Medicine and Health Sciences Commons^™

Sex Differences In Cardiovascular Adaptations To Chronic Endurance Exercise, Jacqueline A. Augustine

Dissertations - ALL

Endurance exercise typically leads to beneficial cardiac adaptations manifested as increased cardiac mass, higher cardiac function and lower central hemodynamic load (blood pressure, aortic stiffness and wave reflections). However, studies in male marathoners suggest detrimental cardiac remodeling, such that larger cardiac mass is associated with reduced cardiac function and higher central hemodynamic load. There are well-established sex differences in cardiac adaptations to endurance exercise and central hemodynamics across the lifespan. Whether there are sex differences in cardiovascular adaptations in marathoners requires further scrutiny. We examined sex differences in 1) Left ventricle (LV) structure, 2) LV function 3) 24-hour central hemodynamic …

Identification Of Genes Required For Eye Development By High-Throughput Screening Of Mouse Knockouts., Bret A Moore, Brian C Leonard, Lionel Sebbag, Sydney G Edwards, Ann Cooper, Denise M Imai, Ewan Straiton, Luis Santos, Christopher Reilly, Stephen M Griffey, Lynette Bower, David Clary, Jeremy Mason, Michel J Roux, Hamid Meziane, Yann Herault, Colin Mckerlie, Ann M Flenniken, Lauryl M J Nutter, Zorana Berberovic, Celeste Owen, Susan Newbigging, Hibret Adissu, Mohammed Eskandarian, Chih-Wei Hsu, Sowmya Kalaga, Uchechukwu Udensi, Chinwe Asomugha, Ritu Bohat, Juan J Gallegos, John R Seavitt, Jason D Heaney, Arthur L Beaudet, Mary E Dickinson, Monica J Justice, Vivek M. Philip, Vivek Kumar, Karen L. Svenson, Robert E Braun, Sara Wells, Heather Cater, Michelle Stewart, Sharon Clementson-Mobbs, Russell Joynson, Xiang Gao, Tomohiro Suzuki, Shigeharu Wakana, Damian Smedley, J K Seong, Glauco Tocchini-Valentini, Mark Moore, Colin Fletcher, Natasha Karp, Ramiro Ramirez-Solis, Jacqueline K White, Martin Hrabe De Angelis, Wolfgang Wurst, Sara M Thomasy, Paul Flicek, Helen Parkinson, Steve D M Brown, Terrence F Meehan, Patsy M. Nishina, Stephen A. Murray, Mark P. Krebs, Ann-Marie Mallon, K C Kent Lloyd, Christopher J Murphy, Ala Moshiri

Faculty Research 2018

Despite advances in next generation sequencing technologies, determining the genetic basis of ocular disease remains a major challenge due to the limited access and prohibitive cost of human forward genetics. Thus, less than 4,000 genes currently have available phenotype information for any organ system. Here we report the ophthalmic findings from the International Mouse Phenotyping Consortium, a large-scale functional genetic screen with the goal of generating and phenotyping a null mutant for every mouse gene. Of 4364 genes evaluated, 347 were identified to influence ocular phenotypes, 75% of which are entirely novel in ocular pathology. This discovery greatly increases the …

Tumble Tots: Outcomes Of A Gymnastics Program For Children With Disabilities, Cayla Leichtenberger

Electronic Theses and Dissertations

Despite the benefits, children with disabilities do not participate in recreational activities as often as typically developing peers. The purpose of the program was to: 1) describe the benefit of a gymnastics program on a child’s development, and 2) identify the impact of a staff training program. Engagement in the proposed program aimed to ultimately contribute to a child’s involvement in recreational activities, health and quality of life (QOL). All participants in the gymnastics program demonstrated a positive change in motor and communication skills. Pre-test data from the staff training program indicated that none of the gymnastics staff members were …

Sensory-Based Programming In Mental Health: Sense Of Self, Nikki Yeckel

Electronic Theses and Dissertations

The doctoral experiential component (DEC) for this Capstone was completed at the Veterans Affairs Healthcare System (VA) in Pittsburgh, Pennsylvania. The program, called Sense of Self, was implemented with the Veteran mental health (MH) population in an inpatient psychiatric rehabilitation unit at the VA. Sense of Self was a three-day educational program that educated Veterans on the sensory systems and sensory processing, provided calming or alerting strategies with use of sensory materials, and assisted the Veterans in creating sensory home programs based on personal goals. The goals of this Capstone were to inform the staff of the Veteran demographic population …

Prognostic Relevance Of Ccdc88c (Daple) Transcripts In The Peripheral Blood Of Patients With Cutaneous Melanoma, Ying Dunkel, Anna L. Reid, Jason Ear, Nicolas Aznar, Michael Millward, Elin Gray, Robert Pearce, Melanie Ziman, Pradipta Ghosh

Research outputs 2014 to 2021

A loss of balance between G protein activation and deactivation has been implicated in the initiation of melanomas, and non-canonical Wnt signaling via the Wnt5A/Frizzled (FZD) pathway has been shown to be critical for the switch to an invasive phenotype. Daple [CCDC88C], a cytosolic guanine nucleotide exchange modulator (GEM) which enhances non-canonical Wnt5A/FZD signaling via activation of trimeric G protein, Gαi, has been shown to serve opposing roles-as an inducer of EMT and invasiveness and a potent tumor suppressor-via two isoforms, V1 (full-length) and V2 (short spliced isoform), respectively. Here we report that the relative abundance of these isoforms in …

The Influence Of Age, Gender, And Thiol Repletion In An In Vivo Model Of Lewy Body Disorders, Daniel Mason

Electronic Theses and Dissertations

Lewy body disorders are a family of neurological brain disorders associated with olfactory, motor, and cognitive deficits and are collectively defined as α-synucleinopathies, as they are characterized by hallmark “Lewy bodies” composed of aggregated, fibrillar α-synuclein. It is not certain but often posited that fibrillar α-synuclein seeds the progressive, self-propagating spread of Lewy pathology through neuroanatomical circuitry. Furthermore, the site of disease induction is still debated. In Aim I, we developed a novel protocol for generating reproducible and robust α-synucleinopathy in the limbic temporal lobe following infusions of preformed α-synuclein iv fibrils into the mouse olfactory bulb, which is frequently …

Oculomotor Nerve Palsy After Influenza Vaccine In Inflammatory Bowel Disease., Rajesh Essrani Md, Rajesh K Essrani, Shehriyar Mehershahi, Arjun K Lohana, Anuraj Sudhakaran

Department of Medicine

Influenza and pneumococcal vaccines are recommended in inflammatory bowel disease patients. Several neurologic complications have been reported after influenza vaccines, such as Guillain-Barre syndrome, chronic inflammatory demyelinating polyneuropathy, and acute disseminated encephalomyelitis; however, rarely, oculomotor palsy will occur. We report the case of a 23-year-old male with a past medical history of ulcerative colitis on sulfasalazine who presented to the hospital with a complaint of blurry vision five days after an influenza vaccine. Most of the possible causes of oculomotor nerve palsy, such as stroke, intracranial space-occupying lesions, aneurysms, and infections, were ruled out by history, physical exam, blood work, …

Effects Of Cultural And Language Barriers On The Outcome Of Autism Spectrum Disorder Amongst Children From The Somali Immigrant Population Of Minnesota, Amal Farah

Theses and Graduate Projects

Autism Spectrum Disorder (ASD) is a devastating developmental disorder with a decline in both neurological and behavioral functions. ASK can present with delays in language development, social skills, and restricts behavioral patterns. The prevalence of ASD has been on the rise int he United States with a rate of one in 69 children. Moreover, the prevalence of ASD has been drastically increasing in the Somali community of Minnesota affecting one in 32 children. Many research studies associate the rise of ASD in the Somali community with the elements of culture, tradition, and language barriers. This research paper will explore how …

Hypoxic Preconditioning Attenuates Reoxygenation-Induced Skeletal Muscle Dysfunction In Aged Pulmonary Tnf-Α Overexpressing Mice, China-Chen Chuang, Tingyang Zhou, Mark Olfert, Li Zuo

Faculty & Staff Scholarship

No abstract provided.

Trends In Opioid Use In Pediatric Patients In Us Emergency Departments From 2006 To 2015, Daniel M. Tomaszewski, Cody Arbuckle, Sun Yang, Erik J. Linstead

Pharmacy Faculty Articles and Research

Importance The use of opioids to treat pain in pediatric patients has been viewed as necessary; however, this practice has raised concerns regarding opioid abuse and the effects of opioid use. To effectively adjust policy regarding opioids in the pediatric population, prescribing patterns must be better understood.

Objective To evaluate opioid prescribing patterns in US pediatric patients and factors associated with opioid prescribing.

Design, Setting, and Participants This cross-sectional study used publicly available data from the National Hospital Ambulatory Medical Care Survey from January 1, 2006, to December 31, 2015. Analysis included the use of bivariate and multivariate models to …

Student Hotspotting Kickoff

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Student Hotspotting Kickoff

Academy For Professionalism In Health Care (Aphc) 2019 Annual Meeting

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Academy for Professionalism in Health Care (APHC) 2019 Annual Meeting

Health Mentors Program Reflection Essays, Cecilia Pivarunas, Karmanpreet Singh

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Health Mentors Program Reflection Essays

Meet An Ipe Faculty Champion From Thomas Jefferson University: Janet Jackson-Coty, Pt, Dpt, Pcs, Janet Jackson-Coty, Pt, Dpt, Pcs

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Meet an IPE Faculty Champion from Thomas Jefferson University: Janet Jackson-Coty, PT, DPT, PCS

An Interprofessional Approach To Understanding The Impact Of Poverty As A Social Determinant Of Health, Patrician Dillon, Phd, Rn

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

An Interprofessional Approach to Understanding the Impact of Poverty as a Social Determinant of Health

Meet An Ipe Student Champion From Thomas Jefferson University: Zachary Semenetz, Md Student, Class Fo 2019, Zachary Semenetz

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Meet an IPE Student Champion from Thomas Jefferson University: Zachary Semenetz, MD Student, Class fo 2019

Initiating Collaborative Care In Pain Management Curricula, Sharon Rainer, Phd, Aprn, Anp-Bc, Fnp-Bc, Emily Hajjar, Pharmd, Ms, Bcps, Bcacp, Bcgp

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Research Question/Objectives/Purpose

This article describes a pilot study at Thomas Jefferson University that endeavored to address the following question: Is an IPE simulation session an effective method to improve knowledge and attitudes among prescribers regarding pain?

Interprofessional Care For The 21st Century: 6th Edition

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

JCIPE would like to thank all of our keynote speakers, presenters, participants, session moderators, abstract reviewers, and conference committee members for making this October 2018 conference a success. We are so grateful for your participation! Thank you again and we look forward to seeing you all at our 7th Biennial Conference in 2020!

From The Editors

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

From the Editors

Increasing Colorectal Cancer Screening Among Hispanic Primary Care Patients: Re-Aim Analysis., Beth Careyva M.D., Melanie B. Johnson Mpa, Randa D. Sifri Md, Melissa Dicarlo Mph, Ms, Kyle Shaak Bs, Alicia Rivera, Liselly Diaz, Andrea Barsevick, Rosa Anderson-Deortiz, Evelyn T. Gonzalez Ma, Amy Leader Drph, Mph, Anett Petrich Rn, Msn, Anna Quinn Mph, Ryt, Brian Stello Md, Ronald E. Myers Phd

Beth A. Careyva, M.D.

Context: Hispanic adults experience disparities in rates of colorectal cancer (CRC) screening. This RE-AIM analysis encompassed a multilevel decision support and navigation intervention (DSNI) for CRC screening. Interim findings were previously presented; we now aim to share the final analysis, particularly for effectiveness and implementation. Objective: Apply RE-AIM framework to a completed randomized controlled trial of a CRC screening intervention for Hispanic adults Setting: Five primary care practices Patients or Other Participants: Potential participants included a sampling frame of 2,720 screening-eligible patients, ages 50-75, Hispanic ethnicity, without history of CRC and polyps. 400 participants were enrolled. Intervention/Instrument: Decision support and …

Repeat Crc Screening After Standard And Decision Support And Navigation Interventions Among Hispanic Primary Care Patients., Melanie B. Johnson Mpa, Beth Careyva M.D., Melissa Dicarlo Mph, Ms, Kyle Shaak Bs, Sarah Hegarty Mphil, Evelyn T. Gonzalez Ma, Anna Quinn Mph, Ryt, Randa Sifri Md, Brian Stello Md, Ronald E. Myers Phd

Beth A. Careyva, M.D.

No abstract provided.

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Facilitating Pre-Service Teachers To Engage Emergent Bilinguals In Productive Struggle, Benjamin T. Dickey, Jim Ewing, Melissa Caruso, Emily D. Fulmer

Journal of Multicultural Affairs

This study utilized a multiple case study with qualitative research to examine how Pre-service teachers (PSTs) might engage Emergent Bilinguals (EBs) in productive struggle—grappling to solve problems (Warshauer, 2015). The researchers created a rubric based on Warshauer’s (2015) case study to record the types of questions PSTs asked as they tutored fourth grade EBs. Warshauer (2015) claimed PSTs should allow students more wait time and ask questions. She referred to such questions as affordance and probing guidance, which facilitates productive struggle. In order to discover more about the PSTs’ thinking, the researchers interviewed the PSTs before and after their first, …

Adaptations Made To Evidence-Based Public Health Programs In Low- To Middle- Income Countries: A Concept Mapping Analysis, Elizabeth Holguin

Nursing ETDs

One of the most challenging barriers to implementing successful and sustainable evidence-based programs in public health is the ability to remain faithful to original protocols grounded in scientific evidence while adapting programmatic components to reflect the reality of the communities they are meant to benefit. It is generally accepted that some degree of adaptation should occur in order to achieve positive, sustainable outcomes in public health programs. A concept mapping methodology was used to explore types of adaptation that occur during implementation of evidence-based global health programs in low- to middle-income countries (LMICs). Purposive and snowball sampling produced a sample …

Andrews Student Selected For Api Scholarship, Auburn Health Strategies

Andrews Agenda: Campus News

No abstract provided.