Medicine and Health Sciences Commons^™

A Generalized Framework For Computational Design And Mutational Scanning Of T-Cell Receptor Binding Interfaces, Timothy P. Riley, Cory M. Ayres, Lance M. Hellman, Nishant K. Singh, Michael Cosiano, Jennifer M. Cimons, Michael J. Anderson, Kurt H. Piepenbrink, Brian G. Pierce, Zhiping Weng, Brian M. Baker

Food for Health: Publications

T-cell receptors (TCRs) have emerged as a new class of therapeutics, most prominently for cancer where they are the key components of new cellular therapies as well as soluble biologics. Many studies have generated high affinity TCRs in order to enhance sensitivity. Recent outcomes, however, have suggested that fine manipulation of TCR binding, with an emphasis on specificity may be more valuable than large affinity increments. Structure-guided design is ideally suited for this role, and here we studied the generality of structure-guided design as applied to TCRs. We found that a previous approach, which successfully optimized the binding of a …

What's Happening: November 28, 2016, Maine Medical Center

What's Happening

No abstract provided.

The Complex Evolutionary History Of Aminoacyl-Trna Synthetases, Anargyros Chaliotis, Panayotis Vlastaridis, Dimitris Mossialos, Michael Ibba, Hubert D. Becker, Constantinos Stathopoulos, Grigorios D. Amoutzias

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Aminoacyl-tRNA synthetases (AARSs) are a superfamily of enzymes responsible for the faithful translation of the genetic code and have lately become a prominent target for synthetic biologists. Our large-scale analysis of >2500 prokaryotic genomes reveals the complex evolutionary history of these enzymes and their paralogs, in which horizontal gene transfer played an important role. These results show that a widespread belief in the evolutionary stability of this superfamily is misconceived. Although AlaRS, GlyRS, LeuRS, IleRS, ValRS are the most stable members of the family, GluRS, LysRS and CysRS often have paralogs, whereas AsnRS, GlnRS, PylRS and SepRS are often absent …

A Case Study For Integration Of Legacy Healthcare Electronic Medical Records Into A Trusted Data Warehouse Utilizing Master Data Management, Michael Greer

Theses and Dissertations

This dissertation is focused in the case study of how a large academic, medical, research centers used the principles of master data management to design, build, and implement an enterprise data warehouse. Data governance, stewardship, entity resolution, and strong supporting metadata programs are at the center of a successful enterprise data warehouse. Migrating legacy clinical and research data in structured, unstructured, text, images, signature, pictures, and multimedia format into a single trusted data warehouse is a significant task. On March 23, 2010, President Obama signed into law one of the most comprehensive revisions to our nation’s health care system in …

Improving Rn Comfort Level In Individualizing Care For Hospice Patients, Tiffany D. Casimiro Bsn, Rn, Danielle G. France Bsn, Rn, Rebecca A. Livesay Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

The Benefits Of Disposable Incontinence Pads, Janeen M. Bendig Bsn, Rn, Shannon E. Hindman Bsn, Rn, Kaitlyn N. Irving Bsn, Rn, Ellen M. Melanson Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Best Practice On Insulin Injection Therapy., Deanna A. Cavallaro Bsn, Rn, Andrew Orzel Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Telemetry Alarm Fatigue In Medical-Surgical Nurses, Kathryn E. Cosentino Bsn, Rn, Richard F. Dyer Bsn, Rn, Emily K. Hegner Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Braden Risk Assessment, Kelly A. Hartley Bsn, Rn, Jessica A. Lobien Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Improving Knowledge Of Picc Line Maintenance, Kiesha M. Custis-Adams Bsn, Rn, Lydia Karlsson Bsn, Rn, Melissa F. Long Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Pained And Confused: A Look At Pain Control In Cognitively Altered Patients, Debra Lobien Bsn, Rn, Jena L. Shomper Bsn, Rn, Marina Tsay Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Diabetic Education: Healthy Carbohydrates And Carbohydrate Counting, Michael J. De Rosa Bsn, Rn, Nelli V. Jordan Bsn, Rn, Emily A. Truesdale Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Effect Of Electrolyzed High-Ph Alkaline Water On Blood Viscosity In Healthy Adults., Joseph J. Weidman, Ralph E. Holsworth, Bradley Brossman, Daniel J. Cho, John St Cyr, Gregory Fridman

Student Papers, Posters & Projects

BACKGROUND: Previous research has shown fluid replacement beverages ingested after exercise can affect hydration biomarkers. No specific hydration marker is universally accepted as an ideal rehydration parameter following strenuous exercise. Currently, changes in body mass are used as a parameter during post-exercise hydration. Additional parameters are needed to fully appreciate and better understand rehydration following strenuous exercise. This randomized, double-blind, parallel-arm trial assessed the effect of high-pH water on four biomarkers after exercise-induced dehydration.

METHODS: One hundred healthy adults (50 M/50 F, 31 ± 6 years of age) were enrolled at a single clinical research center in Camden, NJ and …

The Effect Of Teaching Strategies And Learning Environment On Certification Exam Pass Rates In Dietetic Education, Debra Head

Theses and Dissertations

The obligation for preparing competent graduates begins with an educational experience in an environment that promotes optimal learning. An important outcome of successful health professions education is the passage of the certification exam. The objective of this study was to evaluate learning outcomes and teaching strategies and the effect on certification exam pass rate in dietetic education programs. A non-experimental associational cross-sectional mixed methods design was chosen for the study in order to gather objective data through the use of the previously validated Constructivist Learning Environment Survey. A 30 item electronic survey was administered to faculty in dietetic education programs …

Examining Contraceptive Knowledge, Attitude, Intentions And Willingness To Use Contraceptive Among Adolescents Girls In Ghana, West Africa: Applying The Theory Of Reasoned Action And Theory Of Planned Behavior, Rosina Amenebede

Theses and Dissertations

The primary purpose of this study was to examine contraceptive knowledge, attitude, intentions and willingness to use contraceptives among adolescents’ girls in Ghana, West Africa, by applying the Theory of Planned Behavior. A cross-sectional survey was conducted. Results: 85.3% of the respondent had knowledge of condoms. 88.34% of the adolescent girls intended to use contraceptives during sex and 25.5% of the variance observed in intentions to use contraceptives is explained by subjective norms and attitudes toward behavior. Discussion and Conclusions: 79.05% of the entire sample of adolescents’ girl’s did not have any knowledge of any other contraceptive method aside from …

Health & Kinesiology News, Georgia Southern University

Health Sciences & Kinesiology: News & Publications (2015-2023)

• Faculty and Students Participate in 2016 Southeast Farm to School Conference

Cortisol In Human Milk Predicts Child Bmi, Jennifer Hahn-Holbrook, Tran Bao Le, Anna Chung, Elyssia Poggi Davis, Laura M. Glynn

Psychology Faculty Articles and Research

Objective—Breastfeeding is linked to lower rates of childhood obesity. Human milk contains cortisol, known to regulate glucose storage and metabolism. We aimed to test the hypothesis that early exposure to cortisol in human breast milk helps to modulate infant BMI trajectories over the first two years of life.

Methods—Growth curve modeling was used to examine whether infant exposure to cortisol in human milk at 3 months predicted changes in child body mass index percentile (BMIP) at 6, 12, and 24 months of age in 51 breastfeeding mother-child pairs.

Results—Infants exposed to higher milk cortisol levels at 3 …

Medical School Watercooler Newsletter - November 27, 2016, Lindsey Lyle

Watercooler Newsletter

This is the November 27, 2016 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Latest Issue of CURRents Available Now
• University Physicians Group Recognized
• USA Welcomes Dr. Katie Malozzi
• USA Medical Student Serves as Representative at American Academy of Pediatrics Conference

Sound Sleep: Research Shows We Need Less As We Age But Quality Could Be Tied To Dementia, Erin Arvedlund

Jefferson Sleep Disorders Center in the News

No abstract provided.

Auditory/Vestibular/Tbi Mini-Series: Effects Of Tbi On Auditory Processing, Vestibular Function, And Tinnitus, Frederick Gallum, Paula Myers, Faith W. Akin

ETSU Faculty Works

This session is developed by, and presenters invited by, Hearing, Balance, Tinnitus – Assessment and Intervention: Adult. This combined mini-series will present both clinical and research findings addressing the auditory and vestibular consequences of traumatic brain injury (TBI). Presenters will elucidate TBI’s effect on auditory processing, vestibular function, and tinnitus with case studies to illustrate management strategies relevant for each of the patient groups.

Diminished Quality Of Life Among Women Affected By Ebola, Jessi Hanson, Alexis Decosimo, Megan Quinn

Journal of Social, Behavioral, and Health Sciences

This article analyzes data collected from Liberian women afflicted by the Ebola virus disease, survivors of the virus and noninfected persons living in Ebola-affected homes. This research is one of the first statistical analyses examining factors diminishing quality of life: negative experiences, stigma, and psychosocial symptoms among females affected by the virus after the outbreak. The research presents a thorough literature review, including research related to other infectious diseases like HIV/AIDS, to inform the gap in studies on Ebola’s effects on quality of life. Women who are Ebola virus disease survivors demonstrate significant differences in stigma and psychosocial stress when …

Temporary Nerve Block At Selected Digits Revealed Hand Motor Deficits In Grasping Tasks, Aude Cateron, Kerry Mcpartlan, Christina Gioeli, Emily Reid, Matt Turturro, Barry Hahn, Cynthia Benson, Wei Zhang

Publications and Research

Peripheral sensory feedback plays a crucial role in ensuring correct motor execution throughout hand grasp control. Previous studies utilized local anesthesia to deprive somatosensory feedback in the digits or hand, observations included sensorimotor deficits at both corticospinal and peripheral levels. However, the questions of how the disturbed and intact sensory input integrate and interact with each other to assist the motor program execution, and whether the motor coordination based on motor output variability between affected and non-affected elements (e.g., digits) becomes interfered by the local sensory deficiency, have not been answered. The current study aims to investigate the effect of …

Community Assets And Capabilities To Recruit And Retain Gps: The Community Apgar Questionnaire In Rural Victoria, Daniel R. Terry, Ed Baker, David Schmitz

Public and Population Health Faculty Publications and Presentations

Introduction: Rural communities continue to experience significant challenges recruiting and retaining physicians. The Community Apgar Questionnaire (CAQ) was developed in Idaho in the USA to comprehensively assess the characteristics associated with successful recruitment and retention of rural physicians. The CAQ has been utilised and validated across the USA; however, its value in rural Australia has not been examined. The objective of this study was to use the CAQ in rural Australia to examine its utility and develop a greater understanding of the community factors that impact general practitioner (GP) recruitment and retention.

Method: The project conducted structured face-to-face interviews with …

Development, Validation And Application Of A New Fornix Template For Studies Of Aging And Preclinical Alzheimer's Disease, Christopher A. Brown, Nathan F. Johnson, Amelia J. Anderson-Mooney, Gregory A. Jicha, Leslie M. Shaw, John Q. Trojanowski, Linda J. Van Eldik, Frederick A. Schmitt, Charles D. Smith, Brian T. Gold

Physical Therapy Faculty Publications

We developed a merged younger-older adult template of the fornix and demonstrated its utility for studies of aging and preclinical Alzheimer's disease (AD). In Experiment 1, probabilistic tractography was used to reconstruct the fornix in younger and older adults and successful streamlines were then averaged to create a merged template in standard space. The new template includes the majority of the fornix from the hippocampal formation to the subcallosal region and the thalamus/hypothalamus. In Experiment 2, the merged template was validated as an appropriate measure for studies of aging, with comparisons against manual tracing measures indicating identical spatial coverage in …

5-Hydroxymethylcytosine Localizes To Enhancer Elements And Is Associated With Survival In Glioblastoma Patients, Kevin C. Johnson, E. Andres Houseman, Jessica E. King, Katharine M. Von Herrmann, Camilo E. Fadu, Brock C. Christensen

Dartmouth Scholarship

Glioblastomas exhibit widespread molecular alterations including a highly distorted epigenome. Here, we resolve genome-wide 5-methylcytosine and 5-hydroxymethylcytosine in glioblastoma through parallel processing of DNA with bisulfite and oxidative bisulfite treatments. We apply a statistical algorithm to estimate 5-methylcytosine, 5-hydroxymethylcytosine and unmethylated proportions from methylation array data. We show that 5-hydroxymethylcytosine is depleted in glioblastoma compared with prefrontal cortex tissue. In addition, the genomic localization of 5-hydroxymethylcytosine in glioblastoma is associated with features of dynamic cell-identity regulation such as tissue-specific transcription and super-enhancers. Annotation of 5-hydroxymethylcytosine genomic distribution reveal significant associations with RNA regulatory processes, immune function, stem cell maintenance and …

Palmitoylation Of Desmoglein 2 Is A Regulator Of Assembly Dynamics And Protein Turnover., Brett J. Roberts, Robert A. Svoboda, Andrew M. Overmiller, Joshua D. Lewis, Andrew P. Kowalczyk, My G. Mahoney, Keith R. Johnson, James K. Wahl

Department of Dermatology and Cutaneous Biology Faculty Papers

Desmosomes are prominent adhesive junctions present between many epithelial cells as well as cardiomyocytes. The mechanisms controlling desmosome assembly and remodeling in epithelial and cardiac tissue are poorly understood. We recently identified protein palmitoylation as a mechanism regulating desmosome dynamics. In this study, we have focused on the palmitoylation of the desmosomal cadherin desmoglein-2 (Dsg2) and characterized the role that palmitoylation of Dsg2 plays in its localization and stability in cultured cells. We identified two cysteine residues in the juxtamembrane (intracellular anchor) domain of Dsg2 that, when mutated, eliminate its palmitoylation. These cysteine residues are conserved in all four desmoglein …

Severe Mortality Impact Of The 1957 Influenza Pandemic In Chile., Gerardo Chowell, Lone Simonsen, Rodrigo Fuentes, Jose Flores, Mark A Miller, Cécile Viboud

Microbiology, Immunology, and Tropical Medicine Faculty Publications

INTRODUCTION: Epidemiological studies of the 1957 influenza pandemic are scarce, particularly from lower-income settings.

METHODS: We analyzed the spatial-temporal mortality patterns of the 1957 influenza pandemic in Chile, including detailed age-specific mortality data from a large city, and investigated risk factors for severe mortality impact across regions.

RESULTS: Chile exhibited two waves of excess mortality in winter 1957 and 1959 with a cumulative excess mortality rate of 12 per 10 000, and a ~10-fold mortality difference across provinces. High excess mortality rates were associated with high baseline mortality (R(2) =41.8%; P=.02), but not with latitude (P>.7). Excess mortality rates …

Risk Of Medication Overuse Headache Across Classes Of Treatments For Acute Migraine, Kristian Thorlund, Christina Sun-Edelstein, Eric Druyts, Steve Kanters, Shanil Ebrahim, Rahul Bhambri, Elodie Ramos, Edward Mills, Michel Lanteri-Minet, Stewart Tepper

Dartmouth Scholarship

Background: The most commonly prescribed medications used to treat migraine acutely are single analgesics, ergots, opioids, and triptans. Due to varying mechanisms of action across drug classes, there is reason to believe that some classes may be less likely than others to elicit Medication Overuse Headache (MOH) than others. We therefore aimed to determine whether certain classes of acute migraine drugs are more likely to elicit MOH than others.

Methods: A comprehensive systematic literature was conducted to identify studies of varying designs that reported on MOH within the considered treatment classes. Only studies that reported MOH according to the International …

The Relationship Between Religiosity And Health-Promoting Behaviors In Pregnant Women, Natalie A. Cyphers, Andrea D. Clements, Glenda Lindseth

ETSU Faculty Works

Pender’s health promotion model guided this descriptive/correlational study exploring the relationship between religiosity and health-promoting behaviors of pregnant women at Pregnancy Resource Centers (PRCs). A consecutive sample included women who knew they were pregnant at least 2 months, could read/write English, and visited PRCs in eastern Pennsylvania. Participants completed self-report surveys that examined religiosity, demographics, pregnancy-related variables, services received at PRCs, and health-promoting behaviors. Women reported they “sometimes” or “often” engaged in health-promoting behaviors, Hispanic women reported fewer health-promoting behaviors than non-Hispanic women, and women who attended classes at the centers reported more frequent health-promoting behaviors than those who did …

Regional Variation In Ascaris Lumbricoides And Trichuris Trichiura Infections By Age Cohort And Sex: Effects Of Market Integration Among The Indigenous Shuar Of Amazonian Ecuador, Theresa E. Gildner, Tara J. Cepon-Robins, Melissa A. Liebert, Samuel S. Urlacher, Felicia C. Madimenos, J. Josh Snodgross, Lawrence S. Sugiyama

Publications and Research

Background: Soil-transmitted helminth (STH) infection peaks during childhood and varies by sex. The impact of market integration (MI) (increasing production for and consumption from a market-based economy) on these infection patterns, however, is unclear. In this study, STH infection is examined by sex and age among indigenous Shuar inhabiting two regions of Amazonian Ecuador: (1) the modestly market-integrated Upano Valley (UV) and (2) the more traditional Cross-Cutucú (CC) region.

Methods: Kato-Katz fecal smears were examined for parasite presence and infection intensity. Factorial ANOVAs and post hoc simple effects analyses were performed by sex to compare infection intensity between regions and …