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2018

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Articles 14611 - 14640 of 15422

Full-Text Articles in Medicine and Health Sciences

Fracture Resistance Of Endodontically Treated Premolars With Deep Cervical Lesion Restored With And Without Post In Different Restorations, Phrohphrim Suebsawadphatthana Jan 2018

Fracture Resistance Of Endodontically Treated Premolars With Deep Cervical Lesion Restored With And Without Post In Different Restorations, Phrohphrim Suebsawadphatthana

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: The purpose of this study was to evaluate the effects of fiber posts and different restorations on the fracture resistance of endodontically treated maxillary premolars with cervical cavities. Methods: In forty extracted human first maxillary premolars, cervical cavities were prepared simulating cervical lesions and randomly divided into four groups (n=10): COM-NP, endodontically treated teeth (ETT) restored with resin composite without fiber posts; ON-NP, ETT restored with CAD/CAM ceramic onlays without fiber posts; COM-P, ETT restored with resin composite and fiber posts; and CR-P, ETT restored with CAD/CAM ceramic crowns and fiber posts. After the fiber posts and restorations had …

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Comparison Of Microtensile Bond Strength Of Universal Adhesives Utilizing Various Application Methods: An In Vitro Study, Suthatta Jeansuwannagorn Jan 2018

Comparison Of Microtensile Bond Strength Of Universal Adhesives Utilizing Various Application Methods: An In Vitro Study, Suthatta Jeansuwannagorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Purpose: To investigate microtensile bond strength (μTBS) of a conventional three-step etch and rinse, and universal adhesive systems with etch and rinse mode utilizing various application methods at 24 hour and after 6 month water-­storage. Material and methods: Seventy-­two extracted human third molars were cut to expose a flat dentin surface. Optibond FL (OFL; Kerr, USA), Single Bond Universal (SU; 3M ESPE, USA), Clearfil Universal Bond Quick (CU; Kuraray Noritake Dental Inc., Japan), G-­Premio BOND (GP; GC Corporation, Japan), Prime&Bond Universal (PB; Dentsply, Germany) were used in etch and rinse mode following the manufacturers' instruction and double application method. Subsequently, …

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Relationship Between Maxillary Anterior Alveolar Arch Form And Tooth Root Axis In Class I Occlusion: A Cone Beam Computed Tomography Study, Suweera Petaibunlue Jan 2018

Relationship Between Maxillary Anterior Alveolar Arch Form And Tooth Root Axis In Class I Occlusion: A Cone Beam Computed Tomography Study, Suweera Petaibunlue

Chulalongkorn University Theses and Dissertations (Chula ETD)

Purpose: This study determined the relationships of the angulation between tooth root axis and alveolar bone axis to the anterior alveolar (AA) arch forms and the sagittal root position (SRP) classification in anterior esthetic region using cone-beam computed tomography (CBCT) images.
Materials and Methods: CBCT images which met the inclusion and exclusion criteria were classified according to a novel classification of AA arch forms (Bulyalert 2018) and a SRP classification (Kan 2011). Then, the angulations of the root axis and the alveolar bone axis were measured using the mid-sagittal CBCT images of each tooth. The relationship of the angulations in …

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Effect Of Bitter Gourd Extracts On The Mutagenicity Of 1-Aminopyrene Reacted With Nitrite Using Ames Test, Korkiat Panpasuk Jan 2018

Effect Of Bitter Gourd Extracts On The Mutagenicity Of 1-Aminopyrene Reacted With Nitrite Using Ames Test, Korkiat Panpasuk

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study was conducted to investigate the mutagenic activity of raw and cooked bitter gourd (Momordica charantia) including raw fruit extract (RW), blanching water (BW), hot water extract from blanched fruit (HB), stir-fried fruit extract (SF), and stir-fried fruit (pre-squeezed with salt) extract (SS). In addition, the effects of extracts in modifying the mutagenic activity of mutagen freshly prepared by the reaction between 1-aminopyrene and sodium nitrite and the effects when adding each extract at the beginning of the same reaction using Ames test on Salmonella typhimurium strains TA98 and TA100 without enzymatic activation were also determined. The data for …

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Antioxidant And Antimutagenic Activity Of Extracts From Pericarp And Seed Of Zanthoxylum Limonella Alston, Patamawan Wipoosanapan Jan 2018

Antioxidant And Antimutagenic Activity Of Extracts From Pericarp And Seed Of Zanthoxylum Limonella Alston, Patamawan Wipoosanapan

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study was conducted to investigate the antioxidant and antimutagenic activity of Zanthoxylum limonella seed extract and that of Z. limonella pericarp extract. The total phenolic contents and antioxidant activity assay including DPPH assay and FRAP assay were performed. The results showed that the antioxidant activity of pericarp extract was higher than that of the seed extract. The direct mutagenicity assay was determined, with and without nitrite treatment using the Ames test towards Salmonella typhimurium strains TA98 and TA100. The mutagenic modification assay was performed by measuring the interfering effect of the pericarp extract and the seed extract on the …

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Preparation And Antimicrobial Activity Of Caprylic Acid Emulsion For Food Coating, Raweewan Bunyovimonnat Jan 2018

Preparation And Antimicrobial Activity Of Caprylic Acid Emulsion For Food Coating, Raweewan Bunyovimonnat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Antimicrobial food coating is the interesting method for food preservation, especially in fruits and vegetables. Previous studies have been reported that the caprylic acid had the antimicrobial activity against a variety of microorganisms. However, little research has been conducted on the use of caprylic acid in the form of food coatings. Therefore, this study aims to determine the optimum conditions for the caprylic acid emulsion preparation and to evaluate the antimicrobial activity of the emulsion, including the effect of food coatings with caprylic acid emulsion on physical properties and microbial growth inhibition. Emulsions containing 4% w/v caprylic acid (oil) and …

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Carbohydrate Content Of The Medications For Epileptic Children Treated With Ketogenic Diet At King Chulalongkorn Memorial Hospital, Thanarat Sawangrit Jan 2018

Carbohydrate Content Of The Medications For Epileptic Children Treated With Ketogenic Diet At King Chulalongkorn Memorial Hospital, Thanarat Sawangrit

Chulalongkorn University Theses and Dissertations (Chula ETD)

The purposes of this study were to establish a database of the carbohydrate content of medications and investigate carbohydrate content of medications in epileptic children treated with ketogenic diet (KD) at King Chulalongkorn Memorial Hospital. One hundred sixty-nine KD order forms in 3 events (KD initiation, follow-up visit, and hospital re-admission) for epileptic children whose aged younger than 18 years old during 2009-2017 were selected. Clinical and nutritional data were obtained from medical records and KD order forms from the pediatric nutrition unit. The study showed that oral liquid dosage forms had the highest carbohydrate content in the formulations as …

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Validity And Reliability Of Automatic Range Of Motion Measurement Using The Elbow Joint Photograph, Chris Charoenlap Jan 2018

Validity And Reliability Of Automatic Range Of Motion Measurement Using The Elbow Joint Photograph, Chris Charoenlap

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Photographic-based arc of motion measurement methods required human assessors and its accuracy is depend on observer experience. Objectives: Current research proposed method of using digital image processing technique (DIPT) for measuring elbow range of motion. Methods: Participants were enrolled from students and staffs in the university. Fluoroscopic images of both elbows were taken in flexion and extension positions. Two physiotherapists performed goniometer, inclinometer and smartphone gyroscope range of motion (ROM) measurement on bilateral elbows. Photographer took elbow images in fully extension and fully flexion three times for each position with 8-megapixel smartphone camera. The extension and flexion angles were …

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Prescription Of Anti-Osteoporosis Medication Among Orthopedic Surgeon (Pam-Os Study) In Osteoporotic Hip Fracture, Piyabuth Kittithamvongs Jan 2018

Prescription Of Anti-Osteoporosis Medication Among Orthopedic Surgeon (Pam-Os Study) In Osteoporotic Hip Fracture, Piyabuth Kittithamvongs

Chulalongkorn University Theses and Dissertations (Chula ETD)

Summary: As a medication for preventing osteoporotic fracture is recommended but scarcely prescribed, this study surveyed Thai orthopedic surgeons to explore key determinants of their prescription practices. In addition to a set of well-known determinants, the patient's health insurance status could also influence the prescription practice.Purpose: Although many guidelines suggest using anti-osteoporosis medications in patients who suffered from fragility hip fractures, low rate of prescription was encountered all over the world. In this study, we aimed to explore potential determinants affecting the prescription of anti-osteoporosis medications by orthopedic surgeons.Materials and methods:Online questionnaire survey was conducted among randomly selected orthopedic surgeons …

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The Validity And Reliability Of The Patient Health Questionnaire 9 In Screening Poststroke Depression, Piyapat Dajpratham Jan 2018

The Validity And Reliability Of The Patient Health Questionnaire 9 In Screening Poststroke Depression, Piyapat Dajpratham

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Poststroke depression occurred about 30% during the first five years after stroke. Timely diagnosis and management could facilitate motor recovery and improve independence. The Patient Health Questionnaire 9 (PHQ-9) is one of the best screening tools for poststroke depression. Since specific screening tool has not yet presented in Thailand, the validity and reliability of the PHQ-9 in stroke patients is clinically essential. Objectives: To study the criterion validity and reliability of the PHQ-9 (Thai version) in screening poststroke depression by comparing to the psychiatric interview as the gold standard. Material and Methods: First ever stroke patients age 45 years …

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Significant Coronary Artery Stenosis Assessment: Diagnostic Accuracy Of Quantitative 4d-Mspect Stress Radionuclide Myocardial Perfusion Imaging, Tarit Taerakul Jan 2018

Significant Coronary Artery Stenosis Assessment: Diagnostic Accuracy Of Quantitative 4d-Mspect Stress Radionuclide Myocardial Perfusion Imaging, Tarit Taerakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

OBJECTIVES: The objective of this study was to evaluate the effectiveness of quantitative assessment of radionuclide myocardial perfusion imaging in indicating significant coronary artery stenosis. METHODS: Seven hundred and twenty patients with suspicion of coronary artery disease were retrospectively identified. All of them had undergone cardiac catheterization within the 6-month period after having one-day pharmacologic stress radionuclide myocardial perfusion scan. Important parameters were analyzed including myocardial perfusion, wall motion, wall thickening severity scores of 3 coronary artery territories and left ventricular ejection fraction values. These parameters were subsequently compared with the results of gold standard cardiac catheterization. RESULTS: Binary logistic …

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System Dynamics Analysis Of Sugar-Sweetened Beverage Taxing Effect On Sugar Consumption, Dental Health Service Utilization And Oral Health For Thai Adults And Elderly, Nipaporn Urwannachotima Jan 2018

System Dynamics Analysis Of Sugar-Sweetened Beverage Taxing Effect On Sugar Consumption, Dental Health Service Utilization And Oral Health For Thai Adults And Elderly, Nipaporn Urwannachotima

Chulalongkorn University Theses and Dissertations (Chula ETD)

Dental caries is a major oral health problem, particularly among developing countries. Almost half of Thai adults and elderly have at least one untreated dental caries. Dental caries can result in debilitating pain that affects work productivity and even the performance of daily activities. The objectives of this study are to develop system dynamics model addressing the relationship of dental caries, sugar consumption and dental health service utilization of Thai population aged 15 and older; and to estimate the changes of dental caries prevalence when the sugar-sweetened beverage tax is implemented. A multi-sector system dynamics model was developed to consolidate …

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Steady-State Determination Of Continuous Powder Mixing By Near Infrared Spectroscopy As Process Analytical Technology, Katesaraporn Wongves Jan 2018

Steady-State Determination Of Continuous Powder Mixing By Near Infrared Spectroscopy As Process Analytical Technology, Katesaraporn Wongves

Chulalongkorn University Theses and Dissertations (Chula ETD)

Powder mixing is one of an important unit operation in pharmaceutical manufacturing of solid dosage forms. Continuous mixing was developed as an alternative method to reduce disadvantages of traditional batch mixing processes. This process was originally developed using horizontal cylindrical mixer equipped with Process Analytical Technology (PAT) tools for real-time monitoring. In the present study, a vertical cylindrical mixer was developed and evaluated. Near Infrared (NIR) spectra obtained by monitoring the mixing process were pretreated with Multiplicative Scatter Correction (MSC), second derivative treatment and Norris-William smoothing in the 6800 - 8700 cm-1 range before a calibration model using PLS was …

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Preparation And Stabilization Of Saccharide Fiber Produced By Centrifugal Spinning, Pattama Donghuntong Jan 2018

Preparation And Stabilization Of Saccharide Fiber Produced By Centrifugal Spinning, Pattama Donghuntong

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objectives of this study were to prepare saccharide fiber via centrifugal spinning and further investigate its stability under stress condition. Different saccharides were chosen and spun via centrifugal force to form thread like matter. The results indicated that sucrose (SC) and trehalose (TH) could be fabricated as fiber whereas other saccharides were not able to form. The formation of fiber mainly involved with glass transition temperature (Tg), molten ability including stability of saccharide after melting. High Tg saccharides were a good candidate on fiber preparation. Homogeneous melting with appreciable stability was another factor affecting on fiber preparation. Decomposing after …

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B-Cell Activating Factor As An Immunological Marker Of Disease Outcome And Treatment Response In Patients With Chronic Hepatitis B Virus Infection, Apichaya Khlaiphuengsin Jan 2018

B-Cell Activating Factor As An Immunological Marker Of Disease Outcome And Treatment Response In Patients With Chronic Hepatitis B Virus Infection, Apichaya Khlaiphuengsin

Chulalongkorn University Theses and Dissertations (Chula ETD)

B-cell activating factor (BAFF), an important cytokine for B lymphocyte activation that implicated in the pathogenesis and disease progression chronic hepatitis B (CHB) patients. This study aimed at evaluating clinical correlation and prognostic role of plasma BAFF, BAFF receptor and related polymorphisms in patients with CHB undergoing pegylated interferon (peg-IFN) treatment and HBV-related hepatocellular carcinoma (HCC). This study shown that BAFF levels were elevated during treatment but decreased to pre-treatment levels after peg-IFN cessation in HBeAg-positive CHB patients. Patients with HCC had significantly higher BAFF levels compared with the non-HCC group and healthy controls. Moreover, the frequency of rs9514828 CT+TT …

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Dosimetric Comparison Between Using Daily Cone Beam Ct And Planning Ct In Volumetric Modulated Arc Therapy Technique For Prostate Cancer Therapy, Julaluck Chanayota Jan 2018

Dosimetric Comparison Between Using Daily Cone Beam Ct And Planning Ct In Volumetric Modulated Arc Therapy Technique For Prostate Cancer Therapy, Julaluck Chanayota

Chulalongkorn University Theses and Dissertations (Chula ETD)

The variations of shape and size of organs inside, especially bladder and rectum, in prostate cancer patient are mainly factors of external beam radiation therapy that may impact to disease control and normal tissue toxicity. The purpose of this study was to investigate the dosimetric comparison between using daily CBCT and planning CT in Volumetric modulated arc therapy (VMAT) technique for prostate cancer therapy. The HU and electron density between CBCT and planning CT were verified by using Catphan® 600 phantom. Treatment planning system was verified by dose distribution comparison between plans on CBCT and planning CT images of Anthropomorphic …

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The Measurement Of Transverse Relaxation Time (T2) Using Histogram From Roi Setting In Muscle Activity Study At 1.5 Tesla Mri, Kannikar Kanyakham Jan 2018

The Measurement Of Transverse Relaxation Time (T2) Using Histogram From Roi Setting In Muscle Activity Study At 1.5 Tesla Mri, Kannikar Kanyakham

Chulalongkorn University Theses and Dissertations (Chula ETD)

Muscle functional MRI (mfMRI) is the method to evaluate the muscle activity before and immediately after the muscle exercise by the magnetic resonance images. Exercise of skeletal muscles enhances image contrast in T2-weighted magnetic resonance (MR) images. In previous studies, the exercised physiology used multiple-spin-echo (MSE) sequences for calculating transverse relaxation time (T2) with several small regions of interest (ROI) within the target tissue. Such a method may not represent all properties of the target tissue. The purpose of this study is to measure T2 in rest and exercise muscle at 1.5 Tesla MRI using average mode values in histogram …

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Eye Lens Dose Measurement In Patients During Brain Arteriovenous Malformation Interventional Neuro-Radiology Procedure, Rasalin Thana Jan 2018

Eye Lens Dose Measurement In Patients During Brain Arteriovenous Malformation Interventional Neuro-Radiology Procedure, Rasalin Thana

Chulalongkorn University Theses and Dissertations (Chula ETD)

Brain arteriovenous malformation (AVM) interventional neuroradiology (INR) is a complicated procedure which the patients may receive the high radiation dose exceeding the threshold level for detectable eye lens opacities and cataracts (ICRP, 2012). The objectives of this study are to measure the patient eye lens dose using optically stimulated luminescence dosimeter, OSLD, during AVM INR procedure at Interventional Radiology Unit, Department of Radiology, King Chulalongkorn Memorial Hospital (KCMH) and to study the factors affecting the patient eye lens dose. NanoDot OSLDs were attached on the transparent radiation thin film eyewear and closed to the patient eyelids during the procedure. Philips …

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Investigation Of Parameters For Metallic Artifact Reduction Using 3-D Space In Mr Lumbar Spine At 1.5 Tesla: A Phantom Study, Thanatchaya Lowong Jan 2018

Investigation Of Parameters For Metallic Artifact Reduction Using 3-D Space In Mr Lumbar Spine At 1.5 Tesla: A Phantom Study, Thanatchaya Lowong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Metallic artifact reduction in magnetic resonance imaging (MRI) has increasingly interested especially metal implant postoperative in lumbar spine. Recently, the new pulse sequence based on true isotropic 3D voxel with high resolution namely Sampling Perfection with Application Optimized Contrasts using Different Flip Angle Evolutions (SPACE) was introduced. This study aimed to determine the appropriate 3D T2-SPACE parameters for reducing the metallic artifact in MR lumbar spine 1.5 Tesla. Cylindrical phantom filled with 3.3 g/L, NiCl2-6H2O and 2.4 g/L NaCl solution, and two commonly used metal implants (stainless steel and titanium) for lumbar spine were acquired using turbo spin echo (TSE) …

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The Pharmacokinetic Model Of 18f-Fdopa In Pet Brain Imaging For Early Parkinson’S Disease, Wirunpatch Buratachwatanasiri Jan 2018

The Pharmacokinetic Model Of 18f-Fdopa In Pet Brain Imaging For Early Parkinson’S Disease, Wirunpatch Buratachwatanasiri

Chulalongkorn University Theses and Dissertations (Chula ETD)

Parkinson’s disease (PD) symptom usually appears when over half of all dopaminergic neurons have died. Early detection and treatment approach are; therefore, very important. The 18F-FDOPA PET scan is extensively examined to differentiate the normal and pathological dopamine metabolism in the human brain. The purpose of this study was to investigate the transfer rate constants of 18F-FDOPA in PET brain imaging based on compartmental model in early Parkinson’s disease. The retrospective data from five early PD patients who underwent 18F-FDOPA PET brain scan at King Chulalongkorn Memorial Hospital (KCMH) were collected. After 18F-FDOPA was administered intravenously, PET images were acquired …

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Characterization Of Leptospiral Extracellular Vesicles In Stress Conditions, Eakalak Phanchamnan Jan 2018

Characterization Of Leptospiral Extracellular Vesicles In Stress Conditions, Eakalak Phanchamnan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Pathogenic Leptospira spp. is a causative agent of leptospirosis, a worldwide zoonosis with public health concern especially in the urban slum of metropolis and rural areas in tropical and subtropical countries. The pathogenesis of leptospirosis remains elusive. Extracellular vesicles (ECVs), which pinch off from the bacterial membranes, simultaneously harbor multiple active molecules that may serve as a secretion system, communication tool, and vaccine candidates. Recently, chemically induced leptospiral ECVs were studied and used as vaccine candidates. However, the naturally produced leptospiral ECVs has not been characterized. This study aimed to identify proteins in leptospiral ECVs produced under stress conditions including …

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Mechanisms Of Ceftriaxone Resistance In Neisseria Gonorrhoeae Isolated From Thai Patients, Naris Kueakulpattana Jan 2018

Mechanisms Of Ceftriaxone Resistance In Neisseria Gonorrhoeae Isolated From Thai Patients, Naris Kueakulpattana

Chulalongkorn University Theses and Dissertations (Chula ETD)

N. gonorrhoeae is the causative agent of gonorrhea, which is one of the most important sexually transmitted disease. The multidrug resistance in N. gonorrhoeae has been increasingly reported worldwide. The objectives of this study were to investigate the prevalence and the mechanisms of ceftriaxone resistance in N. gonorrhoeae Thai isolates, and to investigate the synergistic activities of antibiotic combinations against N. gonorrhoeae isolates with reduced susceptibility or resistance to ceftriaxone. A total of 134 N. gonorrhoeae isolates were included in this study. The resistance rates of ciprofloxacin, tetracycline, penicillin G, gentamicin, azithromycin, ertapenem, fosfomycin, cefixime, and ceftriaxone were 90.30%, 82.09%, …

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The Role Of Histone Methylation Of H3k4 In Polarization Of Macrophages Stimulated By Immune Complex And Lipopolysaccharide And Its Therapeutic Potential In Sepsis, Vichaya Ruenjaiman Jan 2018

The Role Of Histone Methylation Of H3k4 In Polarization Of Macrophages Stimulated By Immune Complex And Lipopolysaccharide And Its Therapeutic Potential In Sepsis, Vichaya Ruenjaiman

Chulalongkorn University Theses and Dissertations (Chula ETD)

Macrophage plasticity is a process that allows macrophages to switch between two opposing phenotypes based on differential stimuli. Functional plasticity of macrophages contributes to disease pathogenesis such as cancer, metabolic diseases, autoimmune diseases and systemic infections. Epigenetics plays an important role in regulating this process. Macrophages stimulated with lipopolysaccharide (LPS) (M(LPS)) produce high level of pro-inflammatory cytokines such as IL-12, TNFα and IL-6 and low level of anti-inflammatory cytokine IL-10, while macrophages stimulated with LPS in the presence of immune complex (IC) (M(IC)) produce high level of IL-10 and low level of IL-12. In this study, we investigated the plasticity …

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Comprehensive Proteomics Identification Of Ifn-Λ3-Regulated Antiviral Proteins In Hbv-Transfected Cells, Jiradej Makjaroen Jan 2018

Comprehensive Proteomics Identification Of Ifn-Λ3-Regulated Antiviral Proteins In Hbv-Transfected Cells, Jiradej Makjaroen

Chulalongkorn University Theses and Dissertations (Chula ETD)

Interferon (IFN)-λ is a relatively unexplored, yet promising anti-viral agent. IFN-λ has recently been tested in clinical trials of chronic hepatitis B, with the advantage that side effects may be limited compared with IFN-α, as IFN-λ receptors are found only in epithelial cells. To date, IFN-λ downstream signaling pathway remains largely unelucidated, particularly via proteomics methods. Here, we report that IFN-λ3 inhibits HBV replication in HepG2.2.15 cells, reducing levels of both HBV transcripts and intracellular HBV DNA. Quantitative proteomic analysis of HBV-transfected cells was performed following 24-hour IFN-λ3 treatment, with parallel IFN-α2a and PBS treatments for comparison using a dimethyl …

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The Severity Of Cryptococcus Neoformans Infection In Fc Gamma Receptor Iib Deficient Mice, Saowapha Surawut Jan 2018

The Severity Of Cryptococcus Neoformans Infection In Fc Gamma Receptor Iib Deficient Mice, Saowapha Surawut

Chulalongkorn University Theses and Dissertations (Chula ETD)

Cryptococcus neoformans, an encapsulated yeast commonly infecting the central nervous system, refers to as cryptococcal meningitis or cryptococcosis is commonly found in Thailand. C. neoformans is able to replicate, survive inside host macrophages, evade from the cells and use macrophages as a vehicle to disseminate to the target organs, a mechanism known as Trojan horse. Therefore, the containment of C. neoformans in phagocytic cell is important for host protective immunity. Cryptococcosis is common in immunocompromised host such as in patients with low CD4+ T helper cells in HIV-infection and patients taking immunosuppressive drugs. However, the incidence of cryptococcosis in healthy …

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Hsv-1 Induces Filopodia Formation In Activated T Lymphocytes, Thanayod Sasivimolrattana Jan 2018

Hsv-1 Induces Filopodia Formation In Activated T Lymphocytes, Thanayod Sasivimolrattana

Chulalongkorn University Theses and Dissertations (Chula ETD)

Herpes simplex virus type 1 (HSV-1) is a widespread pathogen, which has diverse clinical manifestations from mild localized infection to severe systemic infection. The tissue tropism of HSV-1 is mainly epithelial and mucosal cells. However, it can also multiply in T lymphocytes suggesting a cause of viremia. In this study, CD3+CD4-CD8- Jurkat T lymphocytes were used. Under activation, up-regulation of CD69 molecules on cell surface was observed. Increase yield of HSV-1 production in activated T lymphocytes was demonstrated. In addition, most of HSV-1 virion progenies from infected T lymphocytes were released extracellularly, suggesting the cause of dissemination. The mechanism which …

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Detection Of Flagellated Protozoa Belonging To The Trypanosomatidae Family In Sand Flies Collected From Songkhla Province, Southern Thailand, Komson Chinwirunsirisup Jan 2018

Detection Of Flagellated Protozoa Belonging To The Trypanosomatidae Family In Sand Flies Collected From Songkhla Province, Southern Thailand, Komson Chinwirunsirisup

Chulalongkorn University Theses and Dissertations (Chula ETD)

Autochthonous leishmaniasis cases in Thailand are increasing dramatically, the disease is caused by two major of Leishmania species; L. orientalis and L. martiniquensis. Leishmaniasis is transmitted to the vertebrate hosts through the bite of the infected female sand fly. Moreover, other trypanosomatid protozoa have also been reported in this insect vector. In 2016, Trypanosoma sp. has been detected in sand fly from Songkhla province, where the leishmaniasis case has been reported. The aims of this study are to investigate the potential vectors of trypanosomatids in this area using morphological and molecular identification based on the Cytb gene. The parasites were …

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Effect Of Chronic Paracetamol Treatment On The Alteration Of Learning And Memory In Rats, Laddawan Lalert Jan 2018

Effect Of Chronic Paracetamol Treatment On The Alteration Of Learning And Memory In Rats, Laddawan Lalert

Chulalongkorn University Theses and Dissertations (Chula ETD)

Paracetamol (acetaminophen: APAP) is widely used for treatment of pain and fever. Although APAP is well accepted as a safe drug, several studies have recently demonstrated that treatment with this drug can lead to an alteration of several neurobehaviors. However, the exact impact of the APAP treatment and the mechanisms underlying those effects are still largely unknown. The present study aimed to investigate the effect of APAP treatment on the alteration of learning and memory and the possible mechanism underlying deleterious effects induced by APAP treatment. In this study, APAP at the dose of 200 mg/kg bw was orally fed …

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Antilithogenic Efficacy Of An Innovative Beverage Hydrozitla: In Vitro And In Vivo Studies, Nalinthip Lordumrongkiat Jan 2018

Antilithogenic Efficacy Of An Innovative Beverage Hydrozitla: In Vitro And In Vivo Studies, Nalinthip Lordumrongkiat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Urinary stone disease is a common urologic disease worldwide, and it is highly recurrent. Calcium oxalate (CaOx) stone is the most common type of urinary stones. The main causes of urinary stone formation include inadequate water intake, low urinary citrate excretion and increased oxidative stress. At the present day, potassium citrate is a drug of choice for preventing stone formation and recurrence. We developed a new regimen for preventing urinary stone formation, called HydroZitLa. It was in a form of concentrate in pouch. For consumption, water was added up to 500 mL and shake well before drink. Therefore, drinking of …

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The Anatomic Variation Of The Superior Peroneal Retinaculum And Inferior Peroneal Retinaculum And Its Association To Peroneal Tendon Disorders, Pimpimol Dangintawat Jan 2018

The Anatomic Variation Of The Superior Peroneal Retinaculum And Inferior Peroneal Retinaculum And Its Association To Peroneal Tendon Disorders, Pimpimol Dangintawat

Chulalongkorn University Theses and Dissertations (Chula ETD)

The precise information for SPR and IPR reattachment is essential for the prevention of recurrent symptom of peroneal tendon dislocation/subluxation. Therefore, this study was conducted to investigate the characteristics, the attachments and morphometric parameters of the SPR, IPR and the prevalence, origin and insertion of the accessory peroneal muscles, peroneal tendon tear, and related structures. The association between the peroneal tendon tear and those structures were evaluated. One hundred and nine embalmed cadaveric legs were dissected in prone position. The SPR was variable in its length, width, angle, thickness, and insertion patterns. Based on the characteristics and insertion pattern, it …

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