Medicine and Health Sciences Commons^™

Simulation Learning And Transfer To The Clinical Environment In Undergraduate Nursing Students, David A. Miles

Dissertations

Simulation learning is an integral component of many undergraduate nursing programs throughout the country. Experiential learning through simulation allows students to improve their cognitive, affective, and psychomotor skills. Some clinical experiences lack significant practice of clinical skills for students; including the inability to assume the role of the nurse. A recent literature review revealed a need to advance the understanding of simulation learning and transfer; with many questions still remaining unanswered. The aim of this study was to conceptualize the process by which simulation learning transfers to the clinical environment in undergraduate nursing students. Twenty-five, fourth-year traditional nursing students, who …

Examining The Effects Of Anti-Nogo A Immunotherapy On Post-Stroke Neurogenesis In The Adult Rat, Daniel Shepherd

Dissertations

Stroke is a leading cause of adult disability with no pharmacological treatments to restore lost function. Our laboratory has shown that treatment with neutralizing antibodies against the neurite growth-inhibitory protein Nogo-A improves sensorimotor and cognitive recovery after stroke in adult and aged rats. This recovery is paralleled by increased dendritic and axonal plasticity in anti-Nogo-A-treated rats. Neurogenesis, an alternate form of plasticity involving the de novo production of new neurons, may contribute to post-stroke neural repair. While previous studies have found roles for Nogo-A in adult neurogenesis, neurogenesis has not been investigated after stroke and anti-Nogo-A treatment. The goal of …

Monetizing Personal Data: A Two-Sided Market Approach, Ahmed Saleh Bataineh, Rabeb Mizouni, May El Barachi, Jamal Bentahar

All Works

© 2016 The Authors. Mobile phone-based sensing is a new paradigm that aims at using smartpohnes to answer sensing requests and collect useful data. Nowadays, a wide variety of domains ranging from health-care applications to pollution monitoring are benefiting from such collected data. However, despite its increasing popularity and the huge amount of data provided by users, there is no platform where mobile phone owners can effectively sell their data. In this paper, we propose the idea of a data monetization platform using two-sided market theory. In this platform, the data is viewed as an economic good and the data …

Characterization Of Dielectric Barrier Discharge Atmospheric Air Plasma Treated Chitosan Films, Shashi Pankaj, Carmen Bueno-Ferrer, Luke O'Neill, B.K. Tiwari, Paula Bourke, Patrick J. Cullen

Articles

Dielectric barrier discharge (DBD) plasma is a novel non-thermal food decontamination technology. The effects of DBD plasma on the surface topography, chemical composition and crystal structure, film hydrophilicity, water vapor permeability and oxygen permeability of chitosan films have been examined. DBD plasma treatment increased the surface roughness of chitosan films with emergence of sharp protuberances. X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy spectra confirm a significant increase in the oxygen containing groups in the chitosan film after plasma treatment. Significant increase in the film hydrophilicity was observed after plasma treatment. X-ray diffraction results showed that DBD plasma treatment do …

Conducting Qualitative Interviews By Telephone: Lessons Learned From A Study Of Alcohol Use Among Sexual Minority And Heterosexual Women, Laurie Drabble, Karen Trocki, Brenda Salcedo, Patricia Walker, Rachael Korcha

Faculty Publications

This study explored effective interviewer strategies and lessons learned based on collection of narrative data by telephone with a subsample of women from a population-based survey, which included sexual minority women. Qualitative follow-up, in-depth life history interviews were conducted over the telephone with 48 women who had participated in the 2009–2010 National Alcohol Survey. Questions explored the lives and experiences of women, including use of alcohol and drugs, social relationships, identity, and past traumatic experiences. Strategies for success in interviews emerged in three overarching areas: (1) cultivating rapport and maintaining connection; (2) demonstrating responsiveness to interviewee content, concerns; and (3) …

Attitudes To Lesbian, Gay, Bisexual And Transgender Parents Seeking Health Care For Their Children In Two Early Parenting Services In Australia, E Bennett, K Berry, T Emeto, L Shields

Nursing Papers and Journal Articles

Aim: to examine the attitudes to and knowledge and beliefs about homosexuality, of nurses and allied professionals in two early parenting services in Australia.

Background: Early parenting services employ nurses and allied professionals. Access and inclusion policies are important in community health and early childhood service settings. However, little is known about the perceptions of professionals who work within early parenting services in relation to lesbian, gay, bisexual and transgender families.

Design: This is the final in a series of studies and was undertaken in two early parenting services in two states in Australia using a cross-sectional design with …

Self-Management Interventions To Improve Skin Care For Pressure Ulcer Prevention In People With Spinal Cord Injuries: A Systematic Review Protocol, J Baron, J Swaine, J Presseau, A Aspinall, S Jaglal, B White, D Wolfe, J Grimshaw

Health Sciences Papers and Journal Articles

Background: Pressure ulcers are a serious, common, lifelong, and costly secondary complication of spinal cord injury (SCI). Community-dwelling people with a SCI can prevent them with appropriate skin care (i.e. pressure relieving activities, skin checks). Adherence to skin care remains suboptimal however, and self-management interventions that focus on improving this have been designed. Little is known on their content, effectiveness, or theoretical basis. The aim of the proposed systematic review is to synthesize the literature on self-management interventions to improve skin care in people with a SCI. Specific objectives are to describe these interventions in relation to their content, effectiveness, …

Identifying Patient-Specific Epstein-Barr Nuclear Antigen-1 Genetic Variation And Potential Autoreactive Targets Relevant To Multiple Sclerosis Pathogenesis, M Tschochner, S Leary, D Cooper, K Strautins, A Chropra, H Clark, L Choo, D Dunn, I James, W Carroll, A Kermode, D Nolan

Health Sciences Papers and Journal Articles

Background: Epstein-Barr virus (EBV) infection represents a major environmental risk factor for multiple sclerosis (MS), with evidence of selective expansion of Epstein-Barr Nuclear Antigen-1 (EBNA1)-specific CD4+ T cells that cross-recognize MS-associated myelin antigens in MS patients. HLA-DRB1*15-restricted antigen presentation also appears to determine susceptibility given its role as a dominant risk allele. In this study, we have utilised standard and next-generation sequencing techniques to investigate EBNA-1 sequence variation and its relationship to HLA-DR15 binding affinity, as well as examining potential cross-reactive immune targets within the central nervous system proteome.

Methods: Sanger sequencing was performed on DNA isolated from peripheral blood …

The Use Of Feedback In Group Counseling In A State Vocational Rehabilitation Setting, Saara Grizzell, Julie Smart, Michael J. Lambert, Jamison Fargo

School of Rehabilitation Services & Counseling Faculty Publications

This study examined the impact of providing progress feedback to individuals with disabilities receiving services at a state vocational rehabilitation (VR) agency. Thirty individuals were randomly assigned to receive either group therapy (treatment-as-usual, TAU) or group therapy plus feedback (treatment, Fb) during a 10-week counseling program at one of five agency offices. Each week, participants attended a 90-minute session and completed a measure of mental health (Outcome Questionnaire-45). Longitudinal multilevel models were used to evaluate the hypothesis that participation in the Fb group would lead to improved mental health. The effect of the intervention was conditional on receipt of public …

Factors Influencing The Decisions Of Women Small Business Owners On Hiring People With Disabilities, Roy K. Chen, Stephen A. Zanskas, Hung-Jen Kuo, Noel A. Ysasi

School of Rehabilitation Services & Counseling Faculty Publications

Despite the passage of disability rights legislation in the United States, individuals with disabilities continue to experience high unemployment and underemployment rates than their counterparts without disabilities. The purpose of the study was to examine the attitudes of women small business owners towards hiring individuals with disabilities, and to determine what factors influence their hiring decisions. A total of 80 women small business owners in a southwestern U.S. state took part in the study. The Employer Attitudes Questionnaire (EAQ) and the Marlowe-Crowne Social Desirability Scale Short Form-C (M-C Form C) were used to assess participants’ attitudes. The results of a …

Physiatrists' Professional Opinions Of Secondary Complications After Sci, Noel A. Ysasi, Irmo Marini, Bradley Mcdaniels, Roy K. Chen, Lisa R. Dunkley, Shelby Kerwin

School of Rehabilitation Services & Counseling Faculty Publications

The professional opinions of physiatrists were collected to ascertain the likelihood of occurrence, frequency of hospitalization, and treatment required as a direct result of 13 secondary complications (SCs) of two otherwise healthy males in their mid-20s, one with a C5-C6 tetraplegia and the other with T6 paraplegia spinal cord injury. Physiatrists responded to our online survey and overall, a general consensus was found among practitioners. Descriptive statistics was implemented with details outlining the frequency, mean, standard deviations, and the probability (51% or greater) versus possibility (50% or less) of SC occurrence is provided. Implications for life care planners and recommendations …

A Comparison Of Physiatrist Life Care Planners Versus Non-Life Care Planner Physiatrists' Professional Opinions Regarding Secondary Complications Of Spinal Cord Injuries, Noel A. Ysasi, Irmo Marini, Danielle Leigh Antol, Kristin Maxwell, Shelby Kerwin

School of Rehabilitation Services & Counseling Faculty Publications

The specialization of life care planning continues to evolve through empirical research and periodic standards of practice symposiums. Within this evolution, the need exists towards advancing the profession through the creation of a universal and standardized approach among all who operate within the field of life care planning regarding when/when not to include secondary complication costs into a life care plan. Opposing life care planners (LCPs) are sometimes millions of dollars apart in projected costs, often generally attributed to the inclusion of such costs which may be possible (51%) from a life care planning certainty threshold. The current study surveyed …

A Comprehensive Literature Review Of Secondary Complications Of Spinal Cord Injury, Noel A. Ysasi, Shelby Kerwin, Irmo Marini, Bradley Mcdaniels, Danielle Leigh Antol

School of Rehabilitation Services & Counseling Faculty Publications

Spinal cord injury (SCI) and secondary complications (SCs) that occur as a direct result of the injury can be a contributing factor for increased hospitalization and need for specialized healthcare. For instance, level of injury, time since injury, gender, age, and personal health care have shown to increase and/or decrease the incidence rate of specific SCs. The authors conducted a comprehensive literature review for 12 SCs to examine the relative prevalence of each for people with SCI. The data utilized was to determine the probability (>50%) versus the possibility (

Positive Psychology And Hope As Means To Recovery From Mental Illness, Jinhee Park, Roy K. Chen

School of Rehabilitation Services & Counseling Faculty Publications

The field of psychiatric rehabilitation has seen a paradigm shift in its perceptions of symptom reduction, recovery, and restoration of personal-growth and -development. Recovery is subjective in nature, as no two individuals achieve identical rehabilitation outcomes; the process is dynamic and influenced by an array of personal and environmental factors, all of which can facilitate a deeply personal, unique progression that changes one's attitudes, values, feelings, goals, skills, and roles. The concept of positive psychology is relevant to the perception from mental illness. Positive psychology seeks to understand what makes life worth living and encourages the use of mental strengths …

The Association Between Physical Activity And Serum Immunoglobulin G (Igg) Antibodies Against Periodontal Bacteria, A. Paige Anderson

Theses and Dissertations

The purpose of this study is to add more research and evidence to the mechanisms surrounding periodontal disease, periodontal microorganisms, and physical activity. The main objective of this study is to evaluate and explore the association between physical activity and serum IgG antibodies, which are grouped into four distinct clusters, formed from species specific 19 periodontal antibody titers. This cross sectional study divided physical activity into three categories: adequately physically active, inadequately physically active, and inactive based on MET scores. Certain models were adjusted for confounders including age, sex, race/ethnicity, income-to-poverty ratio, years of formal education, smoking, alcohol intake, BMI, …

Sleep Disorder Trends, Epigenetic Markers, And Genetic Variation Of Circadian Genes In Adenomatous Polyp Formation, Melannie Alexander

Theses and Dissertations

Introduction: Sleep disturbances and sleep quality have fluctuated over time in the United States (US). Virtually every physiological process follows a circadian pattern, and cellular processes (i.e., cell proliferation, DNA damage response, and apoptosis) are often disrupted by sleep disturbances and other factors, potentially giving rise to adverse health outcomes such as cancer. Additionally, both genetic variation and epigenetic patterns within clock genes, which may affect sleep quality, also may increase one’s risk for developing cancer. The role of sleep disturbances in the formation of adenomas, precursor lesions to colorectal cancer (CRC), has been explored previously; however, little is …

Enhancing Parent-Child Communication And Promoting Physical Activity And Healthy Eating Through Mobile Technology: A Randomized Trial, Danielle E. Schoffman

Theses and Dissertations

Background

Although rates of pediatric and adult obesity remain high in the U.S., finding scalable and engaging ways to disseminate obesity prevention and treatment for families has been challenging. The purpose of the Motivating Families with Interactive Technology (mFIT) study was to test the feasibility, acceptability, and effectiveness of two remotely-delivered family-based health promotion programs for improvements physical activity (PA), healthy eating, and parent-child communication and relationship quality.

Methods

Parent-child (child age 9-12 years) dyads enrolled in a 12-week mobile intervention to increase physical activity and healthy eating, which included weekly email newsletters and the use of pedometers. Dyads were …

Influence Of Built Environment On Physical Activity Outcomes Among African Americans In Community-Based Obesity Intervention Studies, Amanda Sue Thomas

Theses and Dissertations

More than sixty-five percent of people in the U.S. are considered overweight or obese. African-Americans in the U.S. have a higher risk of obesity than any other racial group. One way to reduce this statistic is physical activity. Recreational green spaces (parks) can serve as an avenue to complete the 150 min/wk of recommended physical activity for adults by the ACSM. Data from SISTAS and HEALS interventions, that recruited overweight/obese African-Americans from Columbia and Florence, SC, was used to assess the association of recreational green space (parks) around a residence and physical activity. Physical activity measures of RAPA questionnaire (self-report), …

Determining The Validity Of A Web-Based, Self-Rating Checklist Assessment Of Vocabulary Knowledge, Sheida Abdi

Theses and Dissertations

The purpose of this study is to examine the validity of a web-based, self-rating checklist of vocabulary knowledge. One hundred fifty-nine participants took two norm-referenced assessments in addition to one of three conditions of a developed self-rating checklist. Each condition employed a different combination of follow-up questions (synonym generation to verify participants’ self-ratings) and feedback for student responses (whether or not synonyms are correct). Condition 1 did not provide any follow-up questions or feedback, Condition 2 included follow-up questions and feedback, and Condition 3 presented follow-up questions but no feedback. Results show that participants moderately overestimated vocabulary knowledge. Moderate-to-high statistically …

Quality Over Quantity: Positive Interactions During Family Meals In Food-Insecure Households Compensate For The Negative Impacts Of Household Chaos On Child Emotional Well-Being, But Not Diet Quality, Tiara Nicόl Rosemond

Theses and Dissertations

Family meals are important family activities that have many positive nutritional and emotional benefits for children. Positive family meal experiences may provide opportunities for children to strengthen emotional bonds, leading to a sense of security and, fostering improved children’s self-regulation of healthier food intake and emotional well-being. Unfortunately, children in food insecure households experience higher amounts of chaos, lower diet quality, and worry about having enough to eat compared to children in food-secure households, all of which may affect both family meal frequency and interpersonal quality. Yet, the relationships between food insecurity, household chaos, and family meal frequency and interpersonal …

The Role Of Epidermal Stem/Progenitor-Like Cells In Hpv-Mediated Pre-Neoplastic Transformation, Yvon L. Woappi

Theses and Dissertations

The role of epidermal basal stem cells in dysplasia is a matter of great interest in the human papillomavirus (HPV)-driven cancers. To assess the relationship between “stemness” and HPV-mediated transformation, we made use of 3-D suspension culture and fluorescence activated cell sorting (FACS) to purify stem/progenitor-like cells from primary normal human keratinocyte (NHKc) cultures. We found that NHKc cells derived from multicellular keratinocyte spheroids were enriched for a basal subpopulation of epidermal stem-like cells, that could be maintained for prolonged time in culture and used to conduct transfection experiments with full-length HPV16 DNA. Thus, by using these stem cell enrichment …

The Influence Of Prenatal And Early Life Factors On Bmi Z Scores And The Risk Of Being Obese In Early Childhood, Junxiu Liu

Theses and Dissertations

Childhood obesity is a serious public health challenge. The underlying causes behind the rising levels of childhood obesity might be driven by prenatal and early life factors. Recently, several studies have examined the association between gestational weight gain (GWG) and the risk of obesity in the pediatric population. Findings on the association of both inadequate and excessive GWG with offspring obesity are inconsistent and vary by maternal prepregnancy body mass index (BMI) status. Inconsistent findings also exist for the association of GWG and BMIZ as a continuous outcome. Nevertheless, existing studies mainly focus on the BMIZ upper centiles using logistic …

Deciphering The Interacting Regions And Functions Of The Rad51d-Nono Protein Complex During Dna Damage Response, Latarsha Porcher

Theses and Dissertations

Genomic instability is one of the major components represented in the “Hallmarks of Cancer.” DNA interstrand crosslinks and double-stranded breaks are two of the most severe causes of genomic instability. Homologous recombination (HR) plays a major role in resolving both types of DNA lesions, requiring a homologous template and the RAD51 paralog complex of proteins. One member of this complex is the RAD51D ovarian cancer susceptibility gene product. To better elucidate RAD51D modifications and functions, several protein interaction screens were performed, and one of the novel proteins identified was NONO (a.k.a. p54nrb). Decreased expression of either RAD51D or NONO conferred …

Differences In Resting-State Functional Connectivity Of Chronic Migraine, With And Without Medication Overuse Headache, And The Effectiveness Of Sphenopalatine Ganglion Block As A Treatment For Repairing Dysfunctional Connectivity., Kaitlin Krebs

Theses and Dissertations

Chronic Migraine (CM) is a debilitating neurological condition that occurs when the migraine frequency progresses to a chronic state of more than 15 headache days per month. The overuse of analgesic medication (MOH) is one of the most prominent risk factor of this chronification and little is known about why it is a cause. The repetitive inhibition of the Sphenopalatine Ganglion is one promising treatment that is used to treat chronic migraine. The purpose of this study is to determine if a specific pattern of disruption is present for chronic migraine, both with and without medication overuse headache, and if …

The Informational And Emotional Support Needs Of Grandparents Of Children With Pompe Disease, Natasha Lousie Rudy

Theses and Dissertations

The complex roles and experiences of grandparents of children with various diagnoses have been described, but previous studies have not investigated the roles and experiences of grandparents of children with treatable, Mendelian conditions such as Pompe disease. The availability of treatment and heritable nature of Pompe introduce the possibility for unique grandparent roles, experiences and needs. This is a particularly timely investigation given the advent of newborn screening for Pompe. This study aimed to characterize grandparents’ roles and involvement, identify grandparents’ information and emotional support needs, and explore the psychosocial impact felt by grandparents of children with Pompe. An online …

Protocol For Care After Lymphoma (Caly) Trial: A Phase Ii Pilot Randomised Controlled Trial Of A Lymphoma Nurse-Led Model Of Survivorship Care, K Taylor, D Joske, M Bulsara, C Bulsara, L Monterosso

Nursing Papers and Journal Articles

Introduction: Lymphoma is the sixth most common cancer diagnosed in Australia and internationally. Owing to the aggressive nature of the disease and intensity of treatment, survivors face long-term effects that impact on quality of life. Current models of follow-up post-treatment fail to address these complex issues. Given that 74% of patients with lymphoma cancer now survive 5 years beyond diagnosis and treatment, it is important to address this gap in care.

Aim: To determine self-reported informational and practical needs, anxiety, depression, stress, coping and empowerment at baseline, 3 and 6 months.

Methods and analysis: A pilot randomised controlled trial will …

Models For Community Based Day Care For Older People: A Narrative Review, Caroline Bulsara, Christopher Etherton-Beer, Rosemary Saunders

Nursing Papers and Journal Articles

Objectives: Older Australians are choosing to live within the community and there are a number of initiatives to enable this sector of the population to do so for longer. In an effort to ensure that they remain both physically and psychologically engaged, one initiative has been to provide community based day care (CBDC). Method: A narrative review was undertaken through searching MEDLINE, CINAHL Plus, Scopus and AgeInfo using keywords related to facility related, target group related and purpose/program of CBDC services. Results: Results indicated that there is a much research investigating different approaches but little consensus regarding the optimal delivery …

Cellular Consequences Of Lysosomal Rupture Induced By Alpha Synuclein, Zachary Carpenter Green

Master's Theses

Misfolded, toxic forms of amyloid alpha synuclein (α-syn) have been implicated in Parkinson’s disease (PD) pathology and have been shown to spread throughout the brain in a prion-like manner, explaining the progressive loss of neurons in PD. The mechanisms of spread and cell death are unknown, however, evidence from previous studies suggests that neurons may undergo apoptosis due to the uptake of exogenous α-syn aggregate through the endocytic pathway and subsequent lysosomal rupture.

This study aimed to corroborate previous evidence of α-syn induced lysosomal rupture and investigate the cellular repercussions of rupture with respect to cell death and α-syn transfer. …

Estrogen Regulation Of Mir-181a Stability In Neurons, Chun Kim

Master's Theses

Estrogens are an important class of steroid hormones involved in many cellular signaling processes. Levels of estrogens fluctuate across the lifespan suggesting that they target intracellular mediators, such as microRNAs, to fine-tune homeostatic cellular processes. Previous work in our lab demonstrated that 17β-estradiol (E2), the predominant circulating estrogen, stabilized miR-181a in a neuronal cell line derived from rat hypothalamus. These results lead to the hypothesis that E2 regulated miR-181a stability by altering the pool of endogenous RNA and by recruiting PNRC2 away from the miRNA degradation machinery. By utilizing miRNA degradation assays and immunostaining techniques, it was determined that the …

Results From The Survey Of Antibiotic Resistance (Soar) 2011-14 In The Democratic Republic Of Congo, Ivory Coast, Republic Of Senegal And Kenya, A. Kacou-Ndouba, Gunturu Revathi, P. Mwathi, A. Seck, A. Diop, M. J. Kabedi-Bajani, W. Mwiti, M. J. Anguibi-Pokou, I. Morrissey, D. Torumkuney

Pathology, East Africa

Objectives: To assess antibiotic susceptibility of community-acquired respiratory tract isolates from Ivory Coast, Kenya, Democratic Republic of Congo (DRC) and Senegal in 2011–14.

Methods: Bacterial isolates were collected and MICs determined using Etest^® for all antibiotics except erythromycin, for which testing was by disc diffusion. Susceptibility was assessed using CLSI, EUCAST and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. For macrolide interpretation, CLSI breakpoints were adjusted for incubation in CO₂.

Results: Susceptibility to penicillin (using CLSI oral or EUCAST breakpoints) was low among isolates of Streptococcus pneumoniae from the DRC and Kenya (17.4% and 19%, respectively) but higher among isolates from …