Medicine and Health Sciences Commons^™

Stall Seat Journal As A Social Norms Intervention For Risky Drinking Among College Students, Zackaria I. Niazi, Mariam Alshagra, Rhianna G. Ericson, Jinni Su Ph.D., Linda C. Hancock Ph.D.

Undergraduate Research Posters

Alcohol use is prevalent among college students and many participate in risky drinking behaviors over the course of their college careers, leading to negative consequences. The social norms theory posits that individuals behave based on their perceptions of peer behavior. Overestimation of peers’ problem behavior is associated with increase in their own problem behavior. The Stall Seat Journal (SSJ), developed by the Wellness Resource Center, is used in part to help correct common misperceptions, including those related to peer alcohol use. Our study aimed to see if Stall Seat Journal readership was associated with perception of peer alcohol use among …

Umls::Association - Measuring The Association Between Biomedical Terms, Keith B. Herbert

Undergraduate Research Posters

UMLS::Association - A Semantic Association Framework for Biomedical Texts

Keith Herbert

Natural Language Processing Lab, Department of Computer Science

Introduction

We present UMLS::Association, a software package to explore the semantic association of biomedical terms with applications for literature-based discovery. Literature-based discovery is an endeavour to ”connect the dots” for scientists between the topics of their research and those of unexpected relevance. However, many approaches rely on the exact wording for the ideas in the research papers being analyzed. The Unified Medical Language System (UMLS) provides a way to map natural language phrases in these papers to sequences of abstract yet …

Potential For Aerobic Exercise To Release Growth Factors To Induce Cognitive Changes In Children With Autism Spectrum Disorder, Maya Harrington

Undergraduate Research Posters

Autism Spectrum Disorder (ASD) is becoming increasingly prevalent among adolescents, and while the number of individuals diagnosed with the disorder grows, there continues to be no cure or even a clear treatment path for ASD. This study analyzes the biological stimulations that create cognitive changes—which are induced by intensive aerobic exercise—within the brains of individuals ages 8-18 diagnosed with autism. I studied journal articles on the current treatments available for ASD, the increasing prevalence of the disease, the cognitive alterations of the autistic brain relative to the brains of individuals without the disease, the release of growth factors due to …

Subjective Measures Of Mz And Dz Twins During Anxiety-Provoking Tasks, Sravya Uppalapati

Undergraduate Research Posters

Temporary anxiety is a healthy response to stress; however, continuous anxiety can threaten an individual’s day-to-day living by eliciting negative responses. In the study, monozygotic 84 (MZ) and 153 dizygotic (DZ) adolescent twins pairs, ages 15 to 20 years, participated in anxiety-provoking tasks and subjective experiences of anxiety were measured using subjective units of distress (SUDS). The twin participants were recruited through the Mid-Atlantic Twin Registry (MATR) at Virginia Commonwealth University. The twins participated in a carbon dioxide (CO₂) breathing task and a trier social stress task (TSST). The study aims were to evaluate the relationship between anxiety-provoking …

The Relationship Between Exercise And Depression And Anxiety In College Students, Joshua Frank, Dr. Amy Adkins, Nathan Thomas, Dr. Danielle Dick

Undergraduate Research Posters

The literature shows an inverse association between exercise and mental disorders. The aim of this study is to further elaborate on this association with regards to exercise and its relationship with anxiety and depression in a college sample. The subject group focused on seniors in the Spit for Science data set which incorporated a total of 821 students. Physical activity was assessed using the International Physical Activity Questionnaire (IPAQ) to estimate the overall metabolic equivalents (MET’s) each student spent in walking, moderate, or vigorous activity levels in the previous week. Sum scores were used to measure depression and anxiety. Overall,the …

Can A Metallated Cyclen Species Be Used To Prepare New Odorants?, Jalynn Taylor-Farmer

Undergraduate Research Posters

Scientists in the fragrance industry are constantly searching for new odors to create as well as new, more efficient processes to create them. Scientists mainly look for new ways to synthesize fragrances that will reduce the impact on the environment, produce them at lower costs, produce higher yields, and sometimes to produce a more potent odor [4]. In this research, we investigated the use of metallic macrocycles and/or metal-dioxygen chemistry to prepare new fragrances.

Cyclen (1,4,7,10-tetraazacyclododecane) has significant uses in many pharmaceutical and medicinal research developments such as advances in targeted cancer and Alzheimer’s agents. Macrocyclic amines like cyclen are …

Healthcare Access In Women’S Prisons: An Intersectional Perspective, Megan R. Bray

Undergraduate Research Posters

This project will be identifying the key factors that contribute to the significant lack of health care in prisons in the U.S., specifically in women’s correctional facilities. I will be lending my focus to disparities in mental health, HIV/AIDs care, reproductive health, trans health, and physical health issues among women who are either currently incarcerated or those who have completed their sentences and are at higher risk for re-entry after attempting re-integration. There is a lack of care, access, and proper treatment for women inmates in U.S. prisons and reform is needed. I foresee the best possible way to accomplish …

Socioeconomic Factors Associated With Cataract-Related Blindness Treatment In Women In Rural Regions Of Andhra Pradesh, Kiranpreet Kaur 4198353

Undergraduate Research Posters

Despite efforts of Vision 2020 in India, the Andhra Pradesh Eye Disease Study (APEDS) extrapolated, in 2000, approximately 18.7 million blind people in India and also, projected an increase to 31.6 million blind people by 2020. Within the state Andhra Pradesh itself, preventable corneal blindness increased to 1.84% from 1.5% in the late 1980s.

Numerous public health studies have been conducted to outline factors that cause and preclude treatment of avoidable corneal blindness in the India. Conclusively, the escalation of corneal blindness can be largely attributed to personal, social, and economic barriers in utilizing available eye-care services. However, due to …

Placental Epigenetics In Children’S Environmental Health, Carmen Marsit

Dartmouth Scholarship

There is a growing interest in understanding the mechanisms that drive the developmental origins of health and disease, and the role of epigenetic regulation has risen to the forefront of these studies. In particular, the placenta may be a model organ to consider as a mediator of the impact of the environment on developmental programming of children's health, as this organ plays a critical role in directing development and regulating the fetal environment. Several recent studies have begun to examine how environmental toxicant exposures can impact the placental epigenome, focusing on studies of DNA methylation and microRNA expression. This review …

Parsing The Behavioral And Brain Mechanisms Of Third-Party Punishment, Owen D. Jones, Matthew Ginther, Richard J. Bonnie, Morris B. Hoffman, Francis X. Shen, Kenneth W. Simons, Rene Marois

Vanderbilt Law School Faculty Publications

The evolved capacity for third-party punishment is considered crucial to the emergence and maintenance of elaborate human social organization and is central to the modern provision of fairness and justice within society. Although it is well established that the mental state of the offender and the severity of the harm he caused are the two primary predictors of punishment decisions, the precise cognitive and brain mechanisms by which these distinct components are evaluated and integrated into a punishment decision are poorly understood.

Using a brain-scanning technique known as functional magnetic resonance imaging (fMRI), we implemented a novel experimental design to …

Political, Economic, And Health Determinants Of Tuberculosis Incidence, Ashley Rutherford

Electronic Theses and Dissertations

The epidemiologic transition has shifted major causes of mortality from infectious disease to chronic disease; however, infectious diseases are again re-emerging as a major global concern (Diamond, 1997; Karlen, 1995; McNeil, 1976). This research aimed to identify potential areas of infectious disease influence that are not health-related in order to help governments and policymakers establish new policies, correct current policies, or further address these issues in order to effectively prevent and combat infectious disease. This study employed a retrospective, cross-sectional, non-experimental design via structural equation modeling (SEM) and examined tuberculosis incidence rates at the country-level. Secondary data from open-source, international …

The Mauc Gene Encodes A Versatile Signal Sequence And Redox Protein That Can Be Utilized In Native And Non-Native Protein Expression And Electron Trnasfer Systems, Brian Dow

Electronic Theses and Dissertations

The redox-active type 1 copper site of amicyanin is composed of a single copper ion that is coordinated by two histidines, a methionine, and a cysteine residue. This redox site has a potential of +265 mV at pH7.5. Over ten angstroms away from the copper site resides a tryptophan residue whose fluorescence is quenched by the copper. The effects of the tryptophan on the electron transfer (ET) properties were investigated by site-directed mutagenesis. Lessons learned about the hydrogen bonding network of amicyanin from the aforementioned study were attempted to be used as a model to increase the stability of another …

The Reproducibility And Validity Of Using The Dmax Method To Predict Physical Working Capacity At Fatigue Threshold, Joshua Riffe

Electronic Theses and Dissertations

Although the original (ORG) physical working capacity at fatigue threshold (PWCFT) assessment has demonstrated strong reliability and sensitivity to training and/or nutritional interventions, limitations may exist regarding the method of PWCFT estimation. However, a relatively new mathematical method, called Dmax, has been shown to be objective and reliable when estimating metabolic and neuromuscular fatigue thresholds. To date, however, no study has examined whether the Dmax method for estimating the work rate at PWCFT is similar to the ORG method. PURPOSE: The purpose of this study is to evaluate the reliability and validity of the Dmax-EMG method for estimating and tracking …

Perceived Readiness To Transition To Adult Health Care For Youth With Cystic Fibrosis And Congruence With Their Caregivers' Views, Valerie Lapp

Electronic Theses and Dissertations

Youth with cystic fibrosis must gradually assume considerable self-care management skills in order to optimize longevity and quality of life, and healthcare providers and caregivers play a role in youth gradually assuming these skills. The purpose of this study was to determine how youth with cystic fibrosis perceive their self-care management skills required for transition to adult healthcare, the relationship between age and skill acquisition, youth and caregiver congruence on perceived transition readiness, and frequency of transition discussion with provider. In this descriptive, correlational, cross-sectional design, 58 youth ages 14-22 rated their skill ability in managing cystic fibrosis using the …

Preschool Attendance: A Parental And Teacher Perspective Of Barriers And Behaviors Using Grounded Theory Research, Anne Meoli

Electronic Theses and Dissertations

Background: Preschool children from single-parent households with lower socioeconomic status (SES) are absent from preschool at rates higher than any other group. Some children are chronically absent, missing more than 10% of the school year. The phenomenon of preschool attendance related to behaviors, practices, and parental decision making associated with health and illness in lower SES households has not been previously studied using grounded theory methodology. Aim: The purpose of this study was to explore decision making related to supporting attendance in a preschool of 67 children (aged 3 to 4 years) with primarily low-income, single parents and preschool teachers …

Role Of Klf8-Cxcr4 Signaling In Breast Cancer Metastasis, Debarati Mukherjee

Electronic Theses and Dissertations

Krüppel-like factor 8 (KLF8) has been strongly implicated in breast cancer metastasis. However, the underlying mechanisms remain largely unknown. In this study we report a novel signaling from KLF8 to C-X-C cytokine receptor type 4 (CXCR4) in breast cancer. Overexpression of KLF8 in MCF-10A cells induced CXCR4 expression at both mRNA and protein levels. This induction was well correlated with increased Boyden chamber migration, matrigel invasion and transendothelial migration (TEM) of the cells towards the ligand CXCL12. On the other hand, knockdown of KLF8 in MDA-MB-231 cells reduced CXCR4 expression associated with decreased cell migration, invasion and TEM towards CXCL12. …

An Evaluation Of Anxiety Following Substance Abuse Withdrawal And Assessment Of Somatic Treatments Presently Available With A Focus On Cranial Electrotherapy Stimulation, Janet Hutchison

Electronic Theses and Dissertations

Addictive disorders/substance use disorders (SUDS) affect almost everyone in the United States, either directly or indirectly. The cost of substance abuse to the social and economic structure in the United States is huge. Anxiety is one of the most frequently mentioned symptoms which lead to relapse during the early weeks of recovery due to neurohormonal changes in the limbic system as well as cortisol production which occur during this time. Present research in the treatment of anxiety in substance abuse and long term recovery is focused on genetics and pharmaceuticals, however most pharmaceuticals produce sedation. Additional therapies in early recovery, …

Patterns Of Human Herpesvirus-8 Oral Shedding Among Diverse Cohorts Of Human Herpesvirus-8 Seropositive Persons, Rachel A. Bender Ignacio, Jason D. Goldman, Amalia S. Magaret, Stacy Selke, Meei-Li Huang, Soren Gantt, Christine Johnston, Warren Phipps, Joshua Schiffer, Richard Zuckerman

Dartmouth Scholarship

Human herpesvirus-8 (HHV-8), the etiologic agent of Kaposi sarcoma (KS), establishes lifelong latent infection with periodic lytic replication (“shedding”) at mucosal sites, especially the oropharynx. Patterns of HHV-8 shedding are not well understood, and require elucidation to better predict risk of HHV-8 related malignancies in those infected. We sought to characterize patterns of HHV-8 oropharyngeal shedding among diverse cohorts that enrolled HHV-8 seropositive persons.

Documento Faz Diferença, Carlos Eduardo Siqueira, Gabriella Barretosoares, Pedro L Araújo Neto, Maria N Tracy

Gastón Institute Publications

Brazilian immigrants in the United States experience various social, labor, and health challenges. This study aimed to analyze the profile of female Brazilian domestic workers in Massachusetts, USA, through a description of their working conditions and sel-frated health. This was a cross-sectional study of 198 domestic workers in Massachusetts, recruited with “snowball” sampling. The instrument addressed participants’ demographic characteristics, work conditions, and self-rated health. Data were analyzed with SPSS 21.0. Among the interviewees, 95.5% were women, 62.1% were 30 to 49 years of age, and 55.6% were undocumented. Documented and undocumented participants showed statistically significant differences in demographics, work conditions, …

Oscillation Phase Locking And Late Erp Components Of Intracranial Hippocampal Recordings Correlate To Patient Performance In A Working Memory Task, Jonathan K. Kleen, Markus E. Testorf, David W. Roberts, Rod C. Scott

Dartmouth Scholarship

In working memory tasks, stimulus presentation induces a resetting of intracranial temporal lobe oscillations in multiple frequency bands. To further understand the functional relevance of this phenomenon, we investigated whether working memory performance depends on the phase precision of ongoing oscillations in the hippocampus. We recorded intra-hippocampal local field potentials in individuals performing a working memory task. Two types of trials were administered. For high memory trials presentation of a list of four letters ("List") was followed by a single letter memory probe ("Test"). Low memory load trials, consisting of four identical letters (AAAA) followed by a probe with the …

Measurement Challenges In Shared Decision Making: Putting The ‘Patient’ In Patient‐Reported Measures, Paul J. Barr, Glyn Elwyn

Dartmouth Scholarship

Measuring clinicians' shared decision-making (SDM) performance is a key requirement given the intensity of policy interest in many developed countries - yet it remains one of the most difficult methodological challenges, which is a concern for many stakeholders. In this Viewpoint Article, we investigate the development of existing patient-reported measures (PRMs) of SDM identified in a recent review. We find that patients were involved in the development of only four of the 13 measures. This lack of patient involvement in PRM development is associated with two major threats to content validity, common to all 13 PRMs of SDM: (i) an …

Stress Granules And Rna Processing Bodies Are Novel Autoantibody Targets In Systemic Sclerosis, Michael E. Johnson, Andrew V. Grassetti, Jaclyn N. Taroni, Shawn M. Lyons, Devin Schweppe, Jessica K. Gordon, Robert F. Speira, Robert Lafyatis, Paul J. Anderson, Scott A. Gerber, Michael L. Whitfield

Dartmouth Scholarship

Autoantibody profiles represent important patient stratification markers in systemic sclerosis (SSc). Here, we performed serum-immunoprecipitations with patient antibodies followed by mass spectrometry (LC-MS/MS) to obtain an unbiased view of all possible autoantibody targets and their associated molecular complexes recognized by SSc.

Functional Mechanisms Underlying Pleiotropic Risk Alleles At The 19p13.1 Breast–Ovarian Cancer Susceptibility Locus, Kate Lawrenson, Siddhartha Kar, Karen Mccue, Karoline Kuchenbaeker, Kyriaki Michailidou, Jonathan Tyrer, Jonathan Beesley, Susan J. Ramus, Qiyuan Li, Melissa K. Delgado, Janet M. Lee, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Banu K. Arun, Brita Arver, Elisa V. Bandera, Monica Barile, Rosa B. Barkardottir, Daniel Barrowdale, Matthias W. Beckmann, Javier Benitez, Andrew Berchuck, Maria Bisogna, Line Bjorge, Carl Blomqvist, William Blot, Natalie Bogdanova, Anders Bojesen, Stig E. Bojesen, Manjeet K. Bolla, Bernardo Bonanni, Anne-Lise Børresen-Dale, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Fionna Bruinsma, Joan Brunet, Shaik Ahmad Buhari, Barbara Burwinkel, Ralf Butzow, Sandra S. Buys, Qiuyin Cai, Trinidad Caldes, Ian Campbell, Rikki Canniotto, Jenny Chang-Claude, Jocelyne Chiquette, Ji-Yeob Choi, Kathleen B.M Claes, Gemo Study Collaborators, Linda S. Cook, Angela Cox, Daniel W. Cramer, Simon S. Cross, Cezary Cybulski, Kamila Czene, Mary B. Daly, Francesca Damiola, Agnieszka Dansonka-Mieszkowska, Hatef Darabi, Joe Dennis, Peter Devilee, Orland Diaz, Jennifer A. Doherty

Dartmouth Scholarship

A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P = 9.2 X 10^-20), ER-negative BC (P = 1.1 X 10^-13), BRCA1 -associated BC (P = 7.7 X 10^-16) and triple negative BC (P-diff = 2 X 10^-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P = 2 X 10^{-3 …}

Intracellular Ros Mediates Gas Plasma-Facilitated Cellular Transfection In 2d And 3d Cultures, Dehui Xu, Biqing Wang, Yujing Xu, Zeyu Chen, Qinjie Cui, Yanjie Yang, Hailan Chen, Michael G. Kong

Bioelectrics Publications

This study reports the potential of cold atmospheric plasma (CAP) as a versatile tool for delivering oligonucleotides into mammalian cells. Compared to lipofection and electroporation methods, plasma transfection showed a better uptake efficiency and less cell death in the transfection of oligonucleotides. We demonstrated that the level of extracellular aqueous reactive oxygen species (ROS) produced by gas plasma is correlated with the uptake efficiency and that this is achieved through an increase of intracellular ROS levels and the resulting increase in cell membrane permeability. This finding was supported by the use of ROS scavengers, which reduced CAP-based uptake efficiency. In …

Multi-Segment Trunk Models Used To Investigate The Crunch Factor In Golf And Their Relationship With Selected Swing And Launch Parameters, Christopher Joyce

Health Sciences Papers and Journal Articles

The use of multi-segment trunk models to investigate the crunch factor in golf may be warranted. The first aim of the study was to investigate the relationship between the trunk and lower trunk for crunch factor related variables (trunk lateral bending and trunk axial rotation velocity). The second aim was to determine the level of association between crunch factor related variables with swing (clubhead velocity) and launch (launch angle). Thirty five high level amateur male golfers (Mean ± SD: age = 23.8 ± 2.1 years, registered golfing handicap = 5 ± 1.9) without low back pain had kinematic data collected …

Genetic And Cellular Studies Highlight That A Disintegrin And Metalloproteinase 19 Is A Protective Biomarker In Human Prostate Cancer, Gerard F. Hoyne, Caoline Rudnicka, Qing-Xiang Sang, Mark Roycik, Sarah Howarth, Peter Leedman, Markus Schlaich, Patrick Candy, Vance Matthews

Health Sciences Papers and Journal Articles

Background: Prostate cancer is the second most frequently diagnosed cancer in men worldwide. Current treatments include surgery, androgen ablation and radiation. Introduction of more targeted therapies in prostate cancer, based on a detailed knowledge of the signalling pathways, aims to reduce side effects, leading to better clinical outcomes for the patient. ADAM19 (A Disintegrin And Metalloproteinase 19) is a transmembrane and soluble protein which can regulate cell phenotype through cell adhesion and proteolysis. ADAM19 has been positively associated with numerous diseases, but has not been shown to be a tumor suppressor in the pathogenesis of any human cancers. Our group …

Maturity, Physical Ability, Technical Skill And Coaches' Perception Of Semi-Elite Adolescent Australian Footballers, A Cripps, L Hopper, C Joyce

Health Sciences Papers and Journal Articles

Purpose: To confirm the effect of maturational differences on anthropometric and physical testing and explore the effect of maturation on technical skill and coaches’ perceptions of skill in adolescent Australian footballers.

Methods: Athletes were recruited from a semi-elite under 16 competition (n = 94, age 15.7 ± 0.3 years) and completed anthropometric, physical, and technical skill tests. Coaches from each team provided subjective ratings of athletes’ technical skills. Maturation groups were derived from years from peak height velocity estimates, with classifications either later, average or earlier maturing.

Results: Effect size comparisons revealed very large to moderate effects between groups for …

Male And Female Differences In Health Benefits Derived From Physical Activity: Implications For Exercise Prescription, Beth P. Hands, Helen Parker, Dawne Larkin, Marja Cantell, Elizabeth Rose

Health Sciences Papers and Journal Articles

Abstract:

Males are consistently reported as more physically active than females regardless of age or measure. Often, this difference results in females identified as under active and at risk of longterm poor health outcomes. In this paper a different perspective drawing on evidence from many sources is offered. Males and females gain different health benefits according to the level, mode and intensity of the physical activity. Some potential ramifications of these gender differences in health benefits are evident in the prevalence of hypokinetic diseases across the life span and the interpretation of measured physical activity levels and intensities. By focusing …

Dual Energy X-Ray Absorptiometry Compared With Anthropometry In Relation To Cardio-Metabolic Risk Factors In A Young Adult Population: Is The ‘Gold Standard’ Tarnished?, D Demmer, L Beilin, B Hands, S Burrows, C Pennell, S Lye, J Mountain, T Mori

Health Sciences Papers and Journal Articles

Background and Aims: Assessment of adiposity using dual energy x-ray absorptiometry (DXA) has been considered more advantageous in comparison to anthropometryfor predicting cardio-metabolic risk in the older population, by virtue of its ability to distinguish total and regional fat. Nonetheless, there is increasing uncertainty regarding the relative superiority of DXA and little comparative data exist in young adults. This study aimed to identify which measure of adiposity determined by either DXA or anthropometry is optimal within a range of cardio-metabolic risk factors in young adults.

Methods and Results: 1138 adults aged 20 years were assessed by DXA and standard …

Student Perceptions To Teaching Undergraduate Anatomy In Health Sciences, R Anderton, L Chiu, S Aulfrey

Health Sciences Papers and Journal Articles

Anatomy and physiology teaching has undergone significant changes to keep up with advances in technology and to cater for a wide array of student specific learning approaches. This paper examines perceptions towards a variety of teaching instruments, techniques, and innovations used in the delivery and teaching of anatomy and physiology for health science students, and asks whether active learning through more progressive methods of teaching is beneficial for students across health science disciplines. In total, 138 health science students consisting of 32 biomedical science students, 52 exercise and sports science students, and 54 health and physical education students completed the …