Medicine and Health Sciences Commons^™

Pengembangan Model Instrumen Penilaian Kinerja Dokter Spesialis Obsgyn Melalui Analisis Kinerja Di Rumah Sehat Ibu Dan Anak Budi Kemuliaan, Titi Setyorini

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

The purpose of this studyis to develop an instrument that appropriate to measured Obstetrician and Gynecologist performance in Budi Kemuliaan Hospital through Performance Analysis. Descriptive study with qualitative method aims to constructed a Performance Appraisal’s Instrument. A convenience Informan of Obstetrician and Gynecologists and stakeholders in Budi Kemuliaan Hospital participated in this study. This study successfully developed a valid method to constructed a Performance Appraisal’s Instrument in Budi Kemuliaan Hospital by using Nominal Group Technique Method. A performance appraisal’s instrument contains 8 (eight) specific measurable criteria for Obstetrician and Gynecologists using the JCAHO’s six competencies to evaluated Medical Doctors performance …

Duloxetine And Pregabalin: A Comparison And Contrast For The Treatment Of Painful Diabetic Neuropathy, Maggie Hartmann

Nursing Capstones

No abstract provided.

Structures Of Eccb1 And Eccd1 From The Core Complex Of The Mycobacterial Esx-1 Type Vii Secretion System, Jonathan Mark Wagner, Sum Chan, Timothy J. Evans, Sara Kahng, Jennifer Kim, Mark A. Arbing, David Eisenberg, Konstantin V. Korotkov

Molecular and Cellular Biochemistry Faculty Publications

Background: The ESX-1 type VII secretion system is an important determinant of virulence in pathogenic mycobacteria, including Mycobacterium tuberculosis. This complicated molecular machine secretes folded proteins through the mycobacterial cell envelope to subvert the host immune response. Despite its important role in disease very little is known about the molecular architecture of the ESX-1 secretion system.

Results: This study characterizes the structures of the soluble domains of two conserved core ESX-1 components – EccB₁ and EccD₁. The periplasmic domain of EccB₁ consists of 4 repeat domains and a central domain, which together form a quasi …

Costs Of Diagnostic And Preoperative Workup With And Without Breast Mri In Older Women With A Breast Cancer Diagnosis, Tracy Onega, Anna N.A Tosteson, Julie Weiss, Jennifer Alford-Teaster, Rebecca A. Hubbard, Louise M. Henderson, Karla Kerlikowske, Martha E. Goodrich, Cristina O'Donoghue, Karen J. Wernli, Wendy B. Demartini, Beth A. Virnig

Dartmouth Scholarship

Background: Breast cancer in the U.S. - estimated at 232,670 incident cases in 2014 - has the highest aggregate economic burden of care relative to other female cancers. Yet, the amount of cost attributed to diagnostic/ preoperative work up has not been characterized. We examined the costs of imaging and biopsy among women enrolled in Medicare who did and did not receive diagnostic/preoperative Magnetic Resonance Imaging (MRI). Methods: Using Surveillance, Epidemiology and End Results (SEER)- Medicare data, we compared the per capita costs (PCC) based on amount paid, between diagnosis date and primary surgical treatment for a breast cancer diagnosis …

Novel Collaborative Cardiology And Maternal Fetal Medicine Practice – Continued Experience At The Heart And Pregnancy Program, Joanne Quiñones Md, Msce, Margaret Bettin, Irena B. Cabrera Md, Adetola Louis-Jacques Md, Amy M. Ahnert Md, Ronald S. Freudenberger Md

Department of Obstetrics & Gynecology

No abstract provided.

Dnah6 And Its Interactions With Pcd Genes In Heterotaxy And Primary Ciliary Dyskinesia, Stephen M. King

UCHC Articles - Research

Heterotaxy, a birth defect involving left-right patterning defects, and primary ciliary dyskinesia (PCD), a sinopulmonary disease with dyskinetic/immotile cilia in the airway are seemingly disparate diseases. However, they have an overlapping genetic etiology involving mutations in cilia genes, a reflection of the common requirement for motile cilia in left-right patterning and airway clearance. While PCD is a monogenic recessive disorder, heterotaxy has a more complex, largely non-monogenic etiology. In this study, we show mutations in the novel dynein gene DNAH6 can cause heterotaxy and ciliary dysfunction similar to PCD. We provide the first evidence that trans-heterozygous interactions between DNAH6 and …

Associations Between Domestic-Dog Morphology And Behaviour Scores In The Dog Mentality Assessment, Holly R. Stone, Paul D. Mcgreevy, Melissa J. Starling, Bjorn Forkman

Morphology Collection

The domestic dog shows a wide range of morphologies, that humans have selected for in the process of creating unique breeds. Recent studies have revealed correlations between changes in morphology and behaviour as reported by owners. For example, as height and weight decrease, many undesirable behaviours (non-social fear, hyperactivity and attention seeking) become more apparent. The current study aimed to explore more of these correlations, but this time used reports from trained observers. Phenotypic measurements were recorded from a range of common dog breeds (n = 45) and included cephalic index (CI: the ratio of skull width to skull length), …

Dean Li Attends Meijer Alumni Breakfast, College Of Education And Human Development

Family and Consumer Sciences News

Dean Ming Li attended a WMU Alumni Breakfast at Meijer in Grand Rapids on February 17.

Optimizing The Distribution Of Leg Muscles For Vertical Jumping., Jeremy D Wong, Maarten F Bobbert, Arthur J Van Soest, Paul L Gribble, Dinant A Kistemaker

Brain and Mind Institute Researchers' Publications

A goal of biomechanics and motor control is to understand the design of the human musculoskeletal system. Here we investigated human functional morphology by making predictions about the muscle volume distribution that is optimal for a specific motor task. We examined a well-studied and relatively simple human movement, vertical jumping. We investigated how high a human could jump if muscle volume were optimized for jumping, and determined how the optimal parameters improve performance. We used a four-link inverted pendulum model of human vertical jumping actuated by Hill-type muscles, that well-approximates skilled human performance. We optimized muscle volume by allowing the …

Neurogenesis-Mediated Forgetting Minimizes Proactive Interference., Jonathan R Epp, Rudy Silva Mera, Stefan Köhler, Sheena A Josselyn, Paul W Frankland

Brain and Mind Institute Researchers' Publications

Established memories may interfere with the encoding of new memories, particularly when existing and new memories overlap in content. By manipulating levels of hippocampal neurogenesis, here we show that neurogenesis regulates this form of proactive interference. Increasing hippocampal neurogenesis weakens existing memories and, in doing so, facilitates the encoding of new, conflicting (but not non-conflicting) information in mice. Conversely, decreasing neurogenesis stabilizes existing memories, and impedes the encoding of new, conflicting information. These results suggest that reduced proactive interference is an adaptive benefit of neurogenesis-induced forgetting.

I Am The Dream 2016, Pcom Office Of Diversity And Community Relations

Diversity and Inclusion

Program for the 2016 event I am the Dream: the Past, Present and Future at Philadelphia College of Osteopathic Medicine. Consists of the Dr. Martin Luther King, Jr. Award Ceremony and William M. King, DO '62 Award Presentation.

Mistress of Ceremonies: Megan Cleghorn, JD, MBA

Awardees: Judith A. Lightfoot, DO ‘92, FACOI; Barbara Williams-Page, DO ‘92; Yuma Iannotti Tomes, PhD, ABA; Olivia Menardy (DO ‘16); Michael Stefanowicz (DO ‘16); Jameel Shareef (DO ‘16); J. Steven Blake, DO ’89, MSc; Israel D. Benjamin (DO ‘19)

Cddo-Me Redirects Activation Of Breast Tumor Associated Macrophages, Michael S. Ball, Emilie P. Shipman, Hyunjung Kim, Karen T. Liby, Patricia A. Pioli

Dartmouth Scholarship

Tumor-associated macrophages can account for up to 50% of the tumor mass in breast cancer patients and high TAM density is associated with poor clinical prognosis. Because TAMs enhance tumor growth, development, and metastatic potential, redirection of TAM activation may have significant therapeutic benefit. Our studies in primary human macrophages and murine breast TAMs suggest that the synthetic oleanane triterpenoid CDDO-methyl ester (CDDO-Me) reprograms the activation profile of TAMs from tumor-promoting to tumor-inhibiting. We show that CDDO-Me treatment inhibits expression of IL-10 and VEGF in stimulated human M2 macrophages and TAMs but increases expression of TNF-α and IL-6. Surface expression …

Incidence And Risk Factors Of Thromboembolism With Multiple Myeloma In The Presence Of Death As A Competing Risk: An Empirical Comparison Of Statistical Methodologies, Joshua D. Brown, Val R. Adams

Pharmacy Practice and Science Faculty Publications

Multiple myeloma (MM) has an inherent high risk of thromboembolic events associated with patient as well as disease- and treatment-related factors. Previous studies have assessed the association of MM-related thromboembolism using “traditional” Kaplan–Meier (KM) and/or Cox proportional hazard (PH) regression. In the presence of high incidence of death, as would be the case in cancer patients with advanced age, these statistical models will produce bias estimates. Instead, a competing risk framework should be used. This study assessed the baseline patient demographic and clinical characteristics associated with MM-related thromboembolism and compared the cumulative incidence and the measures of association obtained using …

Social Network Characteristics And Cervical Cancer Screening Among Quechua Women In Andean Peru, John S. Luque, Samuel T. Opoku, Daron Ferris, Wendy S. Guevara Condorhuaman

Health Policy & Community Health: Faculty Publications

Background: Peru has high cervical cancer incidence and mortality rates compared to other Andean countries. Therefore, partnerships between governmental and international organizations have targeted rural areas of Peru to receive cervical cancer screening via outreach campaigns. Previous studies have found a relationship between a person’s social networks and cancer screening behaviors. Screening outreach campaigns conducted by the nonprofit organization CerviCusco created an opportunity for a social network study to examine cervical cancer screening history and social network characteristics in a rural indigenous community that participated in these campaigns in 2012 and 2013. The aim of this study was to explore …

Mri Signal Intensity Differentiation Of Brainstem Encephalitis Induced By Enterovirus 71: A Classification Approach For Acute And Convalescence Stages, Hongwu Zeng, Wenxian Huang, Feiqiu Wen, Yonker Wang, Yungen Gan, Weibin Zeng, Ranran Chen, Yanxia He, Zaiyi Liu, Changhong Liang, Kelvin K. L. Wong

Radiology Faculty Publications

Background: The objective of this study is to assess standardized histograms of signal intensities of T1 signal and T2 signal on sagittal view without enhancement during (1) acute stage, and (2) convalescence stage of pediatric patients with Enterovirus 71 related brainstem encephalitis (BE), and with respect to (3) healthy normal.

Methods: Our subjects were hospitalized between March 2010 and October 2012, and underwent pre- and post-contrast MRI studies. The research question to be answered is whether the comparison of the MRI image intensity histograms and relevant statistical quantification can add new knowledge to the diagnosis of BE patients. So, both …

Interfaces Between Linguistic Systems: Evidence From Child Language, Lyle Lustigman

Faculty Publications

Interfaces between grammatical domains have been considered from various perspectives in child language research and in general linguistics. The study aims to provide evidence for interfaces in acquisition of early clause-structure, based on longitudinal data from three Hebrew-acquiring toddlers. Two facets of their early speech output were examined: Usage productivity in verb-inflection, identified by a criterion of contextual appropriateness; and structural transparency/opacity of children’s speech output, with transparent forms being unambiguous in relation to their grammatical targets. These factors yielded two distinct developmental periods for the three children: I – from the onset of verb usage to productive verb inflection, …

Microcystic, Elongated, And Fragmented (Melf) Pattern Invasion In Ovarian Endometrioid Carcinoma: Immunohistochemical Profile And Prognostic Implications, Allison F. Goldberg, Md, Lauren Cooper, Md, D. De Cotiis, Norman G. Rosenblum, Md, Phd, Joanna Chan, Md

Department of Pathology, Anatomy, and Cell Biology Resident's Posters

BACKGROUND

•Microcystic, Elongated and Fragmented (MELF) is a well-recognized pattern of uterine endometrioid carcinoma (UEC) associated with lymphovascular space invasion and occult lymph node metastasis

•MELF in UEC may be seen with Lynch Syndrome

•MELF in UEC is hypothesized to be histologic evidence of an epithelial mesenchymal transition

•MELF pattern invasion in ovarian endometrioid carcinoma (OEC) was first described at USCAP 2015 •

Current study evaluates MELF in OEC for

•Prognostic implications

•Immunohistochemical (IHC) profile related to

•Lynch Syndrome

•Epithelial mesenchymal transition

DESIGN

•42 consecutive cases of OEC without concurrent UEC (1996-2014) evaluated by 2 pathologists

•MELF defined as at …

Optimizing Guideline-Recommended Antibiotic Doses For Pediatric Infective Endocarditis, Chad A. Knoderer, Kristen R. Nichols, Emily N. Israel, Christopher A. Thomas

Scholarship and Professional Work – COPHS

The American Heart Association recently published an updated scientific statement on the management of infective endocarditis in childhood. The recommendations included for vancomycin, aminoglycoside, and β-lactam dosing and monitoring are based primarily on expert opinion and do not consider available evidence for dose optimization based on pharmacokinetic and pharmacodynamic principles in pediatric patients. This is concerning because even when clinically necessary, some practitioners may be hesitant to deviate from guideline-recommended doses. In this perspective, we highlight potential areas for improvement in the statement-recommended doses and summarize evidence supporting antibiotic dosing optimization. The addition of a pediatric clinical pharmacist with expertise …

Anticipatory Coarticulation And Stability Of Speech In Typically Fluent Speakers And People Who Stutter, Stefan A. Frisch, Nathan Maxfield, Alissa Belmont

Communication Sciences and Disorders Faculty Publications

This project replicates and extends previous work on coarticulation in velar-vowel sequences in English. Coarticulatory data for 46 young adult speakers, 23 who stutter and 23 who do not stutter show coarticulatory patterns in young adults who stutter that are no different from typical young adults. Additionally, the stability of velar-vowel production is analysed in token-to-token variability found in multiple repetitions of the same velar-vowel sequence. Across participants, identical patterns of coarticulation were found between people who do and do not stutter, but decreased stability was found in velar closure production in a significant subset of people who stutter. Other …

Investigation Of The Phenomenological And Psychopathological Features Of Trichotillomania In An Italian Sample, Gioia Bottesi, Silvia Cerea, Enrico Razzetti, Claudio Sica, Randy O. Frost, Marta Ghisi

Psychology: Faculty Publications

Trichotillomania (TTM) is still a scarcely known and often inadequately treated disorder in Italian clinical settings, despite growing evidence about its severe and disabling consequences. The current study investigated the phenomenology of TTM in Italian individuals; in addition, we sought to examine patterns of self-esteem, anxiety, depression, and OCD-related symptoms in individuals with TTM compared to healthy participants. The current study represents the first attempt to investigate the phenomenological and psychopathological features of TTM in Italian hair pullers. One hundred and twenty-two individuals with TTM were enrolled: 24 were assessed face-to-face (face-to-face group) and 98 were recruited online (online group). …

Collaboration Occurring Between Professionals In Today's Schools, Kara Lynn Doglio

Theses and Dissertations

The collaborative service delivery model is beneficial in its approach as it allows educators and SLPs to work together to address communication impairments in naturalistic settings in order to maximize the functional potential of all students. The current utilization of collaboration as a viable service delivery option is unknown. The purpose of this study was to identify whether collaboration was occurring and with whom it was occurring. This study also sought to identify similarities and differences across four participant groups regarding perceived beliefs and reported practices in professional collaboration. While administrators took a separate survey than educators (general and special …

Mechanical Conflict System: A Novel Operant Method For The Assessment Of Nociceptive Behavior, Steven E. Harte, Jessica B. Meyers, Renee R. Donahue, Bradley K. Taylor, Thomas J. Morrow

Physiology Faculty Publications

A new operant test for preclinical pain research, termed the Mechanical Conflict System (MCS), is presented. Rats were given a choice either to remain in a brightly lit compartment or to escape to a dark compartment by crossing an array of height-adjustable nociceptive probes. Latency to escape the light compartment was evaluated with varying probe heights (0, .5, 1, 2, 3, and 4 mm above compartment floor) in rats with neuropathic pain induced by constriction nerve injury (CCI) and in naive control rats. Escape responses in CCI rats were assessed following intraperitoneal administration of pregabalin (10 and 30 mg/kg), morphine …

Chief Huntington’S Disease Drug Hunter: ‘Every Confidence First Treatments' In The Works, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Diagnostic Methods To Determine Microbiology Of Postpartum Endometritis In South Asia: Laboratory Methods Protocol Used In The Postpartum Sepsis Study: A Prospective Cohort Study, Sadia Shakoor, Megan E. Reller, Amnesty Lefevre, Aneeta Hotwani, Shahida M. Qureshi, Farheen Yousuf, Mohammad Shahidul Islam, Nicholas Connor, Iftekhar Rafiqullah, Fatima Mir

Department of Paediatrics and Child Health

Background: The South Asian region has the second highest risk of maternal death in the world. To prevent maternal deaths due to sepsis and to decrease the maternal mortality ratio as per the World Health Organization Millenium Development Goals, a better understanding of the etiology of endometritis and related sepsis is required. We describe microbiological laboratory methods used in the maternal Postpartum Sepsis Study, which was conducted in Bangladesh and Pakistan, two populous countries in South Asia.
Methods/Design: Postpartum maternal fever in the community was evaluated by a physician and blood and urine were collected for routine analysis and culture. …

Methemoglobinemia In Acetaminophen Overdose And Glucose-6-Phosphate Dehydrogenase Deficiency, Maelen Ignacio, Pharmd, Colin Craft, Md, Fern M. Martin, Md, Cara Mcdaniel, Pharmd, Bcps

College of Pharmacy Posters

Background:

• Methemoglobin (MetHb) is formed when the iron moiety of hemoglobin (Hgb) is oxidized from ferrous (Fe²⁺) to ferric (Fe³⁺) state à impaired O₂ delivery to tissues
• Acetaminophen Metabolism:

~90% is metabolized in liver via sulfation and glucuronidation

remainder is metabolized via CYP450 to a toxic oxidizing agent, N-acetyl-p-benzoquinone imine (NAPQI), which is detoxified via glutathione¹

• Acute Acetaminophen Overdose:

saturates sulfation and glucuronidation pathways

depletes glutathione stores

leads to excess NAPQI à oxidative stress à methemoglobinemia¹

• MetHb Reduction Pathway:

cytochrome b5 reductase removes 95% to 99% of endogenous MetHb

nicotinamide adenine dinucleotide phosphate …

Between Crazy And Fine, Annette Aguilera-Gonzalez

SURGE

As a young Latina, I grew up hiding the fact that I met with a therapist and that I suffered from depression and anxiety. Conversations about mental well-being or taking steps to cope with anxiety were non-existent in my community of friends and family. It was always a taboo topic, an area that we never touched. People were labeled as “crazy” and serious situations were swept under the rug. Seldom was I offered empathy or support. [excerpt]

Molecular Manipulation Of Keratin 8/18 Intermediate Filaments: Modulators Of Fas-Mediated Death Signaling In Human Ovarian Granulosa Tumor Cells., Sarah K. Trisdale, Nicolette M. Schwab, Xiaoying Hou, John S. Davis, David H. Townson

Journal Articles: Obstetrics & Gynecology

BACKGROUND: Granulosa cell tumors (GCT) are a rare ovarian neoplasm but prognosis is poor following recurrence. Keratin intermediate filaments expressed in these tumors are a diagnostic marker, yet paradoxically, may also constitute a target for therapeutic intervention. In the current study, we evaluated keratin 8/18 (K8/18) filament expression as a mechanism of resistance to apoptosis in GCT, specifically focusing on regulation of the cell surface death receptor, Fas (FAS).

METHODS: The GCT cell line, KGN, was transiently transfected with siRNA to KRT8 and KRT18 to reduce K8/18 filament expression. Expression of K8/18, FAS, and apoptotic proteins (PARP, cleaved PARP) were …

Activating Clinical Trials: A Process Improvement Approach, Diego Martinez, Athanasios Tsalatsanis, Ali Yalcin, José L. Zayas-Castro, Benjamin Djulbegovic

Industrial and Management Systems Engineering Faculty Publications

Background: The administrative process associated with clinical trial activation has been criticized as costly, complex, and time-consuming. Prior research has concentrated on identifying administrative barriers and proposing various solutions to reduce activation time, and consequently associated costs. Here, we expand on previous research by incorporating social network analysis and discrete-event simulation to support process improvement decision-making.

Methods: We searched for all operational data associated with the administrative process of activating industry-sponsored clinical trials at the Office of Clinical Research of the University of South Florida in Tampa, Florida. We limited the search to those trials initiated and activated between July …

Faith-Based Leaders Caring For Older Adults In A Natural Disaster: A Study Of Hurricane Sandy, Mercy Joseph

Theses & Dissertations

The purpose of this study was to explore how faith-based leaders cared for community-dwelling older adults in a natural disaster. This research focused on Hurricane Sandy, which affected Long Island, New York, in October 2012. The research question was: How do faith-based leaders care for community-dwelling older adults affected by a natural disaster, such as Hurricane Sandy? Natural disasters are often unexpected and can cause disruption, trauma, loss, and devastation of communities. A review of the literature identified that local faith-based leaders have a major role in the recovery process before, during, and after a natural disaster. Community-dwelling older adults …

C-Src/Cav1-Dependent Activation Of The Egfr By Dsg2., Andrew M. Overmiller, Kathleen P. Mcguinn, Brett J. Roberts, Felicia Cooper, Donna M. Brennan-Crispi, Takahiro Deguchi, Sirkku Peltonen, James K. Wahl, Mỹ G. Mahoney

Department of Dermatology and Cutaneous Biology Faculty Papers

The desmosomal cadherin, desmoglein 2 (Dsg2), is deregulated in a variety of human cancers including those of the skin. When ectopically expressed in the epidermis of transgenic mice, Dsg2 activates multiple mitogenic signaling pathways and increases susceptibility to tumorigenesis. However, the molecular mechanism responsible for Dsg2-mediated cellular signaling is poorly understood. Here we show overexpression as well as co-localization of Dsg2 and EGFR in cutaneous SCCs in vivo. Using HaCaT keratinocytes, knockdown of Dsg2 decreases EGFR expression and abrogates the activation of EGFR, c-Src and Stat3, but not Erk1/2 or Akt, in response to EGF ligand stimulation. To determine whether …