Medicine and Health Sciences Commons^™

การวิเคราะห์คลื่นไฟฟ้ากล้ามเนื้อและแรงปฏิกิริยาจากพื้นในการวิ่งลากถ่วงน้ำหนักด้วยมุมเส้นเชือกที่ต่างกัน ในนักกีฬารักบี้ฟุตบอลหญิง, ณัฐณิชา ทองพัฒนวงศ์

Chulalongkorn University Theses and Dissertations (Chula ETD)

วัตถุประสงค์ การวิจัยครั้งนี้มีวัตถุประสงค์เพื่อวิเคราะห์และเปรียบเทียบคลื่นไฟฟ้ากล้ามเนื้อ แรงปฏิกิริยาจากพื้น และความเร็วในการวิ่ง เมื่อวิ่งลากถ่วงน้ำหนักที่มุมเส้นเชือก 30 45 และ 60 องศา จากแนวขนานกับพื้น วิธีดำเนินการวิจัย กลุ่มตัวอย่างเป็นนักกีฬารักบี้ฟุตบอลสังกัด ชมรมรักบี้ฟุตบอลของจุฬาลงกรณ์มหาวิทยาลัย เพศหญิง มีอายุระหว่าง 18-25 ปี จำนวน 15 คน กลุ่มตัวอย่างได้รับการทดลองวิ่งลากถ่วงน้ำหนักด้วยการยืนแบบ 2 จุด ท่าเท้านำเท้าตาม โดยเริ่มทดลองจากการวิ่งไม่มีเครื่องลากถ่วงน้ำหนัก ตามด้วยการสุ่มลำดับการวิ่งลากถ่วงน้ำหนักในความหนัก 30% ของน้ำหนักร่างกายที่มุมเส้นเชือก 30 45 และ 60 องศา ในระยะทาง 5 เมตร โดยทำการวิ่งทั้ง 3 รูปแบบๆ ละ 3 ครั้ง พักระหว่างการวิ่งแต่ละครั้งเป็นเวลา 5 นาที เปรียบเทียบความเร็วในการวิ่งระยะ 5 เมตร แรงปฏิกิริยาจากพื้นของขาก้าวที่ 3 และอัตราส่วนระหว่างความเข้มของคลื่นไฟฟ้ากล้ามเนื้อสูงสุดขณะเคลื่อนไหว ต่อความเข้มของกล้ามเนื้อสูงสุดเมื่อกล้ามเนื้อหดตัวแบบความยาวคงที่ (Maximum intensity/MVC) ใช้ ANOVA และวิเคราะห์คู่ต่างด้วย Tukey โดยกำหนดระดับความมีนัยสำคัญทางสถิติที่ p-value 0.05 ผลการวิจัย พบความแตกต่างอย่างมีนัยสำคัญทางสถิติของความเร็วในการวิ่งเมื่อเปรียบเทียบระหว่างขณะวิ่งโดยไม่มีเครื่องลากถ่วงน้ำหนัก และวิ่งลากถ่วงน้ำหนักทั้งที่มุมเส้นเชือก 30 45 และ 60 องศา อย่างไรก็ตามไม่พบความแตกต่างอย่างมีนัยสำคัญทางสถิติของทั้งแรงปฏิกิริยาจากพื้น และคลื่นไฟฟ้ากล้ามเนื้อ สรุปผลการวิจัย การฝึกวิ่งลากถ่วงน้ำหนักที่มุมเส้นเชือก 60 องศา อาจเหมาะสมต่อการพัฒนากล้ามเนื้อที่ใช้ในการวิ่งออกตัวของนักกีฬารักบี้ฟุตบอลหญิงได้มากที่สุด เนื่องจากรูปแบบการทำงานของกล้ามเนื้อใกล้เคียงกับรูปแบบการทำงานของกล้ามเนื้อในขณะวิ่งไม่มีเครื่องลากถ่วงน้ำหนัก แต่มีคลื่นไฟฟ้ากล้ามเนื้อมากกว่า และแรงปฏิกิริยาจากพื้นในแนวดิ่งน้อยที่สุด อย่างไรก็ตามการวิ่งลากถ่วงน้ำหนักน่าจะมีผลต่อการทำงานของกล้ามเนื้อและแรงปฏิกิริยาเมื่อมีน้ำหนักในการลากถ่วงมากกว่า 30% ของน้ำหนักร่างกาย และมีผลเฉพาะก้าวแรก ส่งผลลดลงเมื่อวิ่งในก้าวที่ 3 และก้าวต่อ ๆ ไป

ผลของการใช้โฟมโรลลิ่งและการยืดเหยียดกล้ามเนื้อแบบมีการเคลื่อนไหวที่มีต่อสมรรถภาพของกล้ามเนื้อขาในนักกีฬาฟุตซอล, ประทักษ์ สระสม

Chulalongkorn University Theses and Dissertations (Chula ETD)

การวิจัยครั้งนี้มีวัตถุประสงค์เพื่อศึกษาและเปรียบเทียบผลของการอบอุ่นร่างกายด้วยโฟมโรลลิ่งและการอบอุ่นร่างกายด้วยการยืดเหยียดกล้ามเนื้อแบบมีการเคลื่อนไหวที่มีต่อสมรรถภาพของกล้ามเนื้อขาในนักกีฬาฟุตซอล กลุ่มตัวอย่างที่ใช้ในการวิจัยครั้งนี้ เป็นนักฟุตซอลของสโมสรมหาวิทยาลัยเกษมบัณฑิต เพศชาย มีอายุระหว่าง 18-25 ปี จำนวน 18 คน โดยเลือกกลุ่มตัวอย่างแบบเจาะจง โดยกลุ่มตัวอย่างทำการทดลองทั้ง 2 รูปแบบ ได้แก่ การอบอุ่นร่างกายด้วยโฟมโรลลิ่ง และการอบอุ่นร่างกายด้วยการยืดเหยียดกล้ามเนื้อแบบมีการเคลื่อนไหว และทำการทดสอบสมรรถภาพของกล้ามเนื้อขาทันทีหลังจากการทดลองโดยการทดลองแต่ละรูปแบบมีระยะเวลาห่างกันอย่างน้อย 1 สัปดาห์ และนำข้อมูลที่ได้มาวิเคราะห์ทางสถิติ หาค่าเฉลี่ย ส่วนเบี่ยงเบนมาตรฐาน และสถิติทดสอบที (Paired Samples t-test) ที่ระดับความมีนัยสำคัญทางสถิติ 0.05 ผลการวิจัยพบว่า ค่าเฉลี่ยของระยะการเคลื่อนไหวข้อเข่าขาขวาหลังการทดลองทันทีของการอบอุ่นร่างกายด้วยโฟมโรลลิ่ง และการอบอุ่นร่างกายด้วยการยืดเหยียดกล้ามเนื้อแบบมีการเคลื่อนไหว แตกต่างกันอย่างมีนัยสำคัญทางสถิติที่ระดับ .05 และค่าเฉลี่ยของระยะการเคลื่อนไหวของข้อสะโพกขาซ้ายและขาขวา ระยะการเคลื่อนไหวของข้อเข่าขาซ้าย ความคล่องแคล่วว่องไว ความสามารถในการเปลี่ยนทิศทาง และความเร็วหลังการทดลองทันทีของการอบอุ่นร่างกายด้วยโฟมโรลลิ่ง และการอบอุ่นร่างกายด้วยการยืดเหยียดกล้ามเนื้อแบบมีการเคลื่อนไหว ไม่แตกต่างกันอย่างมีนัยสำคัญทางสถิติที่ระดับ.05 การอบอุ่นร่างกายด้วยโฟมโรลลิ่ง และการอบอุ่นร่างกายด้วยการยืดเหยียดกล้ามเนื้อแบบมีการเคลื่อนไหวช่วยเพิ่มระยะการเคลื่อนไหวของข้อสะโพก ระยะการเคลื่อนไหวของข้อเข่า ความคล่องแคล่วว่องไว ความสามารถในการเปลี่ยนทิศทาง ความเร็ว ในนักกีฬาฟุตซอลได้

"Burned Out" At Work But Satisfied With One's Job: Anatomy Of A False Paradox, Eric Laurent, Irvin Sam Schonfeld, Renzo Bianchi

Publications and Research

In a recent study of 346 US neurosurgery residents Attenello et al reported that 67% of their participants suffered from burnout. The authors also found that 81% of surveyed residents were satisfied with their career. Attenello et al described their results as paradoxical. We criticize their methodology.

The Effect Of The Annual Training Cycle On Aerobic Capacity In Division I Female Soccer Players, Chase S. Mcpherson

Longwood Senior Theses

Purpose: To assess the effect of variable training stress throughout the annual training cycle on aerobic capacity (AC) in female soccer players. Methods: Eleven Division l female soccer players (Mean ± SD: 19.3 ± 1.0 yrs; 164 ± 6.4 cm; 60.1 ± 5.4 kg; 19.44 ± 3.5 %BF, 48.3 ± 4.0 kg FFM, 43.3 ± 3.3 ml/kg/min VO2max) were tested across the annual training cycle at six specific time points (B1-B6): post-season 2016 (B1), transition (detraining) (B2), spring-season (B3), pre-season (B4), mid-season (B5), and post-season 2017 (B6). Prior to exercise for each testing block, subjects arrived at the lab where …

Root-Cause Analysis Of Persistently High Maternal Mortality In A Rural District Of Indonesia: Role Of Clinical Care Quality And Health Services Organizational Factors, Mohammad Afzal Mahmood, Ismi Mufidah, Steven Scroggs, Amna Rehana Siddiqui, Hafsa Raheel, Koentijo Wibdarminto, Bernardus Dirgantoro, Jorien Vercruyssen, Hayfaa A. Wahabi

Community Health Sciences

Background: Despite significant reduction in maternal mortality, there are still many regions in the world that suffer from high mortality. District Kutai Kartanegara, Indonesia, is one such region where consistently high maternal mortality was observed despite high rate of delivery by skilled birth attendants.
Method: Thirty maternal deaths were reviewed using verbal autopsy interviews, terminal event reporting, medical records' review, and Death Audit Committee reports, using a comprehensive root-cause analysis framework including Risk Identification, Signal Services, Emergency Obstetrics Care Evaluation, Quality, and 3 Delays.
Findings: The root causes were found in poor quality of care, which caused …

Impact Of Pre-Eclampsia On The Cardiovascular Health Of The Offspring: A Cohort Study Protocol, Zahra Hoodbhoy, Babar Hasan, Nuruddin Badruddin Mohammed, Devyani Chowdhury

Department of Paediatrics and Child Health

Introduction: Pre-eclampsia is a common disorder associated with serious maternal and fetal complications. It is associated with abnormal placentation, which significantly reduces flow, resulting in a relative hypoxic state. These pathophysiological changes lead to subtle macrovascular and cardiac structural and functional changes in the fetus. This can predispose the child with maternal history of pre-eclampsia to risk of premature cardiovascular disease.
Methods and analysis: The children will be identified from a cohort of women with pre-eclampsia. The study will be conducted at The Aga Khan University Hospital, Karachi. Inclusion criteria will be children who are between 2 and 5 years …

Optimisation Of Ion Exchange Chromatography Purification Protocols For A Staphylococcal Peptidoglycan Degrading Hydrolase Enzyme, Fiona Maher

Theses

Bacteriophage (phage) are the most abundant biological entities on earth and were first discovered by d’Herelle in 1917. They are found wherever their hosts live and, like all viruses they do not have the ability to make their own protein. Therefore, in order to reproduce, phage must invade and infect bacterial cells. This project focused on the optimisation of Ion Exchange Chromatography purification protocols for a staphylococcal peptidoglycan degrading hydrolase enzyme (CHAPk). The project objective was to obtain the greatest yield of enzyme from the growth of the E.coU XL 1-Blue expression system into which the vector pQE60 was previously …

Designing And Evaluating The Impact Of An Inclusive Aquatics Training Programme For Aquatic Tutors And Teachers, Lucy Cush

Theses

Every human has a fundamental right to physical education, physical activity and sport without discrimination. To achieve quality physical education, physical activity and sport, the associated support personnel, professionals and volunteers alike should be appropriately enabled through suitable training. For people with disabilities, aquatic activities are a recognised method of developing physical and motor skills, social skills and developing selfesteem (Getz, Hutzler and Vermeer, 2006). Hence, aquatics being the most popular physical activity for people with a disability (Irish Sports Monitor, 2015).

A key factor that determines the success of an inclusive aquatic programme is the aquatic instmctor (Conaster et …

Readiness For Assisted Decision-Making: An Exploratory Qualitative Study, Kay Cronin

Theses

Background: Ireland has recently enacted the Assisted Decision-Making (Capacity) Act 2015. The enactment of the legislation has allowed Ireland to ratify the United Nations Convention on the Rights of People with Disabilities (2008). The convention obliges all member states to assist people with disabilities to make their own decisions, with their will and preference taking precedence over what others deem to be in their best interests. Implementation of this legislation requires a change in working practice among health and social care providers to promote autonomy and decision-making among service users. To date, this topic has not been researched in Ireland. …

Perception Of Supervisory Styles And Satisfaction, Stephanie M. Schaaf

Murray State Theses and Dissertations

Supervision is a dynamic and challenging leadership process that remains an essential element within the field of speech-language pathology. This study utilized a descriptive research design in attempt to amass quantifiable information that can be used to statistically analyze elements within the supervisor-supervisee relationship. Agreement of perceived supervisory styles and satisfaction between supervisor-supervisee dyads (n=74) were examined. External and personal characteristics including age, clinical setting, experience, and previous training were also examined in relation to supervisee satisfaction and agreement of supervisory styles within dyads. Data was collected through completion of a demographic questionnaire as well as the Supervisory Style Inventory …

Effects Of Parent Role Modeling Behaviors In Correlation To Child Overweight And Obesity In Preschool-Aged Children, Nicole Van Heek

Electronic Theses and Dissertations

OBJECTIVE: Parents have been proven to shape their children’s health through their growing years.1-6 Extensive research has been done on the correlation between adolescent’s health status and parent’s role modeling behaviors. However, little research has been done in preschool-aged children. Therefore, the purpose of this study was to determine if parenting style with food and meal behaviors was associated with body mass index (BMI) and weight status in preschool-aged children (3-5 years).
METHODS: This study is a part of South Dakota State University’s iGrow Readers study. For this study, a total of 229 child/parent dyads participated from 14 recruited daycare …

Universal Swine Influenza Antigen And Vaccine, Zhao Wang

Electronic Theses and Dissertations

Swine influenza A viruses pose a serious concern for global health and worldwide swine industry considering their evasion from vaccine-induced immune responses. Formulation of effective influenza vaccines can be complicated by both antigenic shift to a different subtype of hemagglutinin (HAs) and antigenic drift within a particular HA subtype. To address these concerns, we employed a systematic approach to determine the antigenic determinants of swine influenza A viruses by focusing on H1 and H3 subtypes. In parallel, we used a cross-disciplinary approach including structural biology and modeling, virology, and immunology to identify swine influenza A virus-derived HA fusion intermediates broadly …

Serological Evidence For The Co-Circulation Of Two Lineages Of Influenza D Virus In Equine Populations Of The Midwest United States, Hunter Theodore Nedland

Electronic Theses and Dissertations

Influenza D virus (IDV) is a newly described lineage of the Orthomyxoviridae virus family that was first isolated from diseased swine in 2011 and has subsequently been detected in cattle around the world in 2014. In addition, serological evidence for IDV infection in humans has been recently established. Despite all the progress, the full range of susceptible hosts for this novel virus has yet to be determined, but includes swine, bovine, small ruminants and human. This study was designed to determine if equine is a possible host to this newly emerging influenza virus. 364 equine serum samples were collected in …

Ischemic Preconditioning Improves Maximal Accumulated Oxygen Deficit In Ncaa Division I Middle-Distance Runners, Emily Paull

Electronic Theses and Dissertations

Purpose: There is an ongoing debate concerning whether ischemic preconditioning elicits consistent and meaningful exercise performance benefits. We have previously demonstrated no performance benefits of ischemic preconditioning at submaximal aerobic exercise intensities. It is likely that the beneficial effects of ischemic preconditioning on performance only involve supramaximal anaerobic exercise bouts, which elicit greater metabolic and neuromuscular stress. The aim of the study was to test the hypothesis that ischemic preconditioning improves maximal accumulated oxygen deficit (aO2D), an indicator of anaerobic capacity, in NCAA Division I middle-distance runners. Methods: A randomized sham-controlled crossover study was employed in which 10 NCAA Division …

The Role Of Programs And Policies In Shaping The Observed School Nutrition Environment And Rural Childhood Obesity, Shadai Martin

Electronic Theses and Dissertations

Childhood obesity is an ongoing public health concern that impacts many children in the United States. Research has shown that the prevalence of childhood obesity is higher in rural populations compared to non-rural populations. This may be attributable to differences in the school nutrition environment, particularly school meals and school wellness policy implementation. In order to design effective intervention targeted at weight management and obesity reduction, information regarding the school nutrition environment must be known. Therefore, the purpose of this research was to examine the school nutrition environment, particularly school lunch participation and weight outcomes between metro, non-metro and rural …

Baseball In The Background: Season Ticket Holder Retention In Summer Collegiate Baseball, Susan Wallrich

Electronic Theses and Dissertations

The purpose of this study was to investigate season ticket purchasing motives in summer collegiate baseball, specifically in the Northwoods League. The Sport Fan Motivation Scale (Wann, Schrader, & Wilson, 1999) was used in this study to determine fan attendance motives at summer collegiate baseball games. The literature review examines fan motivation, sports as entertainment, and season-ticket holder retention. The results from this study were obtained by administering a modified version of the Sport Fan Motivation Scale (Wann et al., 1999), a 20-question, 5 point, Likert scale survey to season ticket holders of a Northwoods League team. The outcome of …

Effects Of Enzymatically Hydrolyzed Yeast Supplementation And Supplementation Frequency On Immune Parameters, Performance, And Digestibility Among Periparturient Beef Cows And Calves, Janine Swartz

Electronic Theses and Dissertations

Effects of enzymatically hydrolyzed yeast (EHY) and supplementation frequency (FREQ) on immune parameters among beef cows and calves was evaluated. Eighty multiparous (parity = 4.2 ± 0.3) cows were fed a common brome hay-based diet (CP = 8.0 ± 0.17%). Cows were blocked by expected calving date and stratified by body condition score (BCS) before random assignment of treatment. Beginning 88 ± 5 d prior to parturition, cows were provided 1 kg daily or 3 kg every 3 d of a soybean hull-based supplement (CP = 34.0, % of DM) that contained 0 or 3 g/kg EHY. The daily supplement …

Chronic Risk And Disease Management Model Using Structured Query Language And Predictive Analysis, Mamata Ojha

Electronic Theses and Dissertations

Individuals with chronic conditions are the ones who use health care most frequently and more than 50% of top ten causes of death are chronic diseases in United States and these members always have health high risk scores. In the field of population health management, identifying high risk members is very important in terms of patient health care, disease management and cost management. Disease management program is very effective way of monitoring and preventing chronic disease and health related complications and risk management allows physicians and healthcare companies to reduce patient’s health risk, help identifying members for care/disease management along …

Perceived Treatment Need And Utilization For Illicit Drug And Opioid Use Disorders In Non-Metropolitan Areas, Tyrone F. Borders, Hefei Wen

Rural & Underserved Health Research Center Publications

The policy brief provides nationally representative estimates of perceived treatment need and utilization for illicit drug and prescription pain reliever use disorders among non-metropolitan and metropolitan adults ages 18-64.

Illicit Drug And Opioid Use Disorders Among Non-Metropolitan Residents, Tyrone F. Borders, Hefei Wen

Rural & Underserved Health Research Center Publications

Illicit drug use disorder rates are similar across metropolitan and non-metropolitan areas and did not decline from 2011-2013 to 2014-2015 despite the implementation of major substance use treatment policies over this time period.

The Effects Of Bovine Viral Diarrhea Virus And Bovine Herpesvirus Type 1 On Monocyte-Derived Dendritic Cells, Jacob Sobraske

Electronic Theses and Dissertations

Bovine viral diarrhea virus (BVDV) and bovine herpesvirus type 1 (BHV-1) are important pathogens that affect cattle. In this in vitro study, the main goal was determining the direct effects of BVDV and BHV-1 infections of monocyte-derived dendritic cells (MDDC) on cytokine mRNA expression. For the BVDV infected MDDC experiments, Holstein Friesian and Brown Swiss calves were included with a breed comparison with cytokine expression. Surface marker expression was also measured in BHV-1-infected MDDCs. For both viruses, a high virulent strain (1373 for BVDV and Cooper for BHV-1) and lower virulent strains (20508 for BVDV and Los Angeles for BHV-1) …

Weight Management Related Factors And Healthy Behaviors In Adults, Sumadhuri Pamarthi

Electronic Theses and Dissertations

Obesity is an ongoing global pandemic that affects more than one in three adults in the United States. Being overweight or obese also increases the risk of chronic health conditions. Weight management does not only center on immediate weight loss but also on the proper maintenance of an appropriate body weight over the years. Methods of weight management include eating a healthy diet and meeting physical activity guidelines. Such weight management practices are important to ensure that the people suffering from obesity can decrease risks of morbidity or even mortality. Nevertheless, unhealthy weight management strategies might lead to unintended health …

Perception And Practice Among Emergency Medicine Health Care Providers Regarding Discharging Patients After Opioid Administration, Ryan M. Surmaitis Do, Alexandra Amaducci Do, Kathryn Henry Do, Michael Jong Md, Emily A. Kiernan Do, Hope Kincaid Mph, Cph, Lindsa Houck Msn, Rn, Nea-Bc, Cen, Cpen, Phrn, Sandra Sabbatini Bsn, Rn, Marna R. Greenberg Do, Mph, Facep, Kenneth D. Katz Md

Department of Emergency Medicine

Abstract

Purpose

This study aimed to determine the current attitudes, perceptions, and practices of emergency medicine providers and nurses (RNs) regarding the discharge of adult patients from the emergency department (ED) after administration of opioid analgesics.

Methods

A cross-sectional survey was administered at 3 hospital sites with a combined annual ED census of >180,000 visits per year. All 59 attending emergency physicians (EPs), 233 RNs, and 23 advanced practice clinicians (APCs) who worked at these sites were eligible to participate.

Findings

Thirty-five EPs (59.3%), 88 RNs (37.8%), and 14 APCs (60.9%) completed the survey for an overall response rate of …

Student Readiness: Examining The Impact Of A University Outdoor Orientation Program, Eddie Hill, Timothy Posey, Edwin Gómez, Stephen L. Shapiro

Human Movement Studies & Special Education Faculty Publications

This study examined the impact of a university outdoor orientation program on participants’ transition to higher education. Researchers focused on participants’ experiences during the program, utilizing a mixed-methods approach to measure resilience and well-being. Pre- and posttest instruments consisted of two pre-established scales and a series of open-ended questions, which were administered during a 4-day university outdoor orientation program. Findings indicated significant improvement of resilience and well-being in participants through outdoor orientation program involvement. Additionally, direct content analysis identified major themes related to resilience, well-being, and readiness for college.

Youth Leisure-Time Physical Activity From The Perspectives Of Young Adults With Visual Impairments, Justin A. Haegele

Human Movement Studies & Special Education Faculty Publications

The purpose of this study was to examine the meaning that young adults with visual impairments ascribe to their youth leisure-time physical activity experiences. This study adopted an interpretative phenomenological analysis (IPA) research approach. Ten participants (aged 21-34 years; eight women, two men) with visual impairments were included in this study. Semi-structured, audio-taped telephone interviews acted as the primary source of data for this study. Data were analyzed thematically using a four-step process informed by IPA and three interrelated themes were constructed: (a) "I just always felt normal when I was doing them": Preferences for unstructured activities, (b) "They didn't …

Dnp Project: Implementation Of Delirium Screening And Prevention Plan In A Rural Critical Access Hospital, Marley R. Braun

Doctor of Nursing Practice (DNP) Practice Innovation Projects

This project aimed to implement a nonpharmacologic delirium prevention protocol in a rural critical access hospital by increasing nursing confidence and knowledge with delirium. Research indicated delirium prevention was the cornerstone of management. The interventions proven beneficial in delirium prevention included: clinical staff education, bowel and bladder management, early removal of patient tethers, adequate nutrition and hydration, environmental cues and reorientation, sleep hygiene, music therapy, active family involvement, ensuring sensory aides were present in the hospital setting, and routine/interval screening for delirium using the Confusion Assessment Method (CAM) (National Institute for Health and Care Excellence, 2014; Siddiqi et al., 2016). …

Whiteboard Implementation In The Emergency Department, Gabrille Price

Doctor of Nursing Practice (DNP) Practice Innovation Projects

Due to an increase in consumer focus and reimbursement rates based on patient satisfaction scores, interventions are being sought to improve satisfaction scores. This DNP project sought improvement in emergency department satisfaction scores by utilizing templated patient whiteboards. Pre- and post-intervention surveys were given to patients to determine if there was a difference in perceived communication and satisfaction ratings prior to and after the implementation of templated whiteboards. Results indicated that the use of templated whiteboards did show a statistically significant increase in satisfaction scores. With these positive results, the setting for this project chose to create a policy to …

Therapeutic Cocktail Approach For Treatment Of Hyperhomocysteinemia In Alzheimer’S Disease, Michael Leon, Darrell Sawmiller, R. Douglas Shytle, Jun Tan

Neurosurgery and Brain Repair Faculty Publications

In the United States, Alzheimer's disease (AD) is the most common cause of dementia, accompanied by substantial economic and emotional costs. During 2015, more than 15 million family members who provided care to AD patients had an estimated total cost of 221 billion dollars. Recent studies have shown that elevated total plasma levels of homocysteine (tHcy), a condition known as hyperhomocysteinemia (HHcy), is a risk factor for AD. HHcy is associated with cognitive decline, brain atrophy, and dementia; enhances the vulnerability of neurons to oxidative injury; and damages the blood–brain barrier. Many therapeutic supplements containing vitamin B12 and folate have …

Progress And Updates In Stroke Research: Introduction To The Special Issue On Stroke, Yu Luo, John H. Zhang, Paul R. Sanberg, Samantha M. Portis

Neurosurgery and Brain Repair Faculty Publications

As guest editors of this special issue, we are delighted to present 13 articles that discuss advances in stroke research including translational stroke research, stroke research milestones, and proposals for future directions. Stroke is a major cause of disability, and, according to the Centers for Disease Control and Prevention, is the fifth leading cause of death in the US alone. Possible factors contributing to stroke pathogenesis are elucidated and possible treatment modalities are explored in the following special issue of Cell Transplantation.

Human Cord Blood Serum-Derived App Α-Secretase Cleavage Activity Is Mediated By C1 Complement, Ahsan Habib, Darrell Sawmiller, Huayan Hou, Manasa Kanithi, Jun Tian, Jin Zeng, Dan Zi, Zhi-Xu He, Paul R. Sanberg, Jun Tan

Neurosurgery and Brain Repair Faculty Publications

Alzheimer’s Disease (AD) is the leading cause of dementia in the elderly. In healthy individuals, amyloid precursor protein (APP) is cleaved by α-secretase, generating soluble α-amyloid precursor protein (sAPPα), which contributes neuroprotective functions in the neuronal environment. In contrast, in the neurodegenerative environment of AD patients, amyloid-β-peptide (Aβ) of either 40 or 42 residues are generated by increased activity of β- and γ-secretase. These proteins amalgamate in specific regions of the brain, which disrupts neuronal functions and leads to cognitive impairment. Human umbilical cord blood cells (HUCBC) have proven useful as potential immunomodulatory therapies in various models of neurodegenerative diseases, …