Spoon Nails: Still Seen In Today's World, Bushra Moiz

Department of Pathology and Laboratory Medicine

Koilonychia is a nail abnormality characterized by thin, brittle, and spoon-shaped nails. It is frequently observed in chronic iron deficiency secondary to malnutrition, chronic blood loss, or malabsorption. It may also be idiopathic or related to occupation and rare systemic disorders. Presence of koilonychia should prompt investigations for iron deficiency.

Neurological Involvement Associated With Plasmodium Vivax Malaria From Pakistan, Yousaf Abdullah Khan, Usman Hameed Mian, Najia Karim Ghanchi, Ali Bin Sarwar Zubairi, Mohammad Asim Beg

Department of Pathology and Laboratory Medicine

Plasmodium vivax is the most common specie causing malaria outside Africa with approximately 13.8 million reported cases worldwide. We report case of P. vivax infection with cerebral involvement. A nine year old boy presented with high grade fever accompanied by projectile vomiting and abnormal behavior later he developed seizures, shock, and unconsciousness. P. vivax monoinfection was diagnosed based on peripheral smears and PCR. After antimalarial therapy, patient made full recovery. Current case highlights increasing trend of cerebral complications caused by P. vivax.

High Heterotrophic Counts In Potable Water And Antimicrobial Resistance Among Indicator Organisms In Two Peri-Urban Communities Of Karachi, Pakistan, Sadia Shakoor, Imran Ahmed, Saima Mukhtiar, Israr Ahmed, Farzeen Hirani, Shazia Sultana, Rumina Hasan

Department of Pathology and Laboratory Medicine

Objective: Fecal contamination of potable water leads to unsafe water supply. Although many urban areas of large metropolitan cities receive safe water, peri-urban areas are often not monitored by public health authorities and water supply and quality remain unknown. We assessed microbiological quality and rates of antimicrobial resistance in viable indicator bacteria in two peri-urban communities of Karachi, Pakistan. Water samples were collected over 5 months (October 2015 to February 2016) from these peri-urban communities and samples were processed for microbiological quality as per Standing Committee of Analysts, United Kingdom and World Health Organization guidelines and criteria for drinking water. …

Fourier Transform Infrared Spectroscopy For Analysis Of Kidney Stones, Aysha Habib Khan, Sheharbano Imran, Jamsheer Talati, Lena Jafri

Department of Pathology and Laboratory Medicine

Purpose:
To compare the results of a chemical method of kidney stone analysis with the results of Fourier transform infrared (FT-IR) spectroscopy.
Materials and Methods:
Kidney stones collected between June and October 2015 were simultaneously analyzed by chemical and FT-IR methods.
Results:
Kidney stones (n=449) were collected from patients from 1 to 81 years old. Most stones were from adults, with only 11.5% from children (aged 3-16 years) and 1.5% from children aged adults, the calcium oxalate stone type, calcium oxalate monohydrate (COM, n=224), was the most common crystal, followed by uric acid and calcium oxalate dihydrate (COD, n=83). In …

Development Of An Integrated Service Model To Achieve Personal Health Libraries For Consumers, Nathan Gauss

Dissertations, Master's Theses and Master's Reports

This concept paper establishes the framework for additional research regarding how medical records are stored and shared. Health Information Technology is rapidly developing, and one large barrier to true interoperability is data silos. This integrated service model proposes using Health Record Banks (HRB) to store and share data, while using open source applications to limit costs and create opportunities for the consumer to be at the center of their own medical records. This includes the authorization phase, in which patients will be able to seamlessly allow access to their records for clinicians they choose. This conceptual framework includes using eXist …

Workplace Standing Desks And Arterial Stiffness, Ian Greenlund

Dissertations, Master's Theses and Master's Reports

Many jobs in today’s society require sitting at a desk with little physical activity. Individuals who engage in ten hours of sedentary behavior per day double their CVD risk. Standing desks are thought to decrease sedentary time and improve cardiovascular health. Acute use of standing desks is shown to lower PWV. However, chronic effects remain unknown. Forty eight participants qualified as seated (19 females, 5 males: age 41 ± 2 years, BMI 25 ± 1 kg/m²) or standing (21 females, 3 males: age 45 ± 2 years, BMI 25 ± 1 kg/m²) groups based on habitual …

2018 Spring Newsletter, Morehead State University. Nursing Department.

Nursing Department Publications Archive

2018 Spring Newsletter of the Department of Nursing at Morehead State University.

2018-2019 Nursing Undergraduate Student Handbook, Morehead State University. Nursing Department.

Nursing Department Publications Archive

2018-2019 Undergraduate Student Handbook of the Department of Nursing at Morehead State University.

Timing Of Vessel Imaging For Suspected Large Vessel Occlusions Does Not Affect Groin Puncture Time In Transfer Patients With Stroke., John W. Liang, Laura Stein, Natalie Wilson, Johanna T. Fifi, Stanley Tuhrim, Mandip S. Dhamoon

Department of Neurology Faculty Papers

BACKGROUND: Access to endovascular therapy (ET) in cases of acute ischemic stroke may be limited, and rapid transfer of eligible patients to hospitals with endovascular capability is needed.

OBJECTIVE: To determine the optimal timing of diagnostic CT angiography to confirm large vessel occlusion (LVO).

METHODS: Of 57 emergency department transfers to Mount Sinai Hospital (MSH) for possible ET from January 2015 through March 2016, 39 (68%) underwent ET, among whom 22 (56%) had CT angiography before transfer and 17 (44%) had CT angiography on arrival. We compared mean outside hospital arrival to groin puncture (OTG) time between the two groups …

Evaluation Of Micro Leakage Of Root Canals Filled With Different Obturation Techniques: An In Vitro Study, Maham Muneeb Lone, Farhan Raza Khan

Section of Dental-Oral Maxillofacial Surgery

Background: Despite a plethora of studies done comparing different obturation techniques using gutta-percha, there is no consensus as to which obturation technique results in a 'better' sealing of root canal space. Aims of the study are to compare mean apical micro leakage in root canals of extracted teeth obturated with cold laterally compacted gutta-percha and thermoplasticised injectable gutta-percha using calcium hydroxide based sealer.
Methods: It was an in-vitro experimental study carried out using extracted teeth. After access cavity preparation and canal preparation in 70 teeth, they were randomly divided into 2 groups and filled with two different obturation …

Factors Affecting Treatment Duration - A Dilemma In Orthodontics, Saman Faruqui, Mubassar Fida, Attiya Shaikh

Section of Dental-Oral Maxillofacial Surgery

Background: One of the first concerns of new orthodontic patients, apart from the outcome, is the duration of treatment. A better understanding of orthodontic treatment duration as well as factors affecting the treatment duration is useful for efficient patient counselling and improved clinical practice. Hence, the objectives of this study are to compare the treatment durations of subjects with Class I and Class II division 1 (II/1) malocclusions, and to identify the factors affecting the treatment duration of these malocclusions.

Methods: This was a chart review conducted in the orthodontic department of the Aga Khan University Hospital, Karachi. …

Evaluation Of Micro Leakage Of Root Canals Filled With Different Obturation Techniques: An In Vitro Study, Maham Muneeb Lone, Farhan Raza Khan

Section of Dental-Oral Maxillofacial Surgery

Background: Despite a plethora of studies done comparing different obturation techniques using gutta-percha, there is no consensus as to which obturation technique results in a 'better' sealing of root canal space. Aims of the study are to compare mean apical micro leakage in root canals of extracted teeth obturated with cold laterally compacted gutta-percha and thermoplasticised injectable gutta-percha using calcium hydroxide based sealer.
Methods: It was an in-vitro experimental study carried out using extracted teeth. After access cavity preparation and canal preparation in 70 teeth, they were randomly divided into 2 groups and filled with two different obturation …

Pulmonary Alveolar Proteinosis- A Case Report, Renee M. Horner, Douglas S. Gardenhire, Ralph D. Zimmerman

Internet Journal of Allied Health Sciences and Practice

ABSTRACT

Background: Pulmonary Alveolar Proteinosis (PAP) is a rare pulmonary disorder caused by a congregation of excessive lipoproteinaceous material in the alveolar spaces due to impaired surfactant metabolism. The congregation of the protein in the alveolar space leads to difficulty in breathing, impaired pulmonary immunity, and susceptibility to both opportunistic and acquired pulmonary infections. Although Pulmonary Alveolar Proteinosis is rare, there are potential treatments. Whole-lung lavage is the most widely accepted therapy and course of treatment. An additional form of therapy, GM-CSF stimulating therapy, uses recombinant deoxyribonucleic acid (DNA) technology to increase white cell production.

Purpose: The purpose …

National Survey Of Lymphedema Therapists’ Dosing Of Complete Decongestive Therapy In Breast Cancer Survivors With Lymphedema, Katie M. Polo, Peter J. Rundquist, Nathaniel D. Krumdick, Gail L. Gamble

Internet Journal of Allied Health Sciences and Practice

Purpose: The purpose of this study was to identify dosing levels of complete decongestive therapy (CDT) with survivors with Breast Cancer-Related Lymphedema (BCRL) and describe factors related to how occupational therapists, occupational therapy assistants, physical therapists, and physical therapists assistants with advanced lymphedema training determine dosing.

Methods: An electronic survey was sent to 598 occupational therapists, occupational therapy assistants, physical therapists, and physical therapists assistants with training in lymphedema. Respondents completed questions regarding demographics, dosing practices, and factors related to dose determination in complete decongestive therapy of survivors with Breast Cancer-Related Lymphedema.

Results: 107 surveys were returned (18% response rate). …

Evaluation Of A Peer Group Model Of Supervision For The Allied Health Workforce In Queensland: A Descriptive Overview, Susan C. Pager, Pim Kuipers, Karen Bell, Fiona Hall

Internet Journal of Allied Health Sciences and Practice

Purpose: An evaluation of a large scale implementation of a peer group model of professional supervision was conducted to inform service planning and guide policy and practice. A descriptive overview of the findings is presented. Method: Allied health staff trained in peer group supervision were surveyed about their experience of the model, its challenges and benefits. Interviews were also conducted with senior managers. Results: Analysis of 248 responses indicated that 72% of trained staff had participated in peer group supervision, and that these peer groups had continued for an average of 17.2 months. The majority of groups adhered …

Reflective Approaches In Medical Education. Implications On Medical Imaging., Raja Farahhana Raja Azhar, Haji Mohamed Nadzri Mohd Yusoff, Zainul Ibrahim Zainuddin Dr.

Internet Journal of Allied Health Sciences and Practice

Abstract

Purpose: This paper reviewed literature regarding the utility and direction of reflective approaches in Medical imaging education.

Methods: The Scopus database was accessed. The word “Reflective” was used as the main search term to look for the relevant literature. The inclusion criteria used in this study comprised of those papers published in English between the years 2006 to 2016, indexed in Scopus database, and limited to those discussing the topic on reflective approaches in medical education. Published papers that have the main search terms in the articles’ title only were tabulated. The data were then filtered using …

Effect Of Experience Facilitating Problem-Based Learning (Pbl) On Physician Assistant Student Outcomes, Susan Hawkins, Anthony Goreczny, Nicole E. Brown

Internet Journal of Allied Health Sciences and Practice

Abstract

Purpose: The impact of prior problem-based learning (PBL) facilitation experience (measured by length of time facilitating) on student learning and student outcomes is unclear. The purpose of this study was to evaluate relationships of facilitator experience in problem-based learning on student outcomes. This study utilized both modified essay questions (MEQ) in the form of patient management assessments and multiple choice question (MCQ) assessments to evaluate different aspects of student acquisition and application of knowledge. Method: This study examined scores from six multiple choice question examinations and six patient management assessments (PMA), one each from six 5-week units …

Collaboration Or Collusion? The New Era Of Commercial Online Resources For Students In The Digital Age: An Opinion Piece, Cristian Lieneck, Salvador Esparza

Internet Journal of Allied Health Sciences and Practice

The purpose of this paper is to share online resources available to students at a global level, to include healthcare administration programs and any other course of study. While somewhat daunting in nature, this editorial offers faculty of healthcare administration (and other related programs of study) the opportunity to explore what course materials (of any format) may be posted to commercial external websites by current and/or previous students for ongoing collaboration among academic cohorts. Findings include an opportunity for students in any program, at any level, to post individual and/or copyrighted course materials on public, external websites, often with an …

Identifying Gaps In The Performance Of Pediatric Trainees Who Receive Marginal/Unsatisfactory Ratings, Su-Ting T. Li, Daniel J. Tancredi, Alan Schwartz, Ann Guillot, Ann Burke, R. Franklin Trimm, Susan Guralnick, John D. Mahan, Kimberly A. Gifford

University Faculty and Staff Publications

Purpose

To perform a derivation study to determine in which subcompetencies marginal/unsatisfactory pediatric residents had the greatest deficits compared with their satisfactorily performing peers and which subcompetencies best discriminated between marginal/unsatisfactory and satisfactorily performing residents.

Method

Multi-institutional cohort study of all 21 milestones (rated on four or five levels) reported to the Accreditation Council for Graduate Medical Education, and global marginal/unsatisfactory versus satisfactory performance reported to the American Board of Pediatrics. Data were gathered in 2013–2014. For each level of training (postgraduate year [PGY] 1, 2, and 3), mean differences between milestone levels of residents with marginal/unsatisfactory and satisfactory performance …

The Development Of The First School Of Nursing In The Seventh-Day Adventist Church, Maria Jankovic

Master's Theses

Problem

This study sought to follow the development of the School of Nursing within Seventh-day Adventist Church. This demanded the study of the School of Nursing within the United States.

Method

This study was historical in its method. Two key parts of this study are historical analysis of the contexts of the United States and Seventh-day Adventist Church in the time when Schools of Nursing of these two entities developed.

Conclusion

Historical context of the United States reveals that the main reasons for development of the School of Nursing in this country were advancement of medical science and technology along …

Veterans Court: Examining The Effectiveness Of Veteran-Specific Rehabilitation, Rochelle Sundeen Diconti

EWU Masters Thesis Collection

Due to the growing percentage of mental health illnesses related to combat trauma and traumatic brain injuries, the rates of incarceration, suicide, and substance use disorders are skyrocketing in the returning veteran population. The Veterans Court program directs veterans with certain criminal issues into a program designed to treat veterans in need, as opposed to incarcerating them. The purpose of this study is to conduct an initial examination of the effectiveness of this program by measuring four specific factors directly linked to veteran trauma and mental health. I included measures of problematic-anger, shame, thriving, and veteran-specific reintegration issues. Data was …

Cetuximab Plus Carboplatin And Paclitaxel With Or Without Bevacizumab Versus Carboplatin And Paclitaxel With Or Without Bevacizumab In Advanced Nsclc (Swog S0819): A Randomised, Phase 3 Study, Roy S. Herbst, Mary W. Redman, Edward S. Kim, Thomas J. Semrad, Lyudmila Bazhenova, Gregory Masters, Kurt Oettel, Perry Guaglianone, Christopher Reynolds, Anand Karnad, Susanne M. Arnold, Marileila Varella-Garcia, James Moon, Philip C. Mack, Charles D. Blanke, Fred R. Hirsch, Karen Kelly, David R. Gandara

Markey Cancer Center Faculty Publications

Background

EGFR antibodies have shown promise in patients with advanced non-small-cell lung cancer (NSCLC), particularly with squamous cell histology. We hypothesised that EGFR copy number by fluorescence in-situ hybridisation (FISH) can identify patients most likely to benefit from these drugs combined with chemotherapy and we aimed to explore the activity of cetuximab with chemotherapy in patients with advanced NSCLC who are EGFR FISH-positive.

Methods

We did this open-label, phase 3 study (SWOG S0819) at 277 sites in the USA and Mexico. We randomly assigned (1:1) eligible patients with treatment-naive stage IV NSCLC to receive paclitaxel (200 mg/m ²; every …

Nanoparticle Orientation To Control Rna Loading And Ligand Display On Extracellular Vesicles For Cancer Regression, Fengmei Pi, Daniel W. Binzel, Tae Jin Lee, Zhefeng Li, Meiyan Sun, Piotr G. Rychahou, Hui Li, Farzin Haque, Shaoying Wang, Carlo M. Croce, Bin Guo, B. Mark Evers, Peixuan Guo

Markey Cancer Center Faculty Publications

Nanotechnology offers many benefits, and here we report an advantage of applying RNA nanotechnology for directional control. The orientation of arrow-shaped RNA was altered to control ligand display on extracellular vesicle membranes for specific cell targeting, or to regulate intracellular trafficking of small interfering RNA (siRNA) or microRNA (miRNA). Placing membrane-anchoring cholesterol at the tail of the arrow results in display of RNA aptamer or folate on the outer surface of the extracellular vesicle. In contrast, placing the cholesterol at the arrowhead results in partial loading of RNA nanoparticles into the extracellular vesicles. Taking advantage of the RNA ligand for …

Biting The Hands That Feed “The Alligators”: A Case Study In Morbid Obesity Extremes, End-Of-Life Care, And Prohibitions On Harming And Accelerating The End Of Life, Michael J. Malinowski

Journal Articles

Obesity, recognized as a disease in the U.S. and at times as a terminal illness due to associated medical complications, is an American epidemic according to the Centers for Disease Control and Prevention (“CDC”), American Heart Association (“AHA”), and other authorities. More than one third of Americans (39.8% of adults and 18.5% of children) are medically obese. This article focuses on cases of “extreme morbid obesity” (“EMO”)—situations in which death is imminent without aggressive medical interventions, and bariatric surgery is the only treatment option with a realistic possibility of success. Bariatric surgeries themselves are very high risk for EMO patients. …

Assessment Of The Neuroprotective Efficacy Of Poly-Arginine-18 (R18) Peptides In A Pre-Clinical Model Of Perinatal Hypoxic-Ischaemic Encephalopathy (Hie), Adam Edwards

Theses

Hypoxic-ischaemic encephalopathy (HIE) is one of the leading causes of mortality and morbidity in infants, globally. This disorder eventuates following a reduction in oxygenated cerebral blood flow to the foetus in utero, leading to excitotoxic-mediated brain cell (e.g. neuron, glia and glial progenitor cell) death. Currently, there is no clinically appropriate neuroprotective treatment to reduce acute brain injury following HIE. Recent studies have demonstrated that poly-arginine and cationic arginine-rich peptides (CARPs; e.g. R18: R = arginine residues) exhibit potent neuroprotective properties in both in vitro and adult animal models of ischaemia, and therefore have the potential to be developed into …

Diagnosing Pulmonary Hypertension Due To Left Heart Disease Using Diastolic Echo Markers: The National Echo Database Of Australia (Neda) Ph-Lhd Predictive Formula, Kevin Chung

Theses

Aims: Pulmonary hypertension (PH) is commonly due to left heart disease caused by ischaemic heart disease, hypertension and valvular heart disease. It is under diagnosed and associated with a high mortality. PH diagnosed using echo requires a measurable tricuspid regurgitation velocity (TRV) to estimate the pulmonary artery systolic pressure (PH = PASP >40mmHg). However, up to 40% of studies have insufficient TRV to calculate a PASP. This can lead to significant delays in the diagnosis of pulmonary hypertension, increased morbidity and delays in the initiation of treatment.

This thesis seeks to determine the prevalence of PH and the diastolic echo …

Day-Level Associations Between Substance Use And Hiv Risk Behavior Among A Diverse Sample Of Transgender Women, Brett M. Millar, Devin English, Raymond L. Moody, H. Jonathon Rendina, Demetria Cain, Nadav Antebi-Gruszka, Joseph A. Carter, Jeffrey T. Parsons

Publications and Research

Purpose: Transgender women in the United States face elevated rates of HIV and of substance use. Studies measuring overall or aggregate levels of substance use have linked use to increased HIV transmission risk behavior (TRB). Although intensive longitudinal studies in other populations have found day-level links between substance use and TRB, no study has yet explored such links among transgender women. This study aimed to fill this gap in the literature.

Methods: Utilizing survey and 60-day timeline follow-back interview data from a sample of 214 transgender women in New York City, we tested whether day-level heavy drinking, marijuana use, and/or …

Regulation Of Prostaglandin D2 And Angiogenesis-Related Factors From Human Skin Mast Cells By Interleukin-6 And Resveratrol, Cody Cody Mchale

Theses and Dissertations

Mast cells are classically recognized as the effector cells of Immunoglobulin E (IgE)-mediated hypersensitivity reactions (i.e. allergic reactions). Mast cells also play an important role in the innate immune response to parasitic helminth infection. Allergic disease including allergic rhinitis, asthma, atopic dermatitis, and anaphylaxis, is a major health concern in the United States with greater than 60 million Americans suffering from allergy and asthma. In addition, mast cells have more recently been implicated in non-allergic disease including various human cancers, which will affect approximately 39.6% of U.S. men and women. Therefore, understanding the immunological and molecular mechanisms that regulate mast …

Family Planning Decisions After A Child’S Diagnosis Of Rett Syndrome: A Pilot Study, Erin E. Huggins

Theses and Dissertations

Rett syndrome (RTT) is a rare neurodevelopmental disorder that primarily affects females. In 99% of cases, RTT is believed to occur sporadically, or de novo. However, in rare cases, RTT can be passed down from parent to child through gonadal mosaicism or asymptomatic carrier mothers. It is known that having a child with an inherited genetic condition can lead to changes in family planning; however, little research has investigated this phenomenon in sporadic genetic conditions, such as RTT. This present study used a questionnaire to assess family planning decisions of parents of children with RTT. Forty-three percent of respondents reported …

Online Risks, Sexual Behaviors, And Mobile Technology Use In Early Adolescent Children: Parental Awareness, Protective Practices, And Mediation, Kendra Allison

Theses and Dissertations

Mobile technologies (e.g., smartphones and associated social media accessed through downloadable mobile applications) have changed the social landscape of adolescent communication. Intertwined with this communication are risks, many of which are sexual. Evidence suggests online risks associated with mobile technology use can be mitigated by (a) parental awareness of online activities; (b) protective practices regarding content and contacts; and (c) mediation aimed at regulating access and use. Prior research on mobile technology use and associated risks in adolescent children focused on exposure to pornography, sexting, online victimization, and associated negative health outcomes. Parental awareness, protective practices, and mediation have also …