Medicine and Health Sciences Commons^™

Pomona Large Vessel Occlusion Screening Tool For Prehospital And Emergency Room Settings, Kessarin Panichpisal, Kenneth Nugent, Maharaj Singh, Richard Rovin, Reji P. Babygirija, Yogesh Moradiya, Karen Tse-Chang, Kimberly A. Jones, Katrina J. Woolfolk, Debbie Keasler, Bhupat Desai, Parinda Sakdanaraseth, Paphavee Sakdanaraseth, Alimohammad Moalem, Nazli Janjua

College of Nursing Faculty Research and Publications

Background: Early identification of patients with acute ischemic strokes due to large vessel occlusions (LVO) is critical. We propose a simple risk score model to predict LVO. Method: The proposed scale (Pomona Scale) ranges from 0 to 3 and includes 3 items: gaze deviation, expressive aphasia, and neglect. We reviewed a cohort of all acute stroke activation patients between February 2014 and January 2016. The predictive performance of the Pomona Scale was determined and compared with several National Institutes of Health Stroke Scale (NIHSS) cutoffs (≥4, ≥6, ≥8, and ≥10), the Los Angeles Motor Scale (LAMS), the Cincinnati Prehospital Stroke …

Radiation Therapy In Metastatic Neuroblastoma, Meenu Gupta, Anupam Dhasmana

School of Medicine Publications

Neuroblastoma is the commonest extracranial solid tumor in children, and metastasis at presentation is seen in more than 50% of cases. The role of radiotherapy as a palliative modality in patients with advanced neuroblastoma provides better symptomatic relief. Palliative radiotherapy dose schedules can be given either in single hypofractionation from 4 to 8 Gy or fractionated radiotherapy that can range from 21 to 30.6 Gy. Doseresponse relationship trend has been reported in the palliative setting of bone metastasis. Because of the proximity of tumor to critical organs, serious adverse effects can be avoided with conformal techniques. Although currently there is …

Hybrid Privacy-Preserving Clinical Decision Support System In Fog-Cloud Computing, Ximeng Liu, Robert H. Deng, Yang Yang, Ngoc Hieu Tran, Shangping Zhong

Research Collection School Of Computing and Information Systems

In this paper, we propose a framework for hybrid privacy-preserving clinical decision support system in fog cloud computing, called HPCS. In HPCS, a fog server uses a lightweight data mining method to securely monitor patients' health condition in real-time. The newly detected abnormal symptoms can be further sent to the cloud server for high-accuracy prediction in a privacy-preserving way. Specifically, for the fog servers, we design a new secure outsourced inner-product protocol for achieving secure lightweight single-layer neural network. Also, a privacy-preserving piecewise polynomial calculation protocol allows cloud server to securely perform any activation functions in multiple-layer neural network. Moreover, …

A Lightweight Policy Preserving Ehr Sharing Scheme In The Cloud, Zuobin Ying, Lu Wei, Qi Li, Ximeng Liu, Jie Cui

Research Collection School Of Computing and Information Systems

Electronic Health Record (EHR) is a digital health documentary. It contains not only the health-related records but also the personal sensitive information. Therefore, how to reliably share EHR through the cloud is a challenging issue. Ciphertext-policy attribute-based encryption (CP-ABE) is a promising cryptography prototype, which can achieve fine-grained access control as well as one-to-many encryption. In CP-ABE, access policy is attached to the ciphertext, and however, the access policy is not protected, which will also cause some privacy leakage. In this paper, we propose a policy preserving EHR system on the basis of CP-ABE. Specifically, we designed an algorithm, which …

Bilateral Sagittal Split Osteotomy-Parameters And Correlations Of Postoperative Pain Management, Gregor F. Raschke, Winfried Meissner, Andre Peisker, Gabriel Djedovic, Ulrich M. Rieger, Arndt Guentsch, Marta Gomez-Dammeier, Stefan Schultze-Mosgau

School of Dentistry Faculty Research and Publications

Objectives

Postoperative pain management is of utmost interest for patients undergoing orthognathic surgery. Currently, there is a lack of information regarding process and outcome parameters of postoperative pain management after bilateral sagittal split osteotomy.

Materials and methods

In a prospective clinical study, 31 adults were evaluated on the first postoperative day following bilateral sagittal split osteotomy using the standardized questionnaire of the Germany-wide project Quality Improvement in Postoperative Pain Management (QUIPS). It allows a standardized assessment of patients’ characteristics, pain parameters, outcome, and pain therapy process parameters.

Results

Pain management consisted mainly of premedication with midazolam, sufentanil, and metamizol intraoperatively; …

Effect Of Membrane Exposure On Guided Bone Regeneration: A Systematic Review And Meta‐Analysis, Jeffrey Garcia, Austin Dodge, Paul Luepke, Hom-Lay Wang, Yvonne Kapila, Guo-Hao Lin

School of Dentistry Faculty Research and Publications

Aims: This review aimed at investigating the effect of membrane exposure on guided bone regeneration (GBR) outcomes at peri-implant sites and edentulous ridges.

Material and Methods: Electronic and manual literature searches were conducted by two independent reviewers using four databases, including MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials, for articles up to February 2017. Articles were included if they were human clinical trials or case series reporting outcomes of GBR procedures with and without membrane exposure. A random-effects meta-analysis was conducted, and the weighted mean difference (WMD) between the two groups and 95% confidence interval …

Immunohistochemical Analysis Of Il-1 Receptor 1 In The Discs Of Patients With Temporomandibular Joint Dysfunction, Luis Eduardo Almeida, Adam Sorenson, Kyle Hresko, Seth Butcher, Rosalia Leonardi, Carla Lorento, Jose A. Bosio, Lobat Tayebi, Andrea Doetzer

School of Dentistry Faculty Research and Publications

Objective

Temporomandibular joint dysfunction (TMD) may affect a patient’s quality of life, and one of the etiologies can be anterior disc displacement with reduction (ADDwR) and anterior disc displacement without reduction (ADDWoR). Interleukin 1 Receptor 1 (IL-1R1) is a membrane receptor that plays an important role on initiating immune and inflammatory response by binding the agonists ligands of IL-1 alpha and IL-1 beta. Therefore, the aim of this study was to evaluate, through immunohistochemical analysis, the association of IL-1R1 with TMD.

Methods

Thirty-nine human disc samples were collected and composed three different groups: ADDwR (n = 19), ADDwoR ( …

The Efficacy Of Commercial Tooth Storage Media For Maintaining The Viability Of Human Periodontal Ligament Fibroblasts, W. Lee, Sheila E. Stover, Morteza Rasoulianboroujeni, K. Sherman, Farahnaz Fahimipour, E. Dashtimoghadam, C. Zito, Hossein E. Jazayeri, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Aim

To evaluate Save‐A‐Tooth (SAT), EMT Toothsaver (EMT) and Hank's Balanced Salt Solution (HBSS) for their influence on the viability and proliferative capacity of human periodontal ligament fibroblasts (HPDLFs).

Methodology

Primary HPDLFs were seeded into 96‐well cell culture plates and exposed to SAT, EMT, HBSS and water (negative control) for 0.5, 1, 3, 6, 12 and 24 h at room temperature (22 °C). After each exposure time, cell viability was measured through quantifying adenosine triphosphate (ATP) using a luminescent dye. The proliferative capacity was also quantified using the PrestoBlue assay after 12 or 24 h storage in each medium. The …

Development Of Chitosan/Gelatin/Keratin Composite Containing Hydrocortisone Sodium Succinate As A Buccal Mucoadhesive Patch To Treat Desquamative Gingivitis, Zahra Davoudi, Mohammad Rabiee, Behzad Houshmand, Niloofar Eslahi, Kimia Khoshroo, Morteza Rasoulianboroujeni, Mohammadreza Tahriri, Lobat Tayebi

School of Dentistry Faculty Research and Publications

The aim of this research was to develop chitosan/gelatin/keratin composite containing hydrocortisone sodium succinate as a buccal mucoadhesive patch to treat desquamative gingivitis, which was fabricated through an environmental friendly process. Mucoadhesive films increase the advantage of higher efficiency and drug localization in the affected region. In this research, mucoadhesive films, for the release of hydrocortisone sodium succinate, were prepared using different ratios of chitosan, gelatin and keratin. In the first step, chitosan and gelatin proportions were optimized after evaluating the mechanical properties, swelling capacity, water uptake, stability, and biodegradation of the films. Then, keratin was added at different percentages …

Survival Rates Of Stainless Steel Crowns And Multi-Surface Composite Restorations Placed By Dental Students In A Pediatric Clinic, Badia A. Zahdan, Aniko Szabo, Cesar D. Gonzalez, Elaye Okunseri, Christopher Okunseri

School of Dentistry Faculty Research and Publications

Purpose: This study examined survival rates of multi-surface composite restorations and stainless steel crowns (SSCs) placed by students in a pediatric dental clinic as well as the length of time it takes for restorations to be replaced with stainless steel crowns. Study design: Data from electronic dental records for all children with at least one 2-surface composite restorations or SSCs on a primary first or second molar from January 1, 2007 to September 30, 2015 were analyzed. The primary outcome was the time to a new restoration or SSC on the same tooth, with time to a crown as a …

Serum S100b, Nse, And Gria1 Levels As Neurological Biomarkers In Lead Exposure, Esra Firat Oğuz, Fatma Meri̇ç Yilmaz, Engi̇n Tutkun, Ömer Hinç Yilmaz, Müjgan Ercan, Sevi̇lay Sezer

Turkish Journal of Medical Sciences

Background/aim: The central nervous system is one of the major targets in lead exposure. Biomarkers for the diagnosis and follow-up of lead exposure have not been identified. In this study, serum S100B, neuron-specific enolase (NSE), and glutamate receptor 1 (GRIA1) levels were determined as possible biomarkers for lead neurotoxicity. Material and methods: Twenty-five subjects with chronic lead exposure and 25 controls were included in the study. NSE and S100B were measured by electrochemiluminescence immunoassay with a Cobas E601 analyzer. GRIA1 levels were measured with an ELISA kit using a quantitative sandwich enzyme immunoassay technique. Results: GRIA1 levels were significantly higher …

Radiological And Functional Comparison Of Single-Bundle Anterior Cruciate Ligamentreconstruction: Transtibial Versus Anteromedial Technique, Mustafa Özer, Hamza Özer, Hakan Yusuf Selek, Yaşar Gül Baltaci, Gülcan Harput, Anil Taşkesen, Mehmet Çeti̇nkaya

Turkish Journal of Medical Sciences

Background/aim: This study aimed to compare radiological and functional outcomes of patients who had single-bundle anterior cruciate ligament (ACL) reconstruction with autologous hamstring tendon grafts using transtibial (TT) versus anteromedial (AM) femoral tunnel drilling techniques. Materials and methods: Sixty patients who had been operated on between 2010 and 2013 were enrolled in this study. Tunnel positions and widenings in the femur and tibia were evaluated with radiographs, arthrometric measurements with a Rolimeter arthrometer (Aircast, Summit, NJ, USA), stability assessment with Lachman and reverse pivot shift tests, and functional assessment with the International Knee Documentation Committee and Tegner and Lysholm scoring …

An Evaluation Of Banana Allergy In Children Living In The Mediterranean Region, Di̇lara Fatma Kocacik Uygun, Serkan Fi̇li̇z, Ayşen Bi̇ngöl

Turkish Journal of Medical Sciences

Background/aim: We aimed to apply a double-blind placebo-controlled food challenge (DBPCFC) test to patients who reported a reaction to banana and showed positivity for banana-specific IgE in Turkey. Materials and methods: Medical data of patients who had been analyzed for banana allergy were reviewed, focusing on banana-specific IgE positivity at the Department of Pediatric Allergy-Immunology at the Akdeniz University Faculty of Medicine between the years 2004 and 2012. Patients were called to the clinic for a DBPCFC test. Results: A total of 47 patients participated. We determined reactions in 13% of DBPCFC patients. A cut-off value was determined as 0.66 …

Development And Testing Of A Novel Symptom Assessment Scale For Behçet's Disease, Fi̇li̇z Özel, Aynur Esen Türeyen, Fi̇sun Şenuzun Aykar, Gökhan Keser

Turkish Journal of Medical Sciences

Background/aim: This study was designed to develop a Behçet's disease (BD) symptom assessment scale based on the theory of unpleasant symptoms, which deals with understanding symptom experiences in a disease. Materials and methods: The BD Symptom Assessment Scale has two sections: the factors influencing symptoms and the situations influenced by symptoms. Both of these sections were developed through an initial item pool, and expert opinions were consulted during a pilot test performed with 30 patients with BD. We then tested the validity and reliability of this scale on 218 different patients with BD fulfilling the ISG criteria. Finally, we scored …

Reliability And Validity Of The Turkish Version Of Thefoot Function Index In Patients With Foot Disorders, Bahar Külünkoğlu, Nesli̇han Firat, Nazim Tolgahan Yildiz, Afra Alkan

Turkish Journal of Medical Sciences

Background/aim: The Foot Function Index (FFI) is a valid, reliable, and widely used self-reported questionnaire for the foot. The purpose of this study was to provide evidence for the validity and reliability of the Turkish version of the FFI (FFI-TR) among patients with foot disorders such as plantar fasciitis, hallux valgus, pes planus, and hammertoe deformities. Materials and methods: One hundred and fifty-nine patients with foot disorders were enrolled. The psychometric properties of the previously translated and adapted FFI-TR were assessed. The internal consistency and test-retest reliability were evaluated. Construct validity was examined for correlations with the Short Form-36 (SF-36) …

High Nucleostemin Expression Has A Favorable Prognostic Effect On Gastric Carcinomas, Güneş Deni̇z Yildirim, Deni̇z Arik, Bülent Yildiz, Murat Di̇ncer, Necdet Fati̇h Yaşar, Özgül Paşaoğlu

Turkish Journal of Medical Sciences

Background/aim: Nucleostemin is a nuclear protein that maintains stem cell features and plays a role as a cell proliferation marker. It also participates in cell cycle regulation by interfering with other intracellular proteins. Recent reports have indicated that this protein plays a role in ribosomal biogenesis and genome protection. High expression level of nucleostemin has been reported in some cancer patients. However, the importance of nucleostemin in gastric cancer needs to be addressed. The aim of this study was to investigate nucleostemin expression in gastric cancer and the effects of this expression on prognosis. Materials and methods: Nucleostemin expression was …

Is The Management Of Rh-Rh Incompatibility With Noninvasive Fetal Rh Genotypingfor Targeted Prophylaxis Cost-Effective In The Turkish Population?, Emi̇ne Demi̇rel, Sefa Kelekçi̇, Emre Ekmekci̇, Mustafa Şengül, Razi̇ye İri̇, Melahat Atasever

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to assess unnecessary immunization rates and compare the cost-effectiveness of targeted prophylaxis with fetal Rh genotyping with that of traditional management of Rh-Rh incompatibility in a virtual economic model. Materials and methods: This retrospective data analysis was conducted at two tertiary centers between 2011 and 2015. The data of 1135 pregnant women were analyzed. The main outcome measure was to determine the unnecessary immunization rate among the whole Rh-Rh incompatibility group. The second outcome measure was to compare the cost-effectiveness of universal immunization with that of targeted prophylaxis with fetal Rh genotyping in …

An Analysis Of The Relationship Between Autoantibodies Andclinical Findings In Patients With Systemic Sclerosis, Müçteba Enes Yayla, Ufuk İlgen, Nurşen Düzgün

Turkish Journal of Medical Sciences

Background/aim: We aimed to investigate the prevalence of anti-RNA polymerase (RNAP) III and other autoantibodies in a group of Turkish patients with systemic sclerosis (SSc) and their relation with clinical features. Materials and methods: The prevalence of anti-RNAP III and other autoantibodies was analyzed in 93 patients with SSc and control groups including 86 patients with systemic lupus erythematosus (SLE) and 65 healthy subjects, respectively. Their relationship with diseases findings was assessed in a cross-sectional manner. Results: Prevalences of anti-RNAP III were 2/93 (2.2%) in SSc, 1/86 (1.2%) in SLE, and 1/65 (1.5%) in the healthy group and there was …

Correlation Between Epicardial Adipose Tissue Thickness And The Degree Of Coronary Artery Atherosclerosis, Arthur Atilla Keresztesi, Gabriela Asofie, Mihai Adrian Simion, Harald Jung

Turkish Journal of Medical Sciences

Background/aim: The purpose of the current study was to evaluate the thickness of the epicardial adipose tissue and its association with the degree of coronary artery disease in a group of autopsied cases. Materials and methods: A number of 79 cases were included in the study. Five preestablished incisions of the epicardial adipose tissue (EAT) were made on each of the hearts. These five points were next to/on the path of the major coronary vessels. The degree of coronary atherosclerosis was evaluated during the autopsy. Results: The results revealed the greatest thickness of the EAT on the incision made on …

Hiv Infection And Poor Renal Outcomes Following Noncardiac Surgery, Yoshan Moodley

Turkish Journal of Medical Sciences

Background/aim: The relevance of HIV infection in perioperative renal risk stratification remains unclear. This research sought to investigate the impact of HIV infection, as well as other established preoperative risk factors for poor perioperative renal outcome (PPRO), in a population of 565,225 adult noncardiac surgery patients whose data were obtained from the 2009-2011 California State Inpatient Database. Materials and methods: HIV status, established preoperative risk factors, and the study outcome (PPRO) were determined with the Clinical Classification Software codes recorded for each patient. Data were analyzed using univariate (Mann-Whitney U test, chi-square, and Fisher′s exact test) and multivariate (binary logistic …

Soft Spot: The Important Zone At The Standard Posterior Portal Of Shoulder Arthroscopy, Burcu Erçakmak, Ceren Günenç Beşer, Mehmet Hakan Özsoy, Mehmet Deni̇z Demi̇ryürek, Alp Bayramoğlu, Kadi̇r Mutlu Hayran

Turkish Journal of Medical Sciences

Background/aim: The localization of the standard posterior portal of shoulder arthroscopy and landmarks mentioned in the literature are unclear. The purpose of this prospective cadaveric study was to determine the localization of the standard posterior portal and its distance to the neural structures. Materials and methods: One fresh frozen and 10 formalin-fixed adult cadaveric shoulders were dissected. In the beach chair position, a 5-mm trocar was placed anteroposteriorly from the superior edge of the subscapularis muscle, superior to the tip of the coracoid process and tangent to the glenoid. The relevant distances of the posterior exit point were measured. Results: …

Evaluation Of Urinary Incontinence And Quality Of Life In Marriedwomen Aged Between 20 And 49 Years (Sakarya, Turkey), Kevser İlçi̇oğlu, Sevi̇l Şahi̇n, Nebahat Özerdoğan, Alaetti̇n Ünsal

Turkish Journal of Medical Sciences

Background/aim: This study aimed to determine the prevalence of urinary incontinence and to evaluate the relationship between urinary incontinence and quality of life in married women. Materials and methods: This is a cross-sectional study conducted among married women aged 20-49 years living in the vicinity of the Çökekler Community Clinic (Family Health Center) in Sakarya, Turkey, from 1 November 2011 to 15 April 2012. The study group consisted of 1161 women. Results: The frequency of urinary incontinence was 71.5% (n = 830). Out of a total of 830 patients with symptoms of urinary incontinence, mixed was the most frequently determined …

Diagnostic Utility Of The Sonographic Median To Ulnar Nervecross-Sectional Area Ratio In Carpal Tunnel Syndrome, Tuğba Atan, Zafer Günendi̇

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to assess the diagnostic utility of the ultrasonographic ratio of median nerve cross-sectional area (m-CSA) to ulnar nerve cross-sectional area (u-CSA), the m-CSA/u-CSA ratio, in carpal tunnel syndrome (CTS). Materials and methods: Fifty patients with positive symptoms and electromyography results of CTS and 50 healthy matched control subjects were evaluated. Ultrasonographic m-CSA and u-CSA measurements of each participant were made at the level of the pisiform bone and the m-CSA/u-CSA ratio was calculated. Results: Using the m-CSA cut-off value of 11.95 mm2 showed a sensitivity of 80% and a specificity of 80% while …

Cross-Cultural Adaptation, Reliability, And Validity Of The Turkish Version Of The Cancer Fatigue Scale In Patients With Breast Cancer, Sedef Şahi̇n, Meral Huri̇, Orkun Tahi̇r Aran, Mi̇ne Uyanik

Turkish Journal of Medical Sciences

Background/aim: The Cancer Fatigue Scale (CFS) was developed to evaluate the severity of fatigue in patients with breast cancer. The aim of this study is to translate and culturally adapt a Turkish version and investigate the validity and reliability of the CFS in Turkish patients with fatigue symptoms. Materials and methods: Eighty participants completed the Turkish version of the CFS for breast cancer and the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire ″Core 30″ (EORTC QLQ-C30). Test-retest reliability was evaluated by repeating the CFS with a 7-day interval. Results: The CFS demonstrated high test-retest …

Effects Of Nefopam With Fentanyl In Intravenous Patient-Controlled Analgesia After Arthroscopic Orthopedic Surgery: A Prospective Double-Blind Randomized Trial, You Na Oh, Kyu Nam Kim, Mi Ae Jeong, Dong Won Kim, Ji Yoon Kim, Hyun Seo Ki

Turkish Journal of Medical Sciences

Background/aim: We performed this prospective randomized double-blind study to compare the effects of nefopam versus ketorolac in intravenous fentanyl-based patient-controlled analgesia (PCA) after shoulder arthroscopic orthopedic surgery. Materials and methods: Ninety-two patients were randomly divided into two groups to receive intravenous PCA. Patients were assigned to either the nefopam group (nefopam 120 mg and fentanyl 20 µg/kg) or the ketorolac group (ketorolac 2 mg/kg and fentanyl 20 µg/kg). Pain was assessed on a visual analogue scale (VAS) and a numeric rating scale (NRS). Additionally, patient satisfaction, adverse events, and vital signs were monitored. Results: There were no significant differences in …

Effects Of Cinnamic Acid On Complications Of Diabetes, Hati̇ce Gül Anlar, Merve Bacanli, Tuğbagül Çal, Sevtap Aydin, Nuray Ari, Ülkü Ündeğer Bucurgat, Ari̇f Ahmet Başaran, Ayşe Nurşen Başaran

Turkish Journal of Medical Sciences

Background/aim: Diabetes mellitus (DM) is a major health problem worldwide. Cinnamic acid (CA) and its derivatives are synthesized in plants and increasing attention has been given to them in recent years due to the high number of beneficial health properties attributed to their consumption. The aim of this study was to investigate the effects of CA on streptozotocin-induced diabetes in Wistar albino rats. Materials and methods: DNA damage was evaluated in the blood, liver, and kidney cells of rats by the alkaline comet assay. Oxidative stress parameters such as catalase, superoxide dismutase, glutathione reductase, glutathione-S-transferase, and glutathione peroxidase activities and …

In Vivo Attenuation Of Angiogenesis In Hepatocellular Carcinoma By Nigella Sativa, Moustafa Fathy, Toshio Nikaido

Turkish Journal of Medical Sciences

Background/aim: Angiogenesis is imperative in malignant tumor growth. Hepatocellular carcinoma is a typical hypervascular tumor that relies on angiogenesis. The aim of this study is to investigate the in vivo molecular mechanism underlying the antitumor properties of Nigella sativa ethanolic extract (NSEE) through its antiangiogenic effect against diethyl nitrosamine (DENA)-induced hepatocarcinogenesis. Materials and methods: Male Wistar rats were divided into 4 groups: normal, NSEE, DENA, and NSEE-DENA groups. Final body weight, hepatosomatic indices, serum AFP, serum vascular endothelial growth factor (VEGF) levels, and liver tissue hepatocyte growth factor ß (HGFß) protein expression were estimated. Liver sections were stained for histological …

The Role Of Apoptosis And The Effect Of Epidermal Growth Factor On Proapoptotic Bnip 3 In An Experimental Rat Priapism Model, Osman Barut, Ahmet Karakeçi̇, Tunç Ozan, Fati̇h Firdolaş, Neci̇p Pi̇ri̇nççi̇, İrfan Orhan

Turkish Journal of Medical Sciences

Background/aim: This study aimed to investigate the effects of apoptosis-inducing Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP 3) and antiapoptotic epidermal growth factor (EGF) on the pathophysiology of experimental low-flow priapism. Materials and methods: Twenty-four adult Sprague-Dawley rats were divided into four equal groups. Group I was the control group. Ischemic priapism was induced for 4 h in Group II rats. In Group III, intraperitoneal EGF at 10 µg/kg was given for 7 days before induction of ischemic priapism for 4 h. In Group IV, intraperitoneal EGF at 20 µg/kg was given for 7 days before induction of ischemic priapism …

A Statistical Approach To Evaluate The Performance Of Cardiac Biomarkers In Predicting Death Due To Acute Myocardial Infarction: Time-Dependent Roc Curve, Eda Karai̇smai̇loğlu, Zeli̇ha Günnur Di̇kmen, Fi̇li̇z Akbiyik, Ahmet Ergun Karaağaoğlu

Turkish Journal of Medical Sciences

Background/aim: Myoglobin, cardiac troponin T, B-type natriuretic peptide (BNP), and creatine kinase isoenzyme MB (CK-MB) are frequently used biomarkers for evaluating risk of patients admitted to an emergency department with chest pain. Recently, time- dependent receiver operating characteristic (ROC) analysis has been used to evaluate the predictive power of biomarkers where disease status can change over time. We aimed to determine the best set of biomarkers that estimate cardiac death during follow-up time. We also obtained optimal cut-o values of these biomarkers, which di erentiates between patients with and without risk of death. A web tool was developed to estimate …

Is Thermal Balloon Ablation In Women With Previous Cesarean Delivery Successful?, Zinatossadat Bouzari, Shahla Yazdani, Mojgan Naeimi Rad, Ali Bijani

Turkish Journal of Medical Sciences

Background/aim: Endometrial ablation is used to treat heavy menstrual bleeding in women who do not respond to standard therapy. is study aimed to compare treatment success in women with previous cesarean delivery and vaginal delivery who were subjected to thermal balloon ablation. Materials and methods: This cohort study enrolled women with symptoms of heavy menstrual bleeding who had major health problems and were considered as high-risk patients for hysterectomy. Patients were divided into two groups, vaginal delivery and cesarean section (C-section). ermal balloon ablation was performed under general or regional anesthesia on days 3?5 of the menstrual cycle. Treatment success …