Medicine and Health Sciences Commons^™

Psychometrically Equivalent Bisyllabic Word Lists For Spanish Pediatric Word Recognition Testing, Brenda Karina Peterson

Theses and Dissertations

While recorded speech audiometry materials have been developed in Spanish for adults, currently there are no speech audiometry materials available in Spanish that are suitable for a pediatric population. Thus, the purposes of this study were (a) to analyze Spanish bisyllabic words previously developed for adults to determine the words' appropriateness when testing word recognition scores in native Spanish-speaking children and (b) to compare the logistic regressions results from the Spanish adult data obtained in a previous study with the logistic regressions from Spanish pediatric data obtained in the present study. Using common-use children's dictionaries in the Spanish language, a …

The Efficacy Of A Literature-Based Social Communication Intervention On Teacher Report Of Sociability For Children With Language Impairment, Mnisa Lyn Harlow

Theses and Dissertations

Recent research indicates that children with language impairment (LI) often experience difficulties with social communication. Although the empirical basis for general social communication intervention is growing, information documenting the efficacy of these interventions for children with LI remains limited. The purpose of this study was to examine the effectiveness of a social communication intervention on teacher perceptions of sociability in five elementary-aged children with LI. The intervention focused on the presentation and use of children's stories to target aspects of emotion understanding. The two sociability subscales of the Teacher Behavior Rating Scale (TBRS), impulse control/likeability and prosocial behavior, were used …

Diagnostic Accuracy Of Anti-Endomysial Antibody In Celiac Disease, Arslaan Javaeed, Walayat Shah, Saaniya Khan Gauri, Rizwan Akhtar

Department of Pathology and Laboratory Medicine

The objective of the study was to determine the diagnostic accuracy of anti-EMA antibody in comparison to histopathological findings in patients suspected of CD. This cross-sectional study was conducted at Gastroenterology Department, Fatima Memorial Hospital, Lahore, from March to October 2014. One hundred and twenty-one patients aged between 5 - 60 years of either gender were recruited in the study. Every patient went through serological testing and biopsy specimens were obtained from second part of the duodenum. Histopathological evaluation was done according to the Modified Marsh classification. The overall sensitivity of anti-EMAcame out to be 85.7% which varied with the …

Glomus Tumor Of Trachea In An Adult Male, Sidra Arshad, Zubair Ahmad, Nasir Ud Din

Department of Pathology and Laboratory Medicine

Glomus tumors most commonly occur in distal extremities, particularly in the subungual region. The origin of these tumors is modified smooth muscle cells of glomus bodies. Trachea is one of the rare sites where normal glomus bodies may be sparse or absent, so occurrence of glomus tumor in trachea is very rare. Only 30 cases have been reported in the literature so far. In this case report, the authors describe a very rare and in fact first case of glomus tumor of trachea in a 45-year male Pakistani patient.

Histomorphometric Analysis Of Maxillary Sinus Grafts: A Randomized Controlled Study, Mina Nishimoto

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this clinical investigation was to evaluate and compare the degree of new bone formation through histomorphometric analysis following maxillary sinus grafts (MSG) using three different bone graft materials. Thirty-one MSG were performed using a lateral window approach for patients who required implant placement in posterior maxilla. Each sinus was randomly selected to receive one of three bone graft materials; Group A: anorganic bovine bone mineral (ABBM) [Bio-Oss®], Group B: anorganic equine bone mineral (AEBM) [Equimatrix®], or Group C: mineralized cancellous bone allograft (MCBA) [OSSIF-i sem™]. A total of 28 bone cores were obtained at a mean time …

Clinical Assessment Of Pragmatics (Caps): A Validation Study, Adriana Lavi

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was bi-fold: to develop and analyze the validity and reliability of a comprehensive pragmatic language diagnostic tool, the Clinical Assessment of Pragmatics as well as comparatively examine and analyze pragmatic language profiles of three groups of adolescents. These included students with Language Impairment (LI), High-Functioning Autism (HFA) and typically developing students. During the validation phase of the study, thirty participants, ages 14 to 16 years old, were administered 3 pragmatic judgment and 3 pragmatic performance subtests comprised of 10 items each for a total of 60 test items. A series of validity and reliability measures …

Effect Of Progressive Gaze Stability Exercises On Holistic Aspects Of Chronic Motion Sensitivity, Shilpa B. Gaikwad

Loma Linda University Electronic Theses, Dissertations & Projects

Background: Motion sensitivity, also referred to as motion sickness, is a common condition among general population. It is a complex syndrome and is associated with presence of nausea and vomiting headache, drowsiness, cold sweating, pallor of varying degrees, increased salivation. Postural instability and anxiety are also identified to be associated with motion sensitivity. There is a close relationship between the vestibular system and motion sensitivity and vestibular system. The aim of this study was to investigate the effect of progressive gaze stability exercises on holistic aspects of chronic motion sensitivity. Methods: A single blind randomized controlled trial was conducted where …

Intimate Partner Violence In A Conservative Christian Denomination: Prevalence And Risk Factors, Carolyn Sallion-Love

Loma Linda University Electronic Theses, Dissertations & Projects

This study examines the prevalence and risk factors of intimate partner violence (IPV) in a Christian denomination. To date, no studies have been found in the literature that looked at IPV in a Christian denomination in South America, Latin America, and the Caribbean. Little is known regarding how church members from these countries experience victimization from IPV. One 2002 Inter-American Division (IAD) data set provides some insight into IPV; and the Seventh-day Adventist (SDA) Church has analyzed cross-sectional data of more than 7,000 SDA respondents from the study area of interest. Discriminant function analysis (DFA) was used to determine if …

Comparative Studies Of Tslp And Il-7 In Normal Early Human Neonatal And Adult B Cell Development, Terry-Ann Milford

Loma Linda University Electronic Theses, Dissertations & Projects

Defining the role of cytokines in promoting human B cell development is important for understanding B cell leukemia and for developing strategies to restore B cell production that is lost during some therapies. The purpose of this study was to investigate the roles of the IL-7R ligands, thymic stromal lymphopoietin (TSLP) and IL- 7, in the early stages of normal postnatal and adult human B cell development. Using novel in vitro and in vivo model systems, we show that TSLP and IL-7 are able to expand B cell precursors individually and in combination from CB hematopoietic stem cells. In this …

Quantitative Method For Detecting Vibrio Parahaemolyticus Using Bio-Theta Doxtm System, Shouichi Tanno, Naoki Fukui, Yukihiro Utaka, Saburo Ohkawa, Yukio Morita, Sumalee Boonmar

The Thai Journal of Veterinary Medicine

This is the first report on the quantitative method for detecting Vibrio parahaemolyticus using the Bio-Theta DOXTM system. Seven V. parahaemolyticus strains and 23 non-V. parahaemolyticus strains were assessed. The rate of positive detection of Vibrio in samples of the 7 V. parahaemolyticus strains at high concentration (105 cfu/ml), medium concentration (103 cfu/ml), and low concentration (10 cfu/ml) was 100%. All 7 V. parahaemolyticus strains displayed good linear calibration curves for detection time relative to bacterial count (r > 0.993). The mean negative rate for the high-concentration (106 cfu/ml) non-V. parahaemolyticus samples was 65.2% (15/23) and that for the medium-concentration (103 …

Interferon Lambda-3 Rs12979860 Variants And Response To Pegylated Interferon In Chronic Hepatitis-C Genotype-3, Zaigham Abbas, Javed Yakoob, Muhammad A. Umer, Ali A. Azeem, Saeed S. Hamid, Wasim Jafri

Department of Medicine

Objective: To assess the role of single nucleotide polymorphisms (SNPs) near the interferon lambda-3 (IFNλ3) (formal IL-28B) gene rs12979860 in predicting sustained virologic response (SVR) in hepatitis-C virus genotype-3 (HCV-3).

Study Design: Descriptive, analytical study.

Place and Duration of Study: Department of Medicine, The Aga Khan University Hospital, Karachi, from July 2012 to June 2014.

Methodology: Patients with HCV-3 were classified as sustained virologic response (SVR), relapsers and non-responders. SNP rs12979860 was determined by PCR-RFLP protocol. Differences between categorical variables were assessed by chi-square or Fisher's exact test, while those between continuous variables were evaluated using the Mann-Whitney U-test. Binary …

Bomb Blast And Its Consequences: Successful Intensive Care Management Of Massive Pulmonary Embolsim., Faisal Shamim, Muhammad Rizwan, Adil Aziz

Department of Medicine

A suicide bomb blast in 2013 at a distant city of Pakistan killed 84 and wounded more than 150 people. Some patients were transferred to our tertiary care hospital because of extreme load on medical services there. This patient arrived at the Aga Khan Hospital, 2 days after the bomb blast injury and underwent an orthopedic procedure. Next day, he developed sudden tachypnea, desaturation, and circulatory collapse. After initial cardiopulmonary resuscitation, he was immediately transferred to surgical intensive care unit. Based on history, echocardiography findings and patient parameters, a clinical diagnosis of massive pulmonary embolism was made and immediate thrombolytic …

Three-Dimensional Bioprinting Materials With Potential Application In Preprosthetic Surgery, Mina D. Fahmy, Hossein E. Jazayeri, Mehdi Razavi, Radi Masri, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Current methods in handling maxillofacial defects are not robust and are highly dependent on the surgeon’s skills and the inherent potential in the patients’ bodies for regenerating lost tissues. Employing custom-designed 3D printed scaffolds that securely and effectively reconstruct the defects by using tissue engineering and regenerative medicine techniques can revolutionize preprosthetic surgeries. Various polymers, ceramics, natural and synthetic bioplastics, proteins, biomolecules, living cells, and growth factors as well as their hybrid structures can be used in 3D printing of scaffolds, which are still under development by scientists. These scaffolds not only are beneficial due to their patient-specific design, but …

Mean Length Of Utterance And Developmental Sentence Scoring In The Analysis Of Children's Language Samples, Laurie Lynne Chamberlain

Theses and Dissertations

Developmental Sentence Scoring (DSS) is a standardized language sample analysis procedure that uses complete sentences to evaluate and score a child’s use of standard American-English grammatical rules. Automated DSS software can potentially increase efficiency and decrease the time needed for DSS analysis. This study examines the accuracy of one automated DSS software program, DSSA Version 2.0, compared to manual DSS scoring on previously collected language samples from 30 children between the ages of 2;5 and 7;11 (years;months). The overall accuracy of DSSA 2.0 was 86%. Additionally, the present study sought to determine the relationship between DSS, DSSA Version 2.0, the …

The Association Between Articulator Movement And Formant Trajectories In Diphthongs, Katherine Morris Mckell

Theses and Dissertations

The current study examined the association between formant trajectories and tongue and lip movements in the American English diphthongs /aɪ/, /aʊ/, and /ɔɪ/. Seventeen native speakers of American English had electromagnetic sensors placed on their tongues and lips to record movement data along with corresponding acoustic data during productions of the diphthongs in isolation. F1 and F2 trajectories were extracted from the middle 50% of the diphthongs and compared with time-aligned kinematic data from tongue and lip movements. The movement and formant tracks were converted to z-scores and plotted together on a common time scale. Absolute difference scores between kinematic …

Zinc Intake, Microrna Dysregulation, And Esophageal Cancer., Louise Y. Fong, John Farber, Carlo M. Croce

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

No abstract provided.

Seroprevalence And Phylogenetic Analysis Of Toxoplasma Gondii From Domestic Cats, Captive Wild Felids, Free-Range Wild Felids And Rats In Certain Regions Of Thailand, Ruangrat Buddhirongawatr, Kridsada Chaichoun, Siriporn Tungsudjai, Ruenruethai Udonsom, Andrew Thompson, Oangart Mahittikorn, Paron Dekumyoy, Yaowalark Sukthana

The Thai Journal of Veterinary Medicine

Toxoplasmosis is an important zoonotic disease caused by Toxoplasma gondii, an obligated zoonotic apicomplexan parasite. The infection varies according to geographical areas. This work aimed to study the seroprevalence and genotype of T. gondii infection in domestic, captive and free-range wild felids, and in their small mammal prey, rats (Rattus spp). Two hundred and ninety three sera, received from the 4 individual animal groups in Thailand, were tested using the indirect latex agglutination test (ILAT) for specific antibody detection. The nested-PCR for glycerol-3-phosphate (B1) and bradyzoite surface antigen (SAG4) gene detection was used to detect seropositive animals and PCR product …

Improving Outcomes Through Performance Improvement, Evidence-Based Practice, Or Research: Choosing The Right Road, Eve Butler, Maria Ojeda, Andrea Prentiss

All Publications

No abstract provided.

Widening Access In Selection Using Situational Judgement Tests: Evidence From The Ukcat, Filip Lievens, Fiona Patterson, Jan Corstjens, Stuart Martin, Sandra Nicholson

Research Collection Lee Kong Chian School Of Business

Widening access promotes student diversity and the appropriate representation of all demographic groups. This study aims to examine diversity-related benefits of the use of situational judgement tests (SJTs) in the UK Clinical Aptitude Test (UKCAT) in terms of three demographic variables: (i) socioeconomic status (SES); (ii) ethnicity, and (iii) gender. Methods: Outcomes in medical and dental school applicant cohorts for the years 2012 (n = 15 581) and 2013 (n = 15 454) were studied. Applicants' scores on cognitive tests and an SJT were linked to SES (parents' occupational status), ethnicity (White versus Black and other minority ethnic candidates), and …

An Atrophic Plaque On The Breast Six Years After Breast Reconstruction Surgery, Michelle Khurana, Richard Torbeck, Young C. Kauh

Department of Dermatology and Cutaneous Biology Faculty Papers

No abstract provided.

Emergency Coronary Artery Bypass Grafting: Indications And Outcomes From 2003 Through 2013, Erin M Schumer, John H Chaney, Jaimin R Trivedi, Paul L Linsky, Matthew L Williams, Mark S Slaughter

The Texas Heart Institute Journal

Emergency coronary artery bypass grafting (CABG) is associated with increased in-hospital mortality rates and adverse events. This study retrospectively evaluated indications and outcomes in patients who underwent emergency CABG.

The Society of Thoracic Surgeons database for a single center (Jewish Hospital) was queried to identify patients undergoing isolated CABG. Univariate analysis was performed.

From January 2003 through December 2013, 5,940 patients underwent CABG; 212 presented with emergency status. A high proportion of female patients (28.2%) underwent emergency surgery. Emergency CABG patients experienced high rates of intra-aortic balloon pump support, bleeding, dialysis, in-hospital death, and prolonged length of stay. The proportion …

Endocarditis And Incomplete Endothelialization 12 Years After Amplatzer Septal Occluder Deployment, Allan K Nguyen, Brian A Palafox, Joanne P Starr, Richard N Gates, Farbouch Berdjis

The Texas Heart Institute Journal

A 4-year-old boy had a 15-mm atrial septal defect repaired percutaneously with use of an Amplatzer Septal Occluder. At age 16 years, he presented with a week's history of fever, chills, dyspnea, fatigue, and malaise. Cultures grew methicillin-sensitive Staphylococcus aureus. A transesophageal echocardiogram showed a 1.25 × 1.5-cm pedunculated mass on the left aspect of the atrial septum just superior to the mitral valve, and a smaller vegetation on the right inferior medial aspect of the septum. At surgery, visual examination of both sides of the septum revealed granulation tissue, the pedunculated mass, the small vegetation, and exposed metal …

Fresh Autologous Pericardium To Reconstruct The Pulmonary Valve At The Annulus When Tetralogy Of Fallot Requires A Transannular Patch At Midterm, Shantanu Pande, Jugal K Sharma, C R Siddartha, Anubhav Bansal, Surendra K Agarwal, Prabhat Tewari, Aditya Kapoor

The Texas Heart Institute Journal

Tetralogy of Fallot often requires reconstruction of the right ventricular outflow tract with a transannular patch (TAP), but this renders the pulmonary valve incompetent and eventually leads to right ventricular dysfunction.

We retrospectively evaluated the efficacy of a reconstructed pulmonary valve and annulus in 70 patients who underwent, from December 2006 through December 2010, complete correction of tetralogy of Fallot. We divided the 70 patients into 2 groups in accordance with whether they required (n=50) or did not require (n=20) a TAP. We used autologous untreated pericardium to fashion the TAP and to create both an annulus of the correct …

Skepticism, The Trained Eye, And The Telltale Clue, Ethan A Natelson

The Texas Heart Institute Journal

No abstract provided.

Two Cases Of Transcatheter Closure Of Central Aortopulmonary Shunts: One With An Amplatzer Duct Occluder Ii And One With An Amplatzer Vascular Plug I, Ahmet Celebi, Ilker Kemal Yucel, Sevket Balli, Mehmet Kucuk

The Texas Heart Institute Journal

When total correction is not possible in infants who have a cyanotic congenital heart disease, creation of a palliative aortopulmonary shunt is essential. A central aortopulmonary shunt is preferable, because of its technical and hemodynamic advantages. Overcirculation, thrombosis, and stenosis of the shunt are the main postoperative sequelae that necessitate urgent reintervention. Percutaneous transcatheter closure of aortopulmonary shunts can eliminate the need for reoperation and substantially decrease postoperative morbidity and mortality rates. We report our successful transcatheter closures of central aortopulmonary shunts in a 3-month-old infant and a 15-year-old girl, with use of an Amplatzer Duct Occluder II and an …

Prerequisite Conditions For Implementing Job Rotation In An Aircraft Assembler Population In The Aerospace Industry: The Impact Of Quality Requirements On Development Of Versatility And The Learning Process, Denys Denis, Marie St-Vincent, Maud Gonella

Rapports de recherche scientifique

Une grande entreprise du secteur de l’aéronautique désire développer la polyvalence de ses assembleurs-monteurs par l’instauration de la rotation de postes. Convenant qu’il s’agit d’une problématique complexe, l’expertise de l’Institut de recherche Robert-Sauvé en santé et en sécurité du travail (IRSST) est sollicitée. La demande formulée consiste à identifier les conditions requises pour implanter la rotation des postes, souhaitant ainsi prévenir les TMS qui affectent cette population de travailleurs. Le département où sont assemblés les cabines de pilotage de deux des avions-phares de l’entreprise est ciblé à la fois de par les exigences physiques qui le caractérisent, sa …

The Arg59trp Variant In Angptl8 (Betatrophin) Is Associated With Total And Hdl-Cholesterol In American Indians And Mexican Americans And Differentially Affects Cleavage Of Angptl3, Robert L. Hanson, Fatjon Leti, Darwin Tsinajinnie, Sayuko Kobes, Sobha Puppala, Joanne E. Curran, Laura Almasy, Donna M. Lehman, John Blangero, Ravi Duggirala, Johanna K. Distefano

School of Medicine Publications

We previously identified a locus linked to total cholesterol (TC) concentration in Pima Indians on chromosome 19p. To characterize this locus, we genotyped >2000 SNPs in 1838 Pimas and assessed association with log(TC). We observed evidence for association with log(TC) with rs2278426 (3.5% decrease/copy of the T allele; P=5.045×10(-6)) in the ANGPTL8 (angiopoietin-like 8) gene. We replicated this association in 2413 participants of the San Antonio Mexican American Family Study (SAMAFS: 2.0% decrease per copy of the T allele; P=0.005842). In a meta-analysis of the combined data, we found the strongest estimated effect with rs2278426 (P=2.563×10(-7)). The variant T allele …

Utility Of Lymphoblastoid Cell Lines For Induced Pluripotent Stem Cell Generation, Satish Kumar, Joanne E. Curran, David C. Glahn, John Blangero

School of Medicine Publications

A large number of EBV immortalized LCLs have been generated and maintained in genetic/epidemiological studies as a perpetual source of DNA and as a surrogate in vitro cell model. Recent successes in reprograming LCLs into iPSCs have paved the way for generating more relevant in vitro disease models using this existing bioresource. However, the overall reprogramming efficiency and success rate remain poor and very little is known about the mechanistic changes that take place at the transcriptome and cellular functional level during LCL-to-iPSC reprogramming. Here, we report a new optimized LCL-to-iPSC reprogramming protocol using episomal plasmids encoding pluripotency transcription factors …

There Is Relief For Constipated Patients Taking Opioids., Ahmad Mohammadieh, James Choi, Md, Chelsea Gonzalez, Do, Diyanah Elyaman, Md

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Tack J, Lappalainen J, Diva U, Tummala R, Sostek M. Efficacy and safety of naloxegol in patients with opioid-induced constipation and laxative-inadequate response. United European Gastroenterol J. 2015 Oct;3(5):471-80. doi: 10.1177/2050640615604543

Carotid Ultrasound Is Not Helpful In Simple Syncope, Nicholus Yee M.D., Shilin Patel M.D., Raymond Gong

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Scott JW, Schwartz AL, Gates JD, Gerhard-Herman M, Havens JM. Choosing wisely for syncope: low-value carotid ultrasound use. J Am Heart Assoc. 2014 Aug 13;3(4). pii: e001063. doi: 10.1161/JAHA.114.001063