Medicine and Health Sciences Commons^™

Bringing Employment First To Scale: Writing For Families: Tips To Increase The Impact Of Training Materials, Jennifer Bose, John Kramer, Thinkwork! At The Institute For Community Inclusion At Umass Boston

ThinkWork! Publications

This brief covers some of the lessons learned in reviewing literature designed to engage with families about employment. It suggests some tips and strategies to use with families to increase effective involvement and collaboration.

Cognitive Behavioral Therapy Versus Eye Movement Desensitization And Reprocessing In Patients With Posttraumatic Stress Disorder: Systematic Review And Meta-Analysis Of Randomized Clinical Trials, Ali M. Khan, Sabrina Dar, Rizwan A. Ahmed, Ramya Bachu, Mahwish Adnan, Vijaya P. Kotapati

School of Medicine Publications

Background

Post-traumatic stress disorder (PTSD) is prevalent in children, adolescents and adults. It can occur alone or in comorbidity with other disorders. A broad range of psychotherapies such as cognitive behavioral therapy (CBT) and eye movement desensitization and reprocessing (EMDR) have been developed for the treatment of PTSD.

Aim

Through quantitative meta-analysis, we aimed to compare the efficacy of CBT and EMDR: (i) relieving the post-traumatic symptoms, and (ii) alleviating anxiety and depression, in patients with PTSD.

Methods

We systematically searched EMBASE, Medline and Cochrane central register of controlled trials (CENTRAL) for articles published between 1999 and December 2017. Randomized …

08-13-2018 Hsc Committee Meeting Minutes, Patrice Martin

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Fructose 2,6-Bisphosphate In Cancer Cell Metabolism, Ramon Bartrons, Helga Simon-Molas, Ana Rodríguez-García, Esther Castaño, Àurea Navarro-Sabaté, Anna Manzano, Ubaldo E. Martinez-Outshoorn

Department of Medical Oncology Faculty Papers

For a long time, pioneers in the field of cancer cell metabolism, such as Otto Warburg, have focused on the idea that tumor cells maintain high glycolytic rates even with adequate oxygen supply, in what is known as aerobic glycolysis or the Warburg effect. Recent studies have reported a more complex situation, where the tumor ecosystem plays a more critical role in cancer progression. Cancer cells display extraordinary plasticity in adapting to changes in their tumor microenvironment, developing strategies to survive and proliferate. The proliferation of cancer cells needs a high rate of energy and metabolic substrates for biosynthesis of …

Micronutrient Deficiency Independently Predicts Time To Event In Patients With Heart Failure, Terry A. Lennie, Christina Andreae, Mary Kay Rayens, Eun Kyeung Song, Sandra B. Dunbar, Susan J. Pressler, Seongkum Heo, Jinshil Kim, Debra K. Moser

Nursing Faculty Publications

Background—Dietary micronutrient deficiencies have been shown to predict event‐free survival in other countries but have not been examined in patients with heart failure living in the United States. The purpose of this study was to determine whether number of dietary micronutrient deficiencies in patients with heart failure was associated with shorter event‐free survival, defined as a combined end point of all‐cause hospitalization and death.

Methods and Results—Four‐day food diaries were collected from 246 patients with heart failure (age: 61.5±12 years; 67% male; 73% white; 45% New York Heart Association [NYHA] class III/IV) and analyzed using Nutrition Data Systems …

Imaging Of Enzyme Activity By Electron Paramagnetic Resonance: Concept And Experiment Using A Paramagnetic Substrate Of Alkaline Phosphatase, Urikhan Sanzhaeva, Xuan Xu, Priyaankadevi Guggilapu, Mark Tseytlin, Valery V. Khramtsov, Benoit Driesschaert

Clinical and Translational Science Institute

Enzyme activities are well established biomarkers of many pathologies. Imaging enzyme activity directly in vivo may help to gain insight into the pathogenesis of various diseases but remains extremely challenging. In this communication, we report the use of EPR imaging (EPRI) in combination with a specially designed paramagnetic enzymatic substrate to map alkaline phosphatase activity with a high selectivity, thereby demonstrating the potential of EPRI to map enzyme activity.

Inhibition Of Glycolysis Reduces Disease Severity In An Autoimmune Model Of Rheumatoid Arthritis., Georges Abboud, Seung-Chul Choi, Nathalie Kanda, Leilani Zeumer-Spataro, Derry C. Roopenian, Laurence Morel

Faculty Research 2018

The K/BxN mouse is a spontaneous model of arthritis driven by T cell receptor transgenic CD4⁺ T cells from the KRN strain that are activated by glucose-6-phosphate isomerase (GPI) peptides presented by the H-2^g7 allele from the NOD strain. It is a model of autoimmune seropositive arthritis because the production of anti-GPI IgG is necessary and sufficient for joint pathology. The production of high levels of anti-GPI IgG requires on the expansion of CD4⁺ follicular helper T (Tfh) cells. The metabolic requirements of this expansion have never been characterized. Based on the therapeutic effects of the combination …

Ada News - 09/03/2018, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

A Framework For Secondary Cognitive And Motor Tasks In Dual-Task Gait Testing In People With Mild Cognitive Impairment., Susan W Hunter, Alison Divine, Courtney Frengopoulos, Manuel Montero Odasso

Physical Therapy Publications

BACKGROUND: Cognition is a key factor in the regulation of normal walking and dual-task gait assessment is an accepted method to evaluate the relationship. The objective of this study was to create a framework for task complexity of concurrent motor and cognitive tasks with gait in people with mild cognitive impairment (MCI).

METHODS: Community-dwelling people with MCI (n = 41, mean age = 76.20 ± 7.65 years) and cognitively normal controls (n = 41, mean age = 72.10 ± 3.80 years) participated in this study. Gait velocity was collected using an instrumented walkway under one single task and six combined …

Abducens Nerve Palsy As Initial Presentation Of Multiple Myeloma And Intracranial Plasmacytoma, Elochukwu Ibekwe, Neil Bradford Horsley, Lan Jiang, Nadine-Stella Achenjang, Azubuogu Anudu, Zeeshan Akhtar, Karina G. Chornenka, Gregory P. Monohan, Yevgen G. Chornenkyy

Internal Medicine Faculty Publications

Central Nervous System (CNS) involvement in multiple myeloma and/or multifocal solitary plasmacytoma is rare. Although they are unique entities, multiple myeloma (MM) and plasmacytoma represent a spectrum of plasma cell neoplastic diseases that can sometimes occur concurrently. Plasmacytomas very often present as late-stage sequelae of MM. In this case report, we report a 53-year-old female presenting with right abducens cranial nerve (CN) VI palsy as an initial presentation secondary to lesion of the right clivus.

Student Reflections On Position And Experiences In The Doctors Of Tomorrow Program, Gurjit Sandhu, Emily N. Flagler, Kaustubh Prabhu, Paula T. Ross

The Qualitative Report

Racial diversity in the medical field remains elusive. Actively engaging high school students from communities underrepresented in medicine (URiM) through pipeline programs has been identified as a viable strategy to support diversification of the U.S. physician population. However, students’ perspectives toward these programs remains unclear. In this study, we aim to elicit insights of URiM students matriculating to postsecondary education who participated in the Doctors of Tomorrow (DoT) program to better understand their experiences. Semi-structured interviews were conducted with 14 of the 17 high school students from the inaugural year of DoT. We explored URiM students’ experiences during DoT involvement, …

A Prospective Cohort Examination Of Haematological Parameters In Relation To Cancer Death And Incidence: The Busselton Health Study, Niwansa Adris, Anita Chai Geik Chua, Matthew William Knuiman, Mark Laurence Divitini, Debbie Trinder, John K. Olynyk

Research outputs 2014 to 2021

BACKGROUND: Cancer risk is associated with serum iron levels. The aim of this study was to evaluate whether haematological parameters reflect serum iron levels and may also be associated with cancer risk.

METHODS: We studied 1564 men and 1769 women who were enrolled in the Busselton Health Study, Western Australia. Haematological parameters evaluated included haemoglobin (Hb), mean cell volume (MCV), mean cell haemoglobin (MCH) and mean cell haemoglobin concentration (MCHC) and red cell distribution width (RCDW). Statistical analyses included t-tests for quantitative variables, chi-square tests for categorical variables and Cox proportional hazards regression modelling for cancer incidence and death.

RESULTS: …

A Systematic Review Of The Experiences Of Vulnerable People Participating In Research On Sensitive Topics, Susan Alexander, Rona Pillay, Bronwyn Smith

Research outputs 2014 to 2021

Objective: The aim of this paper is to systematically review studies that discuss the experiences of vulnerable populations participating in research on sensitive topics.

Design: Systematic review performed according to PRISMA guidelines.

Data sources: Thirteen databases were searched, locating 197 articles. Following removal of duplicates, screening and full text review, 31 studies remained to be critically appraised.

Review methods: As there was a mix of qualitative and quantitative articles, the Critical Appraisal Skills Program (CASP) toolkit and Effective Public Health Practice Project (EPHPP) tool were used to appraise the methodological quality of the articles. Following critical appraisal, the remaining 11 …

The Human Cib1-Ever1-Ever2 Complex Governs Keratinocyte-Intrinsic Immunity To Β-Papillomaviruses., Sarah Jill De Jong, Amandine Créquer, Irina Matos, David Hum, Vignesh Gunasekharan, Lazaro Lorenzo, Fabienne Jabot-Hanin, Elias Imahorn, Andres A. Arias, Hassan Vahidnezhad, Leila Youssefian, Janet G. Markle, Etienne Patin, Aurelia D'Amico, Claire Q.F. Wang, Florian Full, Armin Ensser, Tina M. Leisner, Leslie V. Parise, Matthieu Bouaziz, Nataly Portilla Maya, Xavier Rueda Cadena, Bayaki Saka, Amir Hossein Saeidian, Nessa Aghazadeh, Sirous Zeinali, Peter Itin, James G. Krueger, Lou Laimins, Laurent Abel, Elaine Fuchs, Jouni Uitto, Jose Luis Franco, Bettina Burger, Gérard Orth, Emmanuelle Jouanguy, Jean-Laurent Casanova

Department of Dermatology and Cutaneous Biology Faculty Papers

Patients with epidermodysplasia verruciformis (EV) and biallelic null mutations of TMC6 (encoding EVER1) or TMC8 (EVER2) are selectively prone to disseminated skin lesions due to keratinocyte-tropic human β-papillomaviruses (β-HPVs), which lack E5 and E8. We describe EV patients homozygous for null mutations of the CIB1 gene encoding calcium- and integrin-binding protein-1 (CIB1). CIB1 is strongly expressed in the skin and cultured keratinocytes of controls but not in those of patients. CIB1 forms a complex with EVER1 and EVER2, and CIB1 proteins are not expressed in EVER1- or EVER2-deficient cells. The known functions of EVER1 and EVER2 in human keratinocytes are …

Medical School Watercooler Newsletter - September 2, 2018, Lindsey Lyle

Watercooler Newsletter

This is the September 2, 2018 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Register Now: First Southern Genome Maintenance Conference
• USA Health Welcomes Dr. Payton Carley
• USA Health Welcomes Dr. Theresa Yarbrough
• USA College of Medicine Welcomes Dr. Robert Kobelja to Neurology

A Systematic Review Of The Efficacy And Safety Of Fecal Microbiota Transplant For Clostridium Difficile Infection In Immunocompromised Patients, Oluwaseun Shogbesan, Dilli Ram Poudel, Samjeris Victor, Asad Jehangir, Opeyemi Fadahunsi, Gbenga Shogbesan, Anthony A. Donato

Reading Hospital Internal Medicine Residency

Background: Fecal microbiota transplantation (FMT) has been shown to be effective in recurrent

Methods: We searched MEDLINE and EMBASE for English language articles published on FMT for treatment of CD infection in immunocompromised patients (including patients on immunosuppressant medications, patients with human immunodeficiency virus (HIV), inherited or primary immunodeficiency syndromes, cancer undergoing chemotherapy, or organ transplant, including-bone marrow transplant) of all ages. We excluded inflammatory bowel disease patients that were not on immunosuppressant medications. Resolution and adverse event rates (including secondary infection, rehospitalization, and death) were calculated.

Results: Forty-four studies were included, none of which were randomized designs. A total …

Assessing Abstinence In Infants Greater Than 28 Days Old, Genieveve J. Cline

USF Tampa Graduate Theses and Dissertations

There are currently no published scoring instruments with prior empirical evidence to support the validity and reliability of the accuracy of the drug withdrawal scores generated in infants greater than 28 days of life with a diagnosis of Neonatal Abstinence Syndrome (NAS). This study was done to identify the signs of withdrawal in infants greater than 28 days of life with NAS and determine if further adaptation of the modified-FNAST was necessary to accurately measure the severity of drug withdrawal in this sub population of infants. This aim could not analyzed due to limitations of the data.

The study was …

Guide Lines Vol. I, Issue 17 - September 2018, College Of Health And Human Services

GUIDE Lines

Periodic Newsletter of the Governors State University - University of Illinois, Chicago - Disparities Education Cancer research training and education project (The GUIDE Project).

Solicitude: Towards A Heideggerian Care Ethics-Of-Assistance, Babette Babich

Articles and Chapters in Academic Book Collections

No abstract provided.

Comparing Congenital Melanocytic Nevus Treatment Effect On Children’S Health-Related Quality Of Life, Yunru Lai

Yale School of Medicine Physician Associate Program Theses

Surgical excision and laser are the two of the most commonly performed treatments for congenital melanocytic nevi, a type of birthmark present at birth or manifest infancy. Children with small to medium-sized congenital melanocytic nevi on the face and neck may elect treatment. However, there is no evidence-based guideline for the choice of treatment for small to medium-sized congenital melanocytic nevi that considers a child’s quality of life. We propose a non-randomized, open-label trial to compare the functional effect of surgical excision and laser treatment on the holistic wellbeing of school-aged children with head and neck congenital melanocytic nevi of …

A Community Based Participatory Approach To Training Young Adults To Design And Implement A Social Marketing Framed Lifestyle Intervention On Their College Campus, Melissa D. Olfert, Makenzie L. Barr, Kristin Riggsbee, Kendra K. Kattelmann, Krista Leischner, Anne E. Mathews, Melissa Vilaro, Sarah E. Colby

Health and Nutritional Sciences Faculty Publications

Background: Using a Community-Based Participatory Research (CBPR) approach may increase the likelihood of relevance and acceptability of the designed intervention, especially on a college campus. Furthermore, recruiting and training college students to design a social marketing framed healthy lifestyle intervention for their peers will allow the intervention to be tailored to the needs of the campus. Objectives: To describe the process of online-course training college students to develop a campus-based, social marketing health promotion intervention. Methods: Four universities recruited current college students (18+ y.o.) to develop a social marketing and environmental intervention (SMEI), which was completed during a 16-week, online/in-person …

Communicating In A Culturally Diverse Workforce, Karen Fowler

Nursing Faculty Publications

No abstract provided.

Barriers And Challenges To Implementing Telehealth Among Physicians And Advanced Practice Nurses In The United States, Mohammad Einolghozati

Health Informatics Student Papers and Projects

A recent Medscape survey among physicians to assess their attitudes toward telemedicine showed that physicians have some concerns regarding telemedicine including liability and reimbursement (Cranford, 2016). Among nurse practitioners, credentialing, reimbursement, patient privacy and the use of appropriate equipment are some of the most critical issues with telemedicine (Balestra, 2018). Healthcare providers play a crucial role in telehealth adoption because their decision to use telehealth is the first step towards the emergence and sustainability of telehealth networks.

The objective of this review is to examine the various barriers and challenges physicians and advanced nurses experience when implementing telemedicine in the …

Improving A Discharge Process To Decrease Readmission Rates, Erni Ensing

Master's Projects

No abstract provided.

Combination Of Cabazitaxel And Plicamycin Induces Cell Death In Drug Resistant B-Cell Acute Lymphoblastic Leukemia, Rajesh R. Nair, Debbie Piktel, Werner J. Geldenhuys, Laura F. Gibson

Clinical and Translational Science Institute

Bone marrow microenvironment mediated downregulation of BCL6 is critical for maintaining cell quiescence and modulating therapeutic response in B-cell acute lymphoblastic leukemia (ALL). In the present study, we have performed a high throughput cell death assay using BCL6 knockdown REH ALL cell line to screen a library of FDA-approved oncology drugs. In the process, we have identified a microtubule inhibitor, cabazitaxel (CAB), and a RNA synthesis inhibitor, plicamycin (PLI) as potential anti-leukemic agents. CAB and PLI inhibited cell proliferation in not only the BCL6 knockdown REH cell line, but also six other ALL cell lines. Furthermore, combination of CAB and …

Efficacy And Safety Of Mechanical Versus Manual Compression In Cardiac Arrest - A Bayesian Network Meta-Analysis, Safi U. Khan, Ahmad N. Lone, Swapna Talluri, Muhammad Z. Khan, Muhammad U. Khan, Edo Kaluski

Clinical and Translational Science Institute

Aim: To compare relative efficacy and safety of mechanical compression devices (AutoPulse and LUCAS) with manual compression in patients with cardiac arrest undergoing cardiopulmonary resuscitation (CPR). Methods: For this Bayesian network meta-analysis, seven randomized controlled trials (RCTs) were selected using PubMed/Medline, EMBASE, and CENTRAL (Inception- 31 October 2017). For all the outcomes, median estimate of odds ratio (OR) from the posterior distribution with corresponding 95% credible interval (Cr I) was calculated. Markov chain Monte Carlo (MCMC) modeling was used to estimate the relative ranking probability of each intervention based on surface under the cumulative ranking curve (SUCRA). Results: In analysis …

Early Versus Late Gamma Knife Radiosurgery Following Transsphenoidal Surgery For Nonfunctioning Pituitary Macroadenomas: A Multicenter Matched-Cohort Study, I. Jonathan Pomeraniec, Hideyuki Kano, Zhiyuan Xu, Brandon Nguyen, Zaid A. Siddiqui, Danilo Silva, Mayur Sharma, Hesham Radwan, Jonathan A. Cohen, Robert F. Dallapiazza, Christian Iorio-Morin, Amparo Wolf, John A. Jane Jr., Inga S. Grills, David Mathieu, Douglas Kondziolka, Cheng-Chia Lee, Chih-Chun Wu, Christopher P. Cifarelli, Tomas Chytka, Gene H. Barnett, L. Dade Lunsford, Jason P. Sheehan

Clinical and Translational Science Institute

OBJECTIVE—Gamma Knife radiosurgery (GKRS) is frequently used to treat residual or recurrent nonfunctioning pituitary macroadenomas. There is no consensus as to whether GKRS should be used early after surgery or if radiosurgery should be withheld until there is evidence of imaging-defined progression of tumor. Given the high incidence of adenoma progression after subtotal resection over time, the present study intended to evaluate the effect of timing of radiosurgery on outcome. METHODS—This is a multicenter retrospective review of patients with nonfunctioning pituitary macroadenomas who underwent transsphenoidal surgery followed by GKRS from 1987 to 2015 at 9 institutions affiliated with the International …

Emergency Department Visits For Sexual Assault By Emerging Adults: Is Alcohol A Factor?, Allison Tadros, Melinda J. Sharon, Shelley M. Hoffman, Danielle M. Davidov

Clinical and Translational Science Institute

Introduction: Emerging adults (18-25 years of age) are at increased risk for sexual assault. There is little Emergency Department (ED) data on sexual assaults that involve alcohol among this population. The purpose of this study was to analyze ED visits for sexual assault and determine if alcohol consumption by the patient was noted. Methods: This study was a retrospective chart review of patients aged 18-25 presenting to an ED in a college town over a four-year period. Extracted variables included age, gender, delay in seeking care, sexual assault nurse examiner (SANE) evaluation, and alcohol consumption by the patient. For analysis …

A Non-Myeloablative Conditioning Approach For Long-Term Engraftment Of Human And Mouse Hematopoietic Stem Cells, Wei Du, Wei Liu, Benjamin Mizukawa, Xun Shang, Jared Sipple, Mark Wunderlich, Hartmut Geiger, Stella Davies, James Mulloy, Qishen Pang, Yi Zheng

Clinical and Translational Science Institute

No abstract provided.

An Examination Of The Perceived Impact Of A Continuing Interprofessional Education Experience On Opiate Prescribing Practices, Roberto Cardarelli, William Elder, Sarah Weatherford, Karen L. Roper, Dana King, Charlotte Workman, Kathryn Stewart, Chong Kim, William Betz

Clinical and Translational Science Institute

Chronic pain is increasingly recognized as a public health problem. We assessed the effectiveness of a multi-modal, interprofessional educational approach aimed at empowering healthcare professionals to make deliberative changes, especially in opiate prescribing practices. Education activities included enduring webcasts, regional interprofessional roundtable events, and state-level conference presentations within targeted Kentucky and West Virginia regions of the United States. Over 1,000 participants accessed the various activities. For the live events, the largest groups reached included nurses (38.1%), nurse practitioners (31.2%), and physicians (22.1%). In addition to our reach, higher levels of educational effectiveness were measured, specifically, learner’s intentions to change practice …