Medicine and Health Sciences Commons^™

Unpacking Generation Hd1, The Roche Phase 3 Huntington's Disease Clinical Trial, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Validation Of A2ds2 Score As Predictor Of Pneumonia Among Patients Hospitalized For Acute Ischemic Stroke, Toman Nababan, Ceva Wicaksono Pitoyo, Salim Harris, Cleopas Martin Rumende

Jurnal Penyakit Dalam Indonesia

Introduction. Pneumonia is the leading cause of morbidity and mortality in acute ischemic stroke patients admitted to hospital. Thus required a valid scoring system which is easy to apply, to predict and stratify the risk of pneumonia in patients with acute ischemic stroke. This study aimed to assess the performance of calibration and discrimination of A2 DS2 score in predicting the incidence of pneumonia in patients with acute ischemic stroke. Methods. A retrospective cohort study was conducted among adult acute ischemic stroke patients who are hospitalized in Cipto Mangunkusumo Hospital, Jakarta. Age, atrial fibrillation, dysphagia, sex (male), and stroke severity …

Intestinal Barrier Tightening By A Cell-Penetrating Antibody To Bin1, A Candidate Target For Immunotherapy Of Ulcerative Colitis., Sunil Thomas, Kevther Hoxha, Walker Alexander, John Gilligan, Rima Dilbarova, Kelly Whittaker, Andrew Kossenkov, George C. Prendergast, James M. Mullin

Kimmel Cancer Center Papers, Presentations, and Grand Rounds

Patients afflicted with ulcerative colitis (UC) are at increased risk of colorectal cancer. While its causes are not fully understood, UC is associated with defects in colonic epithelial barriers that sustain inflammation of the colon mucosa caused by recruitment of lymphocytes and neutrophils into the lamina propria. Based on genetic evidence that attenuation of the bridging integrator 1 (Bin1) gene can limit UC pathogenicity in animals, we have explored Bin1 targeting as a therapeutic option. Early feasibility studies in the dextran sodium sulfate mouse model of experimental colitis showed that administration of a cell-penetrating Bin1 monoclonal antibody (Bin1 mAb 99D) …

Mapping The Research Productivity Of Three Medical Sciences Journals Published In Saudi Arabia: A Comparative Bibliometric Study, Ahmad A. Alanazi, Zameer Baladi, Ikram Ul Haq

Library Philosophy and Practice (e-journal)

Introduction: The purpose of this study was to compare the progress of research outcomes specifically of three old and new established Saudi medical research journals: Saudi Journal of Medicine and Medical Sciences (SJMMS), Journal of Saudi Heart Association (JSHA), and Journal of Infection and Public Health (JIPH) for the period of 2013 to 2017.

Materials and Methods: Scientific papers under the titles of original and review articles, short communications, case and short reports were downloaded from the websites of these journals. The data was analyzed according to three parameters: the growth of publication, the types of publication, and …

The Effect Of Endometriosis On Live Birth Rate And Other Reproductive Outcomes In Art Cycles: A Cohort Study, Charles Muteshi, Eric O. Ohuma, Tim Child, Christian M. Becker

Obstetrics and Gynaecology, East Africa

Study question: What is the effect of endometriosis compared to unexplained subfertility on live birth rate in women undergoing IVF and embryo transfer (ET)?

Summary answer: Endometriosis decreases live birth rate in women undergoing IVF-ET treatment, particularly with increasing severity of the disease.

What is known already: Endometriosis affects up to 50% of women seeking fertility treatment and is known to reduce fecundity. There remains a debate as to effects of endometriosis on the outcomes of IVF treatment, with live birth being a secondary outcome or not reported in most studies.

Study design, size, duration: A retrospective cohort study analyzing …

Information Literacy Of Online Health Consumers In Minnesota, Shanda Hunt, Nicole Theis-Mahon, Katherine Chew

Georgia International Conference on Information Literacy

In the United States 72% of Internet users look online to find health information, with some being high quality and other information dangerous. The University of Minnesota is a land grant institution, and the Health Sciences Libraries have a strong outreach role, educating health information consumers across Minnesota about high quality resources. In 2016, we conducted a study at the Minnesota State Fair to identify where Minnesotans find online health information, how they use it, their confidence in assessing it, and what they think is missing. Convenience sampling yielded a total of 255 participants who valued the ability to access …

Mrsa In The United States, Sweden, And Syria, Derek J. Lillestolen

Montview Journal of Research & Scholarship

Methicillin-resistant Staphylococcus aureus (MRSA) is an opportunistic pathogen that is resistant to many broad and narrow-spectrum antibiotics commonly used in the treatment of S. aureus. There has been much fanfare about MRSA, receiving nicknames like “superbug” because of its varying degrees of resistance to the most common broad and narrow-spectrum antibiotics such as penicillin, oxacillin, methicillin and amoxicillin (2). The reality, however, is that MRSA is still susceptible to certain antibiotics and can be treated effectively. This study displays the factors which help and hurt MRSA treatments. There is shown a strong link between the prescription of broad-spectrum antibiotics …

Barriers To Receipt Of Prenatal Tetanus Toxoid, Reduced Diptheria Toxoid, And Acellular Pertussis Vaccine Among Mothers Of Infants Aged < 4 Months With Pertussis — California, 2016, Sarah New, Kathleen Winter, Kathleen Harriman, Anya Gutman, Amber Christiansen, Sarah Royce

Epidemiology and Environmental Health Faculty Publications

No abstract provided.

Referral Policy For Moderate To High-Risk Obstructive Sleep Apnea Patients Identified By The Stop-Bang Questionnaire: A Quality Improvement Project, Martha Kate Goforth, Price Roberts

Doctoral Projects

BACKGROUND: An increase in the prevalence of Obstructive Sleep Apnea is as high as 70% in the surgical population. OSA is associated with a higher incidence of complications in the perioperative setting showing the increased need for proper identification of moderate to high-riskpatients for referral to local sleep clinics. Identifying and treating OSA is an important step to improve managementof chronic diseases, decrease complications both inside and outside the perioperative setting, and reduce healthcare spending.

METHODS: The purpose of this project was to create an OSA referral program for patients undergoing general anesthesia at a hospital in Mississippi. The recommended …

Implementation Of A Sustainable Peer Mentor Program In Student Registered Nurse Anesthetists (Srnas)”, Kristin Cox

Doctoral Projects

Evidence has shown that Student Registered Nurse Anesthetist’s (SRNAs) stress is perceived as above average and is correlated with substandard patient care during clinical courses (Chipas et al., 2012). Some studies have indicated SRNAs experience low self-efficacy during clinical, which could lead to difficulty in thinking clearly or responding to clinical situations (Imus, Burns, & Weglarz, 2017). Peer mentoring has shown to result in stress reduction and improvement in self-efficacy in students (Barker et al., 2012; Giordana & Wedin, 2010). Despite the current evidence, a nurse anesthesia program in the southeastern United States did not have an organized peer mentor …

A Quality Improvement Project To Increase Hand Hygiene Opportunities For Anesthesia Providers, Brad Margherio

Doctoral Projects

Hand hygiene is considered to be the far more superior method for preventing the spread of bacteria from a patient care provider to the patient (Allegranzi & Pittet, 2009; Rowlands et al., 2014; Tartari & Mamo, 2011). The addition of easily accessible hand hygiene devices to the anesthesia carts in the operating room may help to improve the opportunities for the anesthesia providers to perform hand hygiene. Hand sanitizer devices were placed on each of the eight anesthesia carts located in the surgery department of a rural hospital in south Mississippi. The devices were measured weekly for a two-week period …

Continuous Epidural Analgesia For Postoperative Pain Management: A Policy Analysis, Madison Nowell

Doctoral Projects

Postoperative pain management is a necessary component of the care of every surgical patient. Epidural analgesia is a widely used method to provide excellent postoperative pain relief and enhance postoperative recovery (Sawhney, 2012). Epidural analgesia is associated with fewer side effects than alternative pain management techniques; however, when epidural catheters are managed improperly, or pain is inadequately assessed, epidural analgesia fails to provide adequate pain relief (Deni et al., 2016). More than 80% of surgical patients experience moderate to severe postoperative pain, and 28 to 50% of these patients have a pain score greater than 6 out of 10 at …

Comprehensive Review Of Spinal Neurenteric Cysts With A Focus On Histopathological Findings., Woong Kee Baek, Stefan Lachkar, Joe Iwanaga, Rod J Oskouian, Marios Loukas, W Jerry Oakes, R Shane Tubbs

Articles, Abstracts, and Reports

Among the occult spinal dysraphisms, neurenteric cysts (NECs) are rare and are thought to arise due to a failure of the separation of the primitive endoderm and ectoderm. Patients experience various neurological symptoms depending on the location of the lesion. As the epithelial morphology of NECs share similarities with other intracranial and intraspinal cystic growths, the definitive diagnosis of NEC can be made after a histochemical analysis with endodermal markers. Complete resection is associated with the lowest disease recurrence rate.

Étude Des Qualités Psychométriques De L’Outil D’Identification De La Situation De Handicap Au Travail (Oisht) Utilisé Auprès De Travailleurs Ayant Un Trouble Musculosquelettique Ou Un Trouble Mental Courant, Marie-José Durand, Marie-France Coutu, Éric Vaillancourt, Djamal Berbiche

Rapports de recherche scientifique

L’outil d’identification de la situation de handicap au travail (OISHT) consiste en une entrevue structurée qui a été développée pour aider les cliniciens à identifier de façon systématique les facteurs liés à l’incapacité au travail. L’OISHT est un des rares outils disponibles en réadaptation pour la clientèle en phase chronique d’incapacité au travail. Il tient compte de l’influence de différents systèmes (personnel, santé, travail, indemnisation) et a été élaboré pour les deux principales problématiques de santé associées à l’incapacité au travail, soit les troubles musculosquelettiques (TMS) et les troubles mentaux courants (TMC).

L’objectif de cette étude visait la validation de …

Sure 2018 Undergraduate Science Conference Booklet, Sure Network

Group Reports

The SURE Network hosted the First Annual Science Undergraduate Research Experience (SURE) Conferences (SURE 2018) on 28th September 2018 in Athlone Institute of Technology, Dublin Institute of Technology and Waterford Institute of Technology. The simultaneous conferences had a total of 27 oral presentations and 67 poster presentations, and were attended by over 500 students, academic staff, professional body and industry representatives.

The aims of the conference were to:

1. Provide current students with an opportunity to gain an understanding of the work which has been undertaken by recent graduates, and the career opportunities that exist for graduates in Scientific disciplines.
2. Provide …

Pengembangan Panduan Pelatihan Empati Menggunakan Teknik Sinema Edukasi Untuk Mencegah Perilaku Bullying Siswa Sekolah Menengah Pertama, Vesti Dwi Cahyaningrum, Dany Moenindyah Handarini, Irene Maya Simon

Jurnal Kajian Bimbingan dan Konseling

This study aimed to develop a training guide of empathy attitude skills as prevention of bullying behavior on junior high school students. The method was a research and development model. The subjects of the research were guidance and counseling experts; educational technology expert; and school counselors. The instrument was the empathy attitude skill scale for students; expert assessment instruments and counselor assessment instruments. Data from the assessment results of guidance and counseling expert; educational technology expert; and three school counselors in three different schools in Malang City showed that the developed products were acceptable and feasible to be used to …

Infectious Complications After Deployment Trauma: Following Wounded Us Military Personnel Into Veterans Affairs Care, Jay R Mcdonald, Stephen Y Liang, Ping Li, Salwa Maalouf, Clinton K Murray, Amy C Weintrob, Elizabeth R Schnaubelt, Janis Kuhn, Anuradha Ganesan, William Bradley, David R Tribble, Infectious Disease Clinical Research Program Trauma Infectious Disease Outcomes Study Group

2010-2019 OA Pubs

BACKGROUND: Infectious complications related to deployment trauma significantly contribute to the morbidity and mortality of wounded service members. The Trauma Infectious Disease Outcomes Study (TIDOS) collects data on US military personnel injured in Iraq and Afghanistan in an observational cohort study of infectious complications. Patients enrolled in TIDOS may also consent to follow-up through the Department of Veterans Affairs (VA). We present data from the first 337 TIDOS enrollees to receive VA healthcare.

METHODS: Data were collected from the Department of Defense (DoD) Trauma Registry, TIDOS infectious disease module, DoD and VA electronic medical records, and telephone interview. Cox proportional …

Hubungan Antara Mindfulness Dengan Kepuasan Hidup Mahasiswa Bimbingan Dan Konseling, Pranazabdian Waskito, J.T. Lobby Loekmono, Yari Dwikurnaningsih

Jurnal Kajian Bimbingan dan Konseling

The research aimed at identifying the relation between mindfulness and life satisfaction among guidance and counseling students. The research was a correlational study using Kendall’s Tau-b correlation analysis technique. The respondents were 135 students from the Guidance and Counseling Study Program, Faculty of Teachers Training and Education, Universitas Kristen Satya Wacana. The data were gathered using the mindfulness scale and the life satisfaction scale. The results of the research showed that there had been positive and significant relationship between mindfulness and life satisfaction among the students of Guidance and Counseling Study Program, Faculty of Teachers Training and Education, Universitas Kristen …

Perbedaan Self-Regulated Learning Siswa Sekolah Menengah Kejuruan Berdasarkan Jenis Kelamin, Wahyu Nanda Eka Saputra, Said Alhadi, Agus Supriyanto, Claudy Desya Wiretna, Babay Baqiyatussolihat

Jurnal Kajian Bimbingan dan Konseling

The purpose of this study was to identify the differences in self-regulated learning of male and female students in Sekolah Menengah Kejuruan Muhammadiyah in Yogyakarta, Special Region of Yogyakarta, Indonesia. This quantitative study using comparative method involving 414 students consisting of 226 male students and 188 female students as sample. The sample selection used Stratified Random Sampling technique. The instrument was the Self-regulated Learning Scale. To identify the differences in self-regulated learning of male and female students, Independent Sample Test were used. The results showed that there were significant differences between self-regulated learning of male and female students at Sekolah …

Experiential Learning Untuk Meningkatkan Kompetensi Multikultural Mahasiswa, Mawardi Djamaluddin, Blasius Boli Lasan, Adi Atmoko

Jurnal Kajian Bimbingan dan Konseling

The study aims at measuring the effectiveness of experiential learning model for improving the multicultural competence of non-Javanese students in the Malang City. The true-experiment type quantitative study is conducted by using the pretest-posttest control group design. The subjects were 20 non-Javanese students in several universities in Malang City that had low multicultural competence. The Wilcoxon Signed Rank Test was implemented in order to compare the score of the students before and after the treatment. In addition, Mann-Whitney U Test was also implemented in order to compare the level of effectiveness statistically between the control group and the experimental group …

Engaging Stakeholders In Collaborative And Constructive Course Evaluation, Roger Jerabek, Rebecca Hartley, Nancy Shane, Renee Quintana

HSC Education Days

Implementing a coherent and coordinated curriculum, which prepares students for licensure exams and subsequent phases of their training, requires the concerted expertise and efforts of diverse stakeholders, including administrators, faculty, staff, and students. The Office of Program Evaluation, Education and Research (PEAR) is responsible for student evaluations of courses at the University of New Mexico School of Medicine (SOM). In 2016, members of PEAR collaborated with the SOM Curriculum Committee to restructure the preclinical course review process to engage committee members more fully in monitoring courses. This poster summarizes evaluation processes, shares information on how other medical schools review preclinical …

Intradisciplinary Nursing Simulations: Advanced Practice Nursing With Bsn Students Msn, Rn, Adreanne Cordova, Herica Torres, Debra Serrino, Sharon Schaaf, Joseph Poole

HSC Education Days

With the increasing enrollment of advanced practice nursing students (APN) and the increasing literature supporting interprofessional simulation encouraging a team-based approach for safe patient care, a new clinical relationship among our APN (AGACNP and Midwifery) and BSN (Levels 4 and 5) students has been created at our college. This partnership has yielded an experience rich with collaboration, communication, and collective problem solving for patient care. Both BSN and APN students have gained more experience in: clear SBAR communication, working collaboratively and advocating for patient safety during the simulations in which they practice together. The intraprofessional nursing experience yields prepared, professional, …

Structure-Activity Profiling Of Alkaloid Natural Product Pharmacophores Against A Schistosoma Serotonin Receptor, Jonathan S. Marchant, Wayne W. Harding, John D. Chan

Publications and Research

Serotonin (5-HT) is an important regulator of numerous aspects of flatworm biology, ranging from neuromuscularfunctionto sexualmaturationandegglaying. Intheparasiticblood flukeSchistosomamansoni,5-HTtargets several G-protein coupled receptors (GPCRs), one of which has been demonstrated to couple to cAMP and regulate parasite movement. This receptor, Sm.5HTRL, has been successfully co-expressed in mammalian cells alongside a luminescent cAMP-biosensor, enabling pharmacological profiling for candidate anti-schistosomal drugs. Here, we have utilized this assay to perform structure-activity investigations of 143 compounds containing previously identified alkaloid natural product pharmacophores (tryptamines, aporphines and protoberberines) shown to regulate Sm.5HTRL. These experiments mapped regions of the tryptamine pharmacophore amenable and intolerant to substitution, highlighting …

Permainan Roda Pelangi Sebagai Media Untuk Meningkatkan Karakter Fairness Siswa Sekolah Dasar, Nora Yuniar Setyaputri, Yuanita Dwi Krisphianti, Ikke Yuliani Dhian Puspitarini

Jurnal Kajian Bimbingan dan Konseling

The purpose of this study was to determine the effectiveness of Roda Pelangi game to improve elementary school students’ fairness character. The research method was an experiment with a nonequivalent control group design type. The research instruments were: interview guidelines; observation guidelines; and Fairness Character Measurement Scale. The sample were twelve fourth grade students of Permata Ummat Trenggalek Integrated Islamic Elementary School that was chosen through purposive sampling. The significance score obtained based on data analysis using independent sample t-test was 0.047<0.05. The result showed Roda Pelangi game can improve elementary school students’ fairness character. Based on these results, it recommended: school counselor can use Roda Pelangi game in the guidance and counseling service process, especially to improve elementary school students’ fairness character; further researchers can use Roda Pelangi game to examine other variables and at other school levels using other research designs such as true experiment or guidance and counseling action research.

The Santa Clara, 2018-09-27, Santa Clara University

The Santa Clara

No abstract provided.

Wearable Cardioverter-Defibrillator After Myocardial Infarction, Jeffrey E. Olgin, Mark J. Pletcher, Eric Vittinghoff, Jerzy Wranicz, Rajesh Malik, Daniel P. Morin, Steven Zweibel, Alfred E. Buxton, Claude S. Elayi, Eugene H. Chung, Eric Rashba, Martin Borggrefe, Trisha F Hue, Carol Maguire, Feng Lin, Joel A. Simon, Stephen Hulley, Byron K. Lee, Vest Investigators

Gill Heart & Vascular Institute Faculty Publications

BACKGROUND

Despite the high rate of sudden death after myocardial infarction among patients with a low ejection fraction, implantable cardioverter–defibrillators are contraindicated until 40 to 90 days after myocardial infarction. Whether a wearable cardioverter–defibrillator would reduce the incidence of sudden death during this high-risk period is unclear.

METHODS

We randomly assigned (in a 2:1 ratio) patients with acute myocardial infarction and an ejection fraction of 35% or less to receive a wearable cardioverter–defibrillator plus guideline-directed therapy (the device group) or to receive only guideline-directed therapy (the control group). The primary outcome was the composite of sudden death or death from …

Utilisation Des Cellules Dendritiques En Tant Que Biosenseurs Pour La Surveillance De La Qualité Biologique De L’Air, Magali Boucher, Pascale Blais Lecours, Marc Veillette, Caroline Duchaine, David Marsolais

Rapports de recherche scientifique

Le nombre d’environnements de travail touchés par des problématiques de santé reliées aux bioaérosols est si considérable qu’il est difficile d’en faire un dénombrement précis. Les exemples les plus connus sont les porcheries, fermes laitières, tourbières, scieries et usines alimentaires. Aucune limite d’exposition n’existe pour les différentes composantes des bioaérosols, hormis les recommandations pour les endotoxines et certaines poussières. Toutefois, il est bien connu que l’état sanitaire de ces environnements diffère de site en site et selon leur classe. La nature des bioaérosols détectés dans ces environnements n’est que partiellement définie. Cette situation rend difficile la mise en place des …

A Requirement For Slc15a4 In Imiquimod-Induced Systemic Inflammation And Psoriasiform Inflammation In Mice, Alexis D. Griffith, Asifa K. Zaidi, Ashley Pietro, Matthew Hadiono, Jessica S. Yang, Rachel Davis, Daniel L. Popkin

Faculty Publications

There is competing evidence that plasmacytoid dendritic cells (pDC), the most potent source of IFN-I, may initiate psoriasis. We targeted pDC function using the slc15a4 loss-of-function mouse whose pDC are unresponsive to TLR agonists. slc15a4 treated with the topical TLR7-agonist imiquimod (IMQ) demonstrated decreased epidermal thickening 24 hours post-treatment which was more pronounced by day 5 as compared to wildtype mice. These findings were specific to the acute IMQ model and not the protracted IL23 model that drives inflammation downstream of TLR activation. Systemically, slc15a4 was required for IMQ-induced weight loss and cutaneous accumulation of CD4+ and Siglec H+, but …

The Influence Of Social And Economic Factors On Breastfeeding And Rural Mothers, Rachel Ellen Borton

Theses and Dissertations

Little is known or understood about rural mothers and their experience with breastfeeding. The literature demonstrates a sound understanding of the factors that influence mothers and breastfeeding; however, it is unclear what factors influence breastfeeding among rural mothers. A search of the literature offered thousands of articles related to urban mothers and their breastfeeding experience, but few describe the rural mother’s breastfeeding experience. Therefore, the purpose of this study is to investigate the basic process that characterizes breastfeeding among mothers in the rural setting and to develop a theory based on the investigation of factors that influence breastfeeding among rural …

Epidemiology Of Diabetic Foot Infection In The Metro-Detroit Area With A Focus On Independent Predictors For Pathogens Resistant To Recommended Empiric Antimicrobial Therapy, Oryan Henig, Jason M. Pogue, Raymond Cha, Paul E. Kilgore, Umar Hayat, Mahmoud Ja'ara, Raza Muhamad Ali, Salman Mahboob, Rahul Pansare, Kathryn Deeds, Bushra Joarder, Hyndavi Kandala, Sorabh Dhar, Keith S. Kaye

Department of Pharmacy Practice

Background. The polymicrobial nature of diabetic foot infection (DFI) and the emergence of antimicrobial resistance have complicated DFI treatment. Current treatment guidelines for deep DFI recommend coverage of methicillin-resistant Staphylococcus aureus (MRSA) and susceptible Enterobacteriaceae. This study aimed to describe the epidemiology of DFI and to identify predictors for DFI associated with multidrug-resistant organisms (MDROs) and pathogens resistant to recommended treatment (PRRT).

Methods. Adult patients admitted to Detroit Medical Center from January 2012 to December 2015 with DFI and positive cultures were included. Demographics, comorbidities, microbiological history, sepsis severity, and antimicrobial use within 3 months before DFI were obtained …