Medicine and Health Sciences Commons^™

Crohn's Disease, Mergithu Hubena

Nursing Student Class Projects (Formerly MSN)

Crohn’s disease is a progressive and systemic autoimmune disease that causes inflammation to any part of the gastrointestinal tract. The inflammation causes some of the clinical manifestations of crohn’s disease such as abdominal pain, diarrhea, malnutrition, weight loss and fatigue. The cause of crohn’s disease is unknown; however, studies show genetic predisposition, environmental exposures and the gastrointestinal tract microbiome playing roles in the development of crohn’s disease. Crohn’s disease involves the abnormal response of the immune system or a malfunctioning of mucosal immune system to offensive microorganisms which leads to gastrointestinal tissue injury.

Polycystic Ovarian Syndrome, Emily Knisley

Nursing Student Class Projects (Formerly MSN)

This is an educational poster outlining the topic of Poly Cystic Ovarian Syndrome (PCOS). This is an endocrine disorder that affects women in their childbearing years which can result in fertility issues, obesity, insulin resistance, and the development of cysts on the ovaries. The poster covers the signs and symptoms, a case study, statistics, etiology, implications for nursing, and treatment. The main objective of this poster is to discuss the pathophysiology of PCOS and its significance to the affected population.

Human Papillomavirus, Lauren Leathers

Nursing Student Class Projects (Formerly MSN)

This is a poster reviewing the topic of human papillomavirus (HPV). Information regarding the virus, how it is spread, and outcomes for those infected are discussed. The pathophysiological mechanisms of HPV and pathological significance are also described. Emphasis is placed on HPV prevention, and details regarding such techniques are found throughout the poster.

Aortic Stenosis, Dereck Vonallman

Nursing Student Class Projects (Formerly MSN)

The poster pertains to aortic stenosis (AS) and how it relates to the nurse anesthesia profession. Topic was chosen due to my current role in the cardiovascular intensive care unit and future role as a certified nurse anesthetist. Case presentation was offered in the form of an OR patient who suffered AS and became hypotensive. The underlying pathophysiology was listed as; hereditary, scaring and calcium deposits. Significance of the pathophysiology is identified in the proper management of a patient with AS who suffers from hypertrophic cardiomyopathy and how a hypotension crisis in the OR needs to be managed differently than …

Aortic Stenosis, Meredith Kanet

Nursing Student Class Projects (Formerly MSN)

This poster was completed on the topic of aortic stenosis. Emphasis on the poster was placed on the underlying pathophysiology of aortic stenosis and its significant impact on the function of the heart. Diagnostic testing, as well as presence of signs and symptoms, can assist the practitioner in assessing the severity of aortic stenosis in the patient. Treatment options, including medical management and surgical interventions, are reviewed and correlate along with nursing implication for care of the patient with aortic stenosis. Concluding facts regarding aortic stenosis are included as a summation of the poster topic.

Lynch Syndrome, Raejeanne B. Nutter

Nursing Student Class Projects (Formerly MSN)

Lynch syndrome (LS) was previously known as Hereditary Non-polyposis colorectal cancer syndrome (HNPCC) (Shulman, 2015) is a hereditary cancer syndrome. The research explored Lynch Syndrome, the identification, and treatment. Lynch syndrome is associated with cancers of the ovary, stomach, urothelial tract, and small bowel, and less frequently, cancers of the brain, biliary tract, pancreas, and prostate. (Cox et al., 2018) “An individual’s lifetime risk for developing colorectal cancer (CRC) estimated at 5% to 6%; an individual with Lynch syndrome has an 80% lifetime risk. Lynch syndrome is an autosomal dominant disorder caused by germline mutations in 1 of 4 mismatch …

Malignant Hyperthermia, Ashley Casimir Vasnaik

Nursing Student Class Projects (Formerly MSN)

The Certified Registered Nurse Anesthetist (CRNA), as well as other anesthesia providers and support staff interact with a variety of patients on a day to day basis. These patients come to the hospital to seek help for their medical and surgical ailments. As every patient is different, they can also have a variety of health-related issues, many of which can also impact their anesthetic plan. One of the most difficult issues and or emergent situations that can impact everyone in the operating room is an exacerbation of Malignant Hyperthermia (MH), whether it is anticipated or unanticipated. The task of preventing …

Sepsis, John Bell

Nursing Student Class Projects (Formerly MSN)

The pathophysiology of sepsis is related to the patient’s immune response. It involves an imbalance between pro-inflammatory and antiinflammatory responses, causing damage by a variety of mechanisms (Keegan & Wira, 2014).

Pathophysiology Of Infective Endocarditis, Blake Splawinski

Nursing Student Class Projects (Formerly MSN)

Infective Endocarditis (IE) is a rare disease that can be difficult to manage and treat due to the complex nature of the disease process. The pathophysiology behind IE involves damage to the cardiac endothelium allowing bacterial infection to occur. Pathogens gain access to the bloodstream adheres to the compromised cardiac tissue. This infection grows and causes a multitude of issues for the patient. Determining the specific bacteria involved allows for the proper antibiotic regimen. Understanding the pathophysiology and treatment plans assist the interdisciplinary team to successfully manage IE. Nursing implications focus on education, monitoring, and identifying patient populations more susceptible …

Assessment Of Hrv After Maximal Exercise In Trained Postmenopausal Women, Julia Orri, E. M. Hughes, D. G. Mistry, A. Scala

Kinesiology (Formerly Exercise and Sport Science)

Increased parasympathetic tone achieved with endurance training may provide cardioprotection after menopause. To compare heart rate variability (HRV) from rest through maximal exercise and recovery in trained postmenopausal women. Thirtysix postmenopausal women who self-reported training at either moderate (MOD; 3-5.9 METS; 58.9±4.4 year) or vigorous (VIG; >6 METS; 59.7±5.2 year) intensities participated. HRV was measured for 5 min in the supine position, in the last minute of the VO2max test and after 2 min of active recovery. HRV in MOD and VIG was compared using a factorial ANOVA with repeated measures on time. MOD and VIG responded similarly over the …

The Relationship Between Hypermobile Joints And Tendonitis, Rachel Braden, Nicole Coughlin

Occupational Therapy Graduate Student Evidenced-Based Research Reviews

No abstract provided.

Post-Operative Nausea And Vomiting In Adults, Kristina Ann Vasnaik

Nursing Student Class Projects (Formerly MSN)

The purpose of this evidence-based poster is to discuss post-operative nausea and vomiting in the adult population undergoing surgery. Post-operative nausea and vomiting is a common concern for patients and providers, a common complication of surgery, and leading cause of unexpected hospital admission of ambulatory care patients. Post-operative nausea and vomiting also increases healthcare costs and causes decreased patient satisfaction as it creates additional discomfort for the surgical patient. The goal of this poster is to discuss common pathophysiology and significance of post-operative nausea and vomiting, signs and symptoms, risk factors for developing post-operative nausea and vomiting, pre-operative/intra-operative/post-operative treatment strategies, …

Simulated Role-Play To Improve Attitudes And Empathy Towards Older Adults In Accelerated Nursing Students, Elizabeth A. Galetz

Nursing Theses and Dissertations

Nearly 18% of the United States population will be at least 65 years or older by 2025. Studies suggest student nurses have a negative attitude toward working with this population. There is a need to increase the number of graduate nurses who have positive attitudes towards older adults and an interest in working with this population upon graduation. This pre- and post-test intervention study aimed to: 1) examine the effectiveness of two educational modalities, a case study and simulated role-playing scenarios, on improving attitudes and empathy towards older adults; 2) explore factors affecting attitudes and empathy in accelerated baccalaureate of …

Implementation Of A Human Trafficking Response Protocol In A Reproductive Healthcare Setting: The Impact On Clinician Preparedness, Gina Liverseed

Nursing Capstones

No abstract provided.

Geographical, Racial And Socio-Economic Variation In Life Expectancy In The Us And Their Impact On Cancer Relative Survival, Angela B. Mariotto, Zhaohui Zou, Christopher J. Johnson, Steve Scoppa, Hannah K. Weir, Bin Huang

Markey Cancer Center Faculty Publications

Purpose

Despite gains in life expectancy between 1992 to 2012, large disparities in life expectancy continue to exist in the United States between subgroups of the population. This study aimed to develop detailed life tables (LT), accounting for mortality differences by race, geography, and socio-economic status (SES), to more accurately measure relative cancer survival and life expectancy patterns in the United States.

Methods

We estimated an extensive set of County SES-LT by fitting Poisson regression models to deaths and population counts for U.S. counties by age, year, gender, race, ethnicity and county-level SES index. We reported life expectancy patterns and …

Bibliometric Analysis Of Gaps In Research On Asbestos-Related Diseases: Declining Emphasis On Public Health Over 26 Years, Ro-Ting Lin, Matthew John Soeberg, Lung-Chang Chien, Scott Fisher, Jukka Takala, Richard Lemen, Tim Driscoll, Ken Takahashi

School of Public Health Faculty Research

Objectives The global burden of asbestos-related diseases (ARDs) is significant, and most of the world’s population live in countries where asbestos use continues. We examined the gaps between ARD research and suggestions of WHO and the International Labour Organization on prevention. Methods From the Web of Science, we collected data on all articles published during 1991–2016 and identified a subset of ARD-related articles. We classified articles into three research areas—laboratory, clinical and public health—and examined their time trends. For all and the top 11 countries publishing ARD-related articles, we calculated the proportions of all ARD-related articles that were in each …

Global Trends In Typhoidal Salmonellosis: A Systematic Review, Daina Als, Amruta Radhakrishnan, Paul Arora, Michelle F. Gaffey, Susan Campisi, Russanthy Velummailum, Farhana Zareef, Zulfiqar Ahmed Bhutta

Department of Paediatrics and Child Health

Typhoid and paratyphoid fever continue to significantly contribute to global morbidity and mortality. Disease burden is higher in low-and middle-income settings where surveillance programs are rare and little systematic information exists at population level. This review evaluates national, regional, and global trends in the incidence of typhoid fever and of related morbidity and mortality. A literature search in Medline, Embase, and Web of Science was conducted in June 2016, followed by screening and data extraction in duplicate. Studies reporting blood culture estimates of typhoid or paratyphoid morbidity and mortality were included in the analysis. Five thousand five hundred sixty-three unique …

Underappreciation Of Endothelial Glycocalyx, Morgan Potts

Nursing Student Class Projects (Formerly MSN)

Vascular endothelial glycocalyx is a fragile, gel-like substance found on the inside of the luminal wall of blood vessels. When damaged, either by hyperglycemia, hypoxia, hypervolemia, or inflammation, this fragile structure is degraded leaving the endothelium exposed. Damaged endothelial glycocalyx causes many side effects including edema, blood vessel vasodilation, and coagulopathy. Despite the lack of treatment options, treating the underlying cause and preventing degradation by avoiding triggers is paramount in reducing morbidity and mortality.

Obstructive Sleep Apnea And It's Relationship To Cardiovascular Disease, Cody Steffes

Nursing Student Class Projects (Formerly MSN)

No abstract provided.

The Influence Of Citrus Urantium And Caffeine Complex Versus Placebo On The Cardiac Autonomic Response: A Double Blind Crossover Design, Brian Kliszczewicz, Emily Bechke, Cassie Williamson, Paul Bailey, Wade Hoffstetter, John R. Mclester, Cherilyn N. Mclester

Faculty Articles

Background: The purpose of this study was to examine the resting cardiac autonomic nervous system’s response to the ingestion of a complex containing Citrus aurantium + Caffeine (CA + C) and its influence on recovery following a high-intensity anaerobic exercise bout in habitual caffeine users. Methods: Ten physically active males (25.1 ± 3.9 years; weight 78.71 ± 9.53 kg; height 177.2 ± 4.6 cm; body fat 15.5 ± 3.13%) participated in this study, which consisted of two exhaustive exercise protocols in a randomized crossover design. On each visit the participants consumed either a CA + C (100 mg of CA …

The Course Of The V2 Segment Of The Vertebral Arteries In Klippel-Feil Syndrome: A Case Report., Asad Rizvi, Joe Iwanaga, Rod J Oskouian, Marios Loukas, R Shane Tubbs

Articles, Abstracts, and Reports

Klippel-Feil syndrome is a congenital disorder characterized by the fusion of one or more cervical vertebrae leading to limitations in the rotation, extension, and flexion of the neck and possible neurological symptoms. Other abnormalities can also be found in these patients. The anatomy of the vasculature can be abnormal in these patients including variations in the course and origin of the vertebral arteries potentially leading to intra-operative complications. Herein, we report a case of Klippel-Feil syndrome and detail the course of the vertebral arteries in an osteological specimen.

Effect Of Comorbidity On Unplanned Readmissions After Percutaneous Coronary Intervention (From The Nationwide Readmission Database)., Chun Shing Kwok, Sara C Martinez, Samir Pancholy, Waqar Ahmed, Khaled Al-Shaibi, Jessica Potts, Mohamed Mohamed, Evangelos Kontopantelis, Nick Curzen, Mamas A Mamas

Articles, Abstracts, and Reports

It is unclear how comorbidity influences rates and causes of unplanned readmissions following percutaneous coronary intervention (PCI). We analyzed patients in the Nationwide Readmission Database who were admitted to hospital between 2010 and 2014. The comorbidity burden as defined by the Charlson Comorbidity Index (CCI). Primary outcomes were 30-day readmission rates and causes of readmission according to comorbidity burden. A total of 2,294,346 PCI procedures were included the analysis. The patients in CCI = 0, 1, 2 and ≥3 were 842,272(36.7%), 701,476(30.6%), 347,537(15.1%) and 403,061(17.6%), respectively. 219,227(9.6%) had an unplanned readmission within 30 days and rates by CCI group were …

Lenalidomide Consolidation Benefits Patients With Cll Receiving Chemoimmunotherapy: Results For Calgb 10404 (Alliance)., John C Byrd, Amy S Ruppert, Nyla A Heerema, Alese E Halvorson, Eva Hoke, Mitchell R Smith, John E Godwin, Stephen Couban, Todd A Fehniger, Michael J Thirman, Martin S Tallman, Frederick R Appelbaum, Richard M Stone, Sue Robinson, Julie E Chang, Sumithra J Mandrekar, Richard A Larson

Articles, Abstracts, and Reports

Prior to novel targeted agents for chronic lymphocytic leukemia (CLL), the best chemoimmunotherapy regimen in patients with non-del(11q) disease was unclear. The role of lenalidomide was also not defined. This phase 2 study randomized 342 untreated patients with non-del(11q) CLL requiring therapy to fludarabine plus rituximab (FR; n = 123), FR plus lenalidomide consolidation (FR+L; n = 109), or FR plus cyclophosphamide (FCR; n = 110) and compared 2-year progression-free survival (PFS) rates of each to the historical control rate with FC (60%). Patients with del(11q) in at least 20% of pretreatment cells continued with FCR (n = 27) or …

Her2 Basolateral Versus Circumferential Ihc Expression Is Dependent On Polarity And Differentiation Of Epithelial Cells In Gastric/Ge Adenocarcinoma, Shahid Pervez, Sidra Arshad, Brooj Abro

Department of Pathology and Laboratory Medicine

Aim: Antigenic expression in epithelial cells can be heterogeneous which may pose a problem in immunohistochemical (IHC) analysis of tumor markers, in particular, predictive markers like HER2. Studies have shown that epithelial cells have distinct apical and basolateral domains which are separated by tight junctions. The cell membrane in these two domains has a different composition of macromolecules and hence can have variable antigen expression on immunohistochemistry. In our study, we aimed to investigate this phenomenon of basolateral versus circumferential IHC staining of HER2 in gastric/GE adenocarcinoma.
Methods: We selected 45 cases of gastric/GE adenocarcinoma and evaluated equal number of …

Potential Biases And Social Stigmas Toward Mental Health On Georgia Southern’S Campus, Brandi N. Hawkins

Honors College Theses

Aims: The purpose of this study is to examine the potential biases and social stigmas toward mental health on Georgia Southern’s campus. The research questions explored are as follows: (1) Are there mental health biases on campus? (2) Are there any differences between college, class status, marital status, race, age, or gender in terms of mental health bias? (3) Do students feel as though there are available resources on campus? (4) Do students feel comfortable reaching out for help?

Methods: Data was collected from 350 undergraduate students over the age of 18 via a Likert-style questionnaire. The questionnaire …

Impact Of The Spop Mutant Subtype On The Interpretation Of Clinical Parameters In Prostate Cancer., Deli Liu, Mandeep Takhar, Mohammed Alshalalfa, Nicholas Erho, Jonathan Shoag, Robert B. Jenkins, R. Jeffrey Karnes, Ashley E. Ross, Edward M. Schaeffer, Mark A. Rubin, Bruce Trock, Eric A. Klein, Robert B. Den, Scott A. Tomlins, Daniel E. Spratt, Elai Davicioni, Andrea Sboner, Christopher E. Barbieri

Department of Radiation Oncology Faculty Papers

Purpose: Molecular characterization of prostate cancer, including The Cancer Genome Atlas, has revealed distinct subtypes with underlying genomic alterations. One of these core subtypes, SPOP (speckle-type POZ protein) mutant prostate cancer, has previously only been identifiable via DNA sequencing, which has made the impact on prognosis and routinely used risk stratification parameters unclear.

Methods: We have developed a novel gene expression signature, classifier (Subclass Predictor Based on Transcriptional Data), and decision tree to predict the SPOP mutant subclass from RNA gene expression data and classify common prostate cancer molecular subtypes. We then validated and further interrogated the association of prostate …

Predicting Gains With Visuospatial Training After Stroke Using An Eeg Measure Of Frontoparietal Circuit Function, Robert J. Zhou, Hossein M. Hondori, Maryam Khademi, Jessica M. Cassidy, Katherine M. Wu, Derek Z. Yang, Nikhita Kathuria, Fareshte R. Erani, Lucy Dodakian, Alison Mckenzie, Cristina V. Lopes, Walt Scacchi, Ramesh Srinivasan, Steven C. Cramer

Physical Therapy Faculty Articles and Research

The heterogeneity of stroke prompts the need for predictors of individual treatment response to rehabilitation therapies. We previously studied healthy subjects with EEG and identified a frontoparietal circuit in which activity predicted training-related gains in visuomotor tracking. Here we asked whether activity in this same frontoparietal circuit also predicts training-related gains in visuomotor tracking in patients with chronic hemiparetic stroke. Subjects (n = 12) underwent dense-array EEG recording at rest, then received 8 sessions of visuomotor tracking training delivered via home-based telehealth methods. Subjects showed significant training-related gains in the primary behavioral endpoint, Success Rate score on a standardized test …

Assessing The Impact Of A Partnership‐Based Work/Study Nursing Upgrade Programme In A Low And Middle‐Income Setting, Sharon Brownie, Samwel Gatimu, Abdul Haq Wahedna, Isabel Kambo, Eunice Ndirangu

School of Nursing & Midwifery, East Africa

Aim: To evaluate the 15‐years impact of the work‐study nursing upgrading programme in East Africa.

Background: Working nurses in Africa are often primary family income earners, with limited ability to leave jobs and upgrade qualifications. In 2001, the university established a work‐study upgrade programme for enrolled‐ and diploma‐level nurses, allowing them to upgrade their qualifications while continuing to work and support families. Donor partnerships provided scholarships to further increase programme access.

Design: A mixed method design was used involving an online alumni survey and 24 interviews and 23 focus groups with 172 purposively selected representatives of nursing graduates, employers, regulatory …

Challenges Of Pain Management In Neurologically Injured Patients: Systematic Review Protocol Of Analgesia And Sedation Strategies For Early Recovery From Neurointensive Care., David Wyler, Michael Esterlis, Brittany Burns Dennis, Andrew Ng, Abhijit Lele

Department of Anesthesiology Faculty Papers

BACKGROUND: A recent paradigm shift within the intensive care discipline has led to implementation of protocols to drive early recovery from the intensive care unit (ICU). These protocols belong to a large knowledge, translation and quality improvement initiative lead by the Society of Critical Care Medicine, aiming to "liberate" patients from the ICU. They "bundle" evidence-based elements shown to lower ICU stay and mortality and optimize pain management. The bundled elements focus on Assessing, preventing and managing pain; Both spontaneous awakening trials and spontaneous breathing trials; Choice of analgesia and sedation; assessment, prevention, and management of Delirium; Early mobility and …

Comparative Efficacy Of Video And Text Instructional Modalities For An Oral Surgery Technique Among Dental Students, Ho-Hyun Brian Sun, Jeffrey A. Elo, Grant D. Mcclendon, Hardev Singh, Chan M. Park

Pacific Journal of Health

Purpose: To gauge the efficacy of video media in pre-doctoral oral and maxillofacial surgery education and compare it to traditional text-based learning materials.

Methods: Twenty novice dental students were randomly divided into two groups to place an Erich arch bar to the maxillary dentition of a dentoform. Group A was given a 10 minute video instruction while Group B was given 10 minutes to review written text instruction. All participants were given 45 minutes to place the arch bar on a dentoform while being recorded. This session concluded with a survey of student perceptions using the SEEQ. The …