Medicine and Health Sciences Commons^™

Mesotocin Influences Pinyon Jay Prosociality, J. F. Duque, W. Leichner, H. Ahmann, Jeffrey R. Stevens

Center for Brain, Biology, and Behavior: Faculty Publications

Many species exhibit prosocial behavior , in which one individual’s actions benefit another individual, often without an immediate benefit to itself. The neuropeptide oxytocin is an important hormonal mechanism influencing prosociality in mammals, but it is unclear whether the avian homologue mesotocin plays a similar functional role in birds. Here, we experimentally tested prosociality in pinyon jays (Gymnorhinus cyanocephalus), a highly social corvid species that spontaneously shares food with others. First, we measured prosocial preferences in a prosocial choice task with two different pay-off distributions: Prosocial trials delivered food to both the subject and either an empty cage …

Permeability Changes And Effect Of Chemotherapy In Brain Adjacent To Tumor In An Experimental Model Of Metastatic Brain Tumor From Breast Cancer, Afroz S. Mohammad, Chris E. Adkins, Neal Shah, Rawaa Aljammal, Jessica I. G. Griffith, Rachel M. Tallman, Katherine L. Jarrell, Paul R. Lockman

Faculty & Staff Scholarship

Abstract

Background: Brain tumor vasculature can be significantly compromised and leakier than that of normal brain blood vessels. Little is known if there are vascular permeability alterations in the brain adjacent to tumor (BAT). Changes in BAT permeability may also lead to increased drug permeation in the BAT, which may exert toxicity on cells of the central nervous system. Herein, we studied permeation changes in BAT using quantitative fluorescent microscopy and autoradiography, while the effect of chemotherapy within the BAT region was determined by staining for activated astrocytes.

Methods: Human metastatic breast cancer cells (MDA-MB-231Br) were injected into left ventricle …

Work-Related Values, Preferences, And Expectations Of Millennials: Implications For Long-Term Care Administrators, Cheryl K. Derynck

All Graduate Theses, Dissertations, and Other Capstone Projects

The purpose of this research is to examine millennials’ work-related values, preferences, and expectations and to understand the impact for administrators in long-term care (LTC) facilities. Supervisors at LTC facilities must understand millennials’ work behavior, and strive to meet their needs, so as to effectively recruit, train, and retain these millennial employees. Allowing for management understanding of millennials work-related values, preferences, and expectations and how these support or detract from employment within LTC settings may pinpoint how facilities may retain these workers. This study will also provide information about work satisfaction of millennial employees and how employers can improve to …

Examining Jordanians' Attitudes Towards Five Types Of Developmental Disabilities, Najah Zaaeed, Mohammad Mohammad, Peter Gleason, Khaled A. Bahjri, Naomi Modeste

Public Health, Food Studies, and Nutrition

Background: The diagnosis and reported rates of persons with developmental disabilities (PWDDs) in Jordan is steadily increasing. Although initiatives have been implemented to improve the lives of PWDDs, attitudes towards PWDDs hinder successful inclusion in the Jordanian society.

Objectives: To examine the relationship between Jordanians socio-economic status and attitudes towards persons with developmental disabilities: autism, blindness, cerebral palsy, Down syndrome and muscular dystrophy.

Methods: Jordanians (N=259), ages 18-65 were recruited for this convergent parallel, mixed-methods study. Participants completed the modified 40-item Community Living Attitude Scale-developmental disability (CLAS-DD) and the modified Intellectual Disability Literacy Scale consisting of five vignettes, representing each …

Integration Of Pet Therapy To Enhance Occupational Performance, Brooke Harrell

MOT Student Capstones

Individuals with a Dementia diagnosis are on the continual rise in America. This debilitating condition remains incurable even with all the research and technology we have available today. Benefits of canine interactions have been demonstrated and it is becoming more common to incorporate canines into therapy practice. Canines have the ability to reduce anxiety and improve an individual's overall mood. By successfully impacting these two variables, canine interaction enhance client's potential and abilities tremendously. Canines provide an alternative outside of the box treatment method for clients with Dementia. Our role as an occupational therapist is to provide client centered care, …

The Benefits Of A Screening Tool For Seating And Mobility During The Initial Occupational Therapy Evaluation In Skilled Nursing Facilities, Ryan Haines

MOT Student Capstones

Occupational therapy practitioners are familiar with the idea that wheelchair positioning and mobility can have an impact on one's ability to participate in daily routines and leisure activities, yet many times it is overlooked during the initial evaluation process. Residents of skilled nursing facilities who rely upon wheelchairs for their mobility are at a particularly high risk of developing medical complications, such as pressure sores, and respiratory issues secondary to long-term seated positioning. The purpose of this project is to create an easy to use wheelchair positioning screening tool to use on both long-term care residents and individuals who are …

The Effect Of An Iadl Group Serving Moderate Functional Adults With Intellectual Disabilities In A Group Home Setting, Megan P. Buckland

MOT Student Capstones

Objective: The purpose of this project is to explore and provide participants an opportunity to engage in meaningful activities in the hopes to increase their performance participation and improve their satisfaction in areas of occupations for Instruments of Daily Activities (IADL 's). These areas included, meal preparation and home management tasks. The IADL's were accomplished through group participation and on an individual basis. Method: The occupational therapy student provided two questionnaires for the parents and or guardians, as well primary caregivers in the group home. The participants were also given the Lawton-Brody's IADL scale and the Canadian Occupational Performance Measure. …

Let It Flow: Increasing Occupation-Centered Practice In Skilled Nursing Facilities, Patrick D. Robbins

MOT Student Capstones

The purpose of this study was to use the Kawa Model to discover and analyze the performance of the occupational therapy profession to incorporate occupation-centered practice in the skilled nursing setting. The guiding questions of the Kawa Model were used to guide phenomenological research inquiry into literature sources to generate drawings of the historical and current aspects of occupation-centered practice in the SNF setting. Environmental restrictions and obstacles from multiple sources were identified to prevent the implementation of occupation-centered services, while professional skills and values were identified with potential to initiate change in current practice trends. Two possible strategies for …

Tmc Facts & Figures, Texas Medical Center

TMC Reports

No abstract provided.

Therapeutic And Immunological Interventions In Primary Biliary Cholangitis: From Mouse Models To Humans, Atsushi Tanaka, Patrick S.C. Leung, Howard A. Young, M. Eric Gershwin

United States Public Health Resources

Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease that predominantly affects women in their fifth and sixth decades. The diagnostic hallmarks of PBC are detection of anti-mitochondrial antibodies (AMAs) and chronic non-suppurative destructive cholangitis (CNSDC) of small- and medium-sized intrahepatic bile ducts in liver histological examination [1, 2]. A significant amount of data suggests that immunological activity against small biliary epithelial cells (BECs), found histologically as portal inflammation, leads to clinical disease. In PBC, as with other autoimmune diseases, both genetic and environmental factors contribute to the development of pathology [3–8]. The first-line therapy of PBC is ursodeoxycholic …

Genomic Differences Between Nasal Staphylococcus Aureus From Hog Slaughterhouse Workers And Their Communities., Yaqi You, Li Song, Bareng A S Nonyane, Lance B Price, Ellen K Silbergeld

Environmental and Occupational Health Faculty Publications

New human pathogens can emerge from the livestock-human interface and spread into human populations through many pathways including livestock products. Occupational contact with livestock is a risk factor for exposure to those pathogens and may cause further spreading of those pathogens in the community. The current study used whole genome sequencing to explore nasal Staphylococcus aureus obtained from hog slaughterhouse workers and their community members, all of whom resided in a livestock-dense region in rural North Carolina. Sequence data were analyzed for lineage distribution, pathogenicity-related genomic features, and mobile genetic elements. We observed evidence of nasal S. aureus differences between …

Gender-Transformative Bandebereho Couples' Intervention To Promote Male Engagement In Reproductive And Maternal Health And Violence Prevention In Rwanda: Findings From A Randomized Controlled Trial., Kate Doyle, Ruti G Levtov, Gary Barker, Gautam G Bastian, Jeffrey B Bingenheimer, Shamsi Kazimbaya, Anicet Nzabonimpa, Julie Pulerwitz, Felix Sayinzoga, Vandana Sharma, Dominick Shattuck

Prevention and Community Health Faculty Publications

BACKGROUND: Rigorous evidence of the effectiveness of male engagement interventions, particularly on how these interventions impact relationship power dynamics and women's decision-making, remains limited. This study assessed the impact of the Bandebereho gender-transformative couples' intervention on impact on multiple behavioral and health-related outcomes influenced by gender norms and power relations.

METHODS: We conducted a multi-site randomised controlled trial in four Rwandan districts with expectant/current fathers and their partners, who were randomised to the intervention (n = 575 couples) or control group (n = 624 couples). Primary outcomes include women's experience of physical and sexual IPV, women's attendance and men's accompaniment …

Piloting Very Early Infant Diagnosis Of Hiv In Lesotho: Acceptability And Feasibility Among Mothers, Health Workers And Laboratory Personnel., Michelle M Gill, Lynne M Mofenson, Mamakhetha Phalatse, Vincent Tukei, Laura Guay, Matsepeli Nchephe

Epidemiology Faculty Publications

INTRODUCTION: Mortality associated with in-utero HIV infection rises rapidly within weeks after birth. Very early infant diagnosis of HIV (VEID)-testing within 2 weeks of birth-followed by immediate initiation of antiretroviral therapy has potential to avert mortality associated with in-utero transmission. However, our understanding of acceptability and feasibility of VEID is limited.

METHODS: VEID was piloted in an observational prospective cohort of HIV-positive pregnant women and their infants in 13 Lesotho health facilities. Between March-July 2016, semi-structured interviews were conducted with HIV-positive women attending 6-week or 14-week postnatal visits and health workers (HWs) in 8 study facilities in 3 districts as …

Sexually Transmitted Infections Among Hiv-Infected Individuals In The District Of Columbia And Estimated Hiv Transmission Risk: Data From The Dc Cohort, Jose Lucar, Rachel Hart, Nabil Rayeed, Arpi Terzian, Amy Weintrob, Amanda D. Castel, Debra A. Benator, Dc Cohort Executive Committee

Epidemiology Faculty Publications

Background

Washington, DC, has one of the highest rates of HIV infection in the United States. Sexual intercourse is the leading mode of HIV transmission, and sexually transmitted infections (STIs) are a risk factor for HIV acquisition and transmission.

Methods

We evaluated the incidence and demographic factors associated with chlamydia, gonorrhea, and syphilis among HIV-infected persons enrolled at 13 DC Cohort sites from 2011 to 2015. Using Poisson regression, we assessed covariates of risk for incident STIs. We also examined HIV viral loads (VLs) at the time of STI diagnosis as a proxy for HIV transmission risk.

Results

Six point …

Rhythm: An Open Source Imaging Toolkit For Cardiac Panoramic Optical Mapping, Christopher Gloschat, Kedar Aras, Shubnam Gupta, N. Rokhana Faye, Hanyu Zhang, Matthew W. Kay, Igor R Efimov, +Several Additional Authors

Pharmacology and Physiology Faculty Publications

Fluorescence optical imaging techniques have revolutionized the field of cardiac electrophysiology and advanced our understanding of complex electrical activities such as arrhythmias. However, traditional monocular optical mapping systems, despite having high spatial resolution, are restricted to a two-dimensional (2D) field of view. Consequently, tracking complex three-dimensional (3D) electrical waves such as during ventricular fibrillation is challenging as the waves rapidly move in and out of the field of view. This problem has been solved by panoramic imaging which uses multiple cameras to measure the electrical activity from the entire epicardial surface. However, the diverse engineering skill set and substantial resource …

Why It Worked: Participants' Insights Into An Mhealth Antiretroviral Therapy Adherence Intervention In China., Lora L Sabin, Lauren Mansfield, Mary Bachman Desilva, Taryn Vian, Zhong Li, Xie Wubin, Allen L Gifford, Yiyao Barnoon, Christopher J Gill

Global Health Faculty Publications

Background: Few Antiretroviral Therapy (ART) adherence trials investigate the reasons for intervention success or failure among HIV-positive individuals.

Objectives: To conduct qualitative research to explore the reasons for effectiveness of a 6-month mHealth (mobile health) trial that improved adherence among ART patients in China. The intervention utilized Wireless Pill Containers (WPCs) to provide, real-time SMS reminders, WPC-generated adherence reports, and report-informed counseling.

Methods: We conducted in-depth interviews with 20 intervention-arm participants immediately following the trial. Sampling was purposeful to ensure inclusion of participants with varied adherence histories. Questions covered adherence barriers and facilitators, and intervention experiences. We analyzed data in …

Modeling The Relationship Between Women’S Perceptions And Future Intention To Use Institutional Maternity Care In The Western Highlands Of Guatemala, Emily Peca, John Sandberg

Global Health Faculty Publications

Background

Despite global gains, women in hard-to-reach areas are at a relatively higher risk of death and disability related to childbirth. Traditional methods of measuring satisfaction may mask negative experiences (such as disrespect and abuse) that can drive down demand for institutional care. Better measurement of women’s perceptions of care quality, especially among marginalized populations with historically low utilization of institutional care, are needed to inform how to improve services and foster greater utilization of (potentially life-saving) clinical care.

Methods

A population-based household survey was conducted in 15 purposively selected villages in the rural Western Highlands of Guatemala among women …

Antiretroviral Therapy Interruptions: Impact On Hiv Treatment And Transmission., Gueorgui Dubrocq, Natella Rakhmanina

Pediatrics Faculty Publications

Introduction: Successful management of pediatric and adult human immunodeficiency virus (HIV) disease includes lifelong administration of antiretroviral therapy (ART). The need for the continuous use of antiretroviral drugs throughout the life course poses a challenge to children, adolescents, and adults living with HIV and their caregivers. Historically, treatment interruptions have been viewed as a negative therapeutic strategy. Recently, however, treatment interruptions or treatment reduction strategies have become a focus of investigations as innovative approaches to the long-term management of HIV disease. Current challenges with treatment interruptions include identifying an appropriate timeframe for length of interruptions and identifying HIV patient populations …

Are Children Of A Diabetic Mother In Comparison To Children Of A Nondiabetic Mother At An Increased Risk For Developing Obesity In The First 10 Years Of Life?, Chhorn Pho

Theses and Graduate Projects

Body weight, glucose, insulin, and leptin were studied in children of mothers with gestational diabetes, type 1 or type 2 diabetes. Breast milk of diabetic mothers was also analyzed to study its relationship to childhood obesity. In the first 2 years of life, infants of mothers with gestational diabetes have no significant difference in weight gain but by the age of 10, most of the children birthed by any diabetic mothers were either overweight or obese. Children of mothers diagnosed with diabetes mellitus type 2 have higher resistance to insulin than children of mothers with other diabetes types. Leptin was …

Among Patients With Endometriosis, Does The Use Of Serum Biomarkers, Versus Laparoscopic Surgery For Diagnosis And Staging Of The Disease Decrease The Incidence Of Disease Related Negative Outcomes, Ellyn C. Hexum

Theses and Graduate Projects

Objective: To determine the ability and efficacy of non-invasive serum biomarker testing as a replacement for laparoscopic surgery in the diagnosis and staging of endometriosis to decrease the incidence of negative disease outcomes, leading to improvement in the accuracy of diagnoses and patient tailored treatment protocols.

Background: Endometriosis is a debilitating inflammatory disease of the reproductive tract. Currently, the gold standard for the diagnosis and staging of endometriosis is exploratory laparoscopic surgery. The use of surgery as the source of achieving a definitive diagnosis holds the potential to increase the incidence of negative disease outcomes. Because of this, the use …

Nobody Likes Flies, Zachary Mattson

Theses and Graduate Projects

Leishmaniasis is a protozoan disease that is common in tropical areas of the globe. Around the world this disease is transmitted from different hosts by various sand-fly species. The most prevalent countries for any type of leishmaniasis are Brazil, India, and Ethiopia. There are three presentations of the disease seen around the world: visceral, mucosal, and cutaneous. Overall cutaneous leishmaniasis is a disease that can be disfiguring and disrupting to individuals across the world. Though it may be difficult to access information for those in rural communities in Central America it is important for providers to provide information in an …

Are Platelet Rich Plasma Injections A Better Choice Compared To Glucocorticoid Injections For The Treatment Of Rotator Cuff Tendinopathy In Adult Patients?, Sawyer Lange

Theses and Graduate Projects

An estimated 16 to 34 percent of the general population will experience shoulder pain at some point in their life. Rotator cuff tendinopathy makes up a large portion of that percentage. Platelet rich plasma (PRP) is an autologous blood product that has supraphsyiologic levels of growth factors and cytokines that have the potential to expedite the tendon healing process. This literature review will look at the current science surrounding PRP and look at studies comparing its efficacy to the commonly used corticosteroid injection.

Do Non-Steroidal Anti-Inflammatory Drugs Increase The Risk For Non- Or Mal-Union Following Acute Fracture? A Literature Review, Bryan Moritz

Theses and Graduate Projects

NSAID medications are among the most commonly used analgesic medications world wide, and it was estimated in 2010 (updated 2015 data is expected to be published next year) that about 29 million adults in the United States regularly used NSAID medications at least three times per week for more than three months. Fracture healing has been shown to be dependent on the inflammatory cascade. NSAID medication use appears to have a mechanistic in-vivo and in-vitro animal risk for the development of non- and mal-union following fracture. However, human data is lacking to support total avoidance of this analgesic option for …

The Impact Of Sexual Education On Decreasing Adolescent Pregnancy In Nicaragua, Allison Greenwood

Theses and Graduate Projects

Half of the females of Nicaragua will have given birth by their 20th birthday.1 Nicaragua has one of the highest fertility rates in the world and exceeds the fertility rate average in Latin America with 109 (births per 1000 females aged 15-19) compared to the average of 79 births.1,2 Young maternal age is linked to higher incidences of pregnancy complications such as preterm birth, low birth weight, and neonatal mortality.2 Nicaragua’s high adolescent pregnancy rate is a result of a multifactorial social and political climate. The initiation of a teen's sexual debut is complex and hinges on multiple factors from …

Analysis Of Intrauterine Device Implementation And Review Of Prevention Strategies To Reduce Adolescent Pregnancy In Nicaragua, Haley Johnson

Theses and Graduate Projects

Adolescent pregnancy is one of the main healthcare issues facing Nicaragua. Prevention strategies are needed to avoid the maternal and fetal outcomes associated with young pregnancies. Extensive literature analysis and face-to-face discussions in Nicaragua were conducted to determine the current incidence of adolescent pregnancy and contraception use, barriers to reproductive health for adolescents, maternal outcomes of adolescent pregnancy, and if intrauterine devices have the potential to be a culturally effective method of contraception. Specific barriers to reproductive health for adolescents were identified to be machismo, societal criticism, lack of reproductive education, fear of infection from IUDs, and underutilization of healthcare …

Drug Therapy Vs. Ablation Therapy For Patients With Atrial Fibrillation, Jessica Ansara

Theses and Graduate Projects

The prevalence of atrial fibrillation is 6.5 percent in the adult population in the United States, in an attempt to treat this patient population, there are numerous options and this study attempts to find the optimal treatment plan that has the least Atrial fibrillation(AF) reoccurrence, best quality of life and is the most effective. This is a Systematic Review comparing catheter ablation therapy vs. drug therapy in treating patients with atrial fibrillation. The search engines used in this analysis include PubMed, UpToDate, Google Scholar and Academic Search Premier. A total of 19 articles were analyzed and data was extracted, and …

Access And Attitudes Regarding Emergency Contraception And Reproductive Health In Nicaragua, Nadia Commers

Theses and Graduate Projects

Unintended pregnancy affects millions of women across the globe and often leads to an increased risk of health complications and socio-economic stress. In Nicaragua, approximately 1 in 6 births are unplanned, a relatively low number in comparison to the United States. However, the rate of unintended pregnancy is particularly problematic within the adolescent age group of Nicaragua, where 50% of women give birth before age 20 and 45% of those births are unplanned. The annual fertility rate of Nicaragua’s adolescents (109 births per 1,000 15-19- year-olds) is the highest in all of North, Central and South America, where the average …

Climate Change: Human Health, The Developing World And The Global Response, Cole James Kriett

Theses and Graduate Projects

Changes to the Earth’s biophysical system will extend and exacerbate the rates of vector-borne infectious disease, non-communicable diseases such as cardiovascular disease and lung disease, and mental health disorders. Developing nations face the greatest burden of climate sensitive human health impacts while also having the lowest capacity to adapt to these changes. Addressing these global ethical challenges cannot be accomplished without supporting organizations like UNEP or the IPCC. However, these organizations cannot achieve global sustainability alone. Human beings collectively taking responsibility for climate change will be vital to this process.

Local Attitudes And Prevention Around The Nicaraguan Sugarcane Worker With Chronic Renal Disease, Matt Cyr

Theses and Graduate Projects

An epidemic of chronic kidney disease (CKD) in Central America and Nicaragua is referred to as Mesoamerican nephropathy (MeN). It’s estimated that the death toll for MeN over the past two decades has reached at least 20,000. Nicaragua is included in the 10 highest overall mortality rate from kidney disease in the world. MeN disproportionately affects young, male agricultural workers who do not exhibit traditional risk factors for CKD such as hypertension and diabetes. A consistent risk factor for MeN is heavy manual labor in the heat, often temperatures over 35 °C with high humidity. Many reasons have been proposed …

Analysis Of The Effects Of Music Therapy On Pain And Anxiety Levels In Pediatric Burn Patients, Maria Cook

Theses and Graduate Projects

Burn injuries resulting in tissue damage are considered one of the most severe traumas that can be experienced. Pain and anxiety continue to be major problems for patients with burn injuries during all stages of the treatment. Proper pain management is essential during recovery because it reduces the chance of developing malnutrition and promotes a stronger immune system. A number of studies have explored the effects of music on pain levels before, during, and after medical procedures for burn patients. Few studies have examined the effects of music therapy in the population of pediatric burn patients. Many studies have shown …