Medicine and Health Sciences Commons^™

Flupirtine Derivatives As Potential Treatment For The Neuronal Ceroid Lipofuscinoses, Joelle Makoukji, Fadi Saadeh, Karl Albert Mansour, Sally El-Sitt, Jamal Al Ali, Nihar Kinarivala, Paul C. Trippier, Rose-Mary Boustany

Journal Articles: Pharmaceutical Sciences

OBJECTIVE: Neuronal Ceroid Lipofuscinoses (NCL) are fatal inherited neurodegenerative diseases with established neuronal cell death and increased ceramide levels in brain, hence, a need for disease-modifying drug candidates, with potential to enhance growth, reduce apoptosis and lower ceramide in neuronal precursor PC12 cells and human NCL cell lines using enhanced flupirtine aromatic carbamate derivatives in vitro.

METHODS: Aromatic carbamate derivatives were tested by establishing growth curves under pro-apoptotic conditions and activity evaluated by trypan blue and JC-1 staining, as well as a drop in pro-apoptotic ceramide in neuronal precursor PC12 cells following siRNA knockdown of the

RESULTS: Retigabine, the benzyl-derivatized …

Hiv Intervention For The Dc Community, Evelyn Rosales, Elias Belhocine, Daniel Ndagha, Tiana Young

DC Health and Academic Prep Program (DC HAPP)

Before the 1980s, the world had little to no knowledge about HIV. Now there has been research conducted on HIV/AIDs that has helped people prevent and be aware of their status. However, there is still an increasing amount of HIV cases in adults (18-34), especially in DC communities. Such disparities in HIV cases occur based on people’s race, gender, sexual orientation, income and geographical location. The social determinants of health also play a role in these cases such as poverty, access to care, stigma and racism. Our program will tackle these issues by providing an emphasis on existing programs by …

The Influence Of Protein Context On Polyglutamine Toxicity In Spinocerebellar Ataxia Type 3, Joanna Rae Sutton

Wayne State University Dissertations

The polyglutamine (polyQ) disease family is composed of nine neurodegenerative diseases caused by CAG trinucleotide repeat expansions in the associated genes. Although these diseases are caused by similar mutations, the polyQ proteins are otherwise structurally and functionally unique. Thus, the protein domains surrounding the polyQ tracts, as well as their interacting partners, are thought to be critical to the pathogenesis of these clinically distinct diseases. Spinocerebellar ataxia type 3 is caused by polyQ expansion of ataxin-3, a deubiquitinating enzyme implicated in protein quality control, transcriptional regulation, and DNA repair. Rad23 and VCP are two of ataxin-3’s protein quality control partners …

Ada News Convention Daily - 2018 Day 2, American Dental Association, Publishing Division

ADA News

The ADA News Daily (also called the ADA News Convention Daily) is a special edition of the ADA News published each day during American Dental Association Annual Sessions.

Determinants Of Health Disparities Among African And Caucasian Americans With Chronic Kidney Disease, Renal Cell Carcinoma, And End-Stage Renal Disease, Kathleen Cosgrove

The Graduate Review

Many studies have confirmed the disparity that black patients have an increased prevalence of severely impaired kidney function compared to whites. Without dialysis, or a kidney transplant, chronic kidney disease will progress to a fatal prognosis of end-stage kidney failure. The most common type of kidney cancer, renal cell carcinoma, occurs most often in adult males, age 50-70. Diabetes and hypertension are two of the most determinant factors of end-stage renal disease (ESRD) in the United States, which most often develops following a chronic kidney disease (CKD) diagnosis. The poor are most susceptible to disease due to high risk community …

Early Results Demonstrate The Importance Of Early Treatment Of Hiv And The Feasibility And Acceptability Of Community-Based Antiretroviral Treatment Delivery For Female Sex Workers In Tanzania, Project Soar

HIV and AIDS

Project SOAR in collaboration with the National AIDS Control Program of the government of Tanzania, National Institute of Medical Research, and Jhpiego’s Sauti Program, is conducting implementation science research to investigate the delivery of community-based antiretroviral treatment (ART) services to female sex workers (FSWs) in Tanzania. This brief summarizes key findings from a baseline survey administered to a cohort of FSWs enrolled in the study, qualitative interviews with FSWs conducted three months after the start of the community-based ART services, and routine monitoring data. Early findings support the feasibility and acceptability of Sauti’s community-based antiretroviral treatment model—important first steps in …

Intracorporeal Versus Extracorporeal Anastomosis For Minimally Invasive Right Colectomy: A Multi-Center Propensity Score-Matched Comparison Of Outcomes., Robert K Cleary, Andrew Kassir, Craig S Johnson, Amir L Bastawrous, Mark K Soliman, Daryl S Marx, Luca Giordano, Tobi J Reidy, Eduardo Parra-Davila, Vincent J Obias, Joseph C Carmichael, Darren Pollock, Alessio Pigazzi

Articles, Abstracts, and Reports

BACKGROUND: The primary objective of this study was to retrospectively compare short-term outcomes of intracorporeal versus extracorporeal anastomosis for minimally invasive laparoscopic and robotic-assisted right colectomies for benign and malignant disease. Recent studies suggest potential short-term outcomes advantages for the intracorporeal anastomosis technique.

METHODS: This is a multicenter retrospective propensity score-matched comparison of intracorporeal and extracorporeal anastomosis techniques for laparoscopic and robotic-assisted right colectomy between January 11, 2010, and July 21, 2016.

RESULTS: After propensity score-matching, there were a total of 1029 minimal invasive surgery cases for analysis-379 right colectomies (335 robotic-assisted and 44 laparoscopic) done with an intracorporeal anastomosis …

Tumor Mutational Burden Is A Determinant Of Immune-Mediated Survival In Breast Cancer., Alexandra Thomas, Eric D Routh, Ashok Pullikuth, Guangxu Jin, Jing Su, Jeff W Chou, Katherine A Hoadley, Cristin Print, Nick Knowlton, Michael A Black, Sandra Demaria, Ena Wang, Davide Bedognetti, Wendell D Jones, Gaurav A Mehta, Michael L Gatza, Charles M Perou, David B Page, Pierre Triozzi, Lance D Miller

Articles, Abstracts, and Reports

Mounting evidence supports a role for the immune system in breast cancer outcomes. The ability to distinguish highly immunogenic tumors susceptible to anti-tumor immunity from weakly immunogenic or inherently immune-resistant tumors would guide development of therapeutic strategies in breast cancer. Genomic, transcriptomic and clinical data from The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) breast cancer cohorts were used to examine statistical associations between tumor mutational burden (TMB) and the survival of patients whose tumors were assigned to previously-described prognostic immune subclasses reflecting favorable, weak or poor immune-infiltrate dispositions (FID, WID or PID, respectively). …

Evaluating State Mental Health And Addiction Parity Statutes: A Technical Report, Megan Douglas, Glenda Wrenn, Samantha Bent-Weber, Lauren Tonti, Garry Carneal, Torie Keeton, Jessica Grillo, Sharon Rachel, David Lloyd, Eve Byrd, Benjamin F. Miller, Albert Lang, Ron Manderscheid, Joe Parks

Articles, Abstracts, and Reports

At an event recognizing the 10th anniversary of the Mental Health Parity and Addiction Equity Act (MHPAEA), the Kennedy-Satcher Center for Mental Health Equity in the Satcher Health Leadership Institute at Morehouse School of Medicine, The Kennedy Forum, The Carter Center, and Well Being Trust (WBT) jointly released “Evaluating State Mental Health and Addiction Parity Statutes,” with 32 states receiving a failing grade for statues designed to ensure equal access to mental health and addiction treatment.

The state-by-state report cards assess the strength of mental health and substance use disorder parity laws. Wyoming (F, 10), Arizona (F, 26), …

“Dignity In Living And In Dying”: The Henry H. H. Remak Memorial Lecture, George P. Smith Ii

Scholarly Articles

Dignity is seen commonly as an ethical obligation owed to human persons. The dimensions of this obligation in today's post secular society are, however, subject to wide discussion and debate; for the term, human dignity, and its preservation, defies universal agreement. Yet, its preservation, together with the prevention of indignity, is a guiding principle or at least a vector of force in a wide range of issues ranging from recognizing and protecting the civil rights of the citizen members of the LGBTQ community throughout the nation to the care of the disabled and to the dying.

In clinical medicine, safeguarding …

Leadership In Community Public-Private Partnership Health And Social Care Initiatives, Hawa Yatera Mshana, Magdeline Aagard, Cheryl Cullen, Patrick A. Tschida

Journal of Sustainable Social Impact

Although the public–private partnerships in health have been adopted as the best pathway to improving health outcomes in many developing nations, implementation lacks collaborative leadership. The purpose of this empirical qualitative case study was to determine key factors that promote leadership synergy (LS) between partners that enhance ownership and accountability of community health and social initiatives in Tanzania. The diffusion of innovation theory and public–private integrated partnership module were the theoretical framework guided this study. Diffusion of innovation theory is based on the importance of effective communication to spread new ideas and foster change in behavior in a social group …

Relationship Between Nutrition Knowledge And Obesity In Southern California Adults, Tatiana Keay, Tonya Larson, Claudinne Herrera

Loma Linda University Research Reports

Background

Over one third of the adult population in the U.S. are obese placing them at higher risk for morbidity or mortality.

Objective

To determine if lack of nutrition knowledge has a positive impact on eating behaviors using obesity status as an indicator.

Design

Participants completed the General Nutrition Knowledge Questionnaire (GNKQ), Anonymous Demographic Questionnaire (ADQ), and anthropometric measurements were taken during a one-time meeting lasting about one hour.

Participants/Setting

Data collection was completed on 334 participants between the ages of 18-55 years in a southern California community sample.

Intervention

Anthropometric measurements were collected by the research team and consisted …

Assessing Assisted Reproductive Technology, Raymond C. O'Brien

Scholarly Articles

Technological innovation possesses both opportunity and challenge. Because assisted reproductive technology (ART) involves sexual intimacy, parenthood, personhood, gender identity, privacy, legacy, and a plethora of religious, historical, sociological, and ethical underpinnings, the challenges presented in such technological innovation are substantial. Nonetheless, the opportunities are significant and progressive. Because of in vitro fertilization, gestational and genetic surrogacy, posthumous conception, and mitochondrial replacement therapy, humans now have the opportunity to overcome infertility, gender obstacles to parentage, dynastic limitations, and diseases that have long plagued mothers and infants. However, challenges include the exploitation of surrogates, unequal access to ART services, possibilities of cloning …

An Epidemiological Study Of Pediatric Sports And Recreational Injuries Reporting To The Emergency Room In Grand Forks, Nd, Carly Bertsch, Lucas Dolan

Physical Therapy Scholarly Projects

PROBLEM: The purpose of this research study is to evaluate the emergency room records from Altru Health System in Grand Forks, ND from 2011-2015 to find trends in pediatric injuries from the ages of 0-19. The justification for the study is to provide Grand Forks with information about the frequency and distribution of pediatric sports and recreational injuries. No injury surveillance system has been implemented to monitor youth injuries, but his study is a continuation of a previous 10-year study and the combining of the two time frames would result in a 15-year compilation of data. By using descriptive data …

A Case Report: Physical Therapy Management Of A 25-Year-Old Female Experiencing A Whiplash Injury And Low Back Pain, Carmen Stanhope

Physical Therapy Scholarly Projects

Background and Purpose. There is a prevalence of whiplash mechanism injuries affecting the cervical spine following motor vehicle accidents. The approximate incidence in Western societies for whiplash associated disorder is 1 case for every 1,000 people in the population. The purpose of this case study is to describe the physical therapy examination, evaluation, diagnosis, prognosis, and interventions used in the treatment of a patient with whiplash associated disorder.

Case Description. This case study describes the clinical presentation, physical therapy intervention, and outcomes of a young adult female following a rear end motor vehicle accident (MVA). The patient presented …

Barefoot Training: Effect On Lateral Pelvic Drop And Emg Activity Of Gluteus Medius And Tfl, Hailey Brinkman, Anna Yanchek, Esley Thorton

Physical Therapy Scholarly Projects

Purpose/Hypothesis: Exercise has been widely accepted for its key role in disease prevention and promotion of healthy lifestyle. Due to its relative ease and low cost, running continues to be one of the most popular forms of exercise today. Although running can have a significant impact on disease prevention, injury prevalence in running is high. Barefoot running is a relatively new form of exercise that has gained popularity amongst the running community. However, enhancing muscular activity at the hip is a rehabilitation strategy, which may reduce lower extremity injury. Research investigating the hip muscle activity and movement with barefoot …

The Co-Treatment Of Physical Therapy And Music Therapy And Its Effect On Parkinson's Disease: A Multidisciplinary Approach, Kayli Muckenhirn, Laura Whiteley

Physical Therapy Scholarly Projects

Background. A multidisciplinary approach combining physical therapy and music therapy can improve functional mobility in individuals with Parkinson's Disease.

Objective. The authors studied whether a multidisciplinary approach of PT and MT would reduce the primary symptoms associated with PD.

Methods. In a single subject design, one patient participated in the following interventions; seated activities, task-specific training, balance and posture, pre-gait activities, and gait activities. The patient was evaluated on the first, mid-term, and last days of treatment. Evaluations included the Parkinson's Disease Questionnaire-39 (PDQ-39), Freezing of Gait Questionnaire (FOGQ), Berg Balance Scale (BBS), Timed-Up-and-Go (TUG), Five Times …

Impact Of A Community-Based Rock Steady Boxing Program For People With Parkinson's Disease: A Pilot Study, Katerina Hoime, Rachel Klein, Jamie Maciejewski, Molly Nienhuis

Physical Therapy Scholarly Projects

Purpose/Hypothesis: High-intensity physical exercise has been shown to be beneficial in managing motor and nonmotor symptoms of Parkinson's Disease (PD). Exercise may also have global effects on factors that influence brain health and cognition. Programs that incorporate goal-based motor skill learning have shown promise in being more effective than aerobic exercise alone. People with PD have a need for ongoing, continuous, community-based exercise programs that are engaging and accessible. The purpose of this study was to examine the effect of a community-based exercise program, Rock Steady Boxing, on improving quality of life and physical mobility skills in people with …

Physical Therapy Rehabilitation Of Arthroscopic Rotator Cuff Repair: A Case Study, Braden Benson

Physical Therapy Scholarly Projects

Background and Purpose. A rotator cuff tear is a common cause of pain and disability among older adults and can lead to a decreased ability to perform daily functions. The purpose of this case report is to look at a single patient's rehabilitation following arthroscopic repair of a rotator cuff tear utilizing therapeutic exercise, neuromuscular re-education, and manual therapy techniques.

Case Description. The patient was a 69-year-old, Caucasian male who was referred to physical therapy for evaluation and treatment following left shoulder arthroscopy for rotator cuff tear and sub-acromial decompression. The patient complained of increased pain and decreased …

Emg Of Serratus Anterior, Upper, Middle, And Lower Trapezius During Glenohumeral Abduction In A Participant With Scapular Dyskinesia: A Case Study, Daniel Garcia, Trevor Roppel, Mekenzie Scheresky, Shane Omdahl

Physical Therapy Scholarly Projects

Introduction and Purpose. The purpose of this case study was to examine the differences in muscle activation between the upper trapezius, middle trapezius, lower trapezius and serratus anterior in a participant with scapular dyskinesia.

Methods. EMG activity was recorded using a Noraxon TeleMyo DTS telemetry unit with a sampling rate of 1 kHz. EMG data was recorded during three different speeds of shoulder abduction. Four scapular muscles were monitored bilaterally during the experiment. The muscles that were monitored included the upper trapezius, middle trapezius, lower trapezius and serratus anterior. The subject was also captured on video using the NiNox 125/250 …

Emg Analysis Of Latissimus Dorsi, Erector Spinae, And Middle Trapezius Muscle Activity During Spinal Rotation: A Pilot Study, Hunter Huberty, Jacob Klingbeil, Michael Miller, Michael Utt

Physical Therapy Scholarly Projects

Purpose/Hypothesis: Rotation of the spine is a common movement used for completing daily activities and participating in sports. As a contributing factor to back injuries, the performance of spine rotation is an important consideration for the rehabilitation and prevention of future back injury. Muscles involved in spine rotation have been researched, though limited findings exist for one of the largest back muscles: Latissimus Dorsi (LD). The LD muscle contributes to many movements of the trunk and limbs given its multiple attachment sites including the pelvis, scapula, ribs and humerus. Influence of the LD on spine rotation, however, has not …

Characterizing The Information Needs Of Rural Healthcare Practitioners With Language Agnostic Automated Text Analysis, Melissa Resnick

Dissertations and Theses (Open Access)

Objectives – Previous research has characterized urban healthcare providers' information needs, using various qualitative methods. However, little is known about the needs of rural primary care practitioners in Brazil. Communication exchanged during tele-consultations presents a unique data source for the study of these information needs. In this study, I characterize rural healthcare providers' information needs expressed electronically, using automated methods.

Methods – I applied automated methods to categorize messages obtained from the telehealth system from two regions in Brazil. A subset of these messages, annotated with top-level categories in the DeCS terminology (the regional equivalent of MeSH), was used to …

Ancestral Dependence On Breast Stemness And Nucleotide Excision Repair In Breast Cancer Stem Cells In Novel Human Model Systems, Omar Ibrahim

Student Theses, Dissertations and Capstones

Precocious puberty, measured by thelarche or menarche, is a well-established breast cancer risk factor. Using a unique and patented tissue engineering system we established cell lines from 48 primary cultures of normal breast tissue from reduction mammoplasties and used them as an in vitro model of thelarche, quantifying episphere formation and ductal differentiation. Differential ductal formation was observed based on ancestry. In light of African American (AA) precocious thelarche both in vivo and as we observed in vitro, we hypothesized that AA women would exhibit an increased proportion of breast stem cells, with greater potency for differentiation. Five AA cell …

Analysis Of Molecular Changes In 2 Types Of Non-Tumor Adjacent Breast Identified By Nucleotide Excision Repair In Early Stage Breast Cancer, Manasi Ramesh Pimpley

Student Theses, Dissertations and Capstones

NER plays an important role in remediating DNA damage. Latimer et al., have previously shown nucleotideexcision repair (NER) to be intrinsically deficient in stage I sporadic BC by function and gene expression. Previous work performed on 12 isogenically matched stage I tumors and non-tumor adjacent (NTA) samples identified 2 types of NTA tissue with regard to functional NER. One type that represented 75% ofthe samples, had lower NER capacity, similar to the tumor (Low: Low pair). The other type had high NER relative to the tumor (High: Low pair). Two isogenic NTA/tumor cell line pairs representing these 2 types ofNTA …

Impact Of Huddles On Provider’S Knowledge Of Medically Complex Patients, Irina G. Trifonova, Troy E. Richardson, Jessica L. Bettenhausen, Matthew B. Johnson

Posters

Background:
The increasing complexity of pediatric inpatients requires that all providers understand a comprehensive child’s medical and social needs. A survey administered to Children’s Mercy Hospital inpatient providers identified gaps in knowledge regarding the daily plan of care and discharge planning needs among Complex Chronic Care (CCC) patients. Multidisciplinary rounds (MDRs) create a shared decision model among all team members to ensure that all aspects of care for CCC patients are addressed.

Objectives:
To improve provider knowledge of the plan of care and discharge planning needs for CCC patients admitted to the Hospitalist service, from 40% to 75% of providers …

Transforming Society Will Require Attention To Social Determinants Of Health, Todd E. Davenport

All Faculty Scholarship

No abstract provided.

Evaluating The Impact Of A Falls Prevention Community Of Practice In A Residential Aged Care Setting: A Realist Approach, J Francis-Coad, C Etherton-Beer, C Bulsara, N Blackburn, P Chivers, A Hill

Physiotherapy Papers and Journal Articles

Background: Falls are a major socio-economic problem among residential aged care (RAC) populations resulting in high rates of injury including hip fracture. Guidelines recommend that multifactorial prevention strategies are implemented but these require translation into clinical practice. A community of practice (CoP) was selected as a suitable model to support translation of the best available evidence into practice, as it could bring together likeminded people with falls expertise and local clinical knowledge providing a social learning opportunity in the pursuit of a common goal; falls prevention. The aims of this study were to evaluate the impact of a falls prevention …

Recent Data From Radiofrequency Denervation Trials Further Emphasise That Treating Nociception Is Not The Same As Treating Pain, Matthew K. Bagg, James H. Mcauley, G Lorimer Moseley, Benedict M. Wand

Physiotherapy Papers and Journal Articles

Chronic low back pain is a condition that current health care provision is failing and we suggest that recent evidence from the interventional pain medicine field points to what these failings are. Radiofrequency denervation is performed on the presumption that denervation of a peripheral structure will eradicate or significantly reduce pain and improve function. The results of six moderately sized and well conducted clinical trials that demonstrate no efficacy and no real-world effectiveness for denervation procedures are a stark illustration of how flawed this approach is. We suggest that these results represent a line-in-the-sand for back pain research and management. …

Trunk Muscle Activity During Drop Jump Performance In Adolescent Athletes With Back Pain, T. Palsson, J. Caneiro, R. Hirata, D. Griffin, William Gibson, Mervyn Travers

Physiotherapy Papers and Journal Articles

It was with great interest we read the recently published article “Trunk Muscle Activity during Drop Jump Performance in Adolescent Athletes with Back Pain.” Investigating back pain (BP) in adolescents is commendable as there is growing evidence that for many, an experience of BP as early as 14 years of age may relate to ongoing pain in adulthood (Coenen et al., 2017). Indeed, the conventional narrative is changing as individual physical factors such as posture, use of schoolbags, and hypermobility are only weakly associated with adolescent BP. Rather, factors which predict BP at a young age are considered to …

Paracetamol, Nsaids And Opioid Analgesics For Chronic Low Back Pain: A Network Meta-Analysis (Protocol), Matthew K. Bagg, Andrew J. Mclachlan, Christopher G. Maher, Steven J. Kamper, Christopher M. Williams, Nicholas Henschke, Benedict M. Wand, G L. Moseley, Markus Hubscher, Neil E. O'Connell, Maurits W. Van Tulder, Adriani Nikolakopoulou, James H. Mcauley

Physiotherapy Papers and Journal Articles

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

To answer the clinical question: ‘what analgesic medicine shall I prescribe this patient with chronic low back pain to reduce their pain?’.

The objectives are to determine the analgesic effects, safety, effect on function, and relative rank according to analgesic effect, safety and effect on function of a single course of opioid analgesics, NSAIDs or paracetamol or combinations of these medicines.