated with the disease, it has been, and will continue to be, an area of intense focus in biomedical, translational, and clinical research. Research steered towards targeting and manipulating the body’s own immune function to fight cancer has accompanied a paradigm shift in treatment modalities that aims to include more precision/personalized medicine. The positive initial findings and clinical results of recent immunotherapies has precipitated a wave of attention and interest into the field, both in the general public and within the biomedical community. While there …

Nontypeable Haemophilus Influenzae Meningitis In The Context Of Endoscopic Endonasal Surgery – A Case Report., Ricky Buckshaw Do, Casey Judge Do, Jennifer Strow Do

Department of Medicine

No abstract provided.

Does Courtesy Bias Affect How Clients Report On Objective And Subjective Measures Of Family Planning Service Quality? A Comparison Between Facility- And Home-Based Interviews, Waqas Hameed, Muhammad Ishaque, Xaher Gul, Junaid-Ur-Rehman Siddiqui, Sharmeen Hussain, Wajahat Hussain, Aftab Ahmed, Asma Balal

Community Health Sciences

Purpose: Despite a general understanding that exit interviews being conducted at service providers' facilities may influence clients' responses favorably to health professionals, there is very little evidence available that demonstrates the extent to which this problem exists. This study aimed at assessing and comparing clients' perceptions of the quality of family planning services and their satisfaction levels between facility- and home-based interviews.
Methods: A cross-sectional survey was conducted among clients receiving family planning services across three service delivery channels - nongovernmental organization (NGO) clinics, social franchise (SF) centers, and outreach camps. The survey took place from December 2015 to January …

Health Information Security And Privacy: A Social Science Exploration Of Nurses' Knowledge And Risk Behaviors With Security And Privacy Issues Focusing On Mobile Device Usage, Keith Richard Weiner

Theses & Dissertations

Background. Health information system security and privacy are critical issues that impact the wide use of the Electronic Health Record (EHR) in healthcare including hospitals, providers and health systems (Breaches Affecting 500 or More Individuals, 2017). These issues have been researched from a technology standpoint in this era of accelerated electronic health record adoption, but less has been done related to the EHR users in the United States. Most of the literature related to security and privacy explores research topics, peripheral and direct, regarding policy adherence mechanisms. Yet to be studied is a social science exploration of nurses’ risk knowledge …

Utility Of Spirometry As A Measurement Tool To Evaluate Breathing And Swallowing Coordination (Bsc), Aamna Malik, Jessica Thurman, Deanna Britton, Andrew Demetrius Palmer, Donna Jensen Graville

Student Research Symposium

Breathing swallowing coordination (BSC) is commonly evaluated using nasal thermistry and respiratory inductance plethysmography. In this study, BSC will be evaluated via spirometry in healthy adults. Spirometry may yield additional useful information regarding BSC in adults with neurodegenerative diseases.

Metallodithiolate Ligands For Reversing Metal Ion Induced Aggregation Of Beta Amyloid, Eleanor K. Adams, Marilyn Rampersad Mackiewicz

Student Research Symposium

Alzheimer’s Disease (AD) is the sixth leading cause of death in the United States with no known methods to cure, reverse or halt disease progression. The “metal hypothesis” states that Fe^II, Cu^II, Zn^II, and Al^II bind to truncated Aβ peptides and form soluble oligomers which deposit as senile plaques. These plaques play a crucial role in AD pathogenesis. For example, metallated-Aβ aggregates are hypothesized to disrupt membranes or generate a reactive oxygen species (ROS) through redox cycling in the presence of Cu^I/II or Fe^III/II and a reducing agent. ROS can lead …

Effects Of Chronic Stimulation Of Nucleus Accumbens On Binge Drinking And Transcriptome, Dar'ya Pozhidayeva, Evan Firsick, Kayla G. Townsley, Dan Iancu, Angela Ozburn, A.T.D. Tran

Student Research Symposium

We previously found that stimulating activity in the nucleus accumbens (NAc) reduced binge-like alcohol drinking in mice. We manipulated the NAc using clozapine-n-oxide (CNO) and Designer Receptors Exclusively Activated by Designer Drugs (DREADDs). In a subsequent study, we tested the hypothesis that chronic administration of CNO (to stimulate excitatory DREADDs expressed in the NAc) could produce lasting reductions in binge drinking (as compared with mice receiving vehicle). We observed that 4 weeks of CNO administration resulted in reductions in binge-like drinking that lasted at least 1 week. Based on these results, we hypothesized that transcriptional changes may underlie the observed …

Baby's Best Start: Wic's Role In The Alleviation Of Childhood Obesity, Ashton Hutcheson

Public Health: Student Scholarship & Creative Works

In the past 50 years, obesity prevalence has risen to epidemic-like levels in the United States with an average of 25% of American children being classified as overweight or obese. Prevalence of obesity is significantly increased in socioeconomically disadvantaged income categories. This paper aims to discuss public health preventions/interventions that address childhood obesity such WIC, a supplemental nutrition program for women, infants, and children. It additionally aims to provide broad obesity-related research and begin to suggest preliminary answers to the question of why obesity is so prevalent as well as a brief overview of current treatment options for obesity-related diseases …

Ssaw: A New Sequence Similarity Analysis Method Based On The Stationary Discrete Wavelet Transform, Jie Lin, Jing Wei, Donald Adjeroh, Bing-Hua Jiang, Yue Jiang

Clinical and Translational Science Institute

Background: Alignment-free sequence similarity analysis methods often lead to significant savings in computational time over alignment-based counterparts. Results: A new alignment-free sequence similarity analysis method, called SSAW is proposed. SSAW stands for Sequence Similarity Analysis using the Stationary Discrete Wavelet Transform (SDWT). It extracts k-mers from a sequence, then maps each k-mer to a complex number field. Then, the series of complex numbers formed are transformed into feature vectors using the stationary discrete wavelet transform. After these steps, the original sequence is turned into a feature vector with numeric values, which can then be used for clustering and/or classification. Conclusions: …

The Complementary Health Approaches For Pain Survey (Chaps): Validity Testing And Characteristics Of A Rural Population With Pain, Termeh Feinberg, Dina L. Jones, Christa Lilly, Amna Umer, Kim Innes

Clinical and Translational Science Institute

Objectives Little is known about patterns and correlates of Complementary Health Approaches (CHAs) in chronic pain populations, particularly in rural, underserved communities. This article details the development and implementation of a new survey instrument designed to address this gap, the Complementary Health Approaches for Pain Survey (CHAPS). Design Following pilot-testing using pre-specified criteria to assess quality and comprehension in our target population, and after feedback regarding face-validity from content experts and stakeholders, the final cross-sectional self-report survey required 10–12 minutes to complete. It contained 69 demographic, lifestyle and health-related factors, and utilized a Transtheoretical Model (TTM) underpinning to assess short- …

Abrogation Of Transforming Growth Factor-Β-Induced Tissue Fibrosis In Tbricacol1a2cre Transgenic Mice By The Second Generation Tyrosine Kinase Inhibitor Ski-606 (Bosutinib)., Peter J. Wermuth, Sergio A. Jimenez

Jefferson Institute of Molecular Medicine Papers and Presentations

Transforming growth factor-β (TGF-β) plays a crucial role in the pathogenesis of Systemic Sclerosis (SSc) and other fibrotic disorders. TGF-β-mediated c-Abl and Src kinase activation induces strong profibrotic cascade signaling. The purpose of this study was to test in vivo the antifibrotic activity of Bosutinib (SKI-606), a second generation c-Abl and Src kinase inhibitor, on TGF-β induced cutaneous and pulmonary fibrosis. For this purpose, we employed the TBRIcaCol1a2Cre transgenic mice expressing an inducible constitutively active TGF-β receptor 1 constitutively activated by Col1a promoter-mediated Cre recombinase. The mice were treated parenterally with 2.5, 5.0 or 10.0 mg/kg/day of Bosutinib for 42 …

Matrix Metalloproteinase-Mediated Blood-Brain Barrier Dysfunction In Epilepsy, Ralf G. Rempe, Anika M. S. Hartz, Emma L. B. Soldner, Brent S. Sokola, Satya R. Alluri, Erin L. Abner, Richard J. Kryscio, Anton Pekcec, Juli Schlichtiger, Björn Bauer

Pharmaceutical Sciences Faculty Publications

The blood-brain barrier is dysfunctional in epilepsy, thereby contributing to seizure genesis and resistance to antiseizure drugs. Previously, several groups reported that seizures increase brain glutamate levels, which leads to barrier dysfunction. One critical component of barrier dysfunction is brain capillary leakage. Based on our preliminary data, we hypothesized that glutamate released during seizures mediates an increase in matrix-metalloproteinase (MMP) expression and activity levels, thereby contributing to barrier leakage. To test this hypothesis, we exposed isolated brain capillaries from male Sprague Dawley rats to glutamate ex vivo and used an in vivo/ex vivo approach of isolated brain capillaries …

Dissecting Structure-Encoded Determinants Of Allosteric Cross-Talk Between Post-Translational Modification Sites In The Hsp90 Chaperones, Gabrielle Stetz, Amanda Tse, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

Post-translational modifications (PTMs) represent an important regulatory instrument that modulates structure, dynamics and function of proteins. The large number of PTM sites in the Hsp90 proteins that are scattered throughout different domains indicated that synchronization of multiple PTMs through a combinatorial code can be invoked as an important mechanism to orchestrate diverse chaperone functions and recognize multiple client proteins. In this study, we have combined structural and coevolutionary analysis with molecular simulations and perturbation response scanning analysis of the Hsp90 structures to characterize functional role of PTM sites in allosteric regulation. The results reveal a small group of conserved PTMs …

Assistive Listening Devices In Primary And Secondary Educational Settings: A Systematic Review, Paige Wagner-Skinner

Dissertations, Theses, and Projects

The purpose of this study was to identify the scientific evidence available to support the use of assistive listening devices in primary and secondary educational settings. The American Speech-Language-Hearing Association (ASHA) makes it clear that it is the role of the speech-language pathologist (SLP) to modify the classroom environment, as needed, to enhance communicative abilities for this population (ASHA, 2016; Carney, 1998). Each journal article included in this study was published in a peer reviewed journal between the years of 2000 and 2018, written in the English language, and comprised of scientific information relevant to the research question proposed. Experimental …

Social Work Trauma Interventions: Dialectical Behavioral Therapy, Kassie Baumann

Senior Honors Theses

According to Lynne Weilart (2013), in her article on the reasons why people seek out therapy, trauma is the number one reason people attend counseling. Many different trauma-informed approaches are designed specifically to address the consequences of trauma and to facilitate healing. Some of these approaches are as follows: Cognitive Behavioral Therapy (CBT); Dialectical Behavioral Therapy (DBT);Mentalization Based Therapy (MBT); Trauma Systems Therapy (TST); Trauma Assessment Pathway (TAP); and Attachment, Self-Regulation, and Competency (ARC) (de Arellano, Danielson, Ko, & Sprauge, 2008). The effectiveness of each trauma intervention will be examined. DBT is one of these trauma interventions that is growing …

Dietary Diversity Predicts The Adequacy Of Micronutrient Intake In Pregnant Adolescent Girls And Women In Bangladesh, But Use Of The 5-Group Cutoff Poorly Identifies Individuals With Inadequate Intake, Phuong Hong Nguyen, Lieven Huybregts, Tina G. Sanghvi, Lan Mai Tran, Edward A. Frongillo Jr., Purnima Menon, Marie T. Ruel

Faculty Publications

Background: The Minimum Dietary Diversity for Women (MDD-W) indicator based on a 10-food group women dietary diversity score (WDDS-10) has been validated to assess dietary quality in nonpregnant women. Little is known about its applicability in pregnant women, and specifically pregnant adolescent girls with higher nutrient requirements. Objectives: This study aimed to 1) compare the adequacy of micronutrient intakes between pregnant adolescent girls and women, 2) examine the performance of WDDS-10 in predicting the mean probability of adequacy (MPA) of 11 micronutrients, and 3) assess how well the MDD-W cutoff of 5 groups performed in pregnant adolescent girls and women. …

Treating Adhd With Suggestion: Neurofeedback And Placebo Therapeutics, Robert T. Thibault, Samuel Vassière, Jay A. Olson, Amir Raz

Psychology Faculty Articles and Research

Objective: We propose that clinicians can use suggestion to help treat conditions such as ADHD. Methods: We use EEG neurofeedback as a case study, alongside evidence from a recent pilot experiment utilizing a sham MRI scanner to highlight the therapeutic potential of suggestion-based treatments. Results: The medical literature demonstrates that many practitioners already prescribe treatments that hardly outperform placebo comparators. Moreover, the sham MRI experiment showed that, even with full disclosure of the procedure, suggestion alone can reduce the symptomatology of ADHD. Conclusion: Non-deceptive suggestion-based treatments, especially those drawing on accessories from neuroscience, may offer a safe complement and potential …

Health & Kinesiology News, Georgia Southern University

Health Sciences & Kinesiology: News & Publications (2015-2023)

• Anderson Named Administrator of New Micro-Hospital

Optimism And Compliance: An Examination Of Disempowering Processes Within Online Patient Communities, Wendi F. Coleman

Technical Communication Capstone Course

Patients diagnosed with long-term conditions (LTCs) are now being asked of medical practitioners to take an active role in their own health care as “expert patients.” This trend has accelerated the increase in people with LTCs who are using the internet for both information and social support. A valuable resource to these patients, and of interest to researchers, is a new type of online space: online patient communities (OPCs) created for patients suffering from specific illnesses. In order to better understand potential disempowering processes within OLPs, I follow the research and examine the illness narratives, focusing on their various external …

Self-Care In Bsn Students: Developing A Self-Care Plan, Jamie Davis Brandon

Nursing Theses and Capstone Projects

Stress is an issue of concern in nursing practice and nursing education. Stress leads to burn out and compassion fatigue in the nurse and student nurse. To combat stress, professional organizations advocate for self-care practices. Research indicates self-care practice can reduce stress levels and increase health and wellness. An evidenced-based DNP project was conducted over a seven-week time frame during a mental health nursing course to educate senior BSN students on different dimensions of self-care to reduce stress levels and increase use of self-care practices.

Text Message Intervention For Latino Adults To Improve Diabetes Outcomes In An Urban Free Clinic Setting, Sharon R. Allen

Nursing Theses and Capstone Projects

Introduction: This text message intervention sought to help patients at a free clinic in the Southeastern U.S. that have uncontrolled diabetes (DM) (A1C > or = 7) improve their DM clinical and behavioral outcomes, and thereby help them to live healthier, more hopeful and productive lives as they deal daily with this chronic illness. Eight weeks of educational text messages were sent to help improve DM care and outcomes. Method: Free clinic patient Latino adults with DM (n=25) pre-post one group design. Results: Statistically significant results (p < .05) were seen in three (SKILLD, p=.001, DSES, p = .000, and SDSCA, p = .042) of the four tools/surveys administered. A1C improvements were significant from the pre-intervention (M = 9.10, SD = 1.51) and the trended post-intervention values/results (M=8.26, SD = 1.29, t [21] = 2.79, p = .0110). Discussion: Does personalized communication, education and follow up for patients at the free clinic improve diabetes knowledge, self-efficacy and self-care? This text message intervention shows great promise to improve outcomes for diabetes self-management.

Rescue The Clinical Nurse Educator With A Transformative Mentorship Program, Sue J. Beaman

Nursing Theses and Capstone Projects

The purpose of this project was to develop a transformative mentorship program for clinical nurse educators. Jean Watson’s Theory of Human Caring (THC) was used as the theoretical framework for the development of this program. The population for this evidenced-based project was 12 clinical nurse educators who work in a private baccalaureate liberal arts college. These educators provide supervision for students in the hospital as well as community clinical practice settings. This evidence-based project examined if the implementation of a mentorship program would help increase the confidence level of the clinical educator. The project was implemented over a three-month period …

Guide Lines Vol. I, Issue 15 - May 2018, College Of Health And Human Services

GUIDE Lines

Periodic Newsletter of the Governors State University - University of Illinois, Chicago - Disparities Education Cancer research training and education project (The GUIDE Project).

Healthnet News V.33:No.3 May-June 2018, Wendy Urciuoli

Articles - Patient Care

In this issue: Dangers of Keyless Cars; Midwives in the U.S., and Transparency in Healthcare Pricing.

Department Of Surgery Update, March 2018, Wright State University Department Of Surgery

Department of Surgery Updates

A four page newsletter created by the Department of Surgery documenting changes to the department. This issue contains a message from the chair, a list of important dates, committee meetings, and more.

Failure Of Primary Total Knee Arthroplasty: Establishing A Baseline For Retrieval Analysis Using Well-Functioning Necropsy Specimens, Meredith Perkins

Theses and Dissertations (ETD)

Introduction. Total knee arthroplasty (TKA) is an effective treatment for end-stage osteoarthritis of the knee. While many patients have positive functional and pain outcomes following primary TKA, a subset of patients have suboptimal outcomes, such as unexplained pain or aseptic loosening of the implant components necessitating revision of the index procedure. The understanding of the exact etiology of these suboptimal outcomes of primary TKA is in its infancy. In order to elucidate the etiology of failure in primary TKAs, a baseline for the factors contributing to arthroplasty failure and dissatisfaction must first be established. The purpose of this study …

Design And Development Of A Phantom For Tomosynthesis With Potential For Automated Analysis Via The Cloud., David Goodenough, Josh Levy, Hildur Olafsdottir, Ingvi Olafsson

Radiology Faculty Publications

This paper describes Development of a Phantom for Tomosynthesis with Potential for Automated Analysis via the Cloud. Several studies are underway to investigate the effectiveness of Tomosynthesis Mammographic Image Screening, including the large TMIST project as funded by the National Cancer Institute https://www.cancer.gov/about-cancer/treatment/clinical-trials/nci-supported/tmist. The development of the phantom described in this paper follows initiatives from the FDA, the AAPM TG245 task group, and European Reference Organization (EUREF) for Quality Assured Breast Screening and Diagnostic Services Committee report noting, that no formal endorsement nor recommendation for use has been sought, or granted by any of these groups. This paper reports on …

Demographic And Environmental Factors Associated With Alarm Fatigue In Critical Care Nurses, Amanda Szczesniak

Nursing Undergraduate

Purpose The purpose of this study is to explore what demographic and work environment factors in the critical care setting influence alarm fatigue in critical care nurses who have patients on continuous monitoring, if any. These influencing factors may allow for future interventions on alarm safety based upon demographics and unit set-up.

Background Alarm fatigue is a multi-dimensional issue in healthcare that can have harmful impacts on patients. Critical care nurses are among those who are consistently affected by the phenomenon. Current literature supports that alarm fatigue is a prevalent problem within the health care setting, but very few studies …

Prognostic Utility Of Tricuspid Annular Plane Systolic Excursion In Pulmonary Embolism, Matthew Drause

Yale School of Medicine Physician Associate Program Theses

Inpatient mortality for hemodynamically stable patients with pulmonary embolism (PE) averages 5-10%. Tricuspid annular plane systolic excursion (TAPSE), a reliable and reproducible measure of right ventricular (RV) dysfunction has been shown to identify patients with worse prognosis in the cardiology literature, but prognostic utility of TAPSE using point-of-care echocardiogram (FOCUS) in the emergency department (ED) population is sparse. We propose that in a prospective cohort of patients with confirmed PE, those with TAPSE less than 15mm on FOCUS will have greater overall mortality and need for escalation of care than those with TAPSE greater than 17mm. We will enroll and …