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2018

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Full-Text Articles in Medicine and Health Sciences

Impact Of Psychosocial Factors On Postpartum Depression Of Mothers, Anita Sadikaj, Artemisi Shehu Oct 2018

Impact Of Psychosocial Factors On Postpartum Depression Of Mothers, Anita Sadikaj, Artemisi Shehu

UBT International Conference

Pregnancy and postpartum period involve many challenges mothers face. In this period, mothers go through a range of emotions and states, because of intensive physical, emotional and hormonal changes. Postpartum depression is an important depression episode which begins in pregnancy or within 4 weeks after giving birth (APA, 2013). This research aims to assess impact of psychological factors especially family support during the postpartum depression. Research is conducted in Gynecology and Obstetrics Clinic, Pediatric Clinic and in private Hospital “Lindja”, in Prishtina, during period may-june in 2018. Study is focused in relation of psychosocial factors such as: birthplace, education, employment, …


Hotspotting Without A Patient, Mirna Rezkalla, Bs, Pharmd Candidate, Nicole Lenegan, Bsn, Rn, Elena Umland, Pharmd Oct 2018

Hotspotting Without A Patient, Mirna Rezkalla, Bs, Pharmd Candidate, Nicole Lenegan, Bsn, Rn, Elena Umland, Pharmd

College of Pharmacy Posters

Introduction

  • Interprofessional (IP) teamwork is the foundation for successful patient care outcomes. Numerous issues can arise from poor teamwork stemming from the lack of acknowledgment and appreciation of the roles of each healthcare provider.
  • Throughout our training in school, students often become focused on their own profession and develop biases or perceptions of the other members of other healthcare disciplines.
  • The Hotspotting program provides students the opportunity to eliminate biases and clarify perceptions.


Functional, Motor, And Sensory Assessment Instruments Upon Nerve Repair In Adult Hands: Systematic Review Of Psychometric Properties, Marisa De Cássia Registro Fonseca, Valéria Meireles Carril Elui, Emily Lalone, Natália Claro Da Silva, Rafael Inácio Barbosa, Alexandre Márcio Marcolino, Flávia Pessoni Faleiros Macedo Ricci, Joy C. Macdermid Oct 2018

Functional, Motor, And Sensory Assessment Instruments Upon Nerve Repair In Adult Hands: Systematic Review Of Psychometric Properties, Marisa De Cássia Registro Fonseca, Valéria Meireles Carril Elui, Emily Lalone, Natália Claro Da Silva, Rafael Inácio Barbosa, Alexandre Márcio Marcolino, Flávia Pessoni Faleiros Macedo Ricci, Joy C. Macdermid

Bone and Joint Institute

© 2018 The Author(s). Background: Outcome after nerve repair of the hand needs standardized psychometrically robust measures. We aimed to systematically review the psychometric properties of available functional, motor, and sensory assessment instruments after nerve repair. Methods: This systematic review of health measurement instruments searched databases from 1966 to 2017. Pairs of raters conducted data extraction and quality assessment using a structured tool for clinical measurement studies. Kappa correlation was used to define the agreement prior to consensus for individual items, and intraclass correlation coefficient (ICC) was used to assess reliability between raters. A narrative synthesis described quality and content …


A Novel Tetracycline-Responsive Transgenic Mouse Strain For Skeletal Muscle-Specific Gene Expression, Masahiro Iwata, Davis A. Englund, Yuan Wen, Cory M. Dungan, Kevin A. Murach, Ivan J. Vechetti Jr., Christopher B. Mobley, Charlotte A. Peterson, John J. Mccarthy Oct 2018

A Novel Tetracycline-Responsive Transgenic Mouse Strain For Skeletal Muscle-Specific Gene Expression, Masahiro Iwata, Davis A. Englund, Yuan Wen, Cory M. Dungan, Kevin A. Murach, Ivan J. Vechetti Jr., Christopher B. Mobley, Charlotte A. Peterson, John J. Mccarthy

Center for Muscle Biology Faculty Publications

Background: The tetracycline-responsive system (Tet-ON/OFF) has proven to be a valuable tool for manipulating gene expression in an inducible, temporal, and tissue-specific manner. The purpose of this study was to create and characterize a new transgenic mouse strain utilizing the human skeletal muscle α-actin (HSA) promoter to drive skeletal muscle-specific expression of the reverse tetracycline transactivator (rtTA) gene which we have designated as the HSA-rtTA mouse.

Methods: To confirm the HSA-rtTA mouse was capable of driving skeletal muscle-specific expression, we crossed the HSA-rtTA mouse with the tetracycline-responsive histone H2B-green fluorescent protein (H2B-GFP) transgenic mouse in order to label myonuclei.

Results: …


Advanced Glycation End Products Are Elevated In Estrogen Receptor-Positive Breast Cancer Patients, Alter Response To Therapy, And Can Be Targeted By Lifestyle Intervention, Katherine R. Walter, Marvella E. Ford, Mathew J. Gregoski, Rita M. Kramer, Kendrea D. Knight, Laura Spruill, Lourdes M. Nogueira, Bradley A. Krisanits, Van Phan, Amanda C. La Rue, Michael B. Lilly, Stefan Ambs, King Chan, Tonya F. Turner, Heidi Varner, Shweta Singh, Jaime Uribarri, Elizabeth Garrett-Mayer, Kent E. Armeson, Ebony J. Hilton, Mark J. Clair, Marian H. Taylor, Andrea M. Abbott, Victoria J. Findlay, Lindsay L. Peterson, Gayenell Magwood Phd, Rn, Faha, Faan, David P. Turner Oct 2018

Advanced Glycation End Products Are Elevated In Estrogen Receptor-Positive Breast Cancer Patients, Alter Response To Therapy, And Can Be Targeted By Lifestyle Intervention, Katherine R. Walter, Marvella E. Ford, Mathew J. Gregoski, Rita M. Kramer, Kendrea D. Knight, Laura Spruill, Lourdes M. Nogueira, Bradley A. Krisanits, Van Phan, Amanda C. La Rue, Michael B. Lilly, Stefan Ambs, King Chan, Tonya F. Turner, Heidi Varner, Shweta Singh, Jaime Uribarri, Elizabeth Garrett-Mayer, Kent E. Armeson, Ebony J. Hilton, Mark J. Clair, Marian H. Taylor, Andrea M. Abbott, Victoria J. Findlay, Lindsay L. Peterson, Gayenell Magwood Phd, Rn, Faha, Faan, David P. Turner

Publications

PURPOSE: Lifestyle factors associated with personal behavior can alter tumor-associated biological pathways and thereby increase cancer risk, growth, and disease recurrence. Advanced glycation end products (AGEs) are reactive metabolites produced endogenously as a by-product of normal metabolism. A Western lifestyle also promotes AGE accumulation in the body which is associated with disease phenotypes through modification of the genome, protein crosslinking/dysfunction, and aberrant cell signaling. Given the links between lifestyle, AGEs, and disease, we examined the association between dietary-AGEs and breast cancer. METHODS: We evaluated AGE levels in bio-specimens from estrogen receptor-positive (ER+) and estrogen receptor-negative (ER-) breast cancer patients, examined …


Bacterial Contamination Of Platelets For Transfusion: Strategies For Prevention., Jerrold H. Levy, Matthew D. Neal, Jay H. Herman Oct 2018

Bacterial Contamination Of Platelets For Transfusion: Strategies For Prevention., Jerrold H. Levy, Matthew D. Neal, Jay H. Herman

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Platelet transfusions carry greater risks of infection, sepsis, and death than any other blood product, owing primarily to bacterial contamination. Many patients may be at particular risk, including critically ill patients in the intensive care unit. This narrative review provides an overview of the problem and an update on strategies for the prevention, detection, and reduction/inactivation of bacterial contaminants in platelets. Bacterial contamination and septic transfusion reactions are major sources of morbidity and mortality. Between 1:1000 and 1:2500 platelet units are bacterially contaminated. The skin bacterial microflora is a primary source of contamination, and enteric contaminants are rare but may …


Assessing Our Judgement: Comparing Librarian And Allied Health Professionals’ Evaluation Of Relevance Of Search Results, Jane Morgan-Daniel, Nancy Schaefer Oct 2018

Assessing Our Judgement: Comparing Librarian And Allied Health Professionals’ Evaluation Of Relevance Of Search Results, Jane Morgan-Daniel, Nancy Schaefer

Southern Chapter/Medical Library Association Annual Conference

Objectives: Information needs, literature searching, librarian’s and requestor’s perceptions


The Resourceful-U Family Caregiving Strengths-Building Education And Support Group: A Florida Library And Aging Network Partnership Project, Mary M. Howrey, Michael Bryant, Sarah Nielsen, Vanessa Rico-Robie, Lucy Osemota Oct 2018

The Resourceful-U Family Caregiving Strengths-Building Education And Support Group: A Florida Library And Aging Network Partnership Project, Mary M. Howrey, Michael Bryant, Sarah Nielsen, Vanessa Rico-Robie, Lucy Osemota

Southern Chapter/Medical Library Association Annual Conference

Project Objective: Two Research Questions What are the information and support needs of family caregivers participating in a newly formed library-aging network educational support group? How can libraries and aging network agencies effectively partner to promote positive outcomes for the health and well-being of informal family caregivers and their care recipients with long-term medical conditions? Methods: Research Steps The following research steps are underway as of January 2018-- (1) A comprehensive and ongoing literature review of family caregiver strengths-building (i.e., resourcefulness), social support, and older adult care recipients’ wellness and quality of life including a JBI systematic review (Lauritzen, Pedersen, …


Piloting Consumer Health Resources To Nurse And Patient Educators, Lindsay Blake, Alice Jaggers Oct 2018

Piloting Consumer Health Resources To Nurse And Patient Educators, Lindsay Blake, Alice Jaggers

Southern Chapter/Medical Library Association Annual Conference

Objective: The objective of this project is to pilot a consumer health resources train the trainer course and accompanying online guide to nurse and patient educators. Methods: The Clinical Services Librarian and Outreach Coordinator at the University of Arkansas for Medical Sciences proposed a plan to educate the nurse and patient educators in the hospital on reliable consumer health resources. Partnerships were formed within the institution with patient educators, patient advocates, and patient- and family-centered care. Librarians created a course presenting general consumer health resources from the National Library of Medicine as well as other reliable sites. The course was …


Changing The Conversation From Avoiding Predatory Journals To Finding And Evaluating The Right Journal, Terri Gotschall, Shalu Gillum Oct 2018

Changing The Conversation From Avoiding Predatory Journals To Finding And Evaluating The Right Journal, Terri Gotschall, Shalu Gillum

Southern Chapter/Medical Library Association Annual Conference

Objective: Predatory publishing is a trending topic in academia. Librarians all over are having conversations with faculty on how to steer clear of predatory publishers. But helping avoid predatory journals doesn’t meet the goal of having an article published. Now is the time to explore changing the conversation from predatory publishing to finding and evaluating the right journal. Methods: Last year librarians went to departmental meetings to present a cautionary tale of the predatory publisher. Outlandish emails from predatory journals were shared, along with what to look for when determining whether or not a journal publisher is legitimate. But just …


Promoting Health Information Access Through Community Partnerships, Margaret Ansell, Susan Harnett, Jane Morgan-Daniel Oct 2018

Promoting Health Information Access Through Community Partnerships, Margaret Ansell, Susan Harnett, Jane Morgan-Daniel

Southern Chapter/Medical Library Association Annual Conference

Funded by a grant from the National Network of Libraries of Medicine, three academic health science librarians collaborated with local public libraries to identify the health information needs of library staff, design and conduct a workshop on providing consumer health and health literacy information services, and assess workshop participants’ increase in confidence related to finding health information online.


Fatal General Aviation Accidents In Furtherance Of Business (1996–2015): Rates, Risk Factors, And Accident Causes, Scott Burgess, Stewart Boyd, Douglas Boyd Oct 2018

Fatal General Aviation Accidents In Furtherance Of Business (1996–2015): Rates, Risk Factors, And Accident Causes, Scott Burgess, Stewart Boyd, Douglas Boyd

Journal of Aviation Technology and Engineering

Introduction: General aviation missions related to furtherance of business potentially carry higher risk (operations in adverse weather, at night, for longer distances) than those undertaken for recreation. The study herein was undertaken to determine fatal accident rates, proportions, and risk factors/causes.

Method: The National Transportation Safety Board aviation accident database was queried for accidents (1996–2015). Annual fleet times were from the general aviation annual activity survey. Statistical analyses used Poisson distributions, proportion testing, and Cohen’s Kappa tests.

Results: The fatal accident rate for business operations was three- to six-fold lower than the rate for recreational flights with a decline evident …


Speeding Ahead: Assessing Trends In Distance Librarian Services For Advanced Practice Nursing Programs, Gregg A. Stevens, Elizabeth G. Hinton, Roy E. Brown Oct 2018

Speeding Ahead: Assessing Trends In Distance Librarian Services For Advanced Practice Nursing Programs, Gregg A. Stevens, Elizabeth G. Hinton, Roy E. Brown

Southern Chapter/Medical Library Association Annual Conference

With the increasing popularity of distance education among universities and busy students, many Advanced Practice Nursing (APN) programs have shifted to become either online or hybrid programs. To meet the research and instruction needs of these students, some nursing librarians are using technology for virtual research and instruction. This study was designed to assess the extent to which nursing librarians in North America are providing virtual research and instruction services for APN students.


Can You Credit This? A Credit-Bearing Information Literacy Course For Graduate Health Science Students, Margaret Ansell, Mary E. Edwards, Hannah F. Norton, Nancy Schaefer, Michele R. Tennant Oct 2018

Can You Credit This? A Credit-Bearing Information Literacy Course For Graduate Health Science Students, Margaret Ansell, Mary E. Edwards, Hannah F. Norton, Nancy Schaefer, Michele R. Tennant

Southern Chapter/Medical Library Association Annual Conference

Objective: University of Florida HSCL librarians have long offered information-related instruction through guest lectures in the programs they serve and stand-alone workshops; however, librarians had not taught any credit-bearing courses focused on information literacy prior to 2016. To more fully integrate information-related skills into curricula, librarians developed a one-credit course for graduate students, initially targeting those in basic science programs but expecting that its modular format would allow easy adaptation for other health science programs. After two successful semesters teaching this course, librarians adapted the instructional content to an audience of graduate students in the College of Public Health and …


Redesigning A Hospital’S Evidence-Based Practice Course, Emily Brennan, Amanda Davis, Rebecca Harper Oct 2018

Redesigning A Hospital’S Evidence-Based Practice Course, Emily Brennan, Amanda Davis, Rebecca Harper

Southern Chapter/Medical Library Association Annual Conference

The Medical University of South Carolina (MUSC) Value Institute, which falls under the hospital’s Quality Department, has contributed to evidence-based practice (EBP) culture through education, evidence synthesis services, and the development of clinical decision support tools. Three members of the Value Institute -- a librarian, Clinical Evidence-Based Analyst, and Senior Value Specialist -- have taught a variety of EBP courses to clinicians over the years. However, because of increasing course dropout rates, the Value Institute conducted focus groups to identify ways to redesign the course. Two focus groups consisted of 6-8 previous course participants each. The focus groups started with …


The Assassin Bug, Lola Alao '20, Harsha Nalam '19, Dwanne Colobong '19, Trisha Sudhakar '19 Oct 2018

The Assassin Bug, Lola Alao '20, Harsha Nalam '19, Dwanne Colobong '19, Trisha Sudhakar '19

Human Diseases Graphic Novels

No abstract provided.


Diseases At Work, Alice Liu '19, Nicholas Opiola '19, Gunnar Bergmann '19, Femi Durodola '20, Suraj Sunkara '19 Oct 2018

Diseases At Work, Alice Liu '19, Nicholas Opiola '19, Gunnar Bergmann '19, Femi Durodola '20, Suraj Sunkara '19

Human Diseases Graphic Novels

No abstract provided.


In The Office, Theo Heilman '19, Nathan Lee '19, Prachi Patil '19, Katie Si '19 Oct 2018

In The Office, Theo Heilman '19, Nathan Lee '19, Prachi Patil '19, Katie Si '19

Human Diseases Graphic Novels

No abstract provided.


Persistent Misconceptions About Mutations Among Graduate Nursing Students, Jane Garvin, Beverly Collins Oct 2018

Persistent Misconceptions About Mutations Among Graduate Nursing Students, Jane Garvin, Beverly Collins

Nursing Collection

Purpose

The purpose of this study was to determine the ongoing misconceptions about mutations, an area of rising public interest, among graduate nursing students.

Design

Using a prospective cohort design, graduate students entering a public university in the Fall of 2014 were followed to graduation in the Fall of 2016.

Methods

Knowledge of mutations was assessed with an anonymous pre-test and post-test using three items from the Genomic Nursing Concept Inventory - 2011 beta version developed by Ward. Differences in pre-test and post-test scores were assessed by T-test. Post-test items with > 30% marked incorrectly were examined further; the most frequent …


Health Behaviors Of Student Community Research Partners When Designing And Implementing A Healthy Lifestyle Intervention On College Campuses., Makenzie L. Barr, Sarah E. Colby, Kristin Riggsbee, Krista Leischner, Anne E. Matthews, Melissa J Vilaro, Kendra Kattelmann, Melissa D. Olfert Oct 2018

Health Behaviors Of Student Community Research Partners When Designing And Implementing A Healthy Lifestyle Intervention On College Campuses., Makenzie L. Barr, Sarah E. Colby, Kristin Riggsbee, Krista Leischner, Anne E. Matthews, Melissa J Vilaro, Kendra Kattelmann, Melissa D. Olfert

Health and Nutritional Sciences Faculty Publications

Few studies work with college students as equal partners in all aspects of Community-Based Participatory Research (CBPR) and even less evaluate behaviors of those college partners. The current study aimed to examine health behaviors of students by designing and implementing a peer-led, social marketing campaign (Get Fruved) to promote healthier lifestyles on their campuses. Enrolled students (n = 376) were trained to either design and implement a health promotion intervention (Social Marketing and Environmental Interventionists; SMEI, n = 78), be peer mentors (PM; n = 205), or serve as control participants (n = 93). Students' behaviors (dietary, activity, and stress) …


Medical Biochemistry Without Rote Memorization: Multi-Institution Implementation And Student Perceptions Of A Nationally Standardized Metabolic Map For Learning And Assessment, Douglas B. Spicer, Kathryn H. Thompson, Michelle S. Tong, Tina M. Cowan, Tracy B. Fulton, Janet E. Lindsley Oct 2018

Medical Biochemistry Without Rote Memorization: Multi-Institution Implementation And Student Perceptions Of A Nationally Standardized Metabolic Map For Learning And Assessment, Douglas B. Spicer, Kathryn H. Thompson, Michelle S. Tong, Tina M. Cowan, Tracy B. Fulton, Janet E. Lindsley

Biomedical Sciences Faculty Publications

Despite the growing number of patients worldwide with metabolism-related chronic diseases, medical biochemistry education is commonly perceived as focusing on recall of facts irrelevant for patient care. The authors suggest that this focus on rote memorization of pathways creates excessive cognitive load that may interfere with learners’ development of an integrated understanding of metabolic regulation and dysregulation. This cognitive load can be minimized by providing appropriate references during learning and assessment. Biochemistry educators collaborated to develop a medically relevant Pathways of Human Metabolism map (MetMap) that is now being used at many medical schools as a nationally standardized resource during …


Kidney Stones, Bopo Taiwo '20, Ishanpepe Jagusah '20 Oct 2018

Kidney Stones, Bopo Taiwo '20, Ishanpepe Jagusah '20

Human Diseases Graphic Novels

No abstract provided.


The Blue Baby, Lola Alao, Harsha Nalam '19, Dwanne Colobong '19, Trisha Sudhakar '19 Oct 2018

The Blue Baby, Lola Alao, Harsha Nalam '19, Dwanne Colobong '19, Trisha Sudhakar '19

Human Diseases Graphic Novels

No abstract provided.


Hpv-Related Cancer Prevention And Control Programs At Community-Based Hiv/Aids Service Organizations: Implications For Future Engagement, Lisa T. Wigfall, Shalanda A. Bynum, Heather M. Brandt, Neethu Sebastian, Marcia G. Ory Oct 2018

Hpv-Related Cancer Prevention And Control Programs At Community-Based Hiv/Aids Service Organizations: Implications For Future Engagement, Lisa T. Wigfall, Shalanda A. Bynum, Heather M. Brandt, Neethu Sebastian, Marcia G. Ory

Faculty Publications

People living with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) and, men who have sex with men (MSM) are disproportionately affected by genital warts and cancers caused by human papillomavirus (HPV). We assessed community-based HIV/AIDS service organizations' (ASOs) staff awareness, knowledge, attitudes, and beliefs about HPV and effective cancer prevention tools, namely HPV vaccination, Pap, and HPV tests. The potential engagement of ASO staff in future efforts to reduce the disproportionate burden of genital warts and HPV-related cancers among HIV-positive women and MSM was explored. In May-June 2016, staff were recruited from three ASOs located in the South United States Census …


Exploring Men Who Have Sex With Men’S Hiv Pre-Exposure Prophylaxis Initiation Decision-Making Processes In The Southern United States, Portia Thomas Oct 2018

Exploring Men Who Have Sex With Men’S Hiv Pre-Exposure Prophylaxis Initiation Decision-Making Processes In The Southern United States, Portia Thomas

Doctorate of Nursing Science Dissertations

In 2012, the first pharmacological HIV preventative agent, pre-exposure prophylaxis (PrEP) was approved in the U.S. for individuals at high-risk of contracting HIV. Men who have sex with men (MSM) are at increased HIV risk, due to their engagement in anal intercourse (AI), which is the most common mode of HIV transmission and the riskiest type of sex. Although evidence indicates that most PrEP paients are MSM, a paucity of evidence exists on MSM’s PrEP initation decision-making process. The purpose of this study was to explore how HIV-negative MSM engaging in protected or unprotected AI decide to initiate PrEP based …


Navigating Health Care Transition: An Exploration Into The Experiences Of Parents And Their Adolescents With Special Health Care Needs Utilizing A Transitional Care Service, Jane Tobias, Dnp, Crnp Oct 2018

Navigating Health Care Transition: An Exploration Into The Experiences Of Parents And Their Adolescents With Special Health Care Needs Utilizing A Transitional Care Service, Jane Tobias, Dnp, Crnp

College of Nursing Posters

Abstract

Adolescents with special health care needs encounter barriers and challenges during transition to adult health care that have the potential to impact health outcomes and satisfaction with the experience. The use of transitional care services can provide resources and support throughout the transition process to the adolescent and their parent/caregiver. This descriptive survey study was conducted to evaluate adolescent and/or parent/caregiver satisfaction with the transitional care services provided by an urban, academic, pediatric health care facility. Nineteen of 39 (49%) eligible participants completed the survey. Findings indicate that adolescents and their parent/caregiver were satisfied with the resources and support …


Collagen Prolyl 4-Hydroxylase 1 Is Essential For Hif-1Α Stabilization And Tnbc Chemoresistance, Gaofeng Xiong, Rachel L. Stewart, Jie Chen, Tianyan Gao, Timothy L. Scott, Luis M. Samayoa, Kathleen L. O'Connor, Andrew N. Lane, Ren Xu Oct 2018

Collagen Prolyl 4-Hydroxylase 1 Is Essential For Hif-1Α Stabilization And Tnbc Chemoresistance, Gaofeng Xiong, Rachel L. Stewart, Jie Chen, Tianyan Gao, Timothy L. Scott, Luis M. Samayoa, Kathleen L. O'Connor, Andrew N. Lane, Ren Xu

Markey Cancer Center Faculty Publications

Collagen prolyl 4-hydroxylase (P4H) expression and collagen hydroxylation in cancer cells are necessary for breast cancer progression. Here, we show that P4H alpha 1 subunit (P4HA1) protein expression is induced in triple-negative breast cancer (TNBC) and HER2 positive breast cancer. By modulating alpha ketoglutarate (α-KG) and succinate levels P4HA1 expression reduces proline hydroxylation on hypoxia-inducible factor (HIF) 1α, enhancing its stability in cancer cells. Activation of the P4HA/HIF-1 axis enhances cancer cell stemness, accompanied by decreased oxidative phosphorylation and reactive oxygen species (ROS) levels. Inhibition of P4HA1 sensitizes TNBC to the chemotherapeutic agent docetaxel and doxorubicin in xenografts and patient-derived …


Metabolic Reprogramming Of Murine Cardiomyocytes During Autophagy Requires The Extracellular Nutrient Sensor Decorin., Maria A. Gubbiotti, Erin L. Seifert, Ulrich Rodeck, Jan B. Hoek, Renato V. Iozzo Oct 2018

Metabolic Reprogramming Of Murine Cardiomyocytes During Autophagy Requires The Extracellular Nutrient Sensor Decorin., Maria A. Gubbiotti, Erin L. Seifert, Ulrich Rodeck, Jan B. Hoek, Renato V. Iozzo

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The extracellular matrix is a master regulator of tissue homeostasis in health and disease. Here we examined how the small, leucine-rich, extracellular matrix proteoglycan decorin regulates cardiomyocyte metabolism during fasting in vivo. First, we validated in Dcn-/- mice that decorin plays an essential role in autophagy induced by fasting. High-Throughput metabolomics analyses of cardiac tissue in Dcn-/- mice subjected to fasting revealed striking differences in the hexosamine biosynthetic pathway resulting in aberrant cardiac O-β-N-Acetylglycosylation as compared with WT mice. Functionally, Dcn-/- mice maintained cardiac function at a level comparable with nonfasted animals whereas fasted WT mice showed …


The Santa Clara, 2018-10-25, Santa Clara University Oct 2018

The Santa Clara, 2018-10-25, Santa Clara University

The Santa Clara

No abstract provided.


The Wilbarger Protocol, Brittany Hatlestad Oct 2018

The Wilbarger Protocol, Brittany Hatlestad

Biology: Student Scholarship & Creative Works

Sensory processing disorder (SPD) is ever-increasing in children with and without disabilities. The prevalence of such a diagnosis has given rise to many different therapeutic practices. The most prescriptive, the Wilbarger protocol, will be the topic of this technique and literature review with discussions of what sensory problems are, the Wilbarger protocol, the deep pressure and proprioceptive portion of the protocol, oral tactile techniques, mechanisms of the protocol, the limitations, other options for treatment, and will conclude by looking to future research.