Medicine and Health Sciences Commons^™

Inter-Segmental Coordination Strategies And Kinematics Utilized During A Single Leg 180⁰ Jump, K. Krajewski, C. Mccabe, S. Brown, C. Connaboy

International Journal of Exercise Science: Conference Proceedings

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Reaching At-Risk Female Adolescents For Inactivity: Case Study For Increasing Educational Interventions, S. Kitts, T. Flink

International Journal of Exercise Science: Conference Proceedings

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The Characterization And Prediction Of A Safe Workload For The Unilateral Loaded Carry, C. Kiess, M. Kelley, K. Calhoun, A. Goodrick, M. Holmstrup

International Journal of Exercise Science: Conference Proceedings

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Muscular Strength Is Inversely Associated With Central Hemodynamic Load In Young Women, A. Keller, W. Lefferts, J. Augustine, J. Deblois, K. Heffernan

International Journal of Exercise Science: Conference Proceedings

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Differences In Neuromuscular Excitation Rates In Young Adult, Older Adult, And People With Parkinson's Disease, M. Josephson, C. Knight

International Journal of Exercise Science: Conference Proceedings

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An Observation Of Resistance Training History In Ultramarathon Runners And Implications On Performance, K. Jones, M. Bayles, K. Storti, M. Sloniger, H. Gerhart

International Journal of Exercise Science: Conference Proceedings

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The Use Of An Experimental, Topical Foam To Enhance Skin Cooling And Sodium Retention, C. Johnson, M. Darnell, B. Nindl, A. Mares, M. Sakr

International Journal of Exercise Science: Conference Proceedings

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Relationship Between Sedentary Behavior And Arterial Stiffness In Physically Active College Students, C. Jentsch, R. Snopkowski, B. Starkoff, E. Lenz

International Journal of Exercise Science: Conference Proceedings

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The Influence Of Emotions On Heart Rate In Horseback Riders, J. Jelinek, S. Razon, J. Harris, C. Stevens

International Journal of Exercise Science: Conference Proceedings

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Memory System Engagement As A Potential Neurocognitive Mechanism Underlying The Effectiveness Of Self-Regulated Practice, K. Jaquess, Y. Lu, A. Ginsberg, C. Lu, B. Ritland, H. Oh, L. Lo, S. Kahl Jr., B. Hatfield, R. Gentili

International Journal of Exercise Science: Conference Proceedings

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Age And Waist Circumference Modify Discordance Of Body Fat Measurements In Adults With Obesity, S. Jamieson, C. Wood, C. Still, J. Seiler, A. Cook, P. Benotti, J. Andreacci, C. Dixon

International Journal of Exercise Science: Conference Proceedings

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The Effects Of A Six-Week Boot Camp Program On Exercise-Related Affects And Perceptions, J. James, A. Schade, A. Battaglino, A. Trumbetti, J. Blose, K. Cooper, P. Stickles, U. Tokac, M. Reed, M. Whidden, S. Razon

International Journal of Exercise Science: Conference Proceedings

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The Effects Of Agonist-Antagonist Paired Set Vs. Traditional Set Training On Forearm Strength, W. Huff, K. Clark, H. Kim, M. Reed

International Journal of Exercise Science: Conference Proceedings

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The Epidemiology Of Dii Baseball, Basketball, And Soccer Injuries And Potential Preventive Strategies, C. Holdren, A. Fradkin

International Journal of Exercise Science: Conference Proceedings

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Samhd1 Phosphorylation Coordinates The Anti-Hiv-1 Response By Diverse Interferons And Tyrosine Kinase Inhibition., Matthew A Szaniawski, Adam M Spivak, James E Cox, Jonathan L Catrow, Timothy Hanley, Elizabeth S C P Williams, Michel J Tremblay, Alberto Bosque, Vicente Planelles

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Macrophages are susceptible to human immunodeficiency virus type 1 (HIV-1) infection despite abundant expression of antiviral proteins. Perhaps the most important antiviral protein is the restriction factor sterile alpha motif domain and histidine/aspartic acid domain-containing protein 1 (SAMHD1). We investigated the role of SAMHD1 and its phospho-dependent regulation in the context of HIV-1 infection in primary human monocyte-derived macrophages and the ability of various interferons (IFNs) and pharmacologic agents to modulate SAMHD1. Here we show that stimulation by type I, type II, and to a lesser degree, type III interferons share activation of SAMHD1 via dephosphorylation at threonine-592 as a …

K2 And K2*: Efficient Alignment-Free Sequence Similarity Measurement Based On Kendall Statistics, Jie Lin, Donald A. Adjeroh, Bing-Hua Jiang, Yue Jiang

Clinical and Translational Science Institute

Motivation: Alignment-free sequence comparison methods can compute the pairwise similarity between a huge number of sequences much faster than sequence-alignment based methods. Results: We propose a new non-parametric alignment-free sequence comparison method, called K2, based on the Kendall statistics. Comparing to the other state-of-the-art alignment-free comparison methods, K2 demonstrates competitive performance in generating the phylogenetic tree, in evaluating functionally related regulatory sequences, and in computing the edit distance (similarity/dissimilarity) between sequences. Furthermore, the K2 approach is much faster than the other methods. An improved method, K 2 , is also proposed, which is able to determine the appropriate algorithmic parameter …

Lgbt Senior Health Disparities: Information Resources To Bridge The Gap, Gregg A. Stevens, Tony Nguyen, Francisco J. Fajardo

Library Faculty Publications

As the senior population in the United States increases, the aging LGBT (lesbian, gay, bisexual, transgender) population should also see comparable growth rates. Health care providers and social service organizations will care for more LGBT seniors with special needs beyond the general population of older adults as they are more at risk for certain conditions. This article identifies some specific health disparities and examines several organizations that work to improve LGBT senior health by providing critical health information to LGBT older adults, caregivers, and health care professionals.

Systematic Analysis Of Copy Number Variation Associated With Congenital Diaphragmatic Hernia., Qihui Zhu, Frances A High, Chengsheng Zhang, Eliza Cerveira, Meaghan K Russell, Mauro Longoni, Maliackal P Joy, Mallory Ryan, Adam Mil-Homens, Lauren Bellfy, Caroline M Coletti, Pooja Bhayani, Regis Hila, Jay M Wilson, Patricia K Donahoe, Charles Lee

Faculty Research 2018

Congenital diaphragmatic hernia (CDH), characterized by malformation of the diaphragm and hypoplasia of the lungs, is one of the most common and severe birth defects, and is associated with high morbidity and mortality rates. There is growing evidence demonstrating that genetic factors contribute to CDH, although the pathogenesis remains largely elusive. Single-nucleotide polymorphisms have been studied in recent whole-exome sequencing efforts, but larger copy number variants (CNVs) have not yet been studied on a large scale in a case control study. To capture CNVs within CDH candidate regions, we developed and tested a targeted array comparative genomic hybridization platform to …

2018 May 15 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Treatment Of Mci And Alzheimer's Disease, Mark A. Lovell, Bert C. Lynn

Chemistry Faculty Patents

The present invention provides, among other things, therapeutic compositions and methods that can effectively treat, slow or prevent a neurological disease (e.g., a neurodegenerative disease, e.g., mild cognitive impairment (MCI) or Alzheimer's disease (AD)), in particular, based on therapeutically effective amount of nifedipine, oxidized or nitroso nifedipine derivatives, lactam (e.g., a compound of formula (Ic) or (Ic-i), e.g., NFD-L1), thyroxine (T4), triiodothyronine (T3) and combinations thereof.

Neural Responses To Naturalistic Clips Of Behaving Animals Under Two Different Task Contexts, Samuel A. Nastase, Yaroslav O. Halchenko, Andrew C. Connolly, M. Ida Gobbini, James V. Haxby

Dartmouth Scholarship

The human brain rapidly deploys semantic information during perception to facilitate our interaction with the world. These semantic representations are encoded in the activity of distributed populations of neurons (Haxby et al., 2001; McClelland and Rogers, 2003; Kriegeskorte et al., 2008b) and command widespread cortical real estate (Binder et al., 2009; Huth et al., 2012). The neural representation of a stimulus can be described as a location (i.e., response vector) in a high-dimensional neural representational space (Kriegeskorte and Kievit, 2013; Haxby et al., 2014). This resonates with behavioral and theoretical work describing mental representations of objects and actions as being …

Preclinical Evaluation Of Novel Fatty Acid Synthase Inhibitors In Primary Colorectal Cancer Cells And A Patient-Derived Xenograft Model Of Colorectal Cancer, Yekaterina Y. Zaytseva, Piotr G. Rychahou, Anh-Thu Le, Timothy L. Scott, Robert M. Flight, Ji Tae Kim, Jennifer Harris, Jinpeng Liu, Chi Wang, Andrew J. Morris, Theru A. Sivakumaran, Teresa Fan, Hunter Moseley, Tianyan Gao, Eun Young Lee, Heidi L. Weiss, Timothy S. Heuer, George Kemble, B. Mark Evers

Toxicology and Cancer Biology Faculty Publications

Fatty Acid Synthase (FASN), a key enzyme of de novo lipogenesis, is upregulated in many cancers including colorectal cancer (CRC); increased FASN expression is associated with poor prognosis. Potent FASN inhibitors (TVBs) developed by 3-V Biosciences demonstrate anti-tumor activity in vitro and in vivo and a favorable tolerability profile in a Phase I clinical trial.

However, CRC characteristics associated with responsiveness to FASN inhibition are not fully understood. We evaluated the effect of TVB-3664 on tumor growth in nine CRC patient-derived xenografts (PDXs) and investigated molecular and metabolic changes associated with CRC responsiveness to FASN inhibition.

CRC cells and PDXs …

Perceived Importance Of Substance Use Prevention In Juvenile Justice: A Multi-Level Analysis, Jessica M. Sales, Gail Wasserman, Katherine S. Elkington, Wayne Lehman, Sheena Gardner, Larkin Mcreynolds, Tisha Wiley, Hannah K. Knudsen

Behavioral Science Faculty Publications

Background: Youth under juvenile justice (JJ) supervision are at high-risk of adverse outcomes from substance use, making prevention important. Few studies have examined prevention-related attitudes of JJ employees, yet such attitudes may be important for implementing prevention programs. Attitudes toward prevention may reflect individual characteristics and organizational contexts.

Methods: Mixed effects regression was used to analyze data from 492 employees in 36 sites participating in the Juvenile Justice-Translational Research on Interventions for Adolescents in the Legal System (JJ-TRIALS) cooperative agreement. JJ employees' perceived importance of substance use prevention was measured. Staff-level variables included attitudes, job type, and demographic characteristics. Site-level …

Impact Of Outpatient Vs Inpatient Absssi Treatment On Outcomes: A Retrospective Observational Analysis Of Medical Charts Across Us Emergency Departments, P. Brandon Bookstaver, Timothy C. Jenkins, Edward Stenehjem, Shira Doron, Jack Brown, Shannon H. Goldwater, Carlos Lopes, Angela Haynes, Chuka Udeze, Yifan Mo, Patrick Gllard, Yan Liu, Katelyn Keyloun

Pharmacy Faculty/Staff Publications

Background

The objective of this study was to characterize treatment of patients with acute bacterial skin and skin structure infections (ABSSSIs) and describe the association between hospital admission and emergency department (ED) visits or readmissions within 30 days after initial episode of care (IEC).

Methods

This was a retrospective, observational, cohort study of adults with ABSSSI who presented to an ED between July 1, 2012, and June 30, 2013. Patient, health care facility, and treatment characteristics, including unplanned ED visits or readmissions, were obtained through manual chart review and abstraction. Adjusted logistic regression analysis examined likelihood of all-cause unplanned ED …

Insertion And Presence Of Fine-Wire Intramuscular Electrodes To The Lumbar Paraspinal Muscles Do Not Affect Muscle Performance And Activation During Highexertion Spinal Extension Activities, Szu-Ping Lee, Jo Armour Smith, Matthew Kimber, Kelsey Houk

Physical Therapy Faculty Articles and Research

Background

Low back pain (LBP) is commonly associated with paraspinal muscle dysfunctions. A method to study deep lumbar paraspinal (i.e. multifidus) muscle function and neuromuscular activation pattern is intramuscular electromyography (EMG). Previous studies have shown that the procedure does not significantly impact muscle function during activities involving low-level muscle contractions. However, it is currently unknown how muscular function and activation are affected during high-exertion contractions.

Objective

To examine the effects of insertion and presence of fine-wire EMG electrodes in the lumbar multifidus on muscle strength, endurance, and activation profiles during high-exertion spinal extension muscle contractions.

Design

Single-blinded, repeated measures intervention …

Implementing Dietary And Physical Activity Guidelines In A College Health Center, Terry Lynn Bartmus

UNLV Theses, Dissertations, Professional Papers, and Capstones

Obesity has been classified as a major national health care problem that results in a significant increase in morbidity, mortality, and health care related costs. Seventy percent of all adults age 18 and older have a body mass index (BMI) of 25 or greater, indicating they are overweight or obese. Thirty-six percent of college students are overweight or obese. Research has shown that lack of time has further decreased weight-related counseling by primary-care providers. Printed materials have been shown to be effective in cueing individuals to engage in healthy behaviors such as following physical activity and recommended nutritional guidelines. Currently, …

Using Pictorial Action Instructions To Train Low-Literacy Adults To Construct A Basic Humanitarian Engineering Project, Kathleen Paco Cadman

UNLV Theses, Dissertations, Professional Papers, and Capstones

Low- and middle-income countries (LMICs) are often disproportionately faced with environmental hazards, which can cause adverse health outcomes. Although humanitarian engineering projects have been created to mitigate these hazards, LMICs are also frequently impacted by literacy deficits, creating a barrier in training low-literacy individuals to construct these projects. The purpose of this dissertation was to develop, refine, and test the usability of pictorial action instructions (PAI) in training low-literacy individuals to construct a humanitarian engineering project. A concept analysis was completed, including the creation of an operational definition, for “lay worker health literacy.” This analysis and definition set a foundation …

Mate Preferences Among Single Mothers, Carol Yvette Franco

UNLV Theses, Dissertations, Professional Papers, and Capstones

As individuals become parents, they shift time and energy towards parenting to ensure the survival and wellbeing of their offspring. However, it is not uncommon for a romantic partnership between parents to dissolve, which may lead a single mother to pursue a new partner in the future. But how does having a dependent child influence whom she will choose for her new partner? And how will resource availability and assistance from family influence the decisions she makes? A significant amount of research has been conducted on female mate preferences in the United States and elsewhere, yet little is specifically focused …

Clinical Instructors' Cultivation Of Pre-Licensure Nursing Students' Pharmacology Ksas, Rieneke Holman

UNLV Theses, Dissertations, Professional Papers, and Capstones

Adverse drug events affect up to 5% of inpatients; half of these events are caused by preventable medication errors (Agency for Healthcare Research and Quality, 2015). Nurses are the final checkpoint between a medication being ordered and the patient taking it. This profound responsibility requires nurses to possess well-developed pharmacology knowledge, skills, and attitudes (KSAs). To acquire these abilities, they must not only receive pharmacology content as part of their educational preparation, but also translate what they have learned during student clinical experiences. This is important in bridging the gap between what is learned in the

classroom and clinical practice. …

Effect Of Bmp Treatment On Periostin Gene Expression In Pre-Osteoblastic Mc3t3-E1 Mouse Cells, Vincent Lee Khang

UNLV Theses, Dissertations, Professional Papers, and Capstones

Periostin is a secreted, extracellular matrix (ECM) protein widely expressed within collagen-rich fibrous connective tissues of the body including the periodontal ligament (PDL), bone, skin, heart, and cornea. Periostin has been shown to serve many important regulatory functions including cell adhesion, cell motility, wound healing and of particular importance to the dental field, differentiation of osteoblasts. The deletion of periostin compromises osteoblast attachment to bone matrix and induces a reduction in mineralization and expression of bone markers, including type I collagen, osteocalcin, osteopontin and alkaline phosphatase. Periostin has also been shown to play a significant role in collagen fibrillogenesis by …