Medicine and Health Sciences Commons^™

Delayed Umbilical Cord Clamping: A Quality Initiative Implementation By The Obstetrics And Nicu Departments, Elizabeth Ciaravino Ms4

USF-LVHN SELECT

No abstract provided.

Laparoscopic Cholecystectomies Performed At Night Versus Day At Lvhn: An Investigation Into Average Length Of Stay, Benjamin T. Fedeles Ms

USF-LVHN SELECT

No abstract provided.

A Retrospective Study Of Outcomes For Penicillin- Allergic Patients Presenting With Staphylococcus Aureus Bacteremia At Lehigh Valley Health Network Hospitals, Colton Faza Ms

USF-LVHN SELECT

No abstract provided.

Lehigh Valley Health Network Total Joint Replacement Clinical Pathway: Pre-Admission Expansion To Target Patient Education, Mary Kate Erdman Msiv

USF-LVHN SELECT

No abstract provided.

Cracking The Code: Hospital-Specific Resuscitation Outcomes And Code Status Discussions, Jameson Dyal Ms4

USF-LVHN SELECT

No abstract provided.

Recruiting And Retaining Women Leaders At Lehigh Valley Health Network (Lvhn), Melanie R. Francis Ms

USF-LVHN SELECT

No abstract provided.

Tailoring A Social Needs Assessment Tool For An Urban Latino Population, Stephanie Fosbenner Ms

USF-LVHN SELECT

No abstract provided.

Implicit Association Of Gender And Leadership In Healthcare, Rachel Fieman Ms4

USF-LVHN SELECT

No abstract provided.

Distress Screening Of Chemotherapy Patients According To Nccn Guidelines In The Lvpg Hematology-Oncology Clinic Demonstrates A Statistically Significant Reduction In Subjective Distress, Andrew Heisel Ms4, Ramona E. Chase Crnp, Brian J. Patson Md, Eliot L. Friedman Md

USF-LVHN SELECT

No abstract provided.

Identifying Provider Strategies To Maintain Humanism In Medicine, Joseph Hall Ms

USF-LVHN SELECT

No abstract provided.

Launching A Veteran-Centered Medical Home Through Improved Care-Coordination Protocols, Keith Groshans Ms

USF-LVHN SELECT

No abstract provided.

Needs Assessment For A Teaching Elective At The University Of South Florida Morsani College Of Medicine Lehigh Valley Campus, Kristian Johnson Ms

USF-LVHN SELECT

No abstract provided.

Identifying Factors To Reduce Readmission Of Surgical Patients At Lvhn, With A Focus On Cardiothoracic Patients, Alvancin Louis Ms, James K. Wu Md

USF-LVHN SELECT

No abstract provided.

“Go See That Patient”: An Examination Of The Amount Of Unsupervised Time Medical Students Spend With Patients During Their First Clinical Year, Pamela H. Kim Ms

USF-LVHN SELECT

No abstract provided.

Direct To Or Resuscitation: A Reevaluation 20 Years After Implementation At Lehigh Valley Health Network, Cameron Paterson Ms

USF-LVHN SELECT

No abstract provided.

An Analysis Of Provider Attitudes Toward A Clinical Decision Support System For The Intrapartum Management Of Group B Strep, Sasha Nelson Ms

USF-LVHN SELECT

No abstract provided.

Identifying Risk Factors For Prolonged Hospital Stay And 30 Day Readmission For Elective Evar For Abdominal Aortic Aneurysms, Daniel Myers Ms

USF-LVHN SELECT

No abstract provided.

Creation Of A Pediatric Obesity Comorbidity Screening Sheet To Be Implemented Into Epic, Susan M. Mothersele Ms

USF-LVHN SELECT

No abstract provided.

“Don’T Shoot The Unicorn!” Finding Transformative Happiness And Resilience Through Developing Your “Anditude”!, M. Bruce Garris, Gary W. Mauk

National Youth Advocacy & Resilience Conference

As a care provider and leader in your community, you understand the challenge of keeping your own resilience high, and maintaining an attitude of hope. This transformational, uplifting program will equip you to develop the skill of happiness, empowering you to lead youths by demonstrating positive approaches in your own life, and impacting them with “Infectious Resilience” as they learn to adopt your Anditude!

Cyclin-Dependent Kinase Crk9, Required For Spliced Leader Trans Splicing Of Pre-Mrna In Trypanosomes, Functions In A Complex With A New L-Type Cyclin And A Kinetoplastid-Specific Protein., Nitika Badjatia, Sung Hee Park, Daniela L. Ambrósio, Justin K. Kirkham, Arthur Günzl

UCHC Articles - Research

In eukaryotes, cyclin-dependent kinases (CDKs) control the cell cycle and critical steps in gene expression. The lethal parasite Trypanosoma brucei, member of the phylogenetic order Kinetoplastida, possesses eleven CDKs which, due to high sequence divergence, were generically termed CDC2-related kinases (CRKs). While several CRKs have been implied in the cell cycle, CRK9 was the first trypanosome CDK shown to control the unusual mode of gene expression found in kinetoplastids. In these organisms, protein-coding genes are arranged in tandem arrays which are transcribed polycistronically. Individual mRNAs are processed from precursor RNA by spliced leader (SL) trans splicing and polyadenylation. CRK9 …

Strengthening Instrumental Variables Through Weighting, Douglas Lehmann, Yun Li, Rajiv Saran, Yi Li

The University of Michigan Department of Biostatistics Working Paper Series

Instrumental variable (IV) methods are widely used to deal with the issue of unmeasured confounding and are becoming popular in health and medical research. IV models are able to obtain consistent estimates in the presence of unmeasured confounding, but rely on assumptions that are hard to verify and often criticized. An instrument is a variable that influences or encourages individuals toward a particular treatment without directly affecting the outcome. Estimates obtained using instruments with a weak influence over the treatment are known to have larger small-sample bias and to be less robust to the critical IV assumption that the instrument …

Incidence And Management Of Polypharmacy, Zillah Mulubisha

Nursing Capstones

No abstract provided.

P-Rex1 Promotes Resistance To Vegf/Vegfr-Targeted Therapy In Prostate Cancer, Hira Lal Goel, Bryan Pursell, Leonard D. Shultz, Dale L. Greiner, Rolf A Brekken, Craig W. Vander Kooi, Arthur M. Mercurio

Molecular and Cellular Biochemistry Faculty Publications

Autocrine VEGF signaling is critical for sustaining prostate and other cancer stem cells (CSCs), and it is a potential therapeutic target, but we observed that CSCs isolated from prostate tumors are resistant to anti-VEGF (bevacizumab) and anti-VEGFR (sunitinib) therapy. Intriguingly, resistance is mediated by VEGF/neuropilin signaling, which is not inhibited by bevacizumab and sunitinib, and it involves the induction of P-Rex1, a Rac GEF, and consequent Rac1-mediated ERK activation. This induction of P-Rex1 is dependent on Myc. CSCs isolated from the PTEN^pc−/− transgenic model of prostate cancer exhibit Rac1-dependent resistance to bevacizumab. Rac1 inhibition or P-Rex1 downregulation increases the …

Integrating Health Services & Systems: What We Know, Think We Know, And Need To Learn, Glen P. Mays

Health Management and Policy Presentations

The delivery and financing systems for medical care, public health, and social and community services pursue many common goals and serve overlapping groups of families and communities. Unfortunately, in most American communities these systems interact in complex and often poorly understood ways through fragmented funding vehicles, information flows, governance and decision-making structures, institutional relationships, implementation rules and strategies, and professional and interpersonal connections. New research approaches are required to untangle these interactions and expose novel pathways of influence that can support equitable improvements in service delivery, resource use, health impact, and wellbeing. This presentation will summarize evidence from recent studies …

Understanding Differences In Hiv/Hcv Prevalence According To Differentiated Risk Behaviors In A Sample Of Pwid In Rural Puerto Rico, Roberto Abadie, Melissa Welch-Lazoritz, Camila Gelpi-Acosta, Juan Carlos Reyes, Kirk Dombrowski

Publications and Research

Background: Blood contained in needles and injection equipment has been identified as a vector for HIV and HCV transmission among people who inject drugs (PWID). Yet, there is often a wide discrepancy in prevalence for both viruses. While microbiological differences between viruses influence prevalence, other variables associated with the way drugs are acquired and used, also play a role.

Methods: Respondent-driven sampling (RDS) methods recruited a sample of 315 current intravenous drug users in rural Puerto Rico. Information about type and frequency of use, HIV and HVC risk behaviors (sharing needles, cookers, cotton, and water), sexual behaviors, and alcohol use …

Smn Protein Can Be Reliably Measured In Whole Blood With An Electrochemiluminescence (Ecl) Immunoassay: Implications For Clinical Trials, Phillip Zaworski, Katharine M. Von Herrmann, Shannon Taylor, Sara S. Sunshine, Kathleen Mccarthy, Nicole Risher, Tara Newcomb, Marla Weetall, Thomas W. Prior, Kathryn J. Swoboda, Karen S. Chen, Sergey Paushkin

Dartmouth Scholarship

Spinal muscular atrophy (SMA) is caused by defects in the survival motor neuron 1 (SMN1) gene that encodes survival motor neuron (SMN) protein. The majority of therapeutic approaches currently in clinical development for SMA aim to increase SMN protein expression and there is a need for sensitive methods able to quantify increases in SMN protein levels in accessible tissues. We have developed a sensitive electrochemiluminescence (ECL)-based immunoassay for measuring SMN protein in whole blood with a minimum volume requirement of 5μL. The SMN-ECL immunoassay enables accurate measurement of SMN in whole blood and other tissues. Using the assay, …

Health & Kinesiology News, Georgia Southern University

Health Sciences & Kinesiology: News & Publications (2015-2023)

• Nutrition Students Educate the Community

Improving Cell Mixture Deconvolution By Identifying Optimal Dna Methylation Libraries (Idol), Devin C. Koestler, Meaghan J. Jones, Joseph Usset, Brock C. Christensen, Rondi A. Butler, Michael S. Kobor, John K. Weincke, Karl T. Kelsey

Dartmouth Scholarship

Background:

Confounding due to cellular heterogeneity represents one of the foremost challenges currently facing Epigenome-Wide Association Studies (EWAS). Statistical methods leveraging the tissue-specificity of DNA methylation for deconvoluting the cellular mixture of heterogenous biospecimens offer a promising solution, however the performance of such methods depends entirely on the library of methylation markers being used for deconvolution. Here, we introduce a novel algorithm for Identifying Optimal Libraries (IDOL) that dynamically scans a candidate set of cell-specific methylation markers to find libraries that optimize the accuracy of cell fraction estimates obtained from cell mixture deconvolution.

Results:

Application of IDOL to training set …

Managing Your Professional Identity: Leveraging Social Media And Emerging Metrics To Demonstrate Professional Impact, Megan R. Sapp Nelson

Libraries Faculty and Staff Presentations

This session will assist graduate students to deliberately develop an online professional identity that will uniquely identify them as an academic as well as positively highlight their personal strengths.

Students will walk away with a plan to create a unique professional identifier and an understanding of how to measure the impact of online scholarly communication.

Topics included are:

ORCID ID

social media, such as LinkedIn & ResearchGate

Alternative Metrics (Altmetrics), such has Kudos, ImpactStory, & AltMetric

Data repositories, such as GitHub & FigShare

“Zipped Synthesis” By Cross-Metathesis Provides A Cystathionine Β‑Synthase Inhibitor That Attenuates Cellular H2S Levels And Reduces Neuronal Infarction In A Rat Ischemic Stroke Model, Christopher D. Mccune, Su Jing Chan, Matthew L. Beio, Weijun Shen, Woo Jin Chung, Laura M. Szczesniak, Chou Chai, Shu Qing Koh, Peter T.-H. Wong, David B. Berkowitz

David Berkowitz Publications

The gaseous neuromodulator H₂S is associated with neuronal cell death pursuant to cerebral ischemia. As cystathionine β-synthase (CBS) is the primary mediator of H2S biogenesis in the brain, it has emerged as a potential target for the treatment of stroke. Herein, a “zipped” approach by alkene cross-metathesis into CBS inhibitor candidate synthesis is demonstrated. The inhibitors are modeled after the pseudo-C₂-symmetric CBS product (L,L)-cystathionine. The “zipped” concept means only half of the inhibitor needs be constructed; the two halves are then fused by olefin cross-metathesis. Inhibitor design is also mechanism-based, exploiting the favorable kinetics associated with …