Medicine and Health Sciences Commons^™

Metabolic And Transcriptional Modules Independently Diversify Plasma Cell Lifespan And Function, Wing Y. Lam, Arijita Jash, Cong-Hui Yao, Lucas D'Souza, Rachel Wong, Ryan M. Nunley, Gordon P. Meares, Gary J. Patti, Deepta Bhattacharya

Faculty & Staff Scholarship

Plasma cell survival and the consequent duration of immunity vary widely with infection or vaccination. Using fluorescent glucose analog uptake, we defined multiple developmentally independent mouse plasma cell populations with varying life- spans. Long-lived plasma cells imported more fluo- rescent glucose analog, expressed higher surface levels of the amino acid transporter CD98, and had more autophagosome mass than did short-lived cells. Low amino acid concentrations triggered re- ductions in both antibody secretion and mitochon- drial respiration, especially by short-lived plasma cells. To explain these observations, we found that glutamine was used for both mitochondrial respira- tion and anaplerotic reactions, yielding …

Evaluation Of Bleeding And Thrombotic Risk In Patients Receiving Triple Antithrombotic Therapy, Katharine Lundy Pharmd, Elizabeth Meisberger Pharmd, Bcps, Kris Howard Pharmd, Bcps, Aacc, Jennifer Sposito Pharmd

Parkview Pharmacy Department

2018 ASHP Midyear Clinical Meeting / Anaheim, California / Poster # 11-309

Objective: Evaluate bleeding and thrombotic risk of patients receiving triple antithrombotic therapy (TAT) versus dual antithrombotic therapy (DAT) and characterize prescribing patterns.

Cow's Milk Protein-Induced Villous Atrophy And Elevated Celiac Autoimmunity In Children With Celiac Disease On A Glutten-Free Diet: A Report Of Three Cases, Kristin Capone, Naire Sansotta, Pankaj Vohra, Stefano Guandalini

Pediatrics Research and Scholarship

Objective: To describe the serologic and histologic response of three patients with celiac disease who had persistent autoimmunity and villous atrophy despite a strict gluten-free diet, to the elimination of cow's milk protein.

Inflammatory Myofibroblastic Tumor Of The Lung, Akshay Khatri, Abhinav Agrawal, Rutuja R. Sikachi, Dhruv Mehta, Sonu Sahni, Nikhil Meena

Touro College of Osteopathic Medicine (New York) Publications and Research

Inflammatory myofibroblastic tumors (IMT) of the lung, first reported in 1939, are considered a subset of inflammatory pseudo-tumors. They are a distinctive lesions composed of myofibroblastic spindle cells accompanied by an inflammatory infiltrate of plasma cells, lymphocytes, and eosinophils. IMTs may be benign, invade surrounding structures, undergo malignant transformation, recur or may even metastasize. They can occur due to a genetic mutation or can occur secondary to infectious or autoimmune diseases. Patients may be asymptomatic, or present with cough, hemoptysis, dyspnea, pleuritic pain, constitutional symptoms or pneumonia. In this article we review the pathophysiology, genetics, clinical presentation, imaging findings of …

Computerized Cognitive Training In Prostate Cancer Patients On Androgen Deprivation Therapy: A Pilot Study, L. M. Wu, A. Amidi, M. L. Tanenbaum, G. Winkel, W. A. Gordon, S. J. Hall, K. Bovbjerg, M. A. Diefenbach

Journal Articles

© 2017, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: Prostate cancer patients who have undergone androgen deprivation therapy (ADT) may experience cognitive impairment, yet there is an unmet need for nonpharmacological interventions to address cognitive impairment in this population. This study examines the feasibility, acceptability, and preliminary efficacy of a home-based computerized cognitive training (CCT) program to treat cancer-related cognitive impairment. Methods: Sixty men who had received ≥ 3 months of ADT were screened for at least mild cognitive or neurobehavioral impairment and randomized to 8 weeks of CCT or usual care. Follow-up assessments occurred immediately post-intervention or equivalent …

Same-Session Placement Of Multiple Lumen-Apposing Metal Stents To Provide Effective Drainage Of Extensive Walled-Off Pancreatic Necrosis, D. V. Sejpal, G. M. Grimaldi, P. C. Benias, A. J. Trindade, C. W. Lee

Journal Articles

No abstract provided.

Effects Of Vedolizumab Therapy On Extraintestinal Manifestations In Inflammatory Bowel Disease, M. Fleisher, J. Marsal, S. D. Lee, L. E. Frado, A. Parian, B. I. Korelitz, B. G. Feagan

Journal Articles

No abstract provided.

Glecaprevir/Pibrentasvir In Patients With Hepatitis C Virus Genotype 1 Or 4 And Past Direct-Acting Antiviral Treatment Failure, F. Poordad, S. Pol, A. Asatryan, M. Buti, D. Shaw, C. Hezode, F. Felizarta, R. W. Reindollar, D. E. Bernstein, F. J. Mensa, +10 Additional Authors

Journal Articles

No abstract provided.

The Social Media Revolution In Nephrology Education, G. B. Colbert, J. Topf, K. D. Jhaveri, T. Oates, M. N. Rheault, S. Shah, S. Hiremath, M. A. Sparks

Journal Articles

© 2018 International Society of Nephrology The past decade has been marked by the increasing use of social media platforms, often on mobile devices. In the nephrology community, this has resulted in the organic and continued growth of individuals interested in using these platforms for education and professional development. Here, we review several social media educational resources used in nephrology education and tools including Twitter, videos, blogs, and visual abstracts. We will also review how these tools are used together in the form of games (NephMadness), online journal clubs (NephJC), interactive learning (GlomCon), and digital mentorship (Nephrology Social Media Collective …

Anticholinergic Toxicity Secondary To Overuse Of Topricin Cream, A Homeopathic Medication., M. Krzyzak, A. Regina, R. C. Jesin, L. Deeb, E. Steinberg, N. Majlesi

Journal Articles

Adverse reactions from over-the-counter medications present a challenge to physicians. Homeopathic medicine is an alternative practice, originating in Germany and gaining popularity in the United States. It utilizes dilute preparations of substances in order to treat and cure disease. Patients may potentially suffer serious effects from the use of these products as the contents and concentrations are often unclear. Here, we describe a case of suspected atropine toxicity due to the overuse of a topical homeopathic cream, Topricin, which contains belladonna, a plant containing atropine.

Chimeric Antigen Receptor T Cell Therapy And The Kidney What The Nephrologist Needs To Know, K. D. Jhaveri, M. H. Rosner

Journal Articles

No abstract provided.

Hybrid Capture–Based Genomic Profiling Of Circulating Tumor Dna From Patients With Advanced Cancers Of The Gastrointestinal Tract Or Anus, A. B. Schrock, D. Pavlick, S. J. Klempner, J. H. Chung, B. Forcier, A. Welsh, L. Young, B. Leyland-Jones, C. Devoe, V. A. Miller, +9 Additional Authors

Journal Articles

© 2018 American Association for Cancer Research. Purpose: Genomic profiling of tumor biopsies from advanced gastrointestinal and anal cancers is increasingly used to inform treatment. In some cases, tissue biopsy can be prohibitive, and we sought to investigate whether analysis of blood-derived circulating tumor DNA (ctDNA) may provide a minimally invasive alternative. Experimental Design: Hybrid capture–based genomic profiling of 62 genes was performed on blood-based ctDNA from 417 patients with gastrointestinal carcinomas to assess the presence of genomic alterations (GA) and compare with matched tissue samples. Results: Evidence of ctDNA was detected in 344 of 417 samples (82%), and of …

Long-Term Safety And Efficacy Of Belimumab In Patients With Systemic Lupus Erythematosus A Continuation Of A Seventy-Six-Week Phase Iii Parent Study In The United States, R. A. Furie, D. J. Wallace, C. Aranow, J. Fettiplace, B. Wilson, P. Mistry, D. A. Roth, D. Gordon

Journal Articles

No abstract provided.

Noninfectious Manifestations And Complications Of Chronic Granulomatous Disease, S. E. Henrickson, A. M. Jongco, K. F. Thomsen, E. K. Garabedian, I. P. Thomsen

Journal Articles

© The Author(s) 2018. Chronic granulomatous disease (CGD), a primary immunodeficiency characterized by a deficient neutrophil oxidative burst and the inadequate killing of microbes, is well known to cause a significantly increased risk of invasive infection. However, infectious complications are not the sole manifestations of CGD; substantial additional morbidity is driven by noninfectious complications also. These complications can include, for example, a wide range of inflammatory diseases that affect the gastrointestinal tract, lung, skin, and genitourinary tract and overt autoimmune disease. These diseases can occur at any age and are especially problematic in adolescents and adults with CGD. Many of …

Considerations In The Diagnosis Of Chronic Granulomatous Disease, J. E. Yu, A. E. Azar, H. J. Chong, A. M. Jongco, B. T. Prince

Journal Articles

© The Author(s) 2018. Chronic granulomatous disease (CGD) is a rare primary immunodeficiency that is caused by defects in the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. The disease presents in most patients initially with infection, especially of the lymph nodes, lung, liver, bone, and skin. Patients with CGD are susceptible to a narrow spectrum of pathogens, and Staphylococcus aureus, Burkholderia cepacia complex, Serratia marcescens, Nocardia species, and Aspergillus species are the most common organisms implicated in North America. Granuloma formation, most frequently in the gastrointestinal and genitourinary systems, is a common complication of CGD and can be seen even …

Examining The Impact Of A Multimedia Intervention On Treatment Decision-Making Among Newly Diagnosed Prostate Cancer Patients: Results From A Nationwide Rct., M. A. Diefenbach, C. Benedict, S. M. Miller, A. L. Stanton, M. E. Ropka, K. Wen, N. E. Mohamed, S. J. Hall

Journal Articles

Men diagnosed with early stage prostate cancer face multiple treatment options, each with distinctive side effects that have significant implications for post-treatment quality of life. Healing Choices for Men with Prostate Cancer is a multimedia educational and decision aid program. This nation-wide randomized controlled trial evaluated the impact of Healing Choices on reducing decisional conflict and distress. Eligible prostate cancer patients who called the National Cancer Institute's Cancer Information Service (CIS) were invited to participate. After a baseline interview, participants were randomized to usual personalized consultation with a CIS specialist (comparison condition) or CIS personalized consultation plus the Healing Choices …

Racial And Ethnic Disparities In Diagnosis Of Chronic Medical Conditions In The Usa, E. J. Kim, T. Kim, J. Conigliaro, J. M. Liebschutz, M. K. Paasche-Orlow, A. D. Hanchate

Journal Articles

No abstract provided.

Lung Ultrasonography In End-Stage Renal Disease: Moving From Evidence To Practice-A Narrative Review, D. W. Ross, M. M. Abbasi, K. D. Jhaveri, M. Sachdeva, I. Miller, R. Barnett, M. Narasimhan, P. Mayo, M. Merzkani, A. T. Mathew

Journal Articles

© The Author 2017. Published by Oxford University Press on behalf of ERA-EDTA. Traditionally, point of care ultrasonography in nephrology has been used for renal biopsies and dialysis line placement. However, there is an emerging literature supporting the value of point of care lung ultrasonography in the assessment of volume status for dialysis patients.We conducted a review and identified 12 studies that examined the utility of lung ultrasonography in assessing volume status in patients with end-stage renal disease.We conclude that lung ultrasonography can be used to determine volume status in chronic dialysis patients by identifying lung congestion using the B-line …

Is 30-Day Posthospitalization Mortality Lower Among Racial/Ethnic Minorities?: A Reexamination, M. Lin, N. R. Kressin, M. K. Paasche-Orlow, E. J. Kim, L. Lopez, J. E. Rosen, A. D. Hanchate

Journal Articles

No abstract provided.

Opportunities For Increasing The Rate Of Preemptive Kidney Transplantation, S. Fishbane, V. Nair

Journal Articles

No abstract provided.

Biliary And Pancreatic Lithotripsy Devices, R. R. Watson, M. A. Parsi, H. R. Aslanian, A. J. Goodman, D. R. Lichtenstein, J. Melson, U. Navaneethan, R. Pannala, A. J. Trindade, J. T. Maple, +4 Additional Authors

Journal Articles

© 2018 Background and Aims: Lithotripsy is a procedure for fragmentation or destruction of stones to facilitate their removal or passage from the biliary or pancreatic ducts. Although most stones may be removed endoscopically using conventional techniques such as endoscopic sphincterotomy in combination with balloon or basket extraction, lithotripsy may be required for clearance of large, impacted, or irregularly shaped stones. Several modalities have been described, including intracorporeal techniques such as mechanical lithotripsy (ML), electrohydraulic lithotripsy (EHL), and laser lithotripsy, as well as extracorporeal shock-wave lithotripsy (ESWL). Methods: In this document, we review devices and methods for biliary and pancreatic …

Nitrous Oxide Cryotherapy Ablation For Refractory Gastric Antral Vascular Ectasia, A. A. Patel, A. J. Trindade, D. L. Diehl, H. S. Khara, T. Lee, C. Lee, A. Sethi

Journal Articles

No abstract provided.

A Unique Approach To Faculty Development Using An Observed Structured Teaching Encounter (Oste), M. A. Smith, R. Cherazard, A. Fornari, P. Adelman, M. Snopkowski, M. Lesser

Journal Articles

We have challenges with poor patient satisfaction scores (Hospital Consumer Assessment of Healthcare Providers and Systems [HCAHPS]) and internal medicine resident (IMR) evaluations of voluntary attending physicians. Using an Observed Structured Teaching Encounter (OSTE), we designed a faculty development project that focused on attendings' teaching and feedback skills. To assess attending communication with interns and improve attending teaching and feedback skills. All IM attendings on the Long Island Jewish Forest Hills (LIJFH) Emergency Department (ED) call schedule participated. OSTE simulation sessions included two clinical scenarios, standardized patients (SPs), fourth-year medical students trained as 'interns,' OSTE checklists, and debriefing. We analyzed …

Tranexamic Acid Increases Early Perioperative Functional Outcomes After Total Knee Arthroplasty., M. J. Grosso, D. P. Trofa, J. R. Danoff, T. R. Hickernell, T. Murtaugh, A. Lakra, J. A. Geller

Journal Articles

Background: The purpose of this study was to investigate the influence of tranexamic acid (TXA) on functional outcomes in the immediate postoperative period after total knee arthroplasty (TKA). We hypothesized that the known benefits of TXA would confer measurable clinical improvements in physical therapy (PT) performance, decrease pain, and decrease hospital length of stay (LOS).

Methods: We retrospectively analyzed 560 TKA patients, including 280 consecutive patients whose surgery was performed before the initiation of a standardized TXA protocol and the first 280 patients who received TXA after protocol initiation. Outcome measurements included postoperative changes in hemoglobin and hematocrit, LOS, pain …

Cost-Effectiveness Of Magnetic Resonance Imaging In Cervical Clearance Of Obtunded Blunt Trauma After A Normal Computed Tomographic Finding, X. Wu, A. Malhotra, B. Geng, V. B. Kalra, K. Abbed, H. P. Forman, P. Sanelli

Journal Articles

© 2018 American Medical Association. All rights reserved. IMPORTANCE Magnetic resonance imaging (MRI) continues to be performed for cervical clearance of obtunded blunt trauma, despite poor evidence regarding its utility after a normal computed tomographic (CT) finding. OBJECTIVE To evaluate the utility and cost-effectiveness of MRI vs no follow-up after a normal cervical CT finding in patients with obtunded blunt trauma. DESIGN, SETTING AND PARTICIPANTS This cost-effectiveness analysis evaluated an average patient aged 40 years with blunt trauma from an institutional practice. The analysis used a Markov decision model over a lifetime horizon from a societal perspective with variables from …

Hybrid 3d/2d Convolutional Neural Network For Hemorrhage Evaluation On Head Ct, P. D. Chang, E. Kuoy, J. Grinband, B. D. Weinberg, M. Thompson, R. Homo, J. Chen, H. Abcede, C. G. Filippi, D. Chow, +5 Additional Authors

Journal Articles

No abstract provided.

Assessment Of The Albumin-Bilirubin (Albi) Grade As A Prognostic Indicator For Hepatocellular Carcinoma Patients Treated With Radioembolization., B. Gui, A. A. Weiner, J. Nosher, S. E. Lu, G. M. Foltz, O. Hasan, S. K. Kim, V. Gendel, N. B. Mani, S. K. Jabbour, +6 Additional Authors

Journal Articles

OBJECTIVE: As the utility of Child-Pugh (C-P) class is limited by the subjectivity of ascites and encephalopathy, we evaluated a previously established objective method, the albumin-bilirubin (ALBI) grade, as a prognosticator for yttrium-90 radioembolization (RE) treatment for patients with hepatocellular carcinoma (HCC).

MATERIALS AND METHODS: A total of 117 patients who received RE for HCC from 2 academic centers were reviewed and stratified by ALBI grade, C-P class, and Barcelona Clinic Liver Cancer stage. The overall survival (OS) according to these 3 criteria was evaluated by Kaplan-Meier survival analysis. The utilities of C-P class and ALBI grade as prognostic indicators …

International Consensus (Icon) On Treatment Of Sudden Sensorineural Hearing Loss, M. Marx, E. Younes, S. S. Chandrasekhar, J. Ito, S. Plontke, S. O'Leary, O. Sterkers

Journal Articles

© 2018 Elsevier Masson SAS Sudden sensorineural hearing loss (SSNHL) is a common and alarming symptom that often prompts an urgent visit to an ENT specialist. Treatment of SSNHL remains one of the most problematic issues for contemporary otorhinolaryngology: although many meta-analyses and national guidelines have been issued, management is not standardized in terms of medical treatment, and duration and route of administration. We present several methodological suggestions for the study of treatments for SSNHL. These were developed from the existing level of evidence of the main treatments used in SSNHL by experts who convened at the IFOS 2017 ENT …

Efficacy Of A Non-Invasive Middle Ear Aeration Device In Children With Recurrent Otitis Media: A Randomized Controlled Trial Protocol, T. Tham, L. Rahman, P. Costantino

Journal Articles

© 2018 The Authors Acute otitis media (AOM) represents a significant disease burden in the pediatric population. Besides vaccinations, there are no robust measures of reducing incidence of AOM in this age-group. This is a randomized controlled clinical trial evaluating the efficacy of a non-invasive middle ear aeration device, the EarPopper device (EP). We aim to investigate the reduction of episodes AOM in children with recurrent otitis media. The control arm will be observational. The intervention arm will have the EP used. The primary endpoint is incidence of AOM. The secondary endpoints are hazard ratio of time to AOM, proportion …

Study Of Flare Assessment In Systemic Lupus Erythematosus Based On Paper Patients, D. Isenberg, J. Sturgess, E. Allen, C. Aranow, A. Askanase, B. Sang-Cheol, S. Bernatsky, I. Bruce, J. Buyon, C. Gordon, +29 Additional Authors

Journal Articles

© 2017, The Authors. Arthritis Care & Research published by Wiley Periodicals, Inc. on behalf of American College of Rheumatology. Objective: To determine the level of agreement of disease flare severity (distinguishing severe, moderate, and mild flare and persistent disease activity) in a large paper-patient exercise involving 988 individual cases of systemic lupus erythematosus. Methods: A total of 988 individual lupus case histories were assessed by 3 individual physicians. Complete agreement about the degree of flare (or persistent disease activity) was obtained in 451 cases (46%), and these provided the reference standard for the second part of the study. This …