Medicine and Health Sciences Commons^™

Assessment Of Effectiveness And Scalability Of Unicef-Sponsored Projects To Prevent Violence Against Children And Women In Papua, South Sulawesi, And Central Java., Marc C. Edberg, Hina Shaikh, Leah Keller

Center for Social Well-Being and Development

No abstract provided.

Examination Of Reticulocytosis Among Chronically Transfused Children With Sickle Cell Anemia., Megha Kaushal, Colleen Byrnes, Zarir Khademian, Natalie Duncan, Naomi L.C. Luban, Jeffery L Miller, Ross M. Fasano, Emily Riehm Meier

Pediatrics Faculty Publications

Sickle cell anemia (SCA) is an inherited hemolytic anemia with compensatory reticulocytosis. Recent studies have shown that increased levels of reticulocytosis during infancy are associated with increased hospitalizations for SCA sequelae as well as cerebrovascular pathologies. In this study, absolute reticulocyte counts (ARC) measured prior to transfusion were analysed among a cohort of 29 pediatric SCA patients receiving chronic transfusion therapy (CTT) for primary and secondary stroke prevention. A cross-sectional flow cytometric analysis of the reticulocyte phenotype was also performed. Mean duration of CTT was 3.1 ± 2.6 years. Fifteen subjects with magnetic resonance angiography (MRA) -vasculopathy had significantly higher …

Chinese Smokers’ Behavioral Response Toward Cigarette Price: Individual And Regional Correlates, Tingzhong Yang, Sihui Peng, Lingwei Yu, Shuhan Jiang, William B. Stroub, Randall R. Cottrell, Ian R. H. Rockett

Faculty & Staff Scholarship

Background:
Many studies have explored smokers’ behavioral response to cigarette prices at the individual level, but none have factored in regional variation and determinants. This study addresses these research gaps in the Chinese context.

Methods:
A cross-sectional multistage sampling process was used to recruit participants in 21 cities in China. Individual-level information was collected using standardized questionnaires. City-level variables were retrieved from a nationall database. Multilevel logistic regression analysis was used to assess price sensitivity variation at both individual and city levels.

Results:
A cross-sectional multistage sampling process was used to recruit participants in 21 cities in China. Individual-level information …

Modified Extracorporeal Photopheresis As An Immunotherapy In Murine Melanoma, Aaron Nathaniel Vassall

Yale Medicine Thesis Digital Library

Extracorporeal Photochemotherapy (ECP) is a widely used immunotherapy for cutaneous T cell lymphoma, as well as an immunomodulatory treatment for graft versus host disease (GVHD) and rejection of allografts. We hypothesized that ECP’s physiologic induction of large-scale monocyte-to-dendritic antigen presenting cell (APC) conversion is mechanistically responsible for both its anti-cancer effect and its tolerogenic impact in the transplant setting. To interrogate this possibility in an experimental system, we developed an ECP device that is scalable from mouse to man and tested its capacity to produce APCs that, when advantageously tuned and tumor antigen-loaded, can limit the growth of otherwise lethal …

Graduate Medical Education 2015-2016 Annual Report, Children's Mercy Hospital

GME Annual Reports

Annual report of the Children's Mercy Hospital Graduate Medical Education department, including pediatric residency, internal medicine/pediatrics residency, fellowship programs, medical students, continuing medical education, and library services.

The Associations Of Selected Lifestyle Patterns And Lung Cancer Risk: An Evidence-Based Update, Joanna Kruk, Basil H. Aboul-Enein

Health & Wellness Department Faculty Publications and Research

Diagnosis of lung cancer (LC) has been fraught with difficulty and by the time of definitive diagnosis, most patients are in later stages of the disease. Epidemiological studies have demonstrated that lifestyle behaviors play an etiological role in LC risk; however data in the literature on this topic often appears inconclusive or require further study. Understanding of the mechanisms operating between lifestyle patterns and their impact on LC is important for the disease’s prevention and treatment. The purpose of this study was to review the current evidence on the role of diet, body mass index (BMI), physical activity, smoking, alcohol …

Minimally Invasive Surgery In Pediatric Trauma: One Institution's 20-Year Experience, Gustavo Stringel, Min Li Xu, Joseph Lopez

NYMC Faculty Publications

BACKGROUND: Minimally invasive surgery (MIS) for trauma in pediatric cases remains controversial. Recent studies have shown the validity of using minimally invasive techniques to decrease the rate of negative and nontherapeutic laparotomy and thoracotomy. The purpose of this study was to evaluate the diagnostic accuracy and therapeutic options of MIS in pediatric trauma at a level I pediatric trauma center.

METHODS: We reviewed cases of patients aged 15 years and younger who had undergone laparoscopy or thoracoscopy for trauma in our institution over the past 20 years. Each case was evaluated for mechanism of injury, computed tomographic (CT) scan findings, …

Interpreting Patient-Reported Outcomes From Clinical Trials In Copd: A Discussion, Paul W. Jones, Stephen I. Rennard, Maggie Tabberer, John H. Riley, Mitra Vahdati-Bolouri, Neil C. Barnes

Journal Articles: Pulmonary & Critical Care Med

One of the challenges faced by the practising physician is the interpretation of patient-reported outcomes (PROs) in clinical trials and the relevance of such data to their patients. This is especially true when caring for patients with progressive diseases such as COPD. In an attempt to incorporate the patient perspective, many clinical trials now include assessments of PROs. These are formalized methods of capturing patient-centered information. Given the importance of PROs in evaluating the potential utility of an intervention for a patient with COPD, it is important that physicians are able to critically interpret (and critique) the results derived from …

Upregulation Of Rgs2: A New Mechanism For Pirfenidone Amelioration Of Pulmonary Fibrosis, Yan Xie, Haihong Jiang, Qian Zhang, Suneet Mehrotra, Peter W. Abel, Myron L. Toews, Dennis W. Wolff, Stephen I. Rennard, Reynold A. Panettieri, Thomas B. Casale, Yaping Tu

Journal Articles: Pulmonary & Critical Care Med

BACKGROUND: Pirfenidone was recently approved for treatment of idiopathic pulmonary fibrosis. However, the therapeutic dose of pirfenidone is very high, causing side effects that limit its doses and therapeutic effectiveness. Understanding the molecular mechanisms of action of pirfenidone could improve its safety and efficacy. Because activated fibroblasts are critical effector cells associated with the progression of fibrosis, this study investigated the genes that change expression rapidly in response to pirfenidone treatment of pulmonary fibroblasts and explored their contributions to the anti-fibrotic effects of pirfenidone.

METHODS: We used the GeneChip microarray to screen for genes that were rapidly up-regulated upon exposure …

Effects Of Roflumilast In Copd Patients Receiving Inhaled Corticosteroid/Long-Acting Β2-Agonist Fixed-Dose Combination: Re(2)Spond Rationale And Study Design, Stephen I. Rennard, Fernando J. Martinez, Klaus F. Rabe, Sanjay Sethi, Emilio Pizzichini, Andrew Mcivor, Shahid Siddiqui, Antonio Anzueto, Haiyuan Zhu

Journal Articles: Pulmonary & Critical Care Med

BACKGROUND: Roflumilast, a once-daily, selective phosphodiesterase-4 inhibitor, reduces the risk of COPD exacerbations in patients with severe COPD associated with chronic bronchitis and a history of exacerbations. The RE(2)SPOND study is examining whether roflumilast, when added to an inhaled corticosteroid/long-acting β2-agonist (ICS/LABA) fixed-dose combination (FDC), further reduces exacerbations. The methodology is described herein.

METHODS: In this Phase IV, multicenter, double-blind, placebo-controlled, parallel-group trial, participants were randomized 1:1 (stratified by long-acting muscarinic antagonist use) to receive roflumilast or placebo, plus ICS/LABA FDC, for 52 weeks. Eligible participants had severe COPD associated with chronic bronchitis, had two or more moderate-severe exacerbations within …

Doctor Of Pharmacy Overview, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Physical Therapy 2016, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Doctor Of Osteopathic Medicine Curriculum, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Com Outlook Winter 2016, College Of Osteopathic Medicine

COM Outlook

No abstract provided.

Fabric Cooling By Water Evaporation, Uwe Reischl, Ravindra S. Goonetilleke

Public and Population Health Faculty Publications and Presentations

Clothing can provide safety and comfort for persons exposed to both cold and hot thermal environments. To assess the potential impact of clothing moisture and wetness on fabric cooling, a series of wind-tunnel tests was conducted to quantify the evaporative cooling capacity of selected fabric samples. Single-layer cotton, polyester, nylon and silk were evaluated. The results showed that onset and magnitude of evaporative cooling was determined by the amount of water contained in a fabric sample. The results also showed that an exposed "skin" exhibited more cooling when covered with a fabric than when it was not. The information obtained …

Unusual Atypical Language Lateralization, Muhammad T. Khan, Roger Oghlakian, Mohamad Z. Koubeissi

Faculty & Staff Scholarship

Determining the language-dominant hemisphere is essential for planning epilepsy surgery. A 60-year-old righthanded woman with epilepsy since age 16 failed a partial right anterior lobectomy at age 21. Later, a brain MRI found extensive right-sided cortical dysplasia and periventricular heterotopia. Subsequently, prolonged videoEEG monitoring localized her seizures to the right temporoparietal region. Functional MRI was inconclusive in lateralizing her language, prompting a Wada test, which strongly lateralized language to the right. This unique case of atypical language representation in a right-handed individual with an extensive right-hemispheric congenital malformation and seizure focus illustrates the important thorough presurgical language assessment.

Sex Differences In The Use Of Complementary And Alternative Medicine Among Adults With Multiple Chronic Conditions, Monira Alwhaibi, Usha Sambamoorthi

Faculty & Staff Scholarship

Objective. To examine sex differences in complementary and alternative medicine (CAM) use among adults with multiple chronic conditions. Methods. This study used a cross-sectional design with data from the 2012 National Health Interview Survey. The participants were interviewed in 2012 and the reference period for the questions in the survey varied from 1 week to 12 months prior to the interview date. The study included adults (age > 21 years) with no missing data on CAM use variables and who had multiple chronic conditions. Multivariable regression analyses were used to examine the association between sex and CAM use. Results. A significantly …

Master Of Public Health Graduate Certificate, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

B.S. Nursing Program Overview, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Graduate Nursing Overview, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Master Of Health Science Doctor Of Health Science Brochure, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Occupational Therapy Clinical Doctorate Curriculum, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Physical Therapy Doctorate Hybrid Program Overview, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Physical Therapy Ph.D. Overview, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

R.N. To M.S.N. Curriculum, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Nurse Practitioner M.S.N. Aprn Overview, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Evaluation Of A Cervical Cancer Surveillance Program At A Community Health Center, Naquita Jackson Manning

Student Theses, Dissertations and Capstones

Background: Cervical cancer is reportedly the easiest gynecologic cancer to prevent, and measures that have the most impact are regular screening and timely follow-up. Although the Papanicolaou (Pap) test used to screen for cervical cancer has been recognized as one of the most valuable clinical preventive service for women, variation in screening and tracking remain a barrier for some women achieving optimal health. Missed opportunities for care in the form of inadequate follow-up is a patient safety and quality of care issue that can be appropriately addressed through implementation of a tool to be used as a component of a …

Sequential And Dynamic Rna:Rna Base-Pairing Interactions Between U6atac And U12 Snrnas Predicted To Form Helix 1a And Helix 1b, Maitri Patel, Jagjit Singh

Undergraduate Research Posters 2016

In eukaryotes, pre-mRNA splicing is important step for gene expression. Splicing is a two-step process which is carried out by a multi-megadalton molecular weight ribonucleoprotein (RNP) machinery called spliceosome. Spliceosome converts pre- mRNA to mRNA by removing non-coding sequence (introns) and splice together coding sequence (exons). Mammalian pre-mRNA are spliced by two different class of spliceosomes which are known as U2- and U12- dependent spliceosomes. U12 dependent spliceosome is composed of five small nuclear RNAs (snRNA). As compared to U2-dependent spliceosome, there is very less known about the catalytic process of U12-dependent splicing. U6atac and U12 snRNA are central to …

Bioinformatic Analysis Of The Sodium Hydrogen Exchanger Protein In Plasmodium Yoelii, Jamira Virk, Raghavendra Yadavalli

Undergraduate Research Posters 2016

Since its discovery over 100 years ago, malaria has been the most important parasitic disease in the world. Malaria affects about 300 to 500 million people every year; killing 5 million people every year. The most virulent causative agent in humans is Plasmodium falciparum; it is an important member of the phylum Apicomplexa, which also includes Toxoplasma gondii. These organisms contain specialized, unique structures, including rhoptry organelles. In Plasmodium and Toxoplasma gondii, they assist invasion into the host cell. Analyses have been performed on proteins located in rhoptries in Toxoplasma and Plasmodium. Among the proteins that have been analyzed, the …

Synthesis And Characterization Of Lectin Mimetics (Neo-Lectins), Czharena Kay Rama, Joshua Whited

Undergraduate Research Posters 2016

The cell surface expresses a variety of carbohydrates such as glycoproteins, proteoglycans and glycolipids. They play critical roles in pathological and physiological processes, including cell signaling, immune responses, pathogen-host interactions, tumor metastasis, and other cellular events. Due to its function and uses in cell communication, it is a curious subject of observation for scientific research. The molecular mechanism of carbohydrate recognition is still undetermined, and lectins, sugar binding proteins, are used to analyze the particular structures expressed on the cell surface. Lectins are normally found in plants and animals, and the isolation process of lectins is laborious, toxic, immunogenic and …