Medicine and Health Sciences Commons^™

Historical Perspective Of Nephrotoxicity, Gary O. Rankin, Monica A. Valentovic

Clinical and Translational Science Institute

No abstract provided.

Hearing And Orally Mimicking Different Acoustic-Semantic Categories Of Natural Sound Engage Distinct Left Hemisphere Cortical Regions, James W. Lewis, Magenta J. Silberman, Jeremy J. Donai, Chris A. Frum, Julie A. Brefczynski-Lewis

Clinical and Translational Science Institute

Oral mimicry is thought to represent an essential process for the neurodevelopment of spoken language systems in infants, the evolution of language in hominins, and a process that could possibly aid recovery in stroke patients. Using functional magnetic resonance imaging (fMRI), we previously reported a divergence of auditory cortical pathways mediating perception of specific categories of natural sounds. However, it remained unclear if or how this fundamental sensory organization by the brain might relate to motor output, such as sound mimicry. Here, using fMRI, we revealed a dissociation of activated brain regions preferential for hearing with the intent to imitate …

Dark Matters: Effects Of Light At Night On Metabolism, Randy J. Nelson, Souhad Chbeir

Clinical and Translational Science Institute

Life on earth has evolved during the past several billion years under relatively bright days and dark night conditions. The wide-spread adoption of electric lights during the past century exposed animals, both human and non-human, to significant light at night for the first time in their evolutionary history. Endogenous circadian clocks depend on light to entrain to the external daily environment and seasonal rhythms depend on clear nightly melatonin signals to assess time of year. Thus, light at night can derange temporal adaptations. Indeed, disruption of naturally evolved light-dark cycles results in several physiological and behavioural changes with potentially serious …

Queering Sexual Health: The Intersection Of Sexual Health And Lgbtq Identities In Worcester, Ma, Sara Richman Davidow

Sustainability and Social Justice

This research examined what support, services, and programming existed at the intersection of sexual health and LGBTQ identities in Worcester MA. The data analyzed were interviews with professionals in sexual health or LGBTQ related fields as well as the public websites of sexual health or LGBTQ organizations. The researcher examined this data, along with literature on the rise of sexual health and LGBTQ communities, to understand (1) how inclusive sexual health resources in Worcester were and (2) what themes still need to be addressed to make gender and sexuality minorities comfortable seeking sexual health medical aid. The findings indicated that …

Hospital Acquired Pressure Injury Gap Analysis, Mary Lou Hall

Master's Projects

Hospital acquired pressure injuries (HAPIs) were identified as an area for a quality improvement (QI) project in a progressive care unit (PCU) in a Midwestern Hospital. In order to reduce HAPIs and provide the best possible preventative care, a gap analysis between the current care practices on the progressive care unit and the best evidence-based practice recommendations for HAPI prevention in the areas of risk/skin assessment, surface support, nutrition and hydration, repositioning/movement, moisture management, and prophylactic dressings was conducted. The Model for Improvement (MFI) was the QI framework that guided this pressure injury gap analysis.

The goals of this gap …

The Role Of Developmental Timing Regulators In Progenitor Proliferation And Cell Fate Specification During Mammalian Neurogenesis, Jennifer S. Romer-Seibert

Graduate School of Biomedical Sciences Theses and Dissertations

Developmental timing is a key aspect of tissue and organ formation in which distinct cell types are generated through a series of steps from common progenitors. These progenitors undergo specific changes in gene expression that signifies both a distinct progenitor type and developmental time point that thereby specifies a particular cell fate at that stage of development. The nervous system is an important setting for understanding developmental timing because different cell types are produced in a certain order and the switch from stem cells to progenitors requires precise timing and regulation. Notable examples of such regulatory molecules include the RNA-binding …

Barriers To The Administration Of The Influenza Vaccine, Lauren Babb, Heather Bishop, Carrie Dozier, Renea Hopple, Hannah Marlin, Jennifer Sartin

MSN Research Projects

The Centers for Disease Control and Prevention (CDC) estimates that since 2010 influenza has caused between 9.2 million and 60.8 million illnesses. Numbers from the 2015-2016 influenza season indicate that influenza vaccination prevented approximately 5.1 million influenza illnesses. Though most healthy individuals recover from the flu within 2 weeks, there is great concern for those who do not as this can lead to serious complications. Vulnerable populations, such as the elderly, children, pregnant women and individuals with chronic disease that contract influenza, are at risk for more severe illnesses such as sinus infections or bacterial pneumonia. Influenza can lead to …

Speech-Language-Hearing Clinic Handbook - August 2018, Department Of Audiology And Speech-Language Pathology, East Tennessee State University

Speech-Language Pathology Handbooks

No abstract provided.

Inhibition Of Ribosome Biogenesis Through Genetic And Chemical Approaches, Leonid Anikin

Graduate School of Biomedical Sciences Theses and Dissertations

In order to maintain the ability to generate proteins, proliferating cells must continuously generate ribosomes, designating up to 80% of their energy to ribosome biogenesis (RBG). RBG involves transcription of rDNA by RNA polymerases I (Pol I) and III (Pol III), expression of approximately 80 ribosomal proteins, and assembly of these components in a process referred to as ribosome maturation. During maturation, the Pol I transcribed 47S pre-rRNA undergoes a number of processing events, while simultaneously interacting with processing factors and ribosomal proteins that drive pre-ribosome assembly. Inhibition of RBG has become one of the pursued targets for cancer therapy …

Psychotropic Pharmacogenomic Testing: Effects On Provider Prescribing Patterns And Phq-9 Depression Screening Scores In A Rural Michigan Family Practice, Nicole Madalinski

Doctor of Nursing Practice Scholarly Projects

The rate of depression across the United States is on the rise with over 16.2 million people experiencing a depressive episode per year (Siu & and the US Preventive Services Task Force [USPSTF], 2016). Medications to treat depression typically take weeks or months to see clinical improvement (Uphold & Graham, 2013). If the medication is not effective, a dose or medication change may occur, lengthening the time spent in a depressive state. This scholarly project retrospectively analyzed charts at a rural primary care practice that implemented GeneSight® psychotropic pharmacogenomic testing for treatment resistant depression. This project sought to understand if …

Implication Of Concussion Preventative Behavior Through Youth Education On Playground Safety, Bryan Harris

Doctor of Nursing Practice Scholarly Projects

The concern with concussions has taken our society by storm as it relates to the health consequences either: acute, chronic, and/or later in life as a result of experiencing a single or multiple concussions. Research is thriving on concussion diagnosis, management, and treatment and will continue to do so in the years to come. Preventative measures in a variety of forms is the cornerstone for dealing with concussions at this time; with evidence showing formal educational programs are effective. ThinkFirst: National Injury Prevention Foundation, provides educational programs for first through eighth grade students on prevention of brain, spinal cord, and …

The Impact Of A Poverty Simulation On Practical Nursing Students’ Attitudes Towards Poverty, Jaime Crabb

Doctor of Nursing Practice Scholarly Projects

Poverty is a multi-faceted global problem. Nurses and providers are front-line caregivers for this vulnerable population. In order to provide effective care, individuals must understand their own attitudes towards poverty. The purpose of this study was to evaluate for changes in Practical Nursing students’ attitudes towards poverty with the use of a poverty simulation based upon the Experiential Learning Theory. Participants were surveyed using the Short Form Attitudes towards Poverty (SFATP) tool. The ELT espouses that the best learning occurs when students actively engage in an experience, reflect upon it, and then apply that learning to future experiences. Statistical significance …

A Rare Case Of Metastases From A High-Grade Astrocytoma To The Pleura, Bones, And Liver Within Six Months Of Diagnosis, Jennifer L. Dotson, Ala Nijim, Krista L. Denning, Yousef R. Shweihat, Yehuda Lebowicz

Internal Medicine

High grade astrocytomas such as anaplastic astrocytoma and glioblastoma multiforme are aggressive central nervous system malignancies with a poor prognosis. Due to shortened survival times, their devastating effects are usually localized intracranially and rarely metastasize outside of the central nervous system. When metastases occur, they usually present in patients with longer survival times and they typically coincide with a primary site recurrence. We present a rare case of metastases from a high-grade astrocytoma/glioblastoma to the pleura, bones and liver within six months of diagnosis, without primary site recurrence.

Identifying Factors That Contribute To The Prevalence Of Obesity Among Nurses In The Acute Care Setting, Jennifer Anderson

Grace Peterson Nursing Research Colloquium

Abstract

Background: Obesity is the most prevalent, yet most controllable health problem threating society’s health and well-being. Nurses are a first line defense to address this pandemic, however, nurses exhibit higher incidence of obesity than the general population. When nurses are not a role model for the message they are delivering, patient care and outcomes are compromised.

Objective: The purpose of an literature review is to explore current research to evaluate the prevalence of obesity among nurses in the acute care setting, identify its causative factors, determine the potential impact on patient education, and recommend possible evidenced-based solutions for the …

Trident - August 2018, Dugoni School Of Dentistry

Trident

The newsletter of the Pacific Orthodontic Alumni Chapter at University of the Pacific, Arthur A. Dugoni School of Dentistry.

Quantifying Photodamage By Noninvasive Mesoscopic Skin Imaging, Christina E. Borchers, Trevor Bihl, Chien Poon, Daniel J. Rohrbach, Samia Borchers, Julian Trevino, Max Rubin, Heidi Donnelly, Karl Kellawan, Lydia Carpenter, Shalini Bahl, Craig Rohan, Elizabeth Muennich, Scott Guenther, Holly Hahn, Ali Rkein, Marc Darst, Nico Mousdicas, Jeffery B. Travers, Ulas Sunar

Dermatology Faculty Publications

Ultraviolet light exposure is the major cause for photodamage. Pathologic effects of UVradiation include precancerous actinic keratosis which can progress into squamous cellcarcinoma. UV exposures commonly encountered include sunlight and indoor tanning bedexposure. Actinic neoplasia (precancerous actinic keratosis and non-melanoma skincancer) are highly prevalent in elderly patients with fair skin, and those with lower immunesystems. The impact on our healthcare system is substantial, as currently the averageannual cost to treat non-melanoma skin cancer is 5 billion dollars [1]. Though often asource of considerable morbidity due to extensive surgical procedures to remove the skincancers in the normal populations, squamous cell carcinomas …

Insight Into Translational Activation In Yeast Mitochondria, Julia Lynn Jones

Graduate School of Biomedical Sciences Theses and Dissertations

Mitochondrial function depends on over a thousand proteins, of which the majority are nuclear DNA-encoded and approximately one percent are mitochondrial DNA-encoded. The mitochondrial DNA of Saccharomyces cerevisiae contains eight protein-encoding genes, seven of which are required for proper function of the respiratory complexes and one encodes a ribosomal protein. The bigenomic nature of the oxidative phosphorylation complexes requires coordinated expression and regulation from both the nuclear and the mitochondrial genomes. It is currently unclear how this regulatory network operates. However, it is thought that nuclear genome-encoded messengers localized to the mitochondria aid in this coordination.

A family of proteins …

Safety And Efficacy Of Routine Bridging Anticoagulation For Subtherapeutic Anticoagulation In Outpatients With A Left Ventricular Assist Device, David C. Shisler, Gaurang N. Vaidya, Lori Muncy, Rajakrishnan Vijayakrishnan, Mark S. Slaughter, Emma J. Birks, Dmitry Abramov

The VAD Journal

Background

Anticoagulation with vitamin K antagonists is vital to prevent pump thrombosis in patients with left ventricular assist devices (LVADs). However, the safety and efficacy of bridging anticoagulation for the routine management of subtherapeutic international normalized ratio (INR) in stable outpatients remains poorly characterized.

Methods

In this retrospective study, a total of 60 LVAD outpatients had 110 episodes of subtherapeutic INR noted on routine testing. 34 of these episodes were managed with parenteral bridging anticoagulation and 76 were managed with only an adjusted dose of warfarin. The rates of bleeding and thromboembolic adverse events following these episodes of subtherapeutic INR …

Gender- And Region-Specific Changes In Estrogen Signaling In Aging Rat Brain Mitochondria, Christopher M. Evola, Tanner L. Hudson, Luping Huang, Adrian M. Corbett, Debra A. Mayes

Neuroscience, Cell Biology & Physiology Faculty Publications

Recently epidemiological studies suggest females lose neuroprotection from neurodegenerative diseases as they go through menopause. It has been hypothesized that this neuroprotection is hormone‐dependent. The current study characterized cell signaling molecules downstream of estrogen receptor beta that are known to play a role in memory, PKC, ERK, and connexin‐43, in regions of the brain associated with memory decline in an attempt to elucidate significant changes that occur post‐estrus. Total whole cell lysates were compared to isolated mitochondrial protein because mitochondrial function is known to be altered during aging. As hypothesized, protein concentrations differed depending on age, gender, and brain region. …

Santa Clara Magazine, Volume 59 Number 2, 3, 4, August 2018 [Print Issues V. 58:2, 3, 4], Santa Clara University

Santa Clara Magazine

3 - GOOOAL! By Giannina Ong ’18

4 - LOVE, ARMAND Letters from a freshman to his widowed mother from a century ago

Conjunctivitis, Infant >/= 29 Days Of Age Or Child, Children's Mercy Kansas City

Clinical Pathways (Formally Known As Care Process Models)

No abstract provided.

Framework For Implementation Of A Partial Hospitalization Program, Katelynn Krause, Erin Bachler, Stephanie Moon

Mental Health

This abstract will be available for download after an embargo period

Implementing Evidence-Based Fall Reduction Interventions In An Urban Emergency Department, Nichole L. Schmidt

Master's Projects

The patient population that is falls in the emergency department (ED) tends to differ from population that falls on inpatient units. However, there is no validated fall risk assessment for the ED setting. In an ED in a western Michigan hospital a fall reference card was designed and trialed by a small group of ED nurses on twenty-five ED patients. The fall reference card was created as a quick-reference guide for the assessment of fall risk, and the implementation of evidence-based fall risk interventions. The card utilized interventions supported by literature as the most common reasons for ED falls. The …

An Electromyography Study Of Muscular Endurance During The Posterior Shoulder Endurance Test, Neil A. Evans, Emily Dressler, Tim Uhl

Physical Therapy Faculty Research

The primary purpose was to determine if there is a difference between the median frequency slopes of 5 posterior shoulder muscles during the initial portion of the Posterior Shoulder Endurance Test (PSET) at the 90⁰ and 135⁰ shoulder abduction positions.

Fifty-five healthy volunteers (31 females) participated. The median frequency of the posterior deltoid (PD), upper trapezius (UT), middle trapezius (MT), lower trapezius (LT), and infraspinatus (INF) was measured during the PSET at 90⁰ and 135⁰ of shoulder abduction. External torque of 13±1 Nm was used for females and 21±1 Nm for males. A fixed effect multi-variable regression model was used …

Nursing Perceptions Of Non-Pharmacologic Protocols For Delirium In The Intensive Care Unit, David Johnson

Nursing Masters

Objective: The purpose of this study was to research current non-pharmacologic strategies used to prevent and combat delirium in the intensive care unit (ICU) setting; and to determine how these strategies are perceived and utilized by nurses. A secondary objective was to assess current nursing knowledge of the impact of delirium on patients.

Design: A cross-sectional design using a survey of the researcher’s design released on social media with snowballing method for subject recruitment.

Subjects: Registered Nurses (RNs) working in the intensive care unit.

Measurements and Main results: Data were analyzed using proportions and frequencies. Main findings identified a fragmented …

Magnetic Resonance Imaging In The Diagnosis Of White Matter Signal Abnormalities., Ravi Datar, Asuri Narayan Prasad, Keng Yeow Tay, Charles Anthony Rupar, Pavlo Ohorodnyk, Michael Miller, Chitra Prasad

Paediatrics Publications

Background White matter abnormalities (WMAs) pose a diagnostic challenge when trying to establish etiologic diagnoses. During childhood and adult years, genetic disorders, metabolic disorders and acquired conditions are included in differential diagnoses. To assist clinicians and radiologists, a structured algorithm using cranial magnetic resonance imaging (MRI) has been recommended to aid in establishing working diagnoses that facilitate appropriate biochemical and genetic investigations. This retrospective pilot study investigated the validity and diagnostic utility of this algorithm when applied to white matter signal abnormalities (WMSAs) reported on imaging studies of patients seen in our clinics. Methods The MRI algorithm was applied to …

Sodium Nitroglycerin Induces Middle Cerebral Artery Vasodilatation In Young, Healthy Adults, Jenna M. Schulz, Baraa K. Al-Khazraji, J. Kevin Shoemaker

Bone and Joint Institute

© 2018 The Authors Experimental Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society New Findings: What is the central question of this study? Nitric oxide causes dilatation in peripheral vessels; however, whether nitric oxide affects basal cerebral artery dilatation has not been explored. What is the main finding and its importance? This study demonstrated that vasodilatation occurs in the right middle cerebral artery in response to exogenous nitric oxide. However, blood velocity decreased and, therefore, overall cerebral blood flow remained unchanged. This study provides new insight into the role of nitric oxide in cerebral …

Editorial Updates For Chest Tumors, Patricia Tai, Edward Yu

Data and Test Instruments

No abstract provided.

Alumni Journal - Volume 89, Number 2, Loma Linda University School Of Medicine

Alumni Journal, School of Medicine

Features
14 | True Sustenance
17 | Department Reports: Pediatrics and Obstetrics and Gynecology
24 | APC 2018 Review

Departments
2 | From the Editor
4 | From the President
6 | From the Dean
9 | This and That
10 | School of Medicine News
12 | AIMS Report and Awards
13 | The Student Fund
34 | Book Review
37 | Classified/Placement Ads
38 | Alumni News
39 | In Memoriam
43 | Historical Snapshot
44 | What's Up Doc? - Daniel L. Bouland '82

Extras
8 | New Board of Directors Members and Alumni Association Officer

Validation Of The Registered Nurse Assessment Of Readiness For Hospital Discharge Scale, Kathleen L. Bobay, Marianne E. Weiss, Debra Oswald, Olga Yakusheva

Nursing: School of Nursing Faculty Publications and Other Works

Background Statistical models for predicting readmissions have been published for high-risk patient populations but typically focus on patient characteristics; nurse judgment is rarely considered in a formalized way to supplement prediction models.

Objectives The purpose of this study was to determine psychometric properties of long and short forms of the Registered Nurse Readiness for Hospital Discharge Scale (RN-RHDS), including reliability, factor structure, and predictive validity.

Methods Data were aggregated from two studies conducted at four hospitals in the Midwestern United States. The RN-RHDS was completed within 4 hours before hospital discharge by the discharging nurse. Data on readmissions and emergency …