Medicine and Health Sciences Commons^™

Development Of Novel Intramolecular Fret-Based Abc Transporter Biosensors To Identify New Substrates And Modulators, Bremansu Osa-Andrews, Kee W. Tan, Angelina Sampson, Surtaj H. Iram

Chemistry and Biochemistry Faculty Publications

Multidrug resistance protein 1 (MRP1) can efflux a wide variety of molecules including toxic chemicals, drugs, and their derivatives out of cells. Substrates of MRP1 include anti-cancer agents, antibiotics, anti-virals, anti-human immunodeficiency virus (HIV), and many other drugs. To identify novel substrates and modulators of MRP1 by exploiting intramolecular fluorescence resonance energy transfer (FRET), we genetically engineered six different two-color MRP1 proteins by changing green fluorescent protein (GFP) insertion sites, while keeping the red fluorescent protein (RFP) at the C-terminal of MRP1. Four of six recombinant proteins showed normal expression, localization, and transport activity. We quantified intramolecular FRET using ensemble …

Nurses Alumni Association Bulletin, Fall 2018, Susan Albrecht Curcio

Nursing Alumni Bulletins

2018 – 2019 Meeting Dates Calendar

2019 Annual Luncheon and Meeting Notice

Officers, Committee Chairs, and Satellite

2018 President’s Message

Treasurer’s Report

Resume of Minutes

Office News

Committee Reports

• Social
• Relief Trust Fund
• Satellite – Harrisburg Satellite Area
• Scholarship
• By-Laws
• Nominating
• Bulletin

Jefferson Office of Alumni Relations

Annual Giving

Janet C. Hindson Award

• Janet C. Hindson Award Winner

News About and From Our Graduates

Pearls of Wisdom

Brain Health by YOU...and by Music!

Three Months at Byberry

Happy Birthday – To Be 80 or More

Annual Luncheon

• 1969 50th Anniversary Class List for 2019 Annual Luncheon
• Luncheon Photos
• Annual Luncheon …

Mid-Atlantic Ethics Committee Newsletter, Fall 2018

Mid-Atlantic Ethics Committee Newsletter

No abstract provided.

Nursing Acnp Program, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Atvs And Agriculture: A Review Of The Literature, Hali Neves, William Brazile, David P. Gilkey

Safety Health & Industrial Hygiene

The purpose of this article was to provide a review of the published literature pertaining to agricultural All-Terrain Vehicle (ATV) use and injury, fatality, exposure assessment, risk estimation and interventions. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) technique was used to identify high quality relevant articles pertaining to ATV-related injury, fatality, exposure assessment, risk estimation, and interventions in an agricultural setting. Inclusion criteria for articles included publications from January 1, 2000 through August 31, 2016, use of injury epidemiology assessment tools, NIOSH hierarchy of controls and the W.K. Kellogg Foundation Logic Model Development Guide. Thirty-four articles met …

Kinesiology Of A Baseball Swing, C.J. White, Brody Rollins, Jack Hoey

EXSI 432/532: Research Methods in Exercise Science: Research Proposal Posters

The purpose of this analysis is to provide feedback of optimal swing analytics that will produce maximal force and the best results in a sport setting.

Comparing Power And Endurance Athletes In The Wingate Test, Micah Balltzglier, Antwann Mccray, Jacob Wall, Megan Wortman

EXSI 432/532: Research Methods in Exercise Science: Research Proposal Posters

The outcome of the Wingate test will be investigated for both power and endurance athletes in regards to physiological adaptations as a response to power and endurance training. It is hypothesized that throughout the Wingate testing, endurance athletes will display greater recovery heart rates and lower blood pressure values due to their superior aerobic capacity. However, power athletes will maintain a lower overall percent of maximum heart rate reached, as well as lower RPE values due to superior adaptations in the creatine-phosphate, lactate clearing, and anaerobic energy systems.

Submaximal Exercise Performance In Fasted Vs. Non-Fasted Individuals, Tia Howell, Kaylin Schuda, Morgan Murphy, Zach Lovelace

EXSI 432/532: Research Methods in Exercise Science: Research Proposal Posters

The purpose of this study is to compare exercise performance and substrate utilization in fasted and non-fasted, healthy college students during submaximal exercise on the leg ergometer. It was hypothesized that consuming a meal prior to submaximal exercise will yield a higher RER value compared to fasting at least three hours prior to the start of exercise.

Practical Pearl: Influenza - October 2018, Mike Klatte Md

Pediatrics Practical Pearls: Referral Guidelines for Common Problems

No abstract provided.

Gw Nursing, Fall 2018, George Washington University, School Of Nursing

GW Nursing Magazine

No abstract provided.

Eye Tissue Regeneration: Seam As A Cure For Prevalent Eye Disease, Molly Bute

Biology: Student Scholarship & Creative Works

SEAM (Self-formed ectodermal autonomous multizone) is a form of eye tissue regeneration discovered by Japanese scientists in 2016. This tissue regeneration encompasses tissues from all areas of the human eye. The SEAM forms tissues using stem cells, induced pluripotent stem cells were used in the first study, and produces four concentric zones. The SEAM that has been created was shown to cure corneal blindness in animal models, and has the potential to cure a multitude of human eye diseases in the future.

The New Hero Of Upper Limb Prosthetics, Erin Miskell

Biology: Student Scholarship & Creative Works

This paper looks at the history and future of upper extremity prosthesis. The goal of this paper was to compare three different up and coming technological advances in the field of prosthesis that may help the devices to become more life-like for their users. Of the three different approaches looked at, the Open Bionics Hero Arm is praised as being the best option.

Hiv Pre-Health Case Study, Halmos College Of Arts And Sciences (Hcas)

HCAS Case Competitions

No abstract provided.

Response Of The Axial Skeleton To Bipedal Loading Behaviors In An Experimental Animal Model, G. A. Russo, D. Marsh, A. D. Foster

Osteopathic Medicine, Jerry M. Wallace School of

No abstract provided.

The Use Of Neuromuscular Electrical Simulation In Glenohumeral Unidirectional Instability When An Exercise-Based Approach Has Failed: A Case Study, Kunal Bhanot, Navpreet Kaur, J Butler

Physical Therapy Collection

Purpose of this case study was to report the role of neuromuscular electrical stimulation (NMES) to restore strength and normal motion in a patient with unidirectional shoulder instability or glenohumeral internal rotation deficit (GIRD).

Artificial Light At Night As An Environmental Pollutant: An Integrative Approach Across Taxa, Biological Functions, And Scientific Disciplines, Davide M. Dominoni, Randy J. Nelson

Clinical and Translational Science Institute

With each day, the world is becoming number of people move into urban areas, and consequently these increase in area to consume rural and natural land (Seto, Guneralp, & Hutyra, 2012). Among the numerous changes that accompany urban sprawl, artificial light at night (ALAN) is one of the most immediate and evident (Falchi et al., 2016; Longcore & Rich, 2004). From a variety of anthropogenic sources, artificial light is introduced at times (the night) and in places where it does not naturally occur (Falchi et al., 2016). The characteristics of the introduced light sources are also very different from natural …

Comparative Analysis Of The Views Of Oncologic Subspecialists And Palliative/Supportive Care Physicians Regarding Advanced Care Planning And End-Of-Life Care, Phillip M. Pifer, Mark K. Farrugia, Malcolm D. Mattes

Clinical and Translational Science Institute

Background—Early palliative/supportive care (PSC) consultation and advance care planning (ACP) improve outcomes for patients with incurable cancer. However, PSC is underutilized in the United States. Objective—To examine philosophical differences among PSC, radiation oncology (RO), and medical oncology (MO) physicians in order to understand barriers to early PSC referral. Design—An electronic survey collected views of a nationwide cohort of health-care professionals regarding ACP and end-of-life care. Setting/Participants/Measurements—A subgroup analysis compared the responses from all 51 PSC, 178 RO, and 81 MO physician participants (12% response rate), using Pearson χ2 and Mann-Whitney U tests for categorical and ordinal data, respectively. Results—More statistically …

Social Influences On Microglial Reactivity And Neuronal Damage After Cardiac Arrest/Cardiopulmonary Resuscitation, Monica M. Gaudier-Diaz, Adam H. Haines, Ning Zhang, A. Courtney Devries

Clinical and Translational Science Institute

Social isolation presents a risk factor and worsens outcome to cerebrovascular diseases; however, the underlying mechanisms remain underspecified. This study examines the effect of social environment on microglial reactivity after global cerebral ischemia, to test the hypothesis that social isolation leads to greater microglial responses. Adult female and male mice were pair-housed or socially isolated for one week prior to cardiac arrest/cardiopulmonary resuscitation (CA/CPR) or the sham procedure, and following either 2 or 24 hours of reperfusion, microglia samples were enriched and analyzed for gene expression. At the 2-hour time point, microglia from both females and males exhibited ischemia-induced inflammation, …

An Effective Approach To Teaching Pharmacogenomics In The First Year Of Pharmacy Curriculum, Marina Gálvez-Peralta, Grazyna D. Szklarz, Werner J. Geldenhuys, Paul R. Lockman

Clinical and Translational Science Institute

Objective. To develop an effective method in teaching pharmacogenomics as a part of a new course, Biopharmaceutics and Pharmacogenomics. Methods. Teaching effectiveness was measured by quizzes, retrospective pre- and post-surveys, team activities, and journal reflections. Four team activities were included in the course: genomic disease, patient case, genetic counselor and a debate about personalized medicine. Outcomes and course impact were evaluated at the end of the course. The evaluation methods included the assessment of knowledge, students’ perceptions regarding the utility of team activities, the impact of the course on students’ confidence to discuss pharmacogenomics with health care providers or patients, …

Executive (Dys)Function After Traumatic Brain Injury: Special Considerations For Behavioral Pharmacology, Jenny E. Ozga, Jessica M. Povroznik, Elizabeth B. Engler-Chiurazzi, Cole Vonder Haar

Clinical and Translational Science Institute

Executive function is an umbrella term that includes cognitive processes such as decision-making, impulse control, attention, behavioral flexibility, and working memory. Each of these processes depends largely upon monoaminergic (dopaminergic, serotonergic, and noradrenergic) neurotransmission in the frontal cortex, striatum, and hippocampus, among other brain areas. Traumatic brain injury (TBI) induces disruptions in monoaminergic signaling along several steps in the neurotransmission process – synthesis, distribution, and breakdown – and in turn, produces long-lasting deficits in several executive function domains. Understanding how TBI alters monoamingeric neurotransmission and executive function will advance basic knowledge of the underlying principles that govern executive function and …

Executive (Dys)Function After Stroke: Special Considerations For Behavioral Pharmacology, Jessica M. Povroznik, Jenny E. Ozga, Cole Vonder Haar, Elizabeth B. Engler-Chiurazzi

Clinical and Translational Science Institute

Stroke is a world-wide leading cause of death and long-term disability with concurrent secondary consequences that are largely comprised of mood dysfunction, as well as sensory, motor, and cognitive deficits. This review focuses on the cognitive deficits associated with stroke specific to executive dysfunction (including decision making, working memory, and cognitive flexibility) in humans, non-human primates, and additional animal models. Further, we review some of the cellular and molecular underpinnings of the individual components of executive dysfunction and their neuroanatomical substrates after stroke, with an emphasis on the changes that occur during biogenic monoamine neurotransmission. We concentrate primarily on changes …

Artificial Light At Night Alters Behavior In Laboratory And Wild Animals, Kathryn L. G. Russart, Randy J. Nelson

Clinical and Translational Science Institute

Life has evolved to internalize and depend upon the daily and seasonal light cycles to synchronize physiology and behavior with environmental conditions. The nightscape has been vastly changed in response to the use of artificial lighting. Wildlife is now often exposed to direct lighting via streetlights or indirect lighting via sky glow at night. Because many activities rely on daily and seasonal light cues, the effects of artificial light at night could be extensive, but remain largely unknown. Laboratory studies suggest exposure to light at night can alter typical timing of daily locomotor activity and shift the timing of foraging/food …

Correlations Of Self-Reported Androgen Deficiency In Ageing Males (Adam) With Stress And Sleep Among Young Adult Males, Camille M. Charlier, Makenzie L. Barr, Sarah E. Colby, Geoffrey W. Greene, Melissa D. Olfert

Clinical and Translational Science Institute

Androgen deficiency in males has traditionally been predominantly limited to older men aged 50+ years. However, little is known of the correlation between hormonal disruption, stress, and sleep in college-aged males. This cross-sectional study investigates lifestyle behavior patterns in young men and a screening for potential androgen deficiency. A survey of 409 male students, as part of a larger USDA-funded GetFruved study, was analyzed for this subproject. Survey instruments used include the Androgen Deficiency in the Aging Male Questionnaire (ADAM) to assess for inadequate ADAM scores, the Perceived Stress Scale to measure stress levels and the Pittsburgh Sleep Quality Index …

Comparison Of Dental Students' Self-Evaluation And Faculty Evaluation Of Communication Skills During A Standardized Patient Exercise, R. Constance Wiener, Christopher Waters, Joan Doris, Daniel W. Mcneil

Clinical and Translational Science Institute

The aims of this retrospective study, conducted in 2017, were to explore dental students’ perceptions of their first standardized patient encounters and to assess the relationship between students’ self-evaluation and faculty members’ evaluation of students’ communication skills in those encounters. Data from a simulation training laboratory at one U.S. dental school were obtained for all 46 second-year students, who had a standardized patient communication learning session. The students had completed self-evaluations before and after a debriefing with a clinical psychology and/or social work faculty member and three or four student peers. The faculty members had also completed evaluations of the …

Mobile Health (Mhealth) Use Or Non-Use By Residents Of West Virginia, Peter Giacobbi Jr, Patrick Cushing, Alexis Popa, Treah Haggerty, Adam Hansell, Cara Sedney

Clinical and Translational Science Institute

Objective: To compare mobile health (mHealth) usage by residents of West Virginia with national estimates. Methods: Pew Research Center data from its Internet and American Life Project were accessed for secondary data analysis. These data, available to the public, are a probability sample of Internet use in the United States, differences in use based on selected variables (eg, education, household income), and how usage affects the lives of Americans. Using SAS software, diagnostics were performed on the data, revealing that the variables of interest were prepared and represented without any need for information. Data were used as is, with categorical …

Meta-Analysis Comparing The Frequency Of Stroke After Transcatheter Versus Surgical Aortic Valve Replacement, Kuldeep Shah, Zakeih Chaker, Tatiana Busu, Vinay Badhwar, Fahad Alqahtani, Muhammad Alvi, Amelia Adcock, Mohamad Alkhouli

Clinical and Translational Science Institute

Stroke is one of the most feared complications of aortic valve replacement. Although the out-comes of transcatheter aortic valve implantation (TAVI) improved substantially over time,concerns remained about a potentially higher incidence of stroke with TAVI compared withsurgical replacement (SAVR). However, comparative data are sparse. We performed ameta-analysis comparing the incidence of stroke among patients undergoing TAVI versusSAVR. Of the 5067 studies screened, 28 eligible studies (22 propensity-score matched studiesand 6 randomized trials) were analyzed. Primary endpoints were 30-day stroke and disablingstroke. Secondary endpoints were 1-year stroke and disabling stroke. A total of 23,587patients were included, of whom 47.27% underwent TAVI …

Massive Spontaneous Hemothorax As A Complication Of Apixaban Treatment, Mohammad Abu Hishmeh, Priyaha Srivastava, Quinn Lougheide, Maria Srinivasan, Shekar Murthy

NYMC Residents/Fellows Publications

Introduction: Hemothorax is usually related to chest or iatrogenic trauma from procedures such as central lines and thoracentesis. Spontaneous hemothorax is defined as pleural fluid hematocrit greater than 50% of serum hematocrit in absence of natural or iatrogenic trauma affecting the lung or pleural space. Coagulopathy secondary to anticoagulant use has been associated with spontaneous hemothorax. We present a case of spontaneous hemothorax in a patient taking apixaban for venous thromboembolism disease. To our knowledge, this is the first case report of apixaban as a cause of spontaneous hemothorax. Case Presentation: A 56-year-old woman with end-stage renal disease (ESRD) was …

Dental Practice Success Special Issue: Marketing Strategies (October 2018), American Dental Association, Publishing Division

Dental Practice Success

No abstract provided.

Layout Movement Analysis, Lauren Bishop, Chris Clary, Anna Henderson

EXSI 432/532: Research Methods in Exercise Science: Research Proposal Posters

No abstract provided.

Knee Angles During A Walking Gait Analysis, Savannah Hollifield, Karlee Moore

EXSI 432/532: Research Methods in Exercise Science: Research Proposal Posters

The purpose is to determine how knee angles change during specific stages of the walking gait compared to research. The subject is a young, healthy, moderately active adult, so it is hypothesized that the subject’s knee angle change during each stage will fall within the range of a healthy adult’s walking gait.