Medicine and Health Sciences Commons^™

Corrigendum: Identification Of The Cftr C.1666a > G Mutation In Hereditary Inclusion Body Myopathy Using Next-Generation Sequencing Analysis, Yan Lu, Yu-Wei Da, Yong-Biao Zhang, Xin-Gang Li, Min Wang, Li Di, Mi Pang, Lin Lei

Research outputs 2014 to 2021

A Corrigendum on Identification of the CFTR c.1666A>G Mutation in Hereditary Inclusion Body Myopathy Using Next-Generation Sequencing Analysis

by Lu, Y., Da, Y.-W., Zhang, Y.-B., Li, X.-G., Wang, M., Di, L., et al. (2018). Front. Neurosci. 12:329. doi: 10.3389/fnins.2018.00329

An error was found in the first and second sentence of the original article's abstract.

The Burden Of Hospitalized Sports-Related Injuries In Children: An Australian Population-Based Study, 2005–2013, Francisco J. Schneuer, Jane C. Bell, Susan E. Adams, Julie Brown, Caroline Finch, Natasha Nassar

Research outputs 2014 to 2021

Background

There is concern about recent increase and severity of sports-related injuries in children. Despite the benefits of sports participation, injuries may carry long-term health consequences. We aimed to evaluate the prevalence, characteristics and types of hospitalized sports-related injuries in children.

Methods

Population-based study of all acute sports-related injuries requiring hospitalization in children 5 to 15 years of age in New South Wales (NSW), Australia, 2005–2013. Health information was obtained from the NSW Admitted Patient Data Collection, a census of all hospital admissions from public and private hospitals. Children with a recorded ICD10-AM injury code (S00-T79) and sport-related activity code …

Insulin Therapy And Autoimmune Disease With Relevance To Non Alcoholic Fatty Liver Disease, Ian James Martins

Research outputs 2014 to 2021

The diabetes epidemic is now expected by the year 2050 to become a global pandemic with approx. 592 million affected in both the developed and developing world. The treatment of diabetes by insulin therapy has been the focus for many diabetics with the improvement and prevention of various diseases such as cardiovascular disease, kidney disease and neurodegeneration. The global nonalcoholic fatty liver disease (NAFLD) epidemic has now become of major concern to diabetes with critical interest in insulin therapy to reverse and stabilize autoimmune disease with relevance to NAFLD and the diabetes pandemic. Dietary components that activate anti-aging genes improve …

The Effects Of Massage Therapy On Delayed Onset Muscle Soreness, Carli Mueller

Dissertations and Theses @ UNI

Context: Cupping massage and petrissage may be beneficial in the treatment of DOMS, however, there is limited research on the application and use of cupping massage on DOMS. This study examines the effectiveness of petrissage versus cupping massage on the pain associated with DOMS among a healthy population. Objective: To determine the efficacy of cupping massage in comparison to petrissage on the treatment of pain associated with acute muscle injury. Design: Experimental, single blinded study with stratification of participants. Participants: Thirty-two healthy individuals between the ages of 18 and 22. Methods: Participants underwent a protocol to induce DOMS on the …

A Literature Review On The Current State Of Security And Privacy Of Medical Devices And Sensors With Bluetooth Low Energy, Todd O. Arney

Dissertations, Master's Theses and Master's Reports

Technology use in healthcare is an integral part of diagnosis and treatment. The use of technology in medical devices and sensors is growing. These devices include implantable medical devices, and consumer health and fitness tracking devices and applications. Bluetooth Low Energy (BLE) is the most commonly used communication method in medical devices and sensors. Security and privacy are important, especially in healthcare technologies that can impact morbidity. There is an increasing need to evaluate the security and privacy of healthcare technology, especially with devices and sensors that use Bluetooth Low Energy due to the increasing prevalence and use of medical …

Chiropractic Usage Among College Students: An Extended Literature Review, Elizabeth A. Schwenker

Honors Program Theses

Chiropractic medicine is a complementary health approach that focuses on the use of adjustments, mainly to the spine, and is typically sought to reduce pain (Chiropractic: In Depth, 2016). The National Center for Complementary and Integrative Health, a part of the National Institute of Health, found in 2007 that more than 18 million American adults had received a chiropractic adjustment or osteopathic manipulation in the previous year. The NIH recognizes that chiropractic adjustments appear beneficial in reducing low back pain and may be beneficial in treating headaches, neck pain, and a number of other conditions with temporary minor adverse effects …

The 12-Year Prevalence And Trends Of Childhood Disabilities In Australia: Findings From The Survey Of Disability, Aging And Carers, Diana Arabiat, Lisa Whitehead, Mohammad Al Jabery

Research outputs 2014 to 2021

Aim: This paper contributes to knowledge on the prevalence and nature of disabilities in Australian children over a 12‐year period (2003–2015). Understanding the current state of childhood disability is imperative for predicting future needs for long‐term care and early intervention services for this population.

Methods: We used data on children 0–14 years from the 2003, 2009, 2012, and 2015 survey of Disability, Aging and Carers, which is an ongoing national survey covering both rural and urban areas of all States and Territories of Australia.

Results: Using the test for trends in population, no significant increases were noted in the prevalence …

Can A Renal Nurse Assess Fluid Status Using Ultrasound On The Inferior Vena Cava? A Cross-Sectional Interrater Study: Ultrasound On The Inferior Vena Cava, Ulrich Steinwandel, Nicholas Gibson, Amanda Towell, James Rippey

Research outputs 2014 to 2021

Introduction: Ultrasound of the inferior vena cava (IVC-US) has been used to estimate intravascular volume status and fluid removal during a hemodialysis session. Usually, renal nurses rely on other, imprecise methods to determine ultrafiltration. To date, no study has examined whether renal nurses can reliably perform ultrasound for volume assessment and for potential prevention of intradialytic hypotension. This pilot study aimed to determine if a renal nurse could master the skill of performing and correctly interpreting Point of Care Ultrasound on patients receiving hemodialysis.

Methods: After receiving theoretical training and performing 100 training scans, a renal nurse performed 60 ultrasound …

Visual-Vestibular Integration During Self-Motion Perception In Younger And Older Adults, Robert Ramkhalawansingh, John Butler, Jennifer Campos

Articles

Younger adults integrate visual and vestibular cues to self-motion in a manner consistent with optimal integration; however, little is currently known about whether this process changes with older age. Our objective was to determine whether older adults, like younger adults, display evidence of optimal visual-vestibular integration, including reductions in bimodal variance (visual-vestibular) compared with unimodal variance (visual or vestibular alone), and reliability-based cue weighting. We used a motion simulator and a head-mounted display to introduce a 2-interval forced-choice heading estimation task. Older (65+ years) and younger adults (18–35 years) judged which of two movements was more rightward. Movements consisted of …

Cognitive Load Reduces The Effects Of Optic Flow On Gait And 2 Electrocortical Dynamics During Treadmill Walking 3, Brenda Malcolm, John J. Foxe, John Butler, Sophie Molholm, Pierfilippo De Sanctis

Articles

While navigating complex environments the brain must continuously adapt to both external demands such as fluctuating sensory inputs, as well as internal demands, such as engagement in a cognitively demanding task. Previous studies have demonstrated changes in behavior and gait with increased sensory and cognitive load, but the underlying cortical mechanisms remain largely unknown. Here, in a Mobile Brain/Body Imaging (MoBI) approach sixteen young adults walked on a treadmill with high-density EEG while 3D motion capture tracked kinematics of the head and feet. Visual load was manipulated with the presentation of optic flow with and without continuous mediolateral perturbations. The …

Comparison Of Two Levels Of Inpatient Dysphagia Treatment Dosages On Swallowing Outcomes, Paige Licht

Honors Program Theses

Current research reveals great variability in many aspects of service delivery for swallowing rehabilitation, including dosage or intensity of treatment. Therefore, there is a need to investigate the effects of treatment intensity on swallowing rehabilitation outcomes. The purpose of this study is to determine whether two levels of treatment intensity produce different patterns of swallowing recovery for inpatients with neurogenic dysphagia. Blinded analysis of pre- and post-treatment videofluoroscopic measures of swallowing were completed for six inpatients at the Rehabilitation Institute of Chicago who were previously randomized to one of two dysphagia exercise programs. One arm consisted of traditional 30-minute treatment …

Introduction To Laser Induced Breakdown Spectroscopy Imaging In Food: Salt Diffusion In Meat, Yash Dixit, Carl Sullivan, Patrick J. Cullen

Articles

This study illustrates the ability of laser induced breakdown spectroscopy (LIBS) to detect and map 22 minerals in food. A LIBS system was used to spatially collect spectra of beef samples. Samples were 23 brined in a 6% salt solution for 2h and 24h along with a control sample. Samples were measured by 24 scanning the cross-section of each sample in a 90 X 90 square grid. Sodium (Na) distribution images 25 with respect to emission peak at 589.05 nm were generated after pre-processing the spectral data which 26 directly corresponds to salt levels. As expected, the control sample showed …

Remodeling Of Wall Mechanics And The Myogenic Mechanism Of Rat Intramural Coronary Arterioles In Response To A Short-Term Daily Exercise Program: Role Of Endothelial Factors, Maria Szekeres, Gyorgy L. Nadasy, Gabriella Dornyei, Annamaria Szenasi, Akos Koller

NYMC Faculty Publications

PURPOSE: Exercise elicits early adaptation of coronary vessels enabling the coronary circulation to respond adequately to higher flow demands. We hypothesized that short-term daily exercise induces biomechanical and functional remodeling of the coronary resistance arteries related to pressure. METHODS: Male rats were subjected to a progressively increasing 4-week treadmill exercise program (over 60 min/day, 1 mph in the final step). In vitro pressure-diameter measurements were performed on coronary segments (119 +/- 5 mum in diameter at 50 mm Hg) with microarteriography. The magnitude of the myogenic response and contribution of endogenous nitric oxide and prostanoid production to the wall mechanics …

Restaurant Inspection Reports As A Proxy Measure For Occupational Health And Safety: South Asian Restaurant Workers In New York City, Ismail Nabeel, Hasanat Alamgir

NYMC Faculty Publications

No abstract provided.

Anxiety, Patricia L. Gerbarg, Heather Mason

NYMC Faculty Publications

No abstract provided.

Does Combined Therapy Of Curcumin And Epigallocatechin Gallate Have A Synergistic Neuroprotective Effect Aainst Spinal Cord Injury?, Jiri Ruzicka, Lucia M. Urdzikova, Anubhav Amin, Sarka Kubinova, Meic Schmidt, Meena Jhanwar-Uniyal, Pavla Jendelova

NYMC Faculty Publications

Systematic inflammatory response after spinal cord injury (SCI) is one of the factors leading to lesion development and a profound degree of functional loss. Anti-inflammatory compounds, such as curcumin and epigallocatechin gallate (EGCG) are known for their neuroprotective effects. In this study, we investigated the effect of combined therapy of curcumin and EGCG in a rat model of acute SCI induced by balloon compression. Immediately after SCI, rats received curcumin, EGCG, curcumin + EGCG or saline [daily intraperitoneal doses (curcumin, 6 mg/kg; EGCG 17 mg/kg)] and weekly intramuscular doses (curcumin, 60 mg/kg; EGCG 17 mg/kg)] for 28 days. Rats were …

Antimicrobial Resistance In Chile And The One Health Paradigm: Dealing With Threats To Human And Veterinary Health Resulting From Antimicrobial Use In Salmon Aquaculture And The Clinic, Ana Millanao, Carolina Barrientos-Schaffeld, Claudio D. Siegel-Tike, Alexandra Tomova, Larisa Ivanova, Henry P. Godfrey, Humberto J. Dolz, Alejandro H. Buschmann, Felipe C. Cabello

NYMC Faculty Publications

The emergence and dissemination of antimicrobial-resistant bacteria (ARB) is currently seen as one of the major threats to human and animal public health. Veterinary use of antimicrobials in both developing and developed countries is many-fold greater than their use in human medicine and is an important determinant in selection of ARB. In light of the recently outlined National Plan Against Antimicrobial Resistance in Chile, our findings on antimicrobial use in salmon aquaculture and their impact on the environment and human health are highly relevant. Ninety-five percent of tetracyclines, phenicols and quinolones imported into Chile between 1998 and 2015 were for …

Ruxolitinib Significantly Enhances In Vitro Apoptosis In Hodgkin Lymphoma And Primary Mediastinal B-Cell Lymphoma And Survival In A Lymphoma Xenograft Murine Model, Sanghoon Lee, Tishi Shah, Changhong Yin, Jessica Hochberg, Janet Ayello, Carmella Van De Ven, Mitchell S. Cairo

NYMC Faculty Publications

Hodgkin lymphoma (HL) and primary mediastinal B-cell lymphoma (PMBL) share similar molecular features by gene expression profiling. Frequent gains of chromosome 9p exhibit higher Janus Kinase 2 (JAK2) transcript levels with increased JAK2 activity, suggesting aberrant activity of JAK2 and STAT pathways. This signaling pathway alteration may in part play an important role in the pathogenesis and/or chemoradiotherapy resistance in HL and PMBL. Ruxolitinib is a potent and selective JAK1/JAK2 inhibitor, with activity against myeloproliferative neoplasms (MPNs) including those harboring the JAK2V617F mutation. We investigated the in vitro and in vivo efficacy of ruxolitinib and changes in downstream signaling pathways …

The Effects Of Enactment On Communicative Competence In Aphasic Casual Conversation: A Functional Linguistic Perspective, Rimke Groenewold, Elizabeth Armstrong

Research outputs 2014 to 2021

Background: Previous research has shown that speakers with aphasia rely on enactment more often than non-brain-damaged language users. Several studies have been conducted to explain this observed increase, demonstrating that spoken language containing enactment is easier to produce and is more engaging to the conversation partner. This paper describes the effects of the occurrence of enactment in casual conversation involving individuals with aphasia on its level of conversational assertiveness. Aims: To evaluate whether and to what extent the occurrence of enactment in speech of individuals with aphasia contributes to its conversational assertiveness. Methods & Procedures: Conversations between a speaker with …

Ghrelin Upregulates The Phosphorylation Of The Glun2b Subunit Of The Nmda Receptor By Activating Ghsr1a And Fyn In The Rat Hippocampus, Liza Berrout, Masako Isokawa

Health & Biomedical Sciences Faculty Publications

Ghrelin and its receptor GHSR1a have been shown to exert numerous physiological functions in the brain, in addition to the well-established orexigenic role in the hypothalamus. Earlier work indicated that ghrelin stimulated the phosphorylation of the GluN1 subunit of the NMDA receptor (NMDAR) and enhanced synaptic transmission in the hippocampus. In the present study, we report that the exogenous application of ghrelin increased GluN2B phosphorylation. This increase was independent of GluN2B subunit activity or NMDAR channel activity. However, it depended on the activation of GHSR1a and Fyn as it was blocked by D-Lys3-GHRP-6 and PP2, respectively. Inhibitors for G-protein-regulated second …

Down Syndrome, Beta-Amyloid And Neuroimaging, Elizabeth Head, Alex M. Helman, David K. Powell, Frederick A. Schmitt

Sanders-Brown Center on Aging Faculty Publications

This review focuses on the role of Aβ in AD pathogenesis in Down syndrome and current approaches for imaging Aβ in vivo. We will describe how Aβ deposits with age, the posttranslational modifications that can occur, and detection in biofluids. Three unique case studies describing partial trisomy 21 cases without APP triplication, and the occurrences of low level mosaic trisomy 21 in an early onset AD patient are presented. Brain imaging for Aβ includes those by positron emission tomography and ligands (Pittsburgh Compound B, Florbetapir, and FDDNP) that bind Aβ have been published and are summarized here. In combination, we …

A Mixed Methods Sequential Explanatory Study Of Male Farmers' Health Beliefs, Attitudes And Practices In Rural Kerry, Chrystal O'Brien

Theses

Aim/Background: Beliefs and attitudes about health directly and indirectly influence concomitant behaviours, practices and health outcomes. In Ireland, male farmers are experiencing a disproportionate burden of ill health in preventable lifestyle diseases, yet there is a lack of behavioural research in relation to male farmers and their health. Therefore, the purpose of this study was to examine the health beliefs, attitudes and practices of male farmers in rural Kerry, and to explore healthcare professionals' insights of male farmers' health beliefs, attitudes and practices.

Methodology: The study adopted a mixed methods design. Phase one of the study involved structured interviews with …

The Ernie Els #Gameon Autism™ Golf Program For Young People With Autism: An Interpretative Phenomenological Analysis, Jerrome Suganthy Selvaraj

Theses

The first evaluation of the #GameON Autism^^ Golf Program was conducted outside of the USA by the UNESCO Chair, I.T. Tralee in conjunction with the Els for Autism Foundation in partnership with LD Golf Ltd. The central aim of this research study was to evaluate the efficacy of the #GameON Autism^ Golf Program on young people with autism (ASD), their families, PGA golf coach, and volunteers. The two main objectives of the research were to analyse the impact of the program on the socia/communication, motor, and golf skills of individuals with autism and to assess the potential for the #GameON …

Tumor Microvessel Density As A Prognostic Marker In High-Risk Renal Cell Carcinoma Patients Treated On Ecog-Acrin E2805, Lucia B. Jilaveanu, Maneka Puligandla, Sarah A. Weiss, Xin Victoria Wang, Christopher Zito, Keith T Flaherty, Marta Boeke, Veronique Neumeister, Robert L. Camp, Adebowale Adeniran, Michael Pins, Judith Manola, Robert S. Dipaola, Naomi B. Haas, Harriet M. Kluger

Internal Medicine Faculty Publications

Purpose—Increased vascularity is a hallmark of renal cell carcinoma (RCC). Microvessel density (MVD) is one measurement of tumor angiogenesis; however, its utility as a biomarker of outcome is unknown. ECOG-ACRIN 2805 (E2805) enrolled 1,943 resected high-risk RCC patients randomized to adjuvant sunitinib, sorafenib, or placebo. We aimed to determine the prognostic and predictive role of MVD in RCC.

Experimental Design—We obtained pretreatment primary RCC nephrectomy tissues from 822 patients on E2805 and constructed tissue microarrays. Using quantitative immunofluorescence, we measured tumor MVD as the area of CD34-expressing cells. We determined the association with disease-free survival (DFS), overall survival …

A Bi-Level Heuristic Solution For The Nurse Scheduling Problem Based On Shift-Swapping, Ahmed Youssef, Samah Senbel

School of Computer Science & Engineering Faculty Publications

This paper presents a new heuristic solution to the well-known Nurse Scheduling Problem (NSP). The NSP has a lot of constraints to satisfy. Some are mandatory and specified by the hospital administration, these are known as hard constraints. Some constraints are put by the nurses themselves to produce a comfortable schedule for themselves, and these are known as soft constraints. Our solution is based on the practice of shift swapping done by nurses after they receive an unsatisfactory schedule. The constraints are arranged in order of importance. Our technique works on two levels, first we generate a schedule that satisfies …

Improvement In Diagnosis Of Histoplasma Meningitis By Combined Testing For Histoplasma Antigen And Immunoglobulin G And Immunoglobulin M Anti-Histoplasma Antibody In Cerebrospinal Fluid, Karen C. Bloch, Thein Myint, Luke Raymond-Guillen, Chadi A. Hage, Thomas E. Davis, Patty W. Wright, Felicia C. Chow, Laila Woc-Colburn, Raed N. Khairy, Alan C. Street, Tomotaka Yamamoto, Amanda Albers, L Joseph Wheat

Internal Medicine Faculty Publications

Background. Central nervous system (CNS) histoplasmosis is a life-threatening condition and represents a diagnostic and therapeutic challenge. Isolation of Histoplasma capsulatum from cerebrospinal fluid (CSF) or brain tissue is diagnostic; however, culture is insensitive and slow growth may result in significant treatment delay. We performed a retrospective multicenter study to evaluate the sensitivity and specificity of a new anti-Histoplasma antibody enzyme immunoassay (EIA) for the detection of IgG and IgM antibody in the CSF for diagnosis of CNS histoplasmosis, the primary objective of the study. The secondary objective was to determine the effect of improvements in the Histoplasma galactomannan …

Optogenetic Examination Of Salt Taste In Mice, Martin Raymond

Master's Theses and Doctoral Dissertations

This thesis describes a series of experiments designed to evaluate the hypothesis that Type I taste receptor cells play a critical role in the detection and transduction of sodium taste via of epithelial sodium channels (ENaCs). Experiment 1 validated the function of a simple and affordable behavioral apparatus (hardware and software) for testing taste preference and taste aversion in mice. Experiment 2 demonstrated a pharmacological method for rapid induction of salt appetite in mice. Experiment 3 showed that optogenetic stimulation of Type I taste receptor cells (TRCs) in transgenic mice could drive consumption of tap water under conditions of salt …

Atop, D.V. Cumming

Quill & Scope

No abstract provided.

Dental Practice Success Vol. 4 No. 4, American Dental Association, Publishing Division

Dental Practice Success

No abstract provided.

Pediatric In-Patient Days Predictive Model, Dana Nicholson Bledsoe

MUSC Theses and Dissertations

The study objective is to develop a predictive model for pediatric inpatient days based on ambulatory outpatient visits and emergency department visits. This model aims to study the relationship between ambulatory visits and inpatient days, and determine if in-patient days can be predicted based on sub-specialty practice. Such a model does not currently exist, and when created and validated such a model could be utilized for various important management decisions, including refined insight into inpatient capacity and operational efficiency for self-governing children’s hospitals with large sub-specialty practices. The data set was a sample of convenience from one health system in …