Medicine and Health Sciences Commons^™

Advertising Content, Platform Characteristics And The Appeal Of Beer Advertising On A Social Networking Site, Jonathan K. Noel, Thomas F. Babor, James J. Grady

Health & Wellness Department Faculty Publications and Research

No abstract provided.

The Role Of The Alcohol Industry In Policy Interventions For Alcohol-Impaired Driving, Thomas F. Babor, Katherine Robaina, Jonathan K. Noel

Health & Wellness Department Faculty Publications and Research

No abstract provided.

Web-Based Research: Strengths, Weaknesses, And Jsad’S Guidance For Authors, Raul Caetano, Jonathan K. Noel

Health & Wellness Department Faculty Publications and Research

No abstract provided.

Tbi Stac Procedures: Touchscreen Tablet-Based Cognitive Assessment Versus Paper-Based Assessments For Traumatic Brain Injury, Sarah E. Wallace Ccc-Slp, Elena V. Donoso Brown Otr/L, James B. Schreiber Ph.D., Sarah Diehl M.S., Cf-Slp, Joanne Kinney M.S., Ccc-Slp, Lani Zangara M.S., Otr/L

Speech-Language Pathology Faculty Scholarship

No abstract provided.

Genetics Home Reference: A Review, Jessica A. Koos, Ashley Bassett

Library Faculty Publications

Genetics Home Reference is a free, online resource created and maintained by the National Library of Medicine. It is designed to provide genetic information to a wide variety of audiences, particularly the general public. The site consists of original information and links to other curated resources.

Human Activity Detection Patterns: A Pilot Study For Unobtrusive Discovery Of Daily Working Routine, Hicham Rifai, Paula Kelly, Yoshiki Shoji, Damon Berry, Matteo Zallio

Articles

Information technology is increasingly becoming an integral part of contemporary life. Most tasks that are performed over the course of a day, involve the use of different types of connected devices. About two billion contemporary consumers use smartphones [1]. These smartphones contain a variety of sensors that can collect information about their users such as their mobility patterns, daily activities and occupancy patterns [2]. Occupancy is an important aspect in developing responsive environments and for optimizing building performance. This work investigates the extent to which smartphones can be used to collect occupancy data in a work …

Determination Of T Follicular Helper Cell Fate By Dendritic Cells., Jayendra Kumar Krishnaswamy, Samuel Alsén, Ulf Yrlid, Stephanie C Eisenbarth, Adam Williams

Faculty Research 2018

T follicular helper (Tfh) cells are a specialized subset of CD4⁺ T cells that collaborate with B cells to promote and regulate humoral responses. Unlike other CD4⁺ effector lineages, Tfh cells require interactions with both dendritic cells (DCs) and B cells to complete their differentiation. While numerous studies have assessed the potential of different DC subsets to support Tfh priming, the conclusions of these studies depend heavily on the model and method of immunization used. We propose that the location of different DC subsets within the lymph node (LN) and their access to antigen determine their potency in …

Synthetic Peptide Ck2.3 Enhances Bone Mineral Density In Senile Mice., John Nguyen, Hilary Weidner, Lora M Schell, Linda Sequeira, Ryan Kabrick, Saurabh Dharmadhikari, Harold Coombs, Randall L Duncan, Liyun Wang, Anja Nohe

Faculty Research 2018

Background: Osteoporosis is a silent disease caused by low bone mineral density that results in bone fractures in 1 out of 2 women and 1 in 4 men over the age of 50. Although several treatments for osteopenia and osteoporosis are available, they have severe side effects and new treatments are desperately needed. Current treatments usually target osteoclasts and inhibit their activity or differentiation. Treatments that decrease osteoclast differentiation and activity but enhance osteogenesis and osteoblast activity are not available. We recently developed a peptide, CK2.3, that induces bone formation and increases bone mineral density as demonstrated by injection over …

Editorial: Axonopathy In Neurodegenerative Disease., Robert W. Burgess, Samuel D Crish

Faculty Research 2018

No abstract provided.

Sebaceous Gland Abnormalities In Fatty Acyl Coa Reductase 2 (Far2) Null Mice Result In Primary Cicatricial Alopecia., John P Sundberg, Tong Shen, Oliver Fiehn, Robert H Rice, Kathleen A Silva, Victoria E. Kennedy, Nicholas E Gott, Louise A. Dionne, Lesley S Bechtold, Stephen A Murray, Raoul Kuiper, C Herbert Pratt

Faculty Research 2018

In a large scale screen for skin, hair, and nail abnormalities in null mice generated by The Jackson Laboratory's KOMP center, homozygous mutant Far2tm2b(KOMP)Wtsi/2J (hereafter referrred to as Far2-/-) mice were found to develop focal areas of alopecia as they aged. As sebocytes matured in wildtype C57BL/NJ mice they became pale with fine, uniformly sized clear lipid containing vacuoles that were released when sebocytes disintegrated in the duct. By contrast, the Far2-/- null mice had sebocytes that were similar within the gland but become brightly eosinophilic when the cells entered the sebaceous gland duct. As sebocytes disintegrated, their contents did …

Cell-Type-Specific Changes In Intrinsic Excitability In The Subiculum Following Learning And Exposure To Novel Environmental Contexts., Amy R Dunn, Sarah M Neuner, Shengyuan Ding, Kevin A Hope, Kristen M S O'Connell, Cathleen Lutz

Faculty Research 2018

The subiculum is the main target of the hippocampal region CA1 and is the principle output region of the hippocampus. The subiculum is critical to learning and memory, although it has been relatively understudied. There are two functional types of principle neurons within the subiculum: regular spiking (RS) and burst spiking (BS) neurons. To determine whether these cell types are differentially modified by learning-related experience, we performed whole-cell patch clamp recordings from male mouse brain slices following contextual fear conditioning (FC) and memory retrieval relative to a number of control behavioral paradigms. RS cells, but not BS cells, displayed a …

Jepegmix2: Improved Gene-Level Joint Analysis Of Eqtls In Cosmopolitan Cohorts., Chris Chatzinakos, Donghyung Lee, Bradley T Webb, Vladimir I Vladimirov, Kenneth S Kendler, Silviu-Alin Bacanu

Faculty Research 2018

Motivation: To increase detection power, researchers use gene level analysis methods to aggregate weak marker signals. Due to gene expression controlling biological processes, researchers proposed aggregating signals for expression Quantitative Trait Loci (eQTL). Most gene-level eQTL methods make statistical inferences based on i) summary statistics from genome-wide association studies (GWAS) and ii) linkage disequilibrium (LD) patterns from a relevant reference panel. While most such tools assume homogeneous cohorts, our Gene-level Joint Analysis of functional SNPs in Cosmopolitan Cohorts (JEPEGMIX) method accommodates cosmopolitan cohorts by using heterogeneous panels. However, JEPGMIX relies on brain eQTLs from older gene expression studies and does …

Nicotinamide Treatment Robustly Protects From Inherited Mouse Glaucoma., Pete A. Williams, Jeffrey M. Harder, Brynn H Cardozo, Nicole E Foxworth, Simon W M John

Faculty Research 2018

Nicotinamide adenine dinucleotide (NAD) is a key molecule in several cellular processes and is essential for healthy mitochondrial metabolism. We recently reported that mitochondrial dysfunction is among the very first changes to occur within retinal ganglion cells during initiation of glaucoma in DBA/2J mice. Furthermore, we demonstrated that an age-dependent decline of NAD contributes to mitochondrial dysfunction and vulnerability to glaucoma. The decrease in NAD renders retinal ganglion cells vulnerable to a metabolic crisis following periods of high intraocular pressure. Treating mice with the NAD precursor nicotinamide (the amide form of vitamin B₃) inhibited many age- and high …

Modularity Of The Metabolic Gene Network As A Prognostic Biomarker For Hepatocellular Carcinoma., Fengdan Ye, Dongya Jia, Mingyang Lu, Herbert Levine, Michael W Deem

Faculty Research 2018

Abnormal metabolism is an emerging hallmark of cancer. Cancer cells utilize both aerobic glycolysis and oxidative phosphorylation (OXPHOS) for energy production and biomass synthesis. Understanding the metabolic reprogramming in cancer can help design therapies to target metabolism and thereby to improve prognosis. We have previously argued that more malignant tumors are usually characterized by a more modular expression pattern of cancer-associated genes. In this work, we analyzed the expression patterns of metabolism genes in terms of modularity for 371 hepatocellular carcinoma (HCC) samples from the Cancer Genome Atlas (TCGA). We found that higher modularity significantly correlated with glycolytic phenotype, later …

Sensing The Cilium, Digital Capture Of Ciliary Data For Comparative Genomics Investigations., Karen R. Christie, Judith A. Blake

Faculty Research 2018

BACKGROUND: Cilia are specialized, hair-like structures that project from the cell bodies of eukaryotic cells. With increased understanding of the distribution and functions of various types of cilia, interest in these organelles is accelerating. To effectively use this great expansion in knowledge, this information must be made digitally accessible and available for large-scale analytical and computational investigation. Capture and integration of knowledge about cilia into existing knowledge bases, thus providing the ability to improve comparative genomic data analysis, is the objective of this work.

METHODS: We focused on the capture of information about cilia as studied in the laboratory mouse, …

Genomic Profiling Of T-Cell Neoplasms Reveals Frequent, Allison Greenplate, Kai Wang, Rati M Tripathi, Norma Palma, Siraj M Ali, Phil J Stephens, Vincent A Miller, Yu Shyr, Yan Guo, Nishitha M Reddy, Lina Kozhaya, Derya Unutmaz, Xueyan Chen, Jonathan M Irish, Utpal P Davé

Faculty Research 2018

Purpose: The promise of precision oncology is that identification of genomic alterations will direct the rational use of molecularly targeted therapy. This approach is particularly applicable to neoplasms that are resistant to standard cytotoxic chemotherapy, like T-cell leukemias and lymphomas. In this study, we tested the feasibility of targeted next-generation sequencing in profiles of diverse T-cell neoplasms and focused on the therapeutic utility of targeting activated JAK1 and JAK3 in an index case.

Patients and Methods: Using Foundation One and Foundation One Heme assays, we performed genomic profiling on 91 consecutive T-cell neoplasms for alterations in 405 genes. The samples …

The International Mouse Phenotyping Consortium (Impc): A Functional Catalogue Of The Mammalian Genome That Informs Conservation., Violeta Muñoz-Fuentes, Pilar Cacheiro, Terrence F Meehan, Juan Antonio Aguilar-Pimentel, Steve D M Brown, Ann M Flenniken, Paul Flicek, Antonella Galli, Hamed Haseli Mashhadi, Martin Hrabě De Angelis, Jong Kyoung Kim, K C Kent Lloyd, Colin Mckerlie, Hugh Morgan, Stephen A Murray, Lauryl M J Nutter, Patrick T Reilly, John R Seavitt, Je Kyung Seong, Michelle Simon, Hannah Wardle-Jones, Ann-Marie Mallon, Damian Smedley, Helen E Parkinson

Faculty Research 2018

The International Mouse Phenotyping Consortium (IMPC) is building a catalogue of mammalian gene function by producing and phenotyping a knockout mouse line for every protein-coding gene. To date, the IMPC has generated and characterised 5186 mutant lines. One-third of the lines have been found to be non-viable and over 300 new mouse models of human disease have been identified thus far. While current bioinformatics efforts are focused on translating results to better understand human disease processes, IMPC data also aids understanding genetic function and processes in other species. Here we show, using gorilla genomic data, how genes essential to development …

Centrilobular Emphysema And Coronary Artery Calcification: Mediation Analysis In The Spiromics Cohort, Surya P. Bhatt, Hrudaya P. Nath, Young-Il Kim, Rekha Ramachandran, Jubal R. Watts, Nina L.J. Terry, Sushil Sonavane, Swati P. Deshmane, Prescott G. Woodruff, Elizabeth C. Oelsner, Sandeep Bodduluri, Meilan K. Han, Wassim W. Labaki, J. Michael Wells, Fernando J. Martinez, R. Graham Barr, Mark T. Dransfield, Spiromics Investigators

Journal Articles: Pulmonary & Critical Care Med

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is associated with a two-to-five fold increase in the risk of coronary artery disease independent of shared risk factors. This association is hypothesized to be mediated by systemic inflammation but this link has not been established.

METHODS: We included 300 participants enrolled in the SPIROMICS cohort, 75 each of lifetime non-smokers, smokers without airflow obstruction, mild-moderate COPD, and severe-very severe COPD. We quantified emphysema and airway disease on computed tomography, characterized visual emphysema subtypes (centrilobular and paraseptal) and airway disease, and used the Weston visual score to quantify coronary artery calcification (CAC). We used …

Can Capture Be Used To Identify Undiagnosed Patients With Mild-To-Moderate Copd Likely To Benefit From Treatment?, Nancy K. Leidy, Fernando J. Martinez, Karen G. Malley, David M. Mannino, Meilan K. Han, Elizabeth D. Bacci, Randall W. Brown, Julia F. Houfek, Wassim W. Labaki, Barry J. Make, Catherine A. Meldrum, Wilson Quezada, Stephen I. Rennard, Byron Thomashow, Barbara P. Yawn

Journal Articles: Pulmonary & Critical Care Med

BACKGROUND: COPD Assessment in Primary Care To Identify Undiagnosed Respiratory Disease and Exacerbation Risk (CAPTURE™) uses five questions and peak expiratory flow (PEF) thresholds (males ≤350 L/min; females ≤250 L/min) to identify patients with a forced expiratory volume in 1 second (FEV

METHODS: Data from the CAPTURE development study were used to test its sensitivity (SN) and specificity (SP) differentiating mild-to-moderate COPD (n=73) from no COPD (n=87). SN and SP for differentiating all COPD cases (mild to severe; n=259) from those without COPD (n=87) were also estimated. The modified Medical Research Council (mMRC) dyspnea scale and COPD Assessment Test (CAT™) …

Examining Practitioner Standards Regarding Periodontal Clearance For The Orthodontic Patient, William P. Brown

Student Theses, Dissertations and Capstones

Introduction: Orthodontic tooth movement relies largely on the physiology of the periodontium, which is comprised of various types of bone and soft tissues that surround and support the teeth. New orthodontic treatment modalities have emerged offering various combinations of improved esthetics and/or speed. However, the impact on standard and quality of care of these alternative treatment modalities is unclear. Institutional concern for the effects of orthodontics on a periodontally-compromised patient remains high, as evidenced by governing dental bodies mandating, and contemporary orthodontic leaders insisting, orthodontic treatment should not be carried out until active dental disease has been addressed. Therefore, this …

Comparison Of Preformed Archwires To Pretreatment Dental Casts Representing Normal Occlusions, Ezra Brown

Student Theses, Dissertations and Capstones

Introduction: Preformed nickel-titanium archwires have become an almost universal standard for archwire selection in clinical practice. However, previous studies have found that that the intercanine and intermolar widths may be altered with the use of these wires. The patient’s original arch form should not be changed. To our knowledge, previous studies have not yet assessed the intercanine and intermolar widths of preformed archwires when categorized into ovoid, tapered, and square arch forms. Therefore, the purpose of this study was to evaluate the inter-arch dimensions of commercially available preformed nickel-titanium archwires relative to normal occlusion dental arches and when compared to …

Depth Of Cure Of Resin Composites: Effect Of Incremental Layering Versus Bulk Placement And Effect Of Curing Light Type, Najat Aldossarry

Student Theses, Dissertations and Capstones

Background: The introduction of resin composite was a revolution in dentistry and it has shown a high level of success as a direct restorative material. Appropriate techniques and light curing units are essential for optimal clinical outcomes. Objective: To assess depth of cure of two bulk-fill composites and one nanofill resin composite, when photopolymerized with two different curing light units (CLU), placed with an incremental layering versus bulk-fill technique. Material and methods: Two Bulk-fill resin composites (Surefil SDR® Flow and Tetric EvoCeram®) and a conventional nanofill (FiltekTM Supreme Ultra) were used to prepare 90 cylindrical specimens. Specimens (n=5/group) were made …

How Can Content Management Systems Be Customized For Better User Experience?, Mikayla Colston

Undergraduate Research Posters 2018

PLAAY (Participation in Leisure Allowing Access for everYone) on the Move is a program promoting independence, mobility, and access for young children with sensory and mobility impairments. As PLAAY on the Move emerged from the preexisting GoBabyGo program at Cleveland State University, a collaborative program, showcasing research and educating the community about the services provided, became a necessity. Conducting primary research as well as secondary research helps determine the best content management system (CMS) to fulfill the needs of the program. Additionally, user testing and surveys about the website, created with the CMS, proves the effectiveness of the platform while …

Programming To Transition Psychological Experiments From Superlab To Matlab, Mudra R. Savaliya

Undergraduate Research Posters 2018

For the past six years, our laboratory has conducted experiments programmed in Superlab, a software package designed exclusively for psychological experiments. Although Superlab has some attractive features, it also has some severe limitations. For example, Superlab cannot read files, meaning that for an experiment in which each participant has a unique stimulus list, a unique program has to be assembled for each participant. For an experiment in which each participant has a unique order of conditions, a unique program with the conditions in that order has to be assembled for each participant. Preparing numerous unique programs provides numerous opportunities for …

Balance Training Using The Multi-Directional Harness System, Araxie Demirjin, Kristy Tachji

Undergraduate Research Posters 2018

Introduction and Purpose Individuals post-stroke frequently have impairments in balance and mobility. This study aims to increase mobility through high intensity balance training in a multi-directional harness system using video gaming to add environmental and tsk complexity. We hypothesize the training will improve balance, mobility, and decrease falls. Methods In this case series, two adults post-stroke completed seven sessions of balance training using four adapted commercial video games from the X-Box Kinect™ (20,000 Leaks (L), Reflex Ridge (R), Table Tennis (T), and Target Kick (K)) on varied types of floor surfaces. These games were chosen to challenge various aspects of …

Perspectives On Adolescent Drug Use: Interviews With Community Providers, Noelle Naser

Undergraduate Research Posters 2018

With a striking rise in drug related deaths over the past few years, researchers have looked towards improving prevention methods as a way to not only react to substance abuse with treatment, but learn to better prevent individuals from following these risk taking behaviors. Adolescents specifically are prone to risk taking behaviors such as substance use as they navigate through the challenges of adolescence and transitioning into their identities. Therefore, research in understanding how and why youth decide to get involved in substances is important for creating stronger prevention. Using qualitative data obtained from semi-structured interviews with community providers (N=4), …

Perception Of Time And Post-Surgery Physical Rehabilitation, Karmen Love

Undergraduate Research Posters 2018

Physical rehabilitation is an important part of a patient’s recovery after surgery. Physical therapists are crucial to the success of that patient’s healing process. Physical rehabilitation can determine how quickly the patient’s healing progresses. It is difficult to determine how long a person will be in rehab and every patient has different expectations of how long their recovery will take. In this study, I explored how a patient’s perception of time affects the estimated versus actual recovery time post-surgery. The participants were patients admitted to the inpatient rehab at Mercy Regional Medical Center in Lorain, Ohio. Each patient was assessed …

Case Concentration: An Academic Arcade Game For Physical Therapist Education, Araxie Demirjian

Undergraduate Research Posters 2018

Case Physical Therapy is the study of patient/client cases to augment a practitioner’s clinical thinking, reasoning, and decision-making skills. Game-based learning, as part of an academic arcade, can add enjoyment and competition to an otherwise mundane process of acquiring knowledge and understanding and may serve to incentivize the student. The development of a case-related match game to teach physical therapy (PT) students about patient/client focused examination and interventional relationships is at the very heart of the design of Physical Therapy Case Concentration. Based in part on the successful, long-running (1958-1991) NBC game show, Physical Therapy Case Concentration features a computerized …

Indication Of Abdominal Wound Complication Within Breast Cancer Reconstruction, Taylor Lawson

Undergraduate Research Posters 2018

Following a mastectomy, breast reconstruction can be performed immediately with one possible procedure being the use of the body’s own tissue. Natural tissue breast reconstruction surgery can result in abdominal wound complications. My research focus is on Retrospective Chart Review of patient’s pre- op risk factors for abdominal wound complications post- surgery; including factors such as diabetes, smoking, prior C-section, etc. Patients’ charts will be examined for medical history and health concerns and if patient had any issues after one- year post surgery such as hematoma, seroma, wound breakdown, and/or belly umbilical necrosis.

Effects Of Greater Palatine Nerve Anesthesia On The Activity Of Hyoid Musculature During Swallowing, Besa Bunjaku

Undergraduate Research Posters 2018

Feeding is an important activity for all animals. An expansive array of sensory provide information to the brain about food handling during feeding. The brain then coordinates muscles to push the bolus into the esophagus, bypassing the airway. Previous work shows considerable coordination among sensor arrays and the nerves supplying them. Therefore it is likely that anesthetizing part of the oral cavity (in this case, the tissue covering the hard palate) will cause changes in the timing of muscles that are active during swallowing, even though these muscles are supplied by completely different nerves. We examined the timing of the …