Medicine and Health Sciences Commons^™

Cyclophilin 40 As A Novel Disaggregase, Jeremy Dustin Baker

USF Tampa Graduate Theses and Dissertations

The negative health and economic impacts of neurodegenerative diseases on Americans is astounding and accelerating with an aging population. The Alzheimer’s Association reports that 5.7 million Americans suffer from Alzheimer’s disease (AD), a number which is expected to increase to 14 million by 2050. In economic terms, AD and other neurodegenerative disorders will cost the US over $275 billion in 2018, rising to over $1 trillion annually by 2050. AD causes gross brain atrophy and is most damaging throughout the cortex and the hippocampus, regions required for higher cognitive function and memory. AD presents as tangles within neurons composed of …

Actinomycin D And Telmisartan Combination Therapy Targets Lung Cancer Stem Cells, Ryan Green

USF Tampa Graduate Theses and Dissertations

The failure of lung cancer treatments has been attributed partly to the development of drug resistance, however the underlying cellular and molecular mechanisms are poorly understood. It has been suggested that a very small group of specific cells within the heterogeneous tumors, cancer initiating stem cells (CSC), develop resistance to treatment, survive and later initiate the growth of new tumors. Due to their pivotal role in maintenance and relapse of tumors following the acquisition of drug resistance, we reasoned that novel drugs targeting cancer cells and CSC might provide the most effective treatments, if not a cure. To this end, …

Foam Sclerotherapy Augmented Phlebectomy (Sap) Procedure For Varicose Veins: Report Of A Novel Technique., Raghu Kolluri, Katherine U Hays, Manjit S Gohel

Surgery Articles

INTRODUCTION: While traditional ambulatory phlebectomy (AP) is a safe and effective procedure, few adverse effects such as hematoma, bleeding, bruising and nerve injury have been reported. To improve AP and to reduce some of these adverse events, herein we report a novel technique - Foam Sclerotherapy Assisted Phlebectomy (SAP).

REPORT: The details of the above technique, along with the potential advantages and limitations will be discussed.

DISCUSSION: Foam sclerotherapy and DUS act as valuable adjuncts to traditional AP. SAP increases precision and creates additional venospasm leading to reduced bruising, reduced nerve injury and sclerosis of residual vein segments.

Nurse Practitioner Students: Providing Wellness Screenings To Underserved Older Adults, Rexanna Tatlock

Purdue Journal of Service-Learning and International Engagement

Rexanna Tatlock (BSN, RN, CCRN) received a BSN from Saint Francis College in 2003. As a registered nurse, she specialized in critical care nursing and eventually enrolled in the Adult Gerontology Nurse Practitioner master’s program in Purdue University’s School of Nursing in 2016. Upon graduation in May 2018, Rexanna has planned to focus on primary health care. The service-learning project provided primary care clinical experience, while meeting the needs of an underserved older adult population. This article will discuss the community partnership, a needs assessment, and a wellness screening offered to Fairington Apartments (FA) residents.

My Experience In Swaziland With Give Hope, Fight Poverty, Megan Kaser

Purdue Journal of Service-Learning and International Engagement

Megan Kaser, a recent 2017 alum in the College of Health and Human Sciences at Purdue University, describes her experience with Give Hope, Fight Poverty (GHFP)—a nonprofit organization in Indianapolis, Indiana. She is currently pursuing a master’s degree in physician assistant studies. GHFP’s mission is “to foster philanthropy domestically by designing service-learning programs that engage U.S. college students with rural communities in Swaziland, Africa, and work together to educate, empower, and lift orphaned and vulnerable children—particularly those living in child-headed households— out of poverty” (Give Hope, Fight Poverty, n.d.). By incorporating college students in the implementation of GHFP orphan education …

The Pharmaceutical Industry: A Pharmacy Student's Guide, Christian Egly, Yaman Kaakeh

Purdue Journal of Service-Learning and International Engagement

Christian Egly is a fourth-year (P4) pharmacy student in the Purdue University College of Pharmacy. During his years at Purdue, he worked in labs performing bench research in clinical pharmacology and biochemistry. He plans to work in the pharmaceutical industry after graduation. During his fourth year, he completed rotations in business development at Kashiv Pharma, LLC, and was hired there for an internship in 2017. In the article, Christian describes his personal experiences at Kashiv Pharma, LLC, and how industry can positively affect patient communities.

Peer Health Educators On Campus: Teaching Safe Medication Practices, Baylee Q. Bryan, Olga O. Vlashyn, Stephanie A. Deremiah, Murphy K. O'Toole, Katherine M. Joseph, Jane E. Krause

Purdue Journal of Service-Learning and International Engagement

Baylee Q. Bryan, Olga O. Vlashyn, Stephanie A. Deremiah, and Murphy K. O’Toole are advanced professional students in the Doctor of Pharmacy program at Purdue University, graduating in May 2019. Katherine M. Joseph is a senior in the School of Nursing, graduating in December 2018. Jane E. Krause (Clinical Associate Professor of Pharmacy Practice, Purdue College of Pharmacy) served as a faculty mentor for this project. In this article, the authors describe their service-learning project intended to increase awareness on campus regarding prescription drug abuse and misuse.

Smart Disease Prevention App: Informing The Public In Their Own Geographic Location, Apoorva Sulakhe, Shafali Rana, Zoe Disori, William Nogay, Kyle Plummer, Meredith Shannon, Morgan Young, Alyssa Zielinski, Vincent G. Duffy

Purdue Journal of Service-Learning and International Engagement

Apoorva Sulakhe and Shefali Rana are graduate students in the School of Industrial Engineering at Purdue. They have both been teaching assistants under their coauthor, Dr. Vincent Duffy, while supervising multiple projects. Coauthors Zoe Disori, William Nogay, Kyle Plummer, Meredith Shannon, Morgan Young, and Alyssa Zielinski are listed in alphabetical order. They were all seniors in School of Industrial Engineering at the time of this project in 2017. The purpose of their study, described in this article, was to develop an application to provide users with accurate information about diseases spreading in their geographic locations.

Leveraging Technology: Enhancing Study Time Through Competition, Ming Yang, Lindsey Eble, Patricia Darbishire

Purdue Journal of Service-Learning and International Engagement

Ming (Max) Yang and Lindsey Eble are students in their final year of the Doctor of Pharmacy program in the Purdue University College of Pharmacy. Max is originally from Chesterfield, Missouri, and Lindsey is from Newburgh, Indiana. After graduation in May 2018, Max will complete residency training at Aurora St. Luke’s Medical Center in Milwaukee, Wisconsin. Lindsey will complete residency training at Barnes-Jewish Hospital in St. Louis, Missouri. Both plan to work in a hospital or clinic setting providing patient care within an interdisciplinary healthcare team. They both worked under the guidance of Dr. Patricia Darbishire to develop a website …

"Wrapping" Up In Kenya: A Student’S Learning Experience In Eldoret, Kenya, Alexander R. Mills, Monica L. Miller, Rakhi Karwa, Sonak D. Pastakia, Aileen Y. Chang, Edith Tonui, Sara Fletcher, Phelix Were, Ellen Schellhase

Purdue Journal of Service-Learning and International Engagement

Alexander R. Mills received his Doctor of Pharmacy degree in May 2017 and has completed a PGY-1 community-based pharmacy practice resident with Walgreen Company and Purdue University College of Pharmacy. During his time at Purdue, he was heavily involved with Purdue’s chapter of The American Red Cross Club, serving as the president and coordinator of community outreach programs. Upon completing his PGY-1, he will continue to pursue his aspirations to care for the medically underserved while currently completing a PGY-2 residency specializing in ambulatory care and academia at the University of Mississippi in Jackson.

Indiana University Health: A Student, An Institution, And The People, Allison Bates

Purdue Journal of Service-Learning and International Engagement

Allison Bates is a student in Purdue University’s Doctor of Pharmacy program with an anticipated graduation date of May 2019. Her future career aspirations are to practice in ambulatory care pharmacy or in an oncology setting. She has volunteered with the Joseph Maley Foundation since 2009 and with the “It’s My Closet” organization in Lafayette since 2014. This article describes her experience working as an intern with Dr. Dawn Moore, Vice President of Pharmacy and Chief Pharmacy Officer at IU Health.

Value-Added Services: Incorporating Pharmacy Students In A Hospital Setting, Megan Unger

Purdue Journal of Service-Learning and International Engagement

Megan Unger, a PharmD candidate in her fourth professional year in the College of Pharmacy, completed an introductory pharmacy practice experience at Deaconess Hospital in Evansville, Indiana, during her third professional year. This was the third of thirteen experiential learning rotations that she will complete prior to graduation in 2019. Her future plans include pursuing a postgraduate residency training program. In this article, Megan highlights the value-added services that pharmacy students can provide to institutional pharmacy settings and the patients served.

Shanghai, China: “Nontraditional” Traditional Chinese Medicine, Joshua Martin

Purdue Journal of Service-Learning and International Engagement

Joshua Martin is a second-year PharmD student in the Purdue University College of Pharmacy. Within the College of Pharmacy, he is the president-elect of the Industry Pharmacist Organization (IPhO), is on the Orientation Steering Committee for newly admitted PharmD students, and preforms nanoparticle research within the Industrial and Physical Pharmacy sector of the College. He hopes to pursue a career in the pharmaceutical industry where he can positively impact patients on a global scale. Josh comes from a family of Boilermakers and avidly supports the Black and Gold. In this article, he describes his experience studying at Shanghai University of …

Food For Thought: My Experience With The Food Finders “Head’S Up” Program And Community Outreach, Amanda Hornbach

Purdue Journal of Service-Learning and International Engagement

Amanda Hornbach is a medical student at the Indiana University School of Medicine’s West Lafayette (IUSM–WL) campus. During the summer between her first and second years of medical school, Hornbach developed a one-time, interactive educational curriculum for children participating in a local summer-long lunch and educational series through the Food Finders Food Bank. This project was completed as part of the IUSM–West Lafayette Primary Care Scholars summer program. This article outlines her experiences, her development of session material, and what she learned as a result of completing the program. Development of this curriculum dovetails her interests in pediatrics and health …

Medication Therapy Management: Empowering The Patient, Aimee Henderson, Krista Brooks, Jordyn Richey, Victoria Thompson

Faculty Articles & Research

Medication Therapy Management provides the community with many benefits. In order to demonstrate the importance, we used pharmacist surveys to convey how often MTM is utilized, pharmacists perspectives on service utilization and challenges, and goals and expectations of the outcomes of MTM services.

Prescription Opioids And Heroin Abuse In New Mexico: Swot Analyses Of Possible Policies/Interventions And The Way Forward, Ali Abbasi

Public Administration ETDs

Throughout the last decade or so, Opioid related fatalities are at all-time high in the United States. New Mexico’s problem with Opioids abuse in not a new phenomenon and a large number of New Mexicans are losing their lives almost on a daily basis. The paper highlights the alarming situation of overdose deaths caused specifically by the abuse of Prescription Opioids and Heroin which, in 2016 alone have taken 347 lives in New Mexico. Policy makers along with other stakeholders play a vital part in shaping the politics along with other interventions which can help tackle the epidemic. The paper …

Access To Dental Care In Fillmore County Minnesota, Katie M. Ristau

Dental Hygiene ETDs

Purpose: Dental care accessibility can be an issue for certain populations and can be an issue for people on Medical Assistance. This has been a struggle throughout our country. The purpose of this research was to assess if the children on Medical Assistance in Fillmore County are in need of dental services and if parents of these children are willing to accept an Advanced Dental Therapist provider. Methods: This descriptive research utilized a survey to collect data on access to care for children on Medical Assistance insurance in Fillmore County, Minnesota. Of the total number of children on Medical Assistance, …

Radiation In Its Origin: Health Risks Resulting From Prolonged Exposure To Radon, Tetiana Soloviova, Evans Lespinasse

Publications and Research

Among non-smokers, radon is the number one cause of lung cancer, and the second cause of lung cancer overall, according to the Environmental Protection Agency. Radon cannot be detected through one's sense of sight, smell, hearing, taste or touch. The only way to detect it is by testing certain spaces or environments with specialized instruments. This radioactive gas is present in trace quantities in the earth and produced by decaying uranium. It enters buildings through cracks in walls, floors, construction joints or gaps around service pipes, electrical wires and sump pits. It emits heavy nuclear fragments of alpha particles (two …

September/October/November 2018, Randy Curry, Cindy Brooks

RURAL ROCKS

Rural Rocks, the Rural Health Network newsletter by the SWOSU College of Pharmacy

Trying To Cover The Sun With Your Thumb: A Critical Ethnography Of Maternity Care Provision In Rural Northern New Mexico, Abigail Reese

Nursing ETDs

Access to maternity care is disappearing for women across rural America. In the state of New Mexico, women often travel long distances to access hospitals and providers that offer childbirth services, as these resources are concentrated primarily in metropolitan areas. Although data on provider distribution is available, very few studies have explored the maternity care access crisis from the perspectives of the midwives and physicians who work in rural areas. The purpose of this critical ethnographic study was to explore barriers and facilitators to the provision of childbirth services from providers’ perspectives with the intent of informing policy debates around …

Prescription And Over-The-Counter Medication Record Integration: A Holistic Patient-Centered Approach, Clark D. Kebodeaux

Pharmacy Practice and Science Faculty Publications

Objective: Nonprescription or over-the-counter (OTC) medications play a crucial role in a patient’s ability to make choices to manage his or her own health care. Often these nonprescription choices are unknown to health care practitioners and thus are often not included as part of patients’ health records. The exclusion of these therapies can pose risks to patient safety. There is a significant need to address the capture of OTC medication use in both the physician and pharmacy electronic health records (EHRs) and during the practitionerepatient medication history and reconciliation process.

Data sources: On October 26, 2016, the National Association of …

Waardenburg Syndrome And Left Persistent Superior Vena Cava, Driss Raissi, Alexander Christie, Kimberly Applegate

Radiology Faculty Publications

Waardenburg syndrome (WS) is a rare genetic disorder secondary to neural crest cell developmental abnormalities. It is predominantly described as an auditory-pigmentary syndrome with diverse patient presentation, typically involving congenital sensorineural hearing loss and pigmentation abnormalities of the skin, hair, and iris. Other developmental abnormalities that may be associated with this syndrome are Hirschsprung's disease and a myriad of cardiovascular congenital defects. We present a case of a young girl with WS who found to have a persistent left superior vena cava (PLSVC) draining into the coronary sinus. The prevalence of PLSVC is increased in patients with chromosomal and genetic …

Upper Gastrointestinal Bleed Embolization With Onyx®: The "Tattoo Effect", Driss Raissi, Qian Yu, S. Houssam Mardini

Radiology Faculty Publications

Endoscopic intervention is well validated for the control of upper gastrointestinal bleeding (UGIB). In cases of refractory bleeding, transarterial embolization is a safe and effective alternative. Ethylene vinyl alcohol (EVOH) commonly known as Onyx^® is an inherently black liquid embolic approved for use in cerebrovascular arteriovenous malformations and is increasingly used as an embolic agent in multiple peripheral and visceral territories. Onyx^® has a uniquely undesirable property of causing black color discoloration when used in peripheral applications adjacent to the skin akin to a "tattoo effect." Knowledge of the agents used by the interventional radiologist, clinical correlation, and …

Proteolysis Of Cx3cl1 Impacts Cx3cr1 Signaling And Therapeutic Benefits In A Tauopathy Model, Dylan John Finneran

USF Tampa Graduate Theses and Dissertations

Alzheimer’s disease (AD) is a progressive, neurodegenerative disorder and the most common form of dementia. The hallmark pathologies of AD are extracellular aggregates of amyloid-beta, intracellular aggregates of microtubule associated protein tau and increased neuroinflammation. Current therapeutics offer only symptomatic relief and clinical trials investigating therapeutic benefits of non-steroidal anti-inflammatory drugs have yielded no positive results. Therefore, recent work has focused on immunomodulators, such as CD200 and fractalkine, as potential therapeutic targets for AD.

Fractalkine (CX3CL1; FKN) is expressed as a transmembrane protein with an N-terminal chemokine domain followed by a long, mucin-like stalk. FKN can signal as a membrane-bound …

The Impact Of Depression On Patient Outcomes In Hip Arthroscopic Surgery., Robroy L Martin, John J Christoforetti, Ryan Mcgovern, Benjamin R Kivlan, Andrew B Wolff, Shane J Nho, John P Salvo, Thomas J Ellis, Geoff Van Thiel, Dean Matsuda, Dominic S Carreira

Surgery Articles

BACKGROUND: Mental health impairments have been shown to negatively affect preoperative self-reported function in patients with various musculoskeletal disorders, including those with femoroacetabular impingement.

HYPOTHESIS: Those with symptoms of depression will have lower self-reported function, more pain, and less satisfaction on initial assessment and at 2-year follow-up than those without symptoms of depression.

STUDY DESIGN: Cohort study; Level of evidence, 3.

METHODS: Patients who were enrolled in a multicenter hip arthroscopic surgery registry and had 2-year outcome data available were included in the study. Patients completed the 12-item International Hip Outcome Tool (iHOT-12), visual analog scale (VAS) for pain, and …

A Program To Treat Hepatitis B In North Korea: A Model Of Antiviral Therapy In A Resource-Poor Setting, Marcia Ann Kilsby, Alice Unah Lee, Heidi Linton, David C. Hilmers

Faculty Publications

Despite the well-proven, safe and effective therapies for hepatitis B infection, delivery of treatment remains a significant challenge in resource-poor settings. Geopolitical and economic restrictions present additional difficulties in providing care in North Korea. However, treatment of patients with chronic hepatitis B remains a top priority for both the North Korean Ministry of Public Health and international agencies working in North Korean hepatitis healthcare facilities. Working in partnership, a path was created to institute this much-needed program. A consortium of United States and Australian humanitarian non-governmental organizations along with generous individual and corporate donors working in concert with local and …

Micu1 Interacts With The D-Ring Of The Mcu Pore To Control Its Ca2+ Flux And Sensitivity To Ru360, Melanie Paillard, György Csordás, Kai-Ting Huang, Peter Várnai, Suresh K. Joseph, György Hajnóczky

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Proper control of the mitochondrial Ca²⁺ uniporter’s pore (MCU) is required to allow Ca²⁺ dependent activation of oxidative metabolism and to avoid mitochondrial Ca²⁺ overload and cell death. The MCU’s gatekeeping and cooperative activation is mediated by the Ca²⁺ sensing MICU1 protein, which has been proposed to form dimeric complexes anchored to the EMRE scaffold of MCU. We unexpectedly find that MICU1 suppresses inhibition of MCU by ruthenium red/Ru360, which bind to MCU’s DIME motif, the selectivity filter. This led us to recognize in MICU1’s sequence, a putative DIME Interacting Domain (DID) which is required for …

Quality Of Care Strategies And The Subsequent Improvement Of Kangaroo Care Incidence Rates In Premature Infants, Sarah Anderson

Posters-at-the-Capitol

Purpose: The benefits of kangaroo care (KC) has long been studied and proven. Despite the research, incidence rates of KC are low in the neonatal ICU at the Kentucky Children’s Hospital. Some barriers to KC exist in our NICU and this study strives to address them. This study aims to develop and implement strategies to increase utilization of KC from 41% to  75% for eligible infants.

Methods: KC occurrence was monitored in 364 infants with birth weight ≤ 1250 grams. Strategies implemented were education of nurses, improved nurse-to-patient ratio, emphasis of KC in multidisciplinary rounding, improved documentation, …

Application And Influence Of Technology On Medication Adherence In Adults With Heart Failure: An Integrative Literature Review, Kristen Loda

Grace Peterson Nursing Research Colloquium

Abstract

Background: Heart failure is a progressive disease that presents itself through multiple debilitating symptoms. Being there is no cure, symptom management and prevention through a tailored polypharmaceutical regimen is key to keeping these patients out of the hospital and improving their quality of life. Considering as of 2014, 6 million Americans are living with heart failure, it is crucial to implement interventions to promote medication adherence. Emerging technologies can provide patients the opportunity to remotely monitor their self-care and better adhere to their drug regimens.

Objectives: The aim of this study was to identify forms of technology available to …

Wound Closure After Posterior Multi-Level Lumbar Spine Surgery: An Anatomical Cadaver Study And Technical Note., Emre Yilmaz, Tamir Tawfik, Thomas M O'Lynnger, Joe Iwanaga, Ronen Blecher, Amir Abdul-Jabbar, R Shane Tubbs, Cameron K Schmidt, Rod J Oskouian, Jens R Chapman

Articles, Abstracts, and Reports

Meticulous attention to wound closure in posterior lumbar spine surgery is an important principle in reducing surgical site infections. We detail standardized wound closure used for posterior lumbar spine surgery at a tertiary care referral center and illustrate this as a step-by-step cadaveric dissection. The lumbar spine of a cadaveric specimen (male, 73 years at death) was used for dissection. Standardizing wound closure in posterior lumbar spine surgery may help limit wound complications and infection. Some key points of our technique, as demonstrated on a cadaveric specimen, include separating fascial compartments, avoiding suture abscesses, and creating a tension-free wound.