Medicine and Health Sciences Commons^™

The Changing Face Of Coagulase-Negative Staphylococci: Diagnostic And Therapeutic Challenges, Shreya Singh, Sujeesh Sebastian, Benu Dhawan

Manipal Journal of Medical Sciences

Coagulase negative Staphylococci (CoNS) are now recognized as the etiological agents of an important range of infections in humans. The increasing importance of CoNS may be due in part to the growing appreciation of this group of organisms as opportunistic pathogens and to the increase in the use of medical devices in seriously ill and immunocompromised patients. The ability of biofilm formation seems to play an essential role in their virulence. CoNS are reservoirs of resistance genes. The similarity of SCCmec regions among Staphylococcus aureus and CoNS suggests horizontal transfer between species of Staphylococci. Hence the methicillin resistant CoNS which …

Anton Babinski Syndrome - A Rare Complication Of Cortical Blindness, Mohammed Khalid, Mohamed Hamdy, Himanshi Singh, Kiran Kumar, Shaikh Altaf Basha

Manipal Journal of Medical Sciences

In this case report, we present a rare complication of cortical blindness, which is Anton Babinski syndrome. Patients with this syndrome usually disaffirm their blindness and confabulate to fill in missing visual information. The commonest etiology of cortical blindness is posterior cerebral artery infarction but in this particular report, we present a case of hypertensive patient with Anton Babinski syndrome who developed bilateral cerebral haematoma confined to parieto-occiput area

Unusual Extramedullary Presentation Of Mixed Phenotype Acute Leukemia – A Case Report, Hasmukh Jain, Manju Sengar, Hari Menon, Tanuja Shet, Raajit Chanana, Uma Dangi

Manipal Journal of Medical Sciences

Mixed phenotype acute leukemia (MPAL) is a rare subtype of acute leukemia. The clinical manifestations are both due to bone marrow failure and extramedullary sites of involvement which can lead to protean manifestations. Accurate and timely diagnosis needs clinical suspicion as well as collaboration with the hematopathologist. Extramedullary (EM) disease poses a unique therapeutic challenge. There is a need for more data to guide treatment decisions and justify the usefulness of radiation and allogeneic stem cell transplant. We present 3 cases of MPAL with unusual EM sites of involvement.

Sleep Disruption And Cancer Incidence In A Southeastern Veteran Population, Alexandria F. Delage

Theses and Dissertations

Sleep disruption influences biological processes that can facilitate carcinogenesis. However, studies examining the relationship between sleep disruption and cancer risk have been inconclusive. This retrospective cohort study used de-identified data from the Veterans Administration (VA) electronic medical record to test the hypothesis that sleep disorder diagnoses among Veterans seeking care in the Southeast United States Service Network are associated with increased risk for cancer of the prostate, breast, colorectum, or total cancer (1999-2010, N=663,869). Sleep disorders were defined as patients with an in- or out-patient diagnosis as specified by the International Classification of Sleep Disorders. Cancer cases were defined as …

Re-Contacting Cancer Genetic Counseling Patients: Expectations Of Patients And Physicians, Zoe Elizabeth Siegel

Theses and Dissertations

The landscape of cancer genetic counseling and testing is rapidly evolving. Genetic testing technology is improving, management guidelines are evolving, and genetic testing options are expanding. These frequent updates to the components of cancer genetics have increased the complexity of managing patient care over time. In particular, this raises questions on the duty to re-contact patients as new information becomes available. This study explored healthcare providers’ duty to re-contact through the interests and expectations of patients, including which circumstances warrant re-contacting, which healthcare provider is responsible for re-contacting the patient, and the preferred method of re-contacting. Physicians’ opinions on whether …

An Exploration Of Dietary Acculturation In Hispanic Males Residing In Mississippi, Diana Cuy Castellanos, Carol L. Connell, Laura Downey, Kathleen Yadrick, Jamie Zoellner

Journal of Human Sciences and Extension

The purpose of this research was to explore dietary acculturation in Hispanic males in the context of the Operant Theory of Acculturation. This was a qualitative study using grounded theory to guide methodological procedures. Semi-structured interviews, a focus group, the Acculturation-Rating Scale for Mexican-Americans-II and the Marginality Scale, and photovoice with follow-up interviews were used to explore dietary acculturation in the participant sample. Thirty-five first- and second-generation Hispanic males residing in Mississippi were recruited and categorized into one of three different bidimensional acculturation groups as determined by the Acculturation-Rating Scale for Mexican-Americans-II and the Marginality Scale. Main dietary influencing themes …

Atypical Mycobacterial Infection Resembles Sporotrichosis In Elderly Patient, Siti Nurani Fauziah, Lili Legiawati, Sri Adi Sularsito, Shannaz Nadia Yusharyahya, Rahadi Rihatmadja, Sondang P. Sirait, Fifi Mifta Huda, Indah Widyasari

Journal of General - Procedural Dermatology and Venereology Indonesia

Atypical mycobacterial (AM) infection is caused by Mycobacterium species other than M.tuberculosis. AM skin infection has clinical manifestations that resemble M. tuberculosis infection and deep fungal infection. Laboratory workup is necessary to confirm the diagnosis.

An 83-year old female came with a painful lump and swelling on her right lower extremity since three months before admission. Physical examination revealed a plaque consisting, of multiple erythematous and hyperpigmented papules and nodules, diffuse erythematous lesion, and shallow ulcers partially covered with pus and crust. Histopathological features showed tuberculoid granuloma. Direct test and periodic acid-Schiff (PAS) staining of the skin biopsy found no …

The Role Of Dermoscopy In Non-Pigmented Skin Disorders, Hafiza Fathan, Wresti Indriatmi, Rahadi Rihatmadja, Inge Ade Krisanti

Journal of General - Procedural Dermatology and Venereology Indonesia

The use of dermoscopy in non-pigmented skin disorders includes dermoscopy as a diagnostic tool for non- pigmented skin tumors, inflammatory diseases (inflammoscopy) and/or infectious disease (entomodermoscopy), lesions on nail fold and as a tool to monitor skin reaction as a response to treatment and/or side effect. The diagnosis becomes easier, faster and less expensive with dermoscopy without the need for invasive procedures. Knowledge on vascular pattern and its architectural arrangement; which is coupled with additional dermoscopic features, can aid clinicians to the diagnosis. Dermatoscopy can also predict, monitor and evaluate therapeutical response and/or side effect of skin disorders. Nonetheless, dermoscopy …

Cuestionario De Proceso Sensorial En Adultos: Comparación De Resultados Entre Población De Usa Y De Chile: Resultados Preliminares/Sensory Processing Questionnaire In Adults: Comparison Of Results Between Usa And Chile Population: Preliminary Results, Silvia Gómez, Megan Chang, Dianne Parham, Erna Imperatore

Faculty Research, Scholarly, and Creative Activity

Spanish: Existen escasos estudios sobre la forma de evaluar el proceso sensorial en adultos; una de estas formas es el uso de perfil sensorial desarrollado por Brown y Dunn en el año 2002, aplicable tanto para la población infantil como adulta de habla inglesa. Hasta el momento no existe una evaluación de procesamiento sensorial del adulto validada en castellano. En base a estos antecedentes, el principal objetivo de este estudio es validar la construcción interna de una escala de procesamiento sensorial en el adulto a través del Cuestionario del Proceso Sensorial del Adulto (CPSA) con una población de habla hispana, …

Can Gait Signatures Provide Quantitative Measures For Aiding Clinical Decision-Making? A Systematic Meta-Analysis Of Gait Variability Behavior In Patients With Parkinson’S Disease, Niklas König Ignasiak

Physical Therapy Faculty Articles and Research

A disturbed, inconsistent walking pattern is a common feature of patients with Parkinson's disease (PwPD). Such extreme variability in both temporal and spatial parameters of gait has been associated with unstable walking and an elevated prevalence of falls. However, despite their ability to discretise healthy from pathological function, normative variability values for key gait parameters are still missing. Furthermore, an understanding of each parameter's response to pathology, as well as the inter-parameter relationships, has received little attention. The aim of this systematic literature review and meta-analysis was therefore to define threshold levels for pathological gait variability as well as to …

Hiv-1 Transgenic Rat: Selective Alterations In Motivation And Histological Examination Of Medium Spiny Neurons Of The Nucleus Accumbens, Michael N. Cranston

Theses and Dissertations

Motivational alterations in HIV-1+ individuals are associated with decreased performance on tasks involving frontal-subcortical circuitry and the nucleus accumbens. In the present study, the HIV-1 transgenic (Tg) rat was used to assess long-term HIV-1 viral protein exposure on motivated behavior using activity chambers (40x40cm) and voluntary wheel running. Adult ovariectomized female HIV-1 Tg animals (n=21) to F344 controls (n=26) were pair-housed under a 12:12 light/dark cycle. Voluntary running was measured with 34 cm-diameter running wheels for ~60 minutes/day for 3 ½ months. There were no significant differences between HIV-1 Tg and F344 control rats in voluntary wheel running during the …

Non-Steroidal Anti-Inflammatory Drug Effects On Core Temperature, Hydration, Gastrointestinal Distress, And Performance In Exercising Humans, Dawn Marie Emerson

Theses and Dissertations

Naproxen is a commonly used non-steroidal anti-inflammatory drug designed to relieve pain and inflammation. Due to potentially adverse effects on the gastrointestinal (GI) tract, cardiovascular and immune system, and renal function, naproxen may negatively affect thermoregulation, fluid and electrolyte balance, and performance during exercise, particularly in the heat. Therefore, the purpose of this study was to determine the effects of naproxen on core temperature (Tc), inflammation, hydration, GI distress, and performance during cycling in a hot environment. We utilized a double-blind, randomized and counterbalanced, cross-over design to determine the effects of naproxen (dose = 3 220 mg naproxen sodium pills) …

Molecular Cues Of Pattern-Recognition-Receptor Pathways In Redox-Toxicity-Driven Environmental Nafld, Suvarthi Das

Theses and Dissertations

With the pandemic proportions of obesity and a correlative increase in fatty liver disease, there was a dire need to explore the missing link between the changed environment and progression of NAFLD in obesity. My research implies that environmental toxin bromodichloromethane induces early liver lesions in obesity, and is mediated by the synchronous insult of oxidative stress and increased levels of the adipokine leptin. In a two-pronged approach to investigate the molecular cues, I looked at the role of Purinergic receptor X7 and Toll 4 receptor. Both rodent models and cell-based systems were used. Also, in order to validate my …

Phonological And Orthographic Repetition Effects Across Words In Adult Skilled Sentence Reading: An Eye Movement Analysis, Ti Yan

Theses and Dissertations

Visual word recognition is central to skilled silent reading. This project investigated the situation in which two words within a sentence share phonological information. Previous eye movement reading studies have made attempts to understand how prior exposure to a word could influence the speed of recognizing another phonologically and/or orthographically similar word. Results have been accounted for by different visual word recognition models which agree on the competition among similar words in the lexicon. However, a closer inspection revealed several concerns. First, there is little direct evidence demonstrating the across-word effect in normal reading. Second, the existing work in English …

Effectiveness Of Community-Based Eibi Treatment: A Longitudinal Analysis Of Adaptive Behavior And Language Outcomes, John Kuntz

Theses and Dissertations

Autism spectrum disorders (ASDs) are a group of lifelong, neurodevelopmental disorders characterized by deficits in social interaction, communication, relationship development and by the presence of repetitive or stereotypical behaviors including restricted interests. Continued advances in understanding treatment outcomes and broadening access to effective treatment is critical to improving the quality of life of children with autism and their families and minimizing the cost associated with care. The overall aim of this study is to assess the effectiveness of a community-based implementation of an Early Intensive Behavioral Intervention (EIBI) treatment program through a large-sample, longitudinal secondary analysis of administrative data. Additionally, …

Transcriptional And Post-Transcriptional Regulation Of Nrf2 In The Heart By The Deubiquitinase Cyld, Bryan J. Mathis

Theses and Dissertations

The cylindromatosis (CYLD) is a K63-linked deubiquitinase (DUB) that has been linked to the regulation of multiple physiological or pathological processes, such as neural development, inflammation and fibrosis. However, a novel paradigm for CYLD has been recently postulated; namely that of CYLD as a mediator of cardiac disease. Nuclear factor, erythroid-2 related factor 2 (Nrf2), a master antioxidant transcription factor, has been shown to suppress cardiac pathological remodeling and dysfunction via downregulation of reactive oxygen species formation (ROS). It is normally regulated by Kelch-like ECH associated protein 1 (Keap1). However, the regulatory link between CYLD and Nrf2 in the diseased …

Examining Infant Health Outcomes Impacted By South Carolina's Regionalized System Of Perinatal Care, Michael Grady Smith

Theses and Dissertations

Perinatal regionalization systems have been shown to reduce the risk of neonatal mortality when very low birth weight infants are delivered in Level III hospitals with neonatal intensive care units, sub-specialist staffing, and adequate experience caring for high-risk pregnancies and neonates. However, studies to date examining the association between delivery in Level III hospitals and neonatal mortality have not accounted for censoring due to fetal deaths. Furthermore, studies of perinatal regionalization to date have not adequately assessed the association between delivery hospital level of care and the infant’s hospital length of stay. This dissertation examined 8,594 very low birth weight …

Conversations About Sexuality On A Public University Campus: Exploring Perspectives From Campus Ministry Leaders And Students, Charis Rebecca Davidson

Theses and Dissertations

Since the 1800s, religious organizations have been a presence on public universities. However, there is limited research on the influence these organizations may have on student health communication and behaviors. Prior research on campus ministries has focused primarily on the culture of individual organizations. In this study, researchers explored the goals and experiences of USC leaders related to communication around sexuality with their students, as well as student perceptions of these messages, and how students incorporate religious messages about sexuality into their lives. The present study had four aims:

1. Assess whether students participating in campus ministries at USC differ …

Prosaposin Is A Regulator Of Progranulin Levels And Oligomerization, Alexandra M. Nicholson, Nicole A. Finch, Marcio Almeida, Ralph B. Perkerson, Marka Van Blitterswijk, Aleksandra Wojtas, Basar Cenik, Laura Almasy, Thomas D. Dyer, Juan M. Peralta, Joanne E. Curran, Donna M. Lehman, Ravindranath Duggirala, John Blangero

School of Medicine Publications

Progranulin (GRN) loss-of-function mutations leading to progranulin protein (PGRN) haploinsufficiency are prevalent genetic causes of frontotemporal dementia. Reports also indicated PGRN-mediated neuroprotection in models of Alzheimer’s and Parkinson’s disease; thus, increasing PGRN levels is a promising therapeutic for multiple disorders. To uncover novel PGRN regulators, we linked whole-genome sequence data from 920 individuals with plasma PGRN levels and identified the prosaposin (PSAP) locus as a new locus significantly associated with plasma PGRN levels. Here we show that both PSAP reduction and overexpression lead to significantly elevated extracellular PGRN levels. Intriguingly, PSAP knockdown increases PGRN monomers, whereas …

Assessment Of Prolonged Occupational Exposure To Heat Stress, Ximena Garzon-Villalba Garzon-Villalba

USF Tampa Graduate Theses and Dissertations

Heat stress is a recognized occupational hazard present in many work environments. Its effects increase with increasing environmental heat loads. There is good evidence that exertional heat illness is associated with ambient thermal conditions in outdoor environments. Further, there is reason to believe that risk of acute injury may also increase with the ambient environment. For these reasons, the assessment of heat stress, which can be done through the characterization of the wet bulb globe temperature (WBGT), is designed to limit exposures to those that could be sustained for an 8-h day. The ACGIH Threshold Limit Value (TLV) for heat …

Relationship Between Teacher Characteristics And Accuracy In Identifying Middle School Students With Symptoms Of Anxiety And Depression, Elizabeth Storey

USF Tampa Graduate Theses and Dissertations

As a universal screening method, teacher nominations have been found to both miss and misidentify a substantial proportion of students with internalizing disorders such as anxiety and depression (Cunningham & Suldo, 2014; Gelley, 2014; Moor et al., 2007). Although some research has explored the accuracy of teacher nominations when used to identify students with anxiety and depression, no research examined the teacher characteristics that are potentially related to accuracy. The current study conducted a secondary analysis of an archival dataset (Gelley, 2014) to determine which characteristics of teachers (N= 19) are more closely related to accuracy in identifying …

Analysis Of Patterns In Handwritten Spelling Errors Among Students With Various Specific Learning Disabilities, Laura Ann Winkler

USF Tampa Graduate Theses and Dissertations

Students diagnosed with specific learning disabilities struggle with spelling accuracy, but they do so for different reasons. For instance, students with dysgraphia, dyslexia, and oral-written language learning disability (OWL-LD) have distinct areas of weakness in cognitive processing and unique difficulties with the linguistic features necessary for accurate spelling (Silliman & Berninger, 2011). This project considered the spelling errors made by such students to determine if their unique learning profiles lead to distinct misspelling patterns.

Academic summaries handwritten by 33 students diagnosed with dysgraphia (n=13), dyslexia (n=15), and OWL-LD (n=5) were analyzed for type/complexity and …

The Influence Of Motivational Salience On Attention Selection: An Erp Investigation, Constanza De Dios

USF Tampa Graduate Theses and Dissertations

The current study used event-related potentials (ERPs) to investigate how motivational salience in the form of expectation violation influences spatial attention. The medial frontal negativity (MFN) ERP indexes expected value, being negative to unexpected punishments and positive to unexpected rewards. The P1 and N1 ERPs index spatial attention, being larger to stimuli in attended locations. This design attached motivational value to locations by making one visual hemifield economically rewarding (greater probability of a rewarding outcome) and the other punishing (greater probability of a punishing outcome). Keypresses to a dot probe following a reward-signifying stimulus were awarded money if correct, and …

Cell Cycle Arrest By Tgfß1 Is Dependent On The Inhibition Of Cmg Helicase Assembly And Activation, Brook Samuel Nepon-Sixt

USF Tampa Graduate Theses and Dissertations

Tumorigenesis is a multifaceted set of events consisting of the deregulation of several cell-autonomous and tissue microenvironmental processes that ultimately leads to the acquisition of malignant disease. Transforming growth factor beta (TGFß) and its family members are regulatory cytokines that function to ensure proper organismal development and the maintenance of homeostasis by controlling cellular differentiation, proliferation, adhesion, and survival, as well as by modulating components of the cellular microenvironment and immune system. The pleiotropic control by TGFß of these cell intrinsic and extrinsic factors is intimately linked to the prevention of tumor formation, the specifics of which are dependent on …

Effects Of A Novel Right Brain Intervention On Stuttering In Familiar And Structured Speech Tasks, Josalyn Elizabeth Perry

USF Tampa Graduate Theses and Dissertations

Over 3 million Americans are disfluent due to developmental stuttering. Current evidence-based treatments typically consist of a rigorous schedule of intensive therapy, followed by the need for maintenance of skills, placing high demands on self-monitoring of one’s speech at all times. Relapse after treatment is very common, at 84%. The demand for further research into treatment possibilities for stuttering is on the forefront. Previous research has connected neural activations in people who stutter (PWS) and people with chronic nonfluent aphasia. The aim of this study was to determine if a novel intervention, based on a treatment for anomia, would change …

Tongue Twisters Quantified: Ultrasound Analysis Of Speech Stability And Speech Errors, Karen Reddick

USF Tampa Graduate Theses and Dissertations

This thesis investigates errors on speech sounds (or phonemes) produced in laboratory speech stimuli designed to generate phonological onset errors. The present study adds to the literature on phonological speech errors with an instrumental analysis of tongue posture during speech error production and an investigation of the nature of speech errors as unintended variation in articulation.

This study utilized ultrasound instrumentation to visualize speech errors made on velar and alveolar stop consonants at the point of stop closure. Two types of errors were of interest, categorical errors and gradient errors. Categorical errors are those that are heard by the listener …

Static And Dynamic Spectral Acuity In Cochlear Implant Listeners For Simple And Speech-Like Stimuli, Benjamin Anderson Russell

USF Tampa Graduate Theses and Dissertations

For cochlear implant (CI) listeners, poorer than normal speech recognition abilities are typically attributed to degraded spectral acuity. However, estimates of spectral acuity have most often been obtained using simple (tonal) stimuli, presented directly to the implanted electrodes, rather than through the speech processor as occurs in everyday listening. Further, little is known about spectral acuity for dynamic stimuli, as compared to static stimuli, even though the perception of dynamic spectral cues is important for speech perception.

The primary goal of the current study was to examine spectral acuity in CI listeners, and a comparison group of normal hearing (NH) …

Interspeech Posture In Spanish-English Bilingual Adults, Merrily Rose Shary

USF Tampa Graduate Theses and Dissertations

Interspeech posture (ISP) is a term used to define the position of a person’s articulators when they are preparing to speak. Research suggests that ISP may be representative of a speaker’s phonological knowledge in a particular language, as determined empirically with ultrasound measures of the tongue in English-French bilinguals (Wilson & Gick, 2014). It is possible, therefore, that measuring ISP could be a diagnostic tool for determining phonological knowledge in bilingual speakers. However, more information on ISP in typical adult bilingual speakers is needed before diagnostic claims can be made. For example, ISP is believed to be language specific, and …

Hexamethylene Diisocyanate Homopolymer And Monomer Exposure Assessment And Characterization At An Automobile Manufacturer In The United States, Karthik Reguram Sivaraman

USF Tampa Graduate Theses and Dissertations

A variety of paint products are used for their aesthetic and anti-corrosive properties. Isocyanates are consistently found in automobile paint products, particularly in clear coat polyurethane products. Clear coat is typically sprayed via pressurized air by means of an auto-spray robot. In clear coat repair situations, manual, air-powered spray guns are used, and manual spray Operators administer the clear coat material. The isocyanates are a primary anti-corrosive agent in polyurethane products. The Occupational Safety and Health Administration (OSHA) has not established a Permissible Exposure Limit (PEL). The National Institute for Occupational Safety and Health (NIOSH) and American Conference of Governmental …

The Effects Of Personal And Family History Of Cancer On The Development Of Dementia In Japanese Americans: The Kame Project, Adam Lee Slotnick

USF Tampa Graduate Theses and Dissertations

An increasing number of studies have shown an inverse association between a personal history of cancer (PHC) and dementia/Alzheimer’s disease (AD), both in those using dementia/AD as the outcome or cancer as the outcome. This is the first study to examine this potential association in Japanese Americans; and to examine family history of cancer and its association with incident dementia. Also, the association between these two diseases in the parents of participants were analyzed.

The Kame Project, conducted from 1992 through 2001 in King County, Washington was a population-based, prospective cohort study of older Japanese Americans. Conversion to incident dementia …