Medicine and Health Sciences Commons^™

Associations Of Maternal Plasma Free Fatty Acid Profiles With Markers Of Inflammation In Healthy Pregnant Women, Xinhua Chen, Thomas P. Stein, Theresa O. Scholl, Robert A. Steer

Rowan-Virtua Research Day

We investigated the relationship between maternal fasting plasma free fatty acid (FFA) profiles and markers of inflammation (MOI) (IL-6, 8, 10, TNF-α, granulocyte macrophage colony-stimulating factor (GMCSF) and resistin) in healthy pregnant women during early gestation (week 16).

These data suggested that maternal functional long-chain FFAs influence inflammatory response during normal pregnancy. Changes in specific FFA composition may reduce low-grade inflammation and inflammation related poor pregnancy outcomes and complications.

Development Of Novel Dual Inhibitor Of Chemokine Receptor 4 And Mcl-1 Against Multiple Myeloma, Kuntal Bhowmick, Kristy K. Patel, Suman Pathi, Subash Jonnalagadda, Tulin Budak-Alpdogan, Manoj K. Pandey

Rowan-Virtua Research Day

Multiple myeloma (MM) is a neoplastic plasma-cell disorder. This is characterized by clonal proliferation of malignant plasma cells in the bone-marrow (BM) microenvironment, monoclonal protein in blood or urine, and associated organ dysfunction. The treatment options approved by FDA are immune-modulatory agents, proteasome inhibitors, and autologous stem cell transplantation (ASCT). Unfortunately, MM remains uniformly fatal owing to intrinsic or acquired drug resistance and the median survival time is 3 to 5 years. Thus, there is a great need for novel strategies to combat MM.

The intimate relationship of myeloma cells to BM microenvironment is “hallmark of myeloma”. The homing of …

Dexmedetomidine (Precedex) Induced Fever, Patrick Dealmeida, Michael Matrale

Rowan-Virtua Research Day

Precedex is an intravenous, α-2 receptor agonist broadly used for analgesia, maintenance of sedation, and alcohol withdrawal treatment in the intensive care unit (ICU).

The most commonly reported adverse effects associated with precedex are hypotension and bradycardia1.

Fever has been reported with a 5-7% incidence rate. Our case shows a very impressive pyrexia in a 49 year old patient most likely associated to Precedex. When compared to the previously three reported cases his fever reached the largest value (T= 107ºF).

As its use becomes more and more common in the ICU, clinicians should be aware of this adverse effect especially …

Wearable Fitness Tracking Improves Self-Efficacy For Exercise, Adam Sturts, Adarsh Gupta

Rowan-Virtua Research Day

The present study was designed to determine the impact of wearable fitness tracking technology use on physical activity and self-efficacy for exercise among wearable fitness device users. This was a cross sectional study. A single questionnaire was administered to participants, providing patient data pertaining to wearable fitness tracking device use, exercise habits and intrinsic self-efficacy for exercise. Wearable fitness tracking device users were found to have higher levels of self-efficacy for exercise than non-users across all participating ages, genders and ethnicities. In addition, wearable fitness device users reported increased engagement in physical activity with the concomitant use of their devices. …

The Unity Project: Camden Community Health Center Building Authentic & Impactful Relationships Through The Ask-First Model, Christian Diliberto, Ruchi Shah, Patrick J. Tempera

Rowan-Virtua Research Day

Last spring, the Camden Community Health Center (CCHC) launched the Unity Project, an initiative aimed at fostering relationships with various Camden, New Jersey organizations to not only educate community members about our services, but also to collaborate with them on improving Camden’s health. Although the CCHC has been in Camden for over 15 years, local organizations were unaware of our existence. There was also a similar disconnect among these organizations themselves. The goal of the Unity Project is to work towards affecting long-term change by forming authentic and impactful relationships with organizations that are already doing meaningful work.

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The Santa Clara, 2018-05-03, Santa Clara University

The Santa Clara

No abstract provided.

The Synergistic Effects Of Saxagliptin And Metformin On Cd34+ Endothelial Progenitor Cells In Early Type 2 Diabetes Patients: A Randomized Clinical Trial., Fiona J Dore, Cleyton C Domingues, Neeki Ahmadi, Nabanita Kundu, Yana Kropotova, Sara Houston, Carol Rouphael, Aytan Mammadova, Linda Witkin, Anamil Khiyami, Richard L Amdur, Sabyasachi Sen

Surgery Faculty Publications

AIMS: Type 2 diabetes is associated with endothelial dysfunction leading to cardiovascular disease. CD34+ endothelial Progenitor Cells (EPCs) are responsible for endothelial repair and neo-angiogenesis and can be used as a cardiovascular disease risk biomarker. This study investigated whether the addition of saxagliptin, a DPP-IV inhibitor, to metformin, may reduce cardiovascular disease risk in addition to improving glycemic control in Type 2 diabetes patients.

METHODS: In 12 week, double-blind, randomized placebo-controlled trial, 42 subjects already taking metformin 1-2 grams/day were randomized to placebo or saxagliptin 5 mg. Subjects aged 40-70 years with diabetes for < 10 years, with no known cardiovascular disease, BMI 25-39.9, HbA1C 6-9% were included. We evaluated EPCs number, function, surface markers and gene expression, in addition to arterial stiffness, blood biochemistries, resting energy expenditure, and body composition parameters. A mixed model regression to examine saxagliptin vs placebo, accounting for within-subject autocorrelation, was done with SAS (p < 0.05).

RESULTS: Although there was no significant …

“But You Still Have The Same Insecurities”—Navigating Personal Trainer And Client Body Image Through Emotional And Aesthetic Labor, Ellen Penn Berry

Masters Theses, 2010-2019

While research on personal trainers’ emotional (controlling the portrayal of own emotions to produce an emotional response in another person) and aesthetic ("looking the part") labor has been conducted, no research currently exists on personal trainer body image. Research demonstrates that body image concerns of athletes and exercising populations may differ from that of the general population. This is an important area to examine due to the personal trainer’s “quasi-professional” role as “cultural intermediaries” between healthcare and exercise science professionals and the average consumer and their provision of “expert service work” to clients, combining emotional labor through service work and …

Distractions In Hearing: Measuring Impulsivity In Service Members With A Mtbi, Kathleen Margaret Chopra

Dissertations, 2014-2019

One of the cognitive symptoms associated with the diagnosis of a mild traumatic brain injury (mTBI) is the degradation of focus and attention. This pilot study was designed to quantify examples of such capabilities in Service Members diagnosed with mTBI and to compare their abilities to peers without an mTBI diagnosis. Specifically, we compared participant groups on their false alarm rates and thresholds for contralateral and informational masking tasks to document the participants’ ability to focus and detect an auditory stimulus in the presence of distracting maskers. In this study, comparing the overall performance of Service Members, with and without …

Development Of A Questionnaire To Assess Attitudes Toward Hearing Aids, Corinne O'Shaughnessy

Dissertations, 2014-2019

Many reasons have been postulated as to why persons with hearing loss are reluctant to engage in the hearing rehabilitation process. While not the only determinant, an individual's attitudes toward hearing loss and hearing aids have been shown to affect adoption of amplification adversely and eventual outcomes of hearing aid use. Several attempts have been made to develop test instruments for attitudes toward hearing loss, but nothing specific to attitudes toward hearing aids or hearing aid technology. The primary objective of this study was to develop a questionnaire to assess attitudes toward hearing aids using the ABC model of attitude …

Objective Differences Between Premium And Mid-Level Digital Hearing Aids, Chelsea C. Barry

Dissertations, 2014-2019

This ongoing study compared premium and mid-level hearing aids from major manufacturers on noise reduction and general electroacoustic characteristics. The findings of this study will contribute to the scarce independent literature evaluating currently available hearing aid technology. Measuring the overall gain reduction in response to a steady state noise can objectively test noise reduction. However, such a method does not specifically test a hearing aid’s ability to reduce speech in specific narrow frequency bands. Hanline & Rout (2008) developed a set of stimuli to evaluate multichannel noise reduction algorithms more precisely. We used these stimuli to test noise reduction abilities …

Melodic Contour Identification And Speech Recognition By School-Aged Children, Michael P. Morikawa

Dissertations, 2014-2019

Using the Sung Speech Corpus (SSC), which encompasses a single database that contains musical pitch, timbre variations and speech information in identification tasks, the current study aimed to explore the development of normal-hearing children’s ability to use the pitch and timbre cues. Thirteen normal hearing children were recruited for the study ages ranging from 7 to 16 years old. Participants were separated into two separate groups: Younger (7-9) and Older (10-16). Musical Experience was taken into account as well. The Angel Sound ™ program was utilized for testing which was adopted from previous studies, most recently Crew, Galvin, and Fu …

Variations In Breastfeeding Practices In The Nicu: A Mixed Methods Investigation, Elizabeth Emaleo Nottingham

Dissertations, 2014-2019

Abstract

Human milk is crucial for the healthy development of infants, particularly preterm infants. Practice patterns and resource allocations to support and promote optimal breastfeeding in this population of infants varies by facility. The purpose of this mixed methods study was to explore differences in practice patterns, describe nurses’ knowledge and perceptions about breastfeeding in the NICU, and identify factors contributing to the differences between hospitals.

Researchers used a sequential explanatory design to gather both quantitative and qualitative data. In the first quantitative phase, a Web-based questionnaire was developed and deployed via Qualtrics to all hospitals with a Neonatal-Perinatal Fellowship …

Envelope-Following Responses And The Effects Of Cochlear Delay, Nicole Jones

Dissertations, 2014-2019

There is great interest in developing clinical applications for phase-locked auditory potentials that are elicited by human speech. A common analysis of vowel-elicited responses is to analyze the envelope-following response (EFR) amplitude at the fundamental frequency (F0) of the eliciting vowel. For this study, we systematically examined the effect of modeled vowel formants on EFR amplitude. EFRs were elicited using a fundamental frequency of 103 Hz, representative of a male speaker’s fundamental frequency. Stimuli consisted of two simultaneously presented sinusoidally amplitude-modulated tones with the same F0. One carrier frequency was fixed at 353 Hz, representing a first formant frequency; the …

The Effect Of Duration Of Foam Rolling On Muscle Recovery, Vincent Lam Ting Luk

Masters Theses, 2010-2019

PURPOSE: Foam rollers are commonly used by athletes, trainers, and therapists to accelerate muscle recovery. The current research suggests foam rolling (FR) may be beneficial in reducing muscle soreness. The objectives of this study were to determine the effect of foam rolling duration on muscle soreness and muscle function (isokinetic leg strength and muscle fatigability). METHODS: Sixteen males (age: 21.8 ± 2.5 yrs, height: 180.8 ± 8.3cm, weight: 82.5 ± 9.6kg) performed 10 sets of 10 reps at 60% 1-RM on a seated leg press machine to induce muscle soreness. For each participant, one leg received no foam rolling treatment; …

Antimicrobial Activity, Biofilm Disruption Capabilities, And Synergistic Interactions Of Novel Amphiphiles, Stephanie Sharpes

Masters Theses, 2010-2019

The increased prevalence of antimicrobial resistant bacteria requires development of new control strategies. Preventative measures such as development of disinfectants and antiseptics with faster killing and anti-biofilm capabilities would help limit the spread of resistance and reduce the incidence of hospital acquired infection. Several series of novel amphiphiles, including three bis-cationic, four tris-cationic and three tetra-cationic double tailed amphiphile series, as well as one hexa-cationic, triple tailed amphiphile series were synthesized and tested for antimicrobial properties. The amphiphiles in this study were previously tested for MIC value against several Gram-positive and negative bacterial species. This work expanded on the antimicrobial …

“We Make Death Look Pretty”: A Qualitative Study Analyzing Reported Effects Of Compassion Fatigue On Hospice Nurse-Patient Communication, Katherine Harville

Masters Theses, 2010-2019

Rationale: Compassion fatigue is present in multiple nursing fields, but hospice poses a significant threat to nurses working within that specific environment. This is due to their consistent proximity with patient suffering, death and dying, and constant communication with patients regarding their death. The hospice nurse-patient relationship requires a deeper connection between nurse and patient which often results in consistent emotional labor for hospice nurses, further amplifying the threat of compassion fatigue. While the effects of compassion fatigue can manifest in many forms, it is typically characterized by a nurses’ decline in job satisfaction, which they do not tend to …

Iron Status In Relation To Well-Being Questionnaire (H10wb) Scores In Division I Female Collegiate Athletes, Jessica L. Fornieri

Masters Theses, 2010-2019

Abstract

Objective: The purpose of this study was to determine the relationship between iron storage and overall well-being in Division I female collegiate athletes. This was done to determine a cost-effective screening method for iron deficiency.

Design: Retrospective Cohort

Subjects and Settings: 117 Division I female athletes at James Madison University. Subjects were ages 17-22 from different teams (Cross Country, Track & Field, Basketball, Field Hockey, Lacrosse, Volleyball, Golf, Swimming & Diving, Soccer, and Softball). We excluded one subject based on a medical diagnosis.

Main Outcome Measure: Data were retrieved from Electronic Medical Records on subjects who have had ferritin …

Factors Contributing To Preschoolers' Communicative Participation Outcomes: Findings From A Population-Based Longitudinal Cohort Study In Ontario, Canada, Barbara Jane Cunningham, Steven E. Hanna, Peter Rosenbaum, Nancy Thomas-Stonell, Bruce Oddson

PRECISe Preschool Speech and Language Publications

Purpose. To identify predictors of communicative participation outcomes for a large cohort of preschoolers with communication disorders.

Method. A secondary analysis of longitudinal program evaluation data from Ontario Canada’s Preschool Speech and Language Program (PSLP). Data available for 46,872 children 18-67 months of age (M = 41.76 mo, SD = 11.92, 68% male) were previously used to predict children’s communicative participation skill development in five levels of function. Demographic and intervention-based variables were added to the models to identify new predictors of growth.

Results. Three demographic and three intervention-based variables were statistically significant predictors of children’s communicative participation …

Family And Support Factors And Positive Body Image, Victoria Gunnufson

Undergraduate Research Celebration 2018

No abstract provided.

Fifteen Years Experience Of Managing Penetrating Extra-Peritoneal Rectal Injuries, Tanzeela Gala, Noman Shahzad, Ahmed Ibrahim Edhi, Fareed Ahmed Shaikh, Hasnain Zafar

Section of General Surgery

Background: Although civilian injuries are generally less severe, they nevertheless remain a challenging problem for the surgeons. In isolated rectal injury patients, though proximal diversion, pre-sacral drainage, distal rectal wash-out and wound debridement are the various surgical options employed in various combinations, the optimum strategy especially for civilian injuries remains unknown. We reviewed our experience of managing penetrating extra peritoneal rectal injuries.
Methods: We conducted a Retrospective review of Adult patients with penetrating extra-peritoneal rectal injuries. Follow-up information of at least one month was needed for early post-operative complications.
Results: A total number of fifteen patients met …

Integration Of Mental Health Into Primary Healthcare: Perceptions Of Stakeholders In Pakistan, Syed S. Hussain, Murad M. Khan Dr., Raisa B. Gul, Nargis Asad

Department of Psychiatry

Background: In Pakistan, there is high prevalence of mental health disorders, but mental health services to address these are not well developed. To provide effective mental health services, the World Health Organization emphasizes the integration of mental health into primary health care (PHC).
Objectives: This study aimed to assess the views of key stakeholders about integration of mental health into PHC in Karachi, Pakistan.
Methods: A qualitative, exploratory study was conducted between June and September 2013 among 15 decision-making (from the Department of Health) and implementation-level stakeholders (mental health and public health professionals and primary care staff) from both the …

Tumor Cure By Radiation Therapy And Checkpoint Inhibitors Depends On Pre-Existing Immunity., Marka R Crittenden, Lauren Zebertavage, Gwen Kramer, Shelly Bambina, David Friedman, Victoria Troesch, Tiffany Blair, Jason R Baird, Alejandro F Alice, Michael J Gough

Articles, Abstracts, and Reports

Radiation therapy is a source of tumor antigen release that has the potential to serve as an endogenous tumor vaccination event. In preclinical models radiation therapy synergizes with checkpoint inhibitors to cure tumors via CD8 T cell responses. To evaluate the immune response initiated by radiation therapy, we used a range of approaches to block the pre-existing immune response artifact initiated by tumor implantation. We demonstrate that blocking immune responses at tumor implantation blocks development of a tumor-resident antigen specific T cell population and prevents tumor cure by radiation therapy combined with checkpoint immunotherapy. These data demonstrate that this treatment …

Understanding The Relationship Between The Neurologic Pupil Index And Constriction Velocity Values., Ifeoluwa Shoyombo, Venkatesh Aiyagari, Sonja E Stutzman, Folefac Atem, Michelle Hill, Stephen A Figueroa, Chad Miller, Amber Howard, Daiwai M Olson

Neuroscience Articles

The pupillary light reflex (PLR) describes the response when light hits the retina and sends a signal (cranial nerve II) to the Edinger-Westphal Nucleus which via cranial nerve III results in pupillary constriction. The Neurological Pupil indexTM (NPi) and pupil constriction velocity (CV) are two distinct variables that can be observed and measured using a pupillometer. We examine NPi and CV in 27,462 pupil readings (1,617 subjects). NPi values < 3.0 and a CV < 0.8 mm/sec were considered abnormal. Regression was used to clarify the effect of pupil size and repeated measures. An odds ratio of abnormal CV given normal NPi (and vice versa) was computed using the glimmixed (SAS) regression. Of 27,462 readings, 49.2% revealed bilaterally normal NPi wtih brisk CV, and 10.8% revealed bilaterally abnormal NPi and slow CV; 9.1% with unilaterally normal NPi and brisk CV where the opposite pupil had an abnormal NPi and slow CV. The remaining 30.9% revealed that one or both PLR had either a normal NPi with slow CV, or abnormal NPi with brisk CV. Brisk CV does not rule out an abnormal PLR; slow CV does not rule in abnormal PLR. Practitioners should consider these implications when interpreting pupillometry readings.

05-08-2018 Hsc Committee Agenda, Patrice Martin

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Synchronous Gastric And Duodenal Metastases From Head And Neck Squamous Cell Carcinoma: A Unique Presentation Of Upper Gastrointestinal Bleeding., Nicholas P. Tarangelo, Charles Andrew Kistler, Zachary Daitch, Wei Jiang, Daniel M. Quirk

Department of Medicine Faculty Papers

Metastatic disease to the stomach or duodenum is an infrequent diagnosis, and head and neck squamous cell carcinoma (HNSCC) is one of the least common primary malignancies that lead to gastric or duodenal metastases. We report the case of a 65-year-old man with human immunodeficiency virus infection and previously diagnosed HNSCC who presented with melena. The patient had a percutaneous endoscopic gastrostomy tube placed 3 months prior to his presentation. Laboratory testing was significant for normocytic anemia and a digital rectal examination was positive for melena. Esophagogastroduodenoscopy revealed numerous cratered nodules with contact bleeding in the stomach as well as …

How Policy Affects Workplace Health: A Comparison Of Workplace Health Policies Between Kentucky & Colorado, Mackenzie Pennington

Mahurin Honors College Capstone Experience/Thesis Projects

With people spending a significant portion of their lives in the workforce, workplace health promotion programs are a growing asset in workplaces across the United States. Due to rising health care costs and an increased prevalence of chronic illnesses and diseases, workplace health promotion programs have been suggested to both reduce health care costs for employers and employees as well as curb risky behaviors that lead to chronic illnesses and diseases. In the U.S., policies have long been used to encourage behavioral change. While a significant amount of workplace health research has addressed the fact that written policies are beneficial …

Intimate Partner Violence, Forced First Sex And Adverse Pregnancy Outcomes In A Sample Of Zimbabwean Women Accessing Maternal And Child Health Care, Simukai Shamu, Stephen Munjanja, Christina Zarowsky, Patience Shamu, Marleen Temmerman, Naeemah Abrahams

Obstetrics and Gynaecology, East Africa

Background: Intimate partner violence (IPV) remains a serious problem with a wide range of health consequences including poor maternal and newborn health outcomes. We assessed the relationship between IPV, forced first sex (FFS) and maternal and newborn health outcomes.

Methods: A cross sectional study was conducted with 2042 women aged 15–49 years attending postnatal care at six clinics in Harare, Zimbabwe, 2011. Women were interviewed on IPV while maternal and newborn health data were abstracted from clinic records. We conducted logistic regression models to assess the relationship between forced first sex (FFS), IPV (lifetime, in the last 12 months and …

The Build-Up Of Auditory Stream Segregation In Adult Cochlear Implant Users: Effect Of Differences In Frequency And Amplitude-Modulation Rate, Alexandria Matz

Dissertations, 2014-2019

This project will use an objective approach to evaluate the effect of inter-subsequence frequency difference and amplitude-modulation rate on build-up stream segregation in CI users. Six post-lingually deafened CI users, between 18 and 75 years old, have been studied and compared to four normal-hearing listeners, between 18 and 75 years old. Repeated pairs of A and B noise bursts were adopted from a previous work (Nie et al., 2014) with modifications and additional conditions, where A and B bursts are narrow-band noise carrying sinusoidal amplitude modulation (AM). The A and B bursts in a stimulus sequence differed either in the …

Hear Me When I’M Well: A Convergent Parallel Mixed Methods Study Of Psychiatric Advance Directives In Virginia, Anne Metz

Dissertations, 2014-2019

Psychiatric advance directives (PADs) are legal documents that allow individuals to express their wishes and desires regarding potential future psychiatric care. PADs have been theorized as a way to empower individuals through improved clinical outcomes, reduced coercion, and minimized involvement of individuals with mental illness in the criminal justice system. Since 2010, the Commonwealth of Virginia has had legislation in place to support the use of these advance planning documents. The purpose of this convergent parallel mixed methods study was to enhance our understanding of PADs in Virginia. Quantitative and qualitative data were collected concurrently via survey and follow-up interview …