Medicine and Health Sciences Commons^™

In Vivo-Expressed Proteins Of Virulent Leptospira Interrogans Serovar Autumnalis N2 Elicit Strong Igm Responses Of Value In Conclusive Diagnosis, Veerapandian Raja, Santhanam Shanmughapriya, Murugesan Kanagavel, Sergey Artiushin, Sridhar Velineni, John F. Timoney, Kalimuthusamy Natarajaseenivasan

Maxwell H. Gluck Equine Research Center Faculty Publications

Leptospirosis is a serious zoonosis that is underdiagnosed because of limited access to laboratory facilities in Southeast Asia, Central and South America, and Oceania. Timely diagnosis of locally distributed serovars of high virulence is crucial for successful care and outbreak management. Using pooled patient sera, an expression gene library of a virulent Leptospira interrogans serovar Autumnalis strain N2 isolated in South India was screened. The identified genes were characterized, and the purified recombinant proteins were used as antigens in IgM enzyme-linked immunosorbent assay (ELISA) either singly or in combination. Sera (n = 118) from cases of acute leptospirosis along …

Reflections On Leadership In Nursing Education: A Minority Perspective, Angela Banks, Chenit Ong-Flaherty, Claire Sharifi

Nursing and Health Professions Faculty Research and Publications

Academic leadership is at once engaging and stimulating, demanding and overwhelming. This article discusses the experiences and perspectives of minority faculty members working at a Jesuit institution. In this article, the authors use Ignatian pedagogical values as the foundation to guide their responses to the challenges they experience in leadership roles and to turn these challenges into opportunities for growth.

Why We Belong - Exploring Membership Of Healthcare Professionals In An Intensive Care Virtual Community Via Online Focus Groups: Rationale And Protocol, K Rolls, Margaret M. Hansen Edd, Msn, Rn, D Jackson, D Elliott

Nursing and Health Professions Faculty Research and Publications

Background: Many current challenges of evidence-based practice are related to ineffective social networks among health care professionals. Opportunities exist for multidisciplinary virtual communities to transcend professional and organizational boundaries and facilitate important knowledge transfer. Although health care professionals have been using the Internet to form virtual communities for many years, little is known regarding “why” they join, as most research has focused on the perspective of “posters,” who form a minority of members.

Objective: Our aim was to develop a comprehensive understanding of why health care professionals belong to a virtual community (VC).

Methods: A qualitative approach will be used …

How Health Care Professionals Use Social Media To Create Virtual Communities: An Integrative Review, K Rolls, Margaret M. Hansen Edd, Msn, Rn, D Jackson, D Elliott

Nursing and Health Professions Faculty Research and Publications

Background: Prevailing health care structures and cultures restrict intraprofessional communication, inhibiting knowledge dissemination and impacting the translation of research into practice. Virtual communities may facilitate professional networking and knowledge sharing in and between health care disciplines.

Objectives: This study aimed to review the literature on the use of social media by health care professionals in developing virtual communities that facilitate professional networking, knowledge sharing, and evidence-informed practice.

Methods: An integrative literature review was conducted to identify research published between 1990 and 2015. Search strategies sourced electronic databases (PubMed, CINAHL), snowball references, and tables of contents of 3 journals. Papers that …

Textwithsurgerypatients-A Research Hypothesis In Enhancing Education And Physical Assessment For Abdominal Surgical Patients, Margaret M. Hansen Edd, Msn, Rn

Nursing and Health Professions Faculty Research and Publications

Medical surgical nurses may not have the time or resources to provide effective pre- and post-operative instructions for patients in today's healthcare system. And, making timely physical assessments following discharge from the hospital is not always straightforward. Therefore, the risk for readmission associated with post-surgical complications is a concern. At present, mobile healthcare technologies and patient care are precipitously evolving and may serve as a resource to enhance communication between the healthcare provider and patient. A mobile telephone text message (short message service [SMS]) intervention for abdominal surgical patients may foster effective education (communication) and timely self-reported physical assessment in …

Early Sex Work Initiation And Condom Use Among Alcohol-Using Female Sex Workers In Mombasa, Kenya: A Cross-Sectional Analysis, A. M. Parcesepe, Kelly L'Engle, S. L. Martin, S. Green, C. Suchindran, P. Mwarogo

Nursing and Health Professions Faculty Research and Publications

Objectives Early initiation of sex work is prevalent among female sex workers (FSWs) worldwide. The objectives of this study were to investigate if early initiation of sex work was associated with: (1) consistent condom use, (2) condom negotiation self-efficacy or (3) condom use norms among alcohol-using FSWs in Mombasa, Kenya.

Methods In-person interviews were conducted with 816 FSWs in Mombasa, Kenya. Sample participants were: recruited from HIV prevention drop-in centres, 18 years or older and moderate risk drinkers. Early initiation was defined as first engaging in sex work at 17 years or younger. Logistic regression modelled outcomes as a function …

Race, Ethnicity, Psychosocial Factors, And Telomere Length In A Multicenter Setting, Shannon M. Lynch, M. K. Peek, Nandita Mitra, Krithika Ravichandran, Charles Branas, Elaine Spangler, Wenting Zhou, Electra D. Paskett, Sarah Gehlert, Cecilia Degraffinreid, Timothy R. Rebbeck, Harold Riethman

School of Medical Diagnostics & Translational Sciences Publications

Background

Leukocyte telomere length(LTL) has been associated with age, self-reported race/ethnicity, gender, education, and psychosocial factors, including perceived stress, and depression. However, inconsistencies in associations of LTL with disease and other phenotypes exist across studies. Population characteristics, including race/ethnicity, laboratory methods, and statistical approaches in LTL have not been comprehensively studied and could explain inconsistent LTL associations.

Methods

LTL was measured using Southern Blot in 1510 participants from a multi-ethnic, multi-center study combining data from 3 centers with different population characteristics and laboratory processing methods. Main associations between LTL and psychosocial factors and LTL and race/ethnicity were evaluated and then …

Modeling Early Stage Bone Regeneration With Biomimetic Electrospun Fibrinogen Nanofibers And Adipose-Derived Mesenchymal Stem Cells, Michael P. Francis, Yas M. Moghaddam-White, Patrick C. Sachs, Matthew J. Beckman, Stephen M. Chen, Gary L. Bowlin, Lynne W. Elmore, Shawn E. Holt

School of Medical Diagnostics & Translational Sciences Publications

The key events of the earliest stages of bone regeneration have been described in vivo although not yet modeled in an in vitro environment, where mechanistic cell-matrix-growth factor interactions can be more effectively studied. Here, we explore an early-stage bone regeneration model where the ability of electrospun fibrinogen (Fg) nanofibers to regulate osteoblastogenesis between distinct mesenchymal stem cells populations is assessed. Electrospun scaffolds of Fg, polydioxanone (PDO), and a Fg:PDO blend were seeded with adipose-derived mesenchymal stem cells (ASCs) and grown for 7-21 days in osteogenic differentiation media or control growth media. Scaffolds were analyzed weekly for histologic and molecular …

Enhanced Osseous Integration Of Human Trabecular Allografts Following Surface Modification With Bioactive Lipids, Tiffany Wang, Jack Krieger, Cynthia Huang, Anusuya Das, Michael P. Francis, Roy Ogle, Edward Botchwey

School of Medical Diagnostics & Translational Sciences Publications

In this study, we used extracellular matrix (ECM) gels and human bone allograft as matrix vehicles to deliver the sphingolipid growth factor FTY720 to rodent models of tibial fracture and a critical-sized cranial defect. We show that FTY720 released from injectable ECM gels may accelerate callous formation and resolution and bone volume in a mouse tibial fracture model. We then show that FTY720 binds directly to human trabecular allograft bone and releases over 1 week in vitro. Rat critical-sized cranial defects treated with FTY720-coated grafts show increases in vascularization and bone deposition, with histological and micro-computed topography (microCT) evidence of …

Message, P Laxminarayana Rao Dr

Manipal Journal of Nursing and Health Sciences

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Message, Anice George Dr

Manipal Journal of Nursing and Health Sciences

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Guest Editorial, Judith A. Noronha Dr

Manipal Journal of Nursing and Health Sciences

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Effect Of Helfer Rhythmic Skin Tap Technique On Procedural Pain Among Patients Receiving Intramuscular Injection, Saleena Shah Dr, Asha Narayanan Ms

Manipal Journal of Nursing and Health Sciences

Objective: The present study aims at comparing the effect of Helfer Rhythmic Skin Tapping Technique (HST) and Conventional Technique (CT) on pain perception of patients receiving IM injection. Methods: Quasiexperimental two groups, interventional study using cross over design was conducted at orthopaedic wards of Govt. Medical College Kozhikode, Kerala from May 2 – 21, 2011. A total of 82 patients admitted in orthopaedic wards, in the first post-operative day after orthopaedic surgery, who were receiving Inj. Voveran were included. After informed consent, subjects were purposively selected to Group I and II. The tools used were, (a) Interview schedule to assess …

Pre-Operative Breathing Exercise Using Instructional Demonstrationin Preventing Post-Operative Pulmonary Complications For Patients Undergoing Elective Abdominal Surgery, Anil Raj A Mr, B V. Kathyayani Dr

Manipal Journal of Nursing and Health Sciences

Introduction: Pulmonary complications are the largest and serious post-operative complications of thorax and abdomen. Patients’ post-operative experience is directly linked to the pre-operative preparations. Objective of the study was to evaluate the effect of pre-operative teaching of breathing exercise in terms of knowledge and practice of patients undergoing elective abdominal surgery and on the incidence of post-operative pulmonary complications among patients undergoing elective abdominal surgery. Methods: A quantitative evaluative approach with a preexperimental one group pre-test – post-test design was adopted for the study. Fifty subjects were selected by using purposive sampling technique. Pre-test was checked by using structured knowledge …

Effectiveness Of Intermittent Normal Saline Flushing In Maintaining The Patency Of Intravenous Cannula, Thingujam Uma Ms, Mayengbam Benita Devi Ms, Mary Anthony Ms

Manipal Journal of Nursing and Health Sciences

Introduction: Blockage of intravenous cannula (IV) is one of the major discomforts faced by the patients. Nurses not only directly administer the medication to the patients but also experience the difficulty while administering the medication through non-patent IV cannula. It is one of the major roles of a nurse to maintain the patency of IV Cannula by just following a flushing technique. Methods: A Quasi-experimental study was conducted among 60 patients on intermittent intravenous medication, 30 each in experimental and control group who met the inclusion criteria. Purposive sampling technique was used for selecting the sample. Data were collected from …

Effectiveness Of Structured Teaching Program On Knowledge Of Health Promotional Activities Among Home Makers Of A Selected Rural Community In Mangalore, Karnataka, Anupama D. S Ms, Rosy K. O Ms

Manipal Journal of Nursing and Health Sciences

Introduction: Health promotion is the process of helping people to gain control over the determinants of health and thereby improve their health. Objectives: Objectives of the study were to determine the effectiveness of structured teaching program in terms of gain in knowledge of homemakers on health promoting activities and to determine the association between health promotional activities of homemakers and selected variables. Methods: A pre-experimental design was used for the study and 60 participants were drawn through simple random sampling technique. The structured interview schedule was used to collect the data. Results: The findings of the study revealed that maximum …

Perception Of Sexual Harassment Among The Undergraduate Students, Aditi Gurung Ms, Sangeetha Priyadarshini Ms, Binu E. Margaret Ms

Manipal Journal of Nursing and Health Sciences

Introduction: Sexual harassment means unwanted sexually determined behaviour such as physical contacts and advances, making sexually derogative comments, and sexual pressures whether by verbal or non- verbal actions. Students may not recognize the harassing behaviours and the harasser can take this as an advantage. Therefore, it becomes very important to understand how the students perceive different types of sexual harassment. Objective: To assess the perception of sexual harassment by the undergraduate students. Methods: A crosssectional survey was conducted among 408 undergraduate students of selected professional colleges of Udupi district. Data was collected using Perception Scale on sexual harassment. Stratified proportionate …

Performance Measurement Processes In Uganda: Role Of Nurse Administrators, Godfrey Katende

Manipal Journal of Nursing and Health Sciences

The concept of performance measurement is relatively new with inadequate documentation in Ugandan health sector. Worldwide, nursing professionals still represent the largest health workforce although their involvement in the policy formulation and development remains minimal. Despite the limited involvement in policy development, the performance measurement and transparency programs continue to target at nursing for quality care improvement. The objective of this paper was to examine performance measurement in the current policy arena with Uganda in order to recommend for use in other developing countries. The paper presents evidence based solutions and strategies for integration of performance measurement when developing standards …

Glomus Jugulare: A Case Series, Wilma P Ms, Roseminu Varghese Ms, Jyothi Chakrabarty Dr, Girish Menon Dr

Manipal Journal of Nursing and Health Sciences

Background: Glomus Jugulare tumours arise within the jugular foramen of the temporal lobe. Treatment and management of these very rare, slow growing and hypervascular tumours are always challenging. Patients with these tumours will have their lower cranial nerves affected. With the involvement of lower cranial nerves, the patients may have altered functions of swallowing, chewing, hearing, speaking, balance and coordination. Thus, these patients can be managed effectively by a nurse with the thorough knowledge and understanding of the signs and symptoms. The nurses taking care of these patients should anticipate these dysfunctions and plan the care of patients accordingly.

Structural Basis For Lipid-And Calmodulin-Mediated Akt Activation In Breast Cancer Cells, Constance Agamasu

All ETDs from UAB

Growth and survival signals initiated at the cell surface by receptor-ligand interactions often involve a downstream activation of Akt, a serine/threonine kinase critical in regulating cell survival, apoptosis and oncogenesis. Hyper-activation of Akt is a common tumorigenic event, thereby making the Akt activation pathway a prime target for cancer therapy. The translocation of Akt to the plasma membrane (PM) for phosphorylation is a critical step in the Akt activation pathway. It has been established that membrane binding of Akt is mediated by direct interactions between its pleckstrin homology domain (PHD) and membrane lipid phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3]. There is now emerging …

Mechanisms Of Innate And Adaptive Immune Function In Parkinson Disease, Heather Elizabeth Allen

All ETDs from UAB

Parkinson disease (PD) is a common neurodegenerative movement disorder characterized pathologically by loss of dopaminergic neurons in the substantia nigra and aggregation of alpha-synuclein (α-syn) into large inclusions. The association of mutations and gene multiplications in SNCA, the gene encoding α-syn, with rare familial forms of PD led to the discovery that α-syn plays a key role in the pathogenesis of PD. The mechanism by which α-syn mediates its toxicity remains uncertain. A leading hypothesis states that the toxic effects of α-syn are mediated by activation of both the innate and adaptive immune systems within the central nervous system. Supporting …

Patient Engagement Functionalities Facilitated By Health Information Technology: An Examination Of The Adoption Rate And Financial Performance Among U.S. Hospitals, Oghale Elijah Asagbra

All ETDs from UAB

The Centers for Medicare and Medicaid (CMS) meaningful use requirement, as well as documented evidence suggest that health information technology (HIT) has the potential to promote patient engagement and consequently improve quality and reduce cost. This prompts a better understanding of hospital adoption of HIT for patient engagement. The purpose of the three papers presented in this dissertation is to examine hospital adoption of health information technology (HIT) to facilitate patient engagement. Emphasis is placed on the functionalities (i.e., functions or capabilities) offered by these technologies that have been determined to allow patients be more involved in their care because …

Retentive Strength At The Zirconia Implant Abutment And Titanium Base Interface With Different Surface Treatments, Celin Arce

All ETDs from UAB

Screw-retained zirconia implant crowns with an internal titanium base have favorable mechanical properties compared to single piece zirconia implant crowns; however, they require adequate bonding between the zirconia crown and the titanium base. This study measures the retention between a titanium base and a full contour zirconia implant crown following different surface treatments of their bonded surfaces. Full contour zirconia implant crowns were fabricated to fit a 3.5mm titanium base. The crowns were bonded to the titanium bases following 4 protocols (n=15): no surface treatment (Group 1), MDP-primer on the intaglio of crown and exterior of base (Group 2), alumina …

Relationship Between Stress-Recovery State And Running Performance In Men's Collegiate Soccer, Nicholas A. Coker

College of Graduate Studies: Theses & Dissertations

Purpose: The purpose of this study was to evaluate the relationship between changes in running performance and the stress-recovery state in Division I collegiate soccer players. Methods: Running performance was evaluated in eight NCAA Division I male soccer players (179.39 ± 5.24 cm; 75.46 ± 5.98 kg; 20.37 ± 1.41 yrs.) over the course of 12 games during a single competitive season. The 12 games were divided into four blocks [B1(n=3), B2(n=3), B3(n=3), and B4(n=3)]. Running performance and game load were assessed using a wearable physiological harness and Global Positioning System (GPS) module. Game load, absolute distance, and distance covered …

The Effect Of Half Time Sports Drink Ingestion On Subsequent Half Performance In U16 Female Soccer Players During Consecutive Matches, Nadima Skeff Ms, Brandonn Harris, Amy Jo Riggs, Adam Wells, John Dobson, Nicholas Coker

College of Graduate Studies: Theses & Dissertations

The purpose of this study was to evaluate the effect of halftime sports drink ingestion on second half performance in U16 female soccer players using GPS technology. While 12 players initially took part in the study, only six players were included in the analysis (age, 15.97±0.45 years; height, 159.62±5.35cm; body mass, 54.87±4.25; body mass index, 21.58±2.10 kg·m^-2). In a double-blinded study design, twelve U16 female soccer players were randomly assigned to two groups (carbohydrate- sports drink or placebo). During half time of each game, players were provided with 500 ml of a drink and consumed the same liquid …

The Contribution Of Self-Regulation To Reading Comprehension In Adolescent Learners, Rebecca Lynn Parker

LSU Doctoral Dissertations

The purpose of this study was to examine the dually implicated processes of language and self-regulation in reading comprehension and to determine if self-regulation contributes unique variance to reading comprehension beyond word recognition/decoding and oral language comprehension. The study also sought to determine if the unique contribution of self-regulation to reading comprehension differs for students with language/learning difficulties and students with typical language/learning histories. Thirty-two 6th, 7th, and 8th graders participated in this study. Of these participants, 17 students had language/learning difficulties and 15 students had typical language/learning histories. All participants attended a low performing public middle school located in …

Contribution Of New Thiol Antioxidant In The Treatment Of Acetaminophen Toxicity, Ahdab Naeem Khayyat

Doctoral Dissertations

"Acetaminophen (N-acetyl-p-aminophenol, APAP) is one of the most widely used over-the-counter antipyretic analgesic medications. It is safe at therapeutic doses, but an overdose can result in severe hepato-nephrotoxicity, a leading cause of drug-induced acute liver failure in the U.S. Although a few different mechanisms have been proposed for APAP-induced toxicity, a significant amount of evidence has pointed to the potential involvement of oxidative stress in acetaminophen toxicity. Depletion of glutathione (GSH) is one of the initiating steps in APAP-induced toxicity; therefore, one strategy for restricting organ damage is to restore GSH levels by using GSH prodrugs like N-acetylcysteine (NAC). Although …

Diabetes And Physical Activity, Jameela Banu

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Diabetes has been on the rise globally. Although many factors contribute to the increasing risk and manifestation of this disease lack and decreased physical activity/ exercise stands out as one of the major factors. Treatment interventions for prediabetic and diabetic patients include diet and lifestyle changes with enhanced physical activity/ exercise. Several types of physical activity are available for these patients but, recommendations have to be made on an individual basis after giving due consideration to the comorbidities and other risks and barriers. Implementation of progressive resistance therapy may be successful in maintaining glucose homeostasis in diabetic patients.

Drawing Comparisons Across Community Health Agents (Acs), Nurses And Physicians In Brazil’S Unified Health System (Uhs), Rahbel Rahman

Social Work Faculty Scholarship

Recent WHO guidelines emphasize on empowering communities to take ownership of their healthcare needs. Brazil’s UHS is a model for delivering community-based care through Family Health Strategy (FHS) interdisciplinary teams - ACS, nurses, and physicians. Our study compares nurses, physicians and ACS on their perceptions of work environment, professional skills, cognitive capacities and job context. Global health administrators and policy makers can leverage on comparisons across providers to develop interprofessional training and implement system-level interventions.

Transdisciplinary Health Teams In Brazil's United Health System, Rahbel Rahman

Social Work Faculty Scholarship

Integration of social services (i.e., civil registration, community mobilization) with disease prevention services (for e.g. HIV prevention services) has been recommended as a key strategy by practitioners, policy makers and researchers to solve the multifactorial determinants of chronic diseases faced by minority groups.