Cytomegalovirus Gastrointestinal Disease In Patients With Aids: A Case Series, Akarin Hiransuthikul, Narin Hiransuthikul

Chulalongkorn Medical Journal

Cytomegalovirus (CMV) is an important opportunistic infection in patients with acquired immunodeficiency syndrome (AIDS), usually in those with low CD4 cell counts. CMV colitis is the most common CMV end-organ diseases after CMV retinitis, though cytomegalovirus the gastrointestinal disease (CMV-GID) can occur at any region of gastrointestinal tract. Its clinical manifestations depend on the region of gastrointestinal tract involved. However, due to indistinguishable clinical features from other diseases, further investigations, preferably endoscopy and histopathological testing, are necessary for diagnosis. Prompt diagnosis and treatment are vital to decrease mortality and reduce morbidity in an otherwise fatal disease. Our case series consist …

สายพันธุ์ของโปรโตซัวบลาสโตซิสทิสและความสัมพันธ์กับการก่อโรคในคน, วิวรพรรณ สรรประเสริฐ, สุรางค์ นุชประยูร

Chulalongkorn Medical Journal

โปรโตซัวบลาสโตซิสทิส เป็นหนึ่งในโปรโตซัวในลำไส้ที่พบได้ทั่วไปในมนุษย์และสัตว์ต่าง ๆทั่วโลก แม้ว่าจะมีการค้นพบโปรโตซัวชนิดนี้มานานกว่าร้อยปีแล้ว แต่ความสามารถในการก่อโรคของเชื้อยังคงไม่ชัดเจนและเป็นคำถามที่สำคัญในปัจจุบัน นอกจากนี้ยังพบการติดเชื้อบลาสโตซิสทิสจำนวนมากขึ้นเรื่อย ๆ ในช่วงหลายสิบปีที่ผ่านมา ซึ่งก่อให้เกิดอาการทางระบบทางเดินอาหารได้หลากหลาย ผู้ติดเชื้อส่วนมากอาจไม่ปรากฎอาการ หรือปรากฎอาการได้ทั้งแบบเฉียบพลันและแบบเรื้อรัง จากการศึกษาทางอณูชีววิทยาพบว่าโปรโตซัวบลาสโตซิสทิสมีความหลากหลายทางพันธุกรรมเป็นอย่างมาก จนถึงปัจจุบันนี้มีรายงานสายพันธุ์ต่าง ๆ แล้วถึง 17 สายพันธุ์ โดยสายพันธุ์ที่ติดเชื้อในคนคือสายพันธุ์ที่ 1 - 9 อย่างไรก็ตาม ความชุกและการกระจายตัวของสายพันธุ์ต่าง ๆ มีความแตกต่างกันไปในแต่ละประเทศทั่วโลก นอกจากนี้ จากความหลากหลายทางพันธุกรรมนี้ จึงสันนิษฐานว่ามีความสัมพันธ์กับการเกิดอาการทางคลินิกที่หลากหลายของผู้ติดเชื้อโปรโตซัวบลาสโตซิสทิสบทความฟื้นฟูวิชาการนี้ จึงรวบรวมความรู้ปัจจุบันของชีววิทยาของโปรโตซัวบลาสโตซิสทิส รวมถึงความชุกและการกระจายตัวของสายพันธุ์ต่าง ๆ ในแต่ละประเทศทั่วโลก ตลอดจนความสัมพันธ์ระหว่างสายพันธุ์ของโปรโตซัวบลาสโตซิสทิสกับอาการทางคลินิกของผู้ติดเชื้อ ซึ่งจะเป็นข้อมูลที่สำคัญเพื่อความเข้าใจความสามารถและบทบาทในการก่อโรคของโปรโตซัวบลาสโตซิสทิส และจะนำไปสู่การวางแผนการรักษาของแพทย์ ซึ่งจะทำให้สามารถป้องกันการแพร่กระจายของเชื้อและป้องกันการเกิดการดื้อยาของเชื้อได้ต่อไป.

Surgical Management Of Inflammatory Bowel Disease: A Low Prevalence, Developing Country Perspective, Sana Nasim, Tabish Chawla, Ghulam Murtaza Sheikh

Department of Surgery Docs

OBJECTIVE:

To determine the outcomes of surgical management of inflammatory bowel disease.

METHODS:

The retrospective case series was conducted at Aga Khan University Hospital, Karachi, and comprised medical record of adult patients operated between January 1986 and December 2010 for inflammatory bowel disease. Outcomes consisted of complications till last follow-up and 30-day mortality (disease or procedure related). Functional status of patients with ileal pouch was determined via telephone. SPSS 16 was used to analyse data.

RESULTS:

Of the 36 patients whose records were reviewed, 21(58%) were males, and body mass index was less than 23 in 34(91%). A total of …

New Dentist News (March 2016), Ada Committee On The New Dentist

New Dentist News

New Dentist News offers timely information on scientific, social, educational, political and economic developments affecting new dentists. This collection is historical and items may not reflect current standards. For up-to-date information contact the ADA. The New Dentist News was alternately titled ADA Lifeline, 1997-June 2001.

Clinical Presentation Of Ovarian Tumors, Qamarunissa Muhabat, Fakharunissa Waheed, Waqar Unissa, Nigar Jabeen

Department of Obstetrics & Gynaecology

Ovarian malignancy is a serious disease affecting women of all ages, more so above 50 years, and they are still difficult to treat, partly because no truly effective therapy has yet been developed although presentation is often vague and non-specific, the symptoms are definitely present. It is important to recognize the symptoms so far, there is no test yet available, which is truly specific and suitable for screening and early detection of epithelial ovarian carcinoma. So, it is concluded that for prognosis and patient survival, early detection and treatment is mandatory.

Micro- And Nanoparticulate Cancer Vaccines: A Vision For The Future, Lipika Chablani

Pharmacy Faculty/Staff Publications

In lieu of an abstract, here is the article's first paragraph:

Formulation scientists are constantly challenged with unique opportunities to deliver chemotherapeutic drug molecules to cancer patients. With the growing rate of cancer diagnoses, new therapies are being introduced to pave their way to the market. Along with drug delivery, these formulation approaches are being screened for formulation, design, and development of cancer vaccines. Can a vaccine be formulated to obtain a protective or therapeutic immune response against cancer?

Long Non-Coding Rnas As Prognostic Markers In Human Breast Cancer, Hairong Liu, Juan Li, Pratirodh Koirala, Xianfeng Ding, Binghai Chen, Yiheng Wang, Zheng Wang, Chuanxin Wang, Xu Zhang, Yin-Yuan Mo

Faculty Publications

Long non-coding RNAs (lncRNAs) have been recently shown to play an important role in gene regulation and normal cellular functions, and disease processes. However, despite the overwhelming number of lncRNAs identified to date, little is known about their role in cancer for vast majority of them. The present study aims to determine whether lncRNAs can serve as prognostic markers in human breast cancer. We interrogated the breast invasive carcinoma dataset of the Cancer Genome Atlas (TCGA) at the cBioPortal consisting of ~ 1,000 cases. Among 2,730 lncRNAs analyzed, 577 lncRNAs had alterations ranging from 1% to 32% frequency, which include …

Unintended Pregnancies In Brazil - A Challenge For The Recommendation To Delay Pregnancy Due To Zika, Cynthia Schuck-Paim, Daniel Lopez, Lone Simonsen, Wladimir Alonso

Global Health Faculty Publications

Because of the potential link between the ongoing Zika virus outbreak and a surge in the number of cases of congenital microcephaly, officials in Latin America have recommended that women postpone pregnancy until this association is firmly established or the outbreak subsides. However, in all these countries a large proportion of babies are still born out of unplanned pregnancies. Teenage girls are particularly at high risk, as they often lack access to preventive contraception methods, or the knowledge to use them appropriately. To gauge the magnitude of the barriers preventing the implementation of such a recommendation in Brazil, the country …

Novel Bone-Targeting Agent For Enhanced Delivery Of Vancomycin To Bone, Zaineb A. F. Albayati, Manjula Sunkara, Suzannah M. Schmidt-Malan, Melissa J. Karau, Andrew J. Morris, James M. Steckelberg, Robin Patel, Philip J. Breen, Mark S. Smeltzer, K. Grant Taylor, Kevyn E. Merten, William M. Pierce, Peter A. Crooks

Saha Cardiovascular Research Center Faculty Publications

We examined the pharmacokinetic properties of vancomycin conjugated to a bone-targeting agent (BT) with high affinity for hydroxyapatite after systemic intravenous administration. The results confirm enhanced persistence of BT-vancomycin in plasma and enhanced accumulation in bone relative to vancomycin. This suggests that BT-vancomycin may be a potential carrier for the systemic targeted delivery of vancomycin in the treatment of bone infections, potentially reducing the reliance on surgical debridement to achieve the desired therapeutic outcome.

Primary Hepatic Carcinoid Tumor With Poor Outcome, Om Parkash, Adil Ayub, Buria Naeem, Sehrish Najam, Zubair Ahmed, Wasim Jafri, Saeed Hamid

Section of Gastroenterology

Primary Hepatic Carcinoid Tumor (PHCT) represents an extremely rare clinical entity with only a few cases reported to date. These tumors are rarely associated with metastasis and surgical resection is usually curative. Herein, we report two cases of PHCT associated with poor outcomes due to late diagnosis. Both cases presented late with non-specific symptoms. One patient presented after a 2-week history of symptoms and the second case had a longstanding two years symptomatic interval during which he remained undiagnosed and not properly worked up. Both these cases were diagnosed with hepatic carcinoid tumor, which originates from neuroendocrine cells. Case 1 …

A Randomised Controlled Trial Comparing The Effect Of Adjuvant Intrathecal 2 Mg Midazolam To 20 Micrograms Fentanyl On Postoperative Pain For Patients Undergoing Lower Limb Orthopaedic Surgery Under Spinal Anaesthesia, Francis Codero, Vitalis Mung’Ayi, Sharif Thikra

Anaesthesiology, East Africa

Background: Intrathecal adjuvants are added to local anaesthetics to improve the quality of neuraxial blockade and prolong the duration of analgesia during spinal anaesthesia. Used intrathecally, fentanyl improves the quality of spinal blockade as compared to plain bupivacaine and confers a short duration of post-operative analgesia. Intrathecal midazolam as an adjuvant has been used and shown to improve the quality of spinal anaesthesia and prolong the duration of post-operative analgesia. No studies have been done comparing intrathecal fentanyl with bupivacaine and intrathecal 2 mg midazolam with bupivacaine.

Objective: To compare the effect of intrathecal 2mg midazolam to intrathecal 20 micrograms …

Surface And Cross-Sectional Characterization Of Titanium-Nitride Coated Nickel–Titanium Endodontic Files, Youssef S. Al Jabbari, Theodoros Koutsoukis, Suliman Al Hadlaq, David W. Berzins, Spiros Zinelis

School of Dentistry Faculty Research and Publications

Background/purpose

Although the effect of experimental surface modifications on various properties (e.g., fatigue, wear) on coated files have been tested in the past, there is no report for the coating quality of commercially available TiN coated files. The aim of this study was to characterize the surface and cross section of TiN coated endodontic files.

Materials and methods

TiN coated nickel–titanium endodontic files (EasyShape) were surface and cross-sectionally analyzed via scanning electron microscopy backscattered electron imaging and energy-dispersive X-ray spectroscopy analysis in spot, area, and line scan modes.

Results

Surface imaging revealed parallel oblong regions with higher mean atomic contrast, …

The Effect Of A Resourcefulness Training Intervention On Relocation Adjustment And Adaptive Functioning Among Older Adults In Retirement Communities, Abir K. Bekhet, Jaclene A. Zauszniewski

College of Nursing Faculty Research and Publications

The population of older adults is increasing rapidly and is expected to reach 83.7 million by the year 2050. Previous research demonstrates that greater resourcefulness is associated with better quality of life and life satisfaction. The purpose of this pilot study was to evaluate the effects of a resourcefulness training intervention on positive cognitions, resourcefulness, relocation adjustment, and adaptive functioning among older adults who have relocated to retirement communities. Resourcefulness theory provided the theoretical framework for this study. Forty older adults who relocated to three retirement communities in Milwaukee, WI were randomly assigned to either a diversional activity group or …

Psychometric Evaluation Of The Physical Activity Enjoyment Scale In Adults With Functional Limitations, Carolyn J. Murrock, Abir K. Bekhet, Jaclene A. Zauszniewski

College of Nursing Faculty Research and Publications

Enjoyment is an important construct for understanding physical activity participation, and it has not been examined in adults with functional limitations. This secondary analysis reported the reliability and validity of the Physical Activity Enjoyment Scale (PACES) in a convenience sample of 40 adults with functional limitations. The participants completed the PACES, Center for Epidemiological Studies Depression Scale (CES-D), and the Late Life Function and Disability Instrument (LLFDI) prior to beginning a 12-week feasibility dance intervention study. Results indicated reliability as Cronbach's alpha was .95 and mean inter-item correlation was .52. To further support reliability, homogeneity of the instrument was evaluated …

Spring: A Time For New Opportunities!, Kristina Dreifuerst

College of Nursing Faculty Research and Publications

No abstract provided.

Surface And Cross-Sectional Characterization Of Titanium-Nitride Coated Nickel–Titanium Endodontic Files, Youssef S. Al Jabbari, Theodoros Koutsoukis, Suliman Al Hadlaq, David W. Berzins, Spiros Zinelis

School of Dentistry Faculty Research and Publications

Background/purpose

Although the effect of experimental surface modifications on various properties (e.g., fatigue, wear) on coated files have been tested in the past, there is no report for the coating quality of commercially available TiN coated files. The aim of this study was to characterize the surface and cross section of TiN coated endodontic files.

Materials and methods

TiN coated nickel–titanium endodontic files (EasyShape) were surface and cross-sectionally analyzed via scanning electron microscopy backscattered electron imaging and energy-dispersive X-ray spectroscopy analysis in spot, area, and line scan modes.

Results

Surface imaging revealed parallel oblong regions with higher mean atomic …

Antimicrobial Stewardship Barriers And Goals In Pediatric Oncology And Bone Marrow Transplantation: A Survey Of Antimicrobial Stewardship Practitioners., Joshua Wolf, Yilun Sun, Li Tang, Jason G. Newland, Jeffrey S. Gerber, Christie J. Van Dyke, Saul R. Hymes, Diana Yu, Delia C. Carias, Penelope A. Bryant, Pediatric Hematology/Oncology Antimicrobial Stewardship Interest Group

Manuscripts, Articles, Book Chapters and Other Papers

We undertook a cross-sectional survey of antimicrobial stewardship clinicians in North America and Australasia regarding practices, goals, and barriers to implementation of stewardship for pediatric oncology patients. Goals and barriers were similar regardless of clinician or institutional characteristics and geographic location. Strategies addressing these factors could help optimize antimicrobial use.

Long-Read Single Molecule Real-Time Full Gene Sequencing Of Cytochrome P450-2d6., Wanqiong Qiao, Yao Yang, Robert Sebra, Geetu Mendiratta, Andrea Gaedigk, Robert J. Desnick, Stuart A. Scott

Manuscripts, Articles, Book Chapters and Other Papers

The cytochrome P450-2D6 (CYP2D6) enzyme metabolizes ∼25% of common medications, yet homologous pseudogenes and copy number variants (CNVs) make interrogating the polymorphic CYP2D6 gene with short-read sequencing challenging. Therefore, we developed a novel long-read, full gene CYP2D6 single molecule real-time (SMRT) sequencing method using the Pacific Biosciences platform. Long-range PCR and CYP2D6 SMRT sequencing of 10 previously genotyped controls identified expected star (*) alleles, but also enabled suballele resolution, diplotype refinement, and discovery of novel alleles. Coupled with an optimized variant-calling pipeline, CYP2D6 SMRT sequencing was highly reproducible as triplicate intra- and inter-run nonreference genotype results were completely concordant. Importantly, …

Walking Mediates Associations Between Neighborhood Activity Supportiveness And Bmi In The Women's Health Initiative San Diego Cohort., Jordan A. Carlson, Rosemay A. Remigio-Baker, Cheryl A M Anderson, Marc A. Adams, Gregory J. Norman, Jacqueline Kerr, Michael H. Criqui, Matthew Allison

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVES: To investigate whether walking mediates neighborhood built environment associations with weight status in middle- and older-aged women.

METHODS: Participants (N=5085; mean age=64 ± 7.7; 75.4% White non-Hispanic) were from the Women's Health Initiative San Diego cohort baseline visits. Body mass index (BMI) and waist circumference were measured objectively. Walking was assessed via survey. The geographic information system (GIS)-based home neighborhood activity supportiveness index included residential density, street connectivity, land use mix, and number of parks.

RESULTS: BMI was 0.22 units higher and the odds ratio for being obese (vs. normal or overweight) was 8% higher for every standard deviation …

Multi-Level Correlates Of Safer Conception Methods Awareness And Attitudes Among Ugandan Hiv Clients With Fertility Intentions., Glenn J. Wagner, Mahlet A. Woldetsadik, Jolly Beyeza-Kashesya, Kathy Goggin, Deborah Mindry, Sarah Finocchario-Kessler, Sarah Khanakwa, Rhoda K. Wanyenze

Manuscripts, Articles, Book Chapters and Other Papers

Many people living with HIV desire childbearing, but low cost safer conception methods (SCM) such as timed unprotected intercourse (TUI) and manual self-insemination (MSI) are rarely used. We examined awareness and attitudes towards SCM, and the correlates of these constructs among 400 HIV clients with fertility intentions in Uganda. Measures included awareness, self-efficacy, and motivation regarding SCM, as well as demographics, health management, partner and provider characteristics. Just over half knew that MSI (53%) and TUI (51%) reduced transmission risk during conception, and 15% knew of sperm washing and pre-exposure prophylaxis. In separate regression models for SCM awareness, motivation, and …

Pharmacokinetics And Bioequivalence Of A Liquid Formulation Of Hydroxyurea In Children With Sickle Cell Anemia., Jeremie H. Estepp, Chiara Melloni, Courtney D. Thornburg, Paweł Wiczling, Zora Rogers, Jennifer A. Rothman, Nancy S. Green, Robert Liem, Amanda M. Brandow, Shelley E. Crary, Thomas H. Howard, Maurine H. Morris, Andrew Lewandowski, Uttam Garg, William J. Jusko, Kathleen A. Neville, Best Pharmaceuticals For Children Act-Pediatric Trials Network Administrative Core Committee

Manuscripts, Articles, Book Chapters and Other Papers

Hydroxyurea (HU) is a crucial therapy for children with sickle cell anemia, but its off-label use is a barrier to widespread acceptance. We found HU exposure is not significantly altered by liquid vs capsule formulation, and weight-based dosing schemes provide consistent exposure. HU is recommended for all children starting as young as 9 months of age with sickle cell anemia (SCA; HbSS and HbSβspan(0) thalassemia); however; a paucity of pediatric data exists regarding the pharmacokinetics (PK) or the exposure-response relationship of HU. This trial aimed to characterize the PK of HU in children and to evaluate and compare the bioavailability …

Techniques And Approaches To Genetic Analyses In Nephrological Disorders., Laurel K. Willig

Manuscripts, Articles, Book Chapters and Other Papers

Inherited renal disease is a leading cause of morbidity and mortality in pediatric nephrology. High throughput advancements in genomics have led to greater understanding of the biologic underpinnings of these diseases. However, the underlying genetic changes explain only part of the molecular biology that contributes to disease manifestation and progression. Other omics technologies will provide a more complete picture of these cellular processes. This review discusses these omics technologies in the context of pediatric renal disease.

Ms171: Interview With Katie Mcgready, Katie Mcgready, Houston Academy Of Medicine-Texas Medical Center Library

Texas Medical Center - Women's History Project

An oral history interview with Mary Catherine Bussey Boice (Katie) McGready, the first medical librarian in the Texas Medical Center, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Mary Catherine Bussey Boice “Katie” McGready became the first medical librarian in the Texas Medical Center when Dr. Ernst W. Bertner asked to her to begin the medical library at what was then the fledgling MD Anderson Cancer Center. She was among the first employees at the Cancer Center, then located at “The Oaks,” the estate of the late Colonel James A. Baker at 2310 Baldwin Street in Houston.

Born …

Ms171: Interview With Marianne Marcus, Marianne Marcus Edd, Rn, Houston Academy Of Medicine-Texas Medical Center Library

Texas Medical Center - Women's History Project

An oral history with Marianne Marcus, Professor Emerita at the University of Texas at Houston School of Nursing. Before she retired and assumed the title of Professor Emerita in 2104, Dr. Marcus chaired the UT Nursing School’s Department of Nursing Systems, directed its Master’s of Nursing Education degree track and directed its Center for Substance Abuse Prevention, Education and Research. While at UT, she was elected to its Academy of Health Science Education and named as a Fellow of the American Academy of Nursing. She was appointed the John P. McGovern Distinguished Professor of Addiction Nursing at UT Health Science …

Ms171: Interview With Huda Zoghbi, Huda Zoghbi Md, Houston Academy Of Medicine-Texas Medical Center Library

Texas Medical Center - Women's History Project

An oral history interview with Dr. Huda Zoghbi about her career at Baylor College of Medicine in the Texas Medical Center. She worked as a professor in the Departments of Pediatrics, Molecular and Human Genetics, Neurology and Neuroscience at Baylor College of Medicine. She was also an investigator at the Howard Hughes Medical Institute and the director of the Jan and Dan Duncan Neurological Research Institute (NRI) at Texas Children's Hospital. See more at Texas Medical Center-Women's History Project and its finding aid.

SOURCE: Baylor College of Medicine website, http://www.bcm.edu

Ms171: Interview With Margaret Caddy, Margaret Caddy, Houston Academy Of Medicine-Texas Medical Center Library

Texas Medical Center - Women's History Project

An oral History interview with Margaret Caddy discussing her nursing and administrative career in Houston and the Texas Medical Center. Caddy worked in hospice care from 1983-2009. Part of that time, She served as the Executive Director for Houston Hospice. See more at Texas Medical Center-Women's History Project and its finding aid.

Ms171: Interview With Dana Rooks, Dana Rooks, Houston Academy Of Medicine-Texas Medical Center Library

Texas Medical Center - Women's History Project

An oral history interview with Dana Rooks, who served as Dean of Libraries at the University of Houston from 1997-2014. See more at Texas Medical Center-Women's History Project and its finding aid.

Medical Help-Seeking For Sexual Concerns In Prostate Cancer Survivors, Melissa K. Hyde, Leah Zajdlewicz, Addie C. Wootten, Christian J. Nelson, Anthony Lowe, Jeff Dunn, Suzanne K. Chambers

Research outputs 2014 to 2021

Introduction: Although sexual dysfunction is common after prostate cancer, men's decisions to seek help for sexual concerns are not well understood.

Aim: Describe predictors of actual prior help-seeking and intended future medical help-seeking for sexual dysfunction in prostate cancer survivors.

Methods: A cross-sectional survey of 510 prostate cancer survivors assessed masculine beliefs, attitudes, support/approval from partner/peer networks (subjective norm), and perceived control as predictors of medical help-seeking for sexual concerns. A theory of planned behavior (TPB) perspective was used to examine actual prior and planned future behavior and contributing factors. Statistical analyses included multiple and logistic regressions.

Main Outcome Measures: …

Pain Management In Dentistry, Diana V. Macri

Publications and Research

The International Association for the Study of Pain (IASP) has defined pain as “an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage." The most common dental complaint is pain, accounting for more than 80%of all dental visits. Pain diminishes the quality of life for many people, although it also may be a vital teacher or a warning message to be heeded. How humans process pain is a complicated, individualized process affected by genetics, personality, life experiences and straight forward physiological process.

Big Data Transforms Discovery-Utilization Therapeutics Continuum., Scott A. Waldman, Andre Terzic

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Enabling omic technologies adopt a holistic view to produce unprecedented insights into the molecular underpinnings of health and disease, in part, by generating massive high-dimensional biological data. Leveraging these systems-level insights as an engine driving the healthcare evolution is maximized through integration with medical, demographic, and environmental datasets from individuals to populations. Big data analytics has accordingly emerged to add value to the technical aspects of storage, transfer, and analysis required for merging vast arrays of omic-, clinical-, and eco-datasets. In turn, this new field at the interface of biology, medicine, and information science is systematically transforming modern therapeutics across …