Medicine and Health Sciences Commons^™

Critically Appraised Paper For “Cognitive Stimulation Of Executive Functions In Mild Cognitive Impairment: Specific Efficacy And Impact In Memory”, Avery Wilson, Yamin Zaw, Malcolm Isely, Kitsum Li

Occupational Therapy | Critically Appraised Papers Series

Executive functions play a pivotal role in an individual’s independence. However, little research has been conducted on the efficacy of specific cognitive training for individuals with deficits consistent with mild cognitive impairment (MCI). The researchers in this study aimed to use a cognitive stimulation program that taught specific strategies to enhance the participants’ attentional and executive functional tasks. The study, using a crossover design involving two groups, included 30 participants affected by the amnestic form of MCI, executive function deficits, or both. The 6-month training sessions addressed challenges through the use of individualized cognitive strategies and proposed activities to exercise …

Critically Appraised Paper For Occupational Therapy Intervention: Effects On Self-Care, Performance, Satisfaction, Self-Esteem/Self-Efficacy, And Role Functioning Of Older Hispanic Females With Arthritis, Jennifer Borcich, Erin Sheehy, Kitsum Li

Occupational Therapy | Critically Appraised Papers Series

Arthritis is a chronic condition that presents physical and psychosocial challenges that can affect daily functioning. The researchers in this study examined two frequently used methods of occupational therapy intervention—enabling or preparatory activities and occupation-based activities—for managing and improving symptoms of arthritis to improve participation, satisfaction, and self-efficacy in activities of daily living (ADLs).

Twenty-nine older Hispanic women with osteoarthritis participated in the study and were randomized into two intervention groups and a control group. Whereas the occupation-based intervention group consisted of 10–15 min of enabling or preparatory activities, followed by 30 min of occupation-based activities, the enabling/preparatory-based intervention group …

Critically Appraised Paper For “Cognitive Training For Improving Executive Function In Chemotherapy-Treated Breast Cancer Survivors”, Kaitlyn M. Williams, Morgan Mousley, Katherine Blank, Jocelle Flores

Occupational Therapy | Critically Appraised Papers Series

The present literature regarding patients with breast cancer after chemotherapy treatment indicates increased occurrence of cognitive deficits, particularly in executive function. To explore these deficits, the researchers used an online, computer-based intervention program aimed to improve impaired cognition. The population of this study was a group of female breast cancer survivors who had previously received chemotherapy treatment with or without hormonal therapy. The participants were randomly assigned to the intervention group or the control group. The implemented intervention was a home-based cognitive training computer program accessible through an online subscription to the Lumos Lab, Inc. The intervention group completed the …

An Unusual Case Of Cauda Equina Secondary To Spinal Metastasis Of Thyroid Cancer, Shabbir Akhtar, Mohammad Adeel

Department of Surgery Docs

Abstract

INTRODUCTION:

Cauda equina secondary to metastatic follicular thyroid cancer of the lumbosacral area is a rare entity.

CASE REPORT:

We report an unusual case of a 52-year-old male who presented with backache, lower limb weakness, and perianal numbness. A CT-scan of the lumbosacral area showed an enhancing mass at the L4, L5 and S1 vertebrae. Histopathology after excision revealed a metastatic thyroid cancer. Hence, a CT scan of the neck and chest was performed which showed a nodule in the left lobe of the thyroid and a mass in the left chest wall. A total thyroidectomy and excision of …

Autologous Transplant In Lymphomas In Current Era Of Immunotherapy, Natasha Ali, Mohammad Khurshid

Department of Pathology and Laboratory Medicine

No abstract provided.

Clinico-Pathological Profile And Outcomes Of Patients With Polycythaemia Vera, Essential Thrombocythaemia And Idiopathic Myelofibrosis: A Tertiary Care Center Experience From Southern Pakistan, Muhammad Shariq Shaikh, Mohammad Usman Shaikh, Salman Naseem Adil, Mohammad Khurshid, Zeeshan Ansar Ahmed

Department of Pathology and Laboratory Medicine

Background: The “Philadelphia Negative Classic Myeloproliferative Neoplasms” include polycythaemia vera (PV), essential thrombocythaemia (ET) andidiopathic myelofibrosis (IMF). These three disorders share several clinical and laboratory features including JAK2 V617F mutation. Our objectives were to determine the clinicoat hological profile and outcomes of Pakistani patients with polycythaemia vera (PV), essential thrombocythaemia (ET) and idiopathic myelofibrosis (IMF) in order to have an insight regarding behaviour of these conditions.
Methods: A retrospective analysis of all the cases of PV, ET and IMF diagnosed at our institute from January 1995 to December 2013 was performed.Age, gender, clinical presentation, laboratory investigations, treatment provided and …

Agreement Of Direct Antifungal Susceptibility Testing From Positive Blood Culture Bottles With The Conventional Method For Candida Species, Kauser Jabeen, Haresh Kumar, Joveria Farooqi, Raunaq Mehboob, Mary E. Brandt, Afia Zafar

Department of Pathology and Laboratory Medicine

Early availability of antifungal susceptibilities can ensure timely institution of targeted therapy in candidemia, which can improve patient outcomes. This study prospectively determines the agreement between the results of direct testing of antifungal susceptibilities from blood culture bottles by disk diffusion and Etest and the results of standardized susceptibility testing methods; direct testing would allow susceptibility results to be available 1 to 2 days earlier. A total of 104 blood cultures with different Candida species (28% C. albicans, 27% C. parapsilosis, 26% C. tropicalis, etc.) were evaluated between January 2012 and May 2013 for agreement of fluconazole, voriconazole, and amphotericin …

Central, Extraventricular And Atypical Neurocytomas: A Clinicopathologic Study Of 35 Cases From Pakistan Plus A Detailed Review Of The Published Literature, Zubair Ahmad, Nasir Ud Din, Aisha Memon, Mohammad Usman Tariq, Romana Idrees, Sheema Hasan

Department of Pathology and Laboratory Medicine

Background: Central neurocytomas are rare neuronal neoplasms with a favorable prognosis. They are typically located in the lateral ventricles of the brain and mostly histologically correspond to WHO grade II with a Mib 1 labelling index of 2 % and are designated as "atypical neurocytomas.AIM: The aim of our study was to describe the common as well as unusual morphologic features and the role of various immunohistochemical stains in the diagnosis of these rare tumors.MATERIALS AND Methods: We retrieved and reviewed 35 cases diagnosed between 2001 and 2015.Results: Sixty percent of patients were males, and the mean age was 26 …

Errors In Surgical Pathology Reports: A Study From A Major Center In Pakistan, Zubair Ahmad, Romana Idrees, Nasir Uddin, Arsalan Ahmed, Saira Fatima

Department of Pathology and Laboratory Medicine

Background:
Errors in surgical pathology diagnosis can have serious consequences for the patient. Since the final product of a surgical pathology lab is the report, errors can be picked by reviewing reports of cases.AIM: To determine the frequency and types of error in surgical pathology reports of cases signed out in 2014 in a laboratory in Karachi, Pakistan.
Material and Methods:
All surgical pathology reports in which changes were made in the original report after sign out and an amended report was issued were included. Errors included: (1) misinterpretations; (2) missing critical information; (3) erroneous critical information; (4) misidentification; and …

Flaviviruses As A Cause Of Undifferentiated Fever In Sindh Province, Pakistan: A Preliminary Report, Erum Khan, Joveria Q. Farooqi, Kelli L. Barr, Dhani Prakoso, Amna Nasir, Akbar Kanji, Sadia Shakoor, Faisal Riaz Malik, Rumina Hasan, John A. Lednicky

Department of Pathology and Laboratory Medicine

Arboviral diseases are expanding worldwide, yet global surveillance is often limited due to diplomatic and cultural barriers between nations. With human encroachment into new habitats, mosquito-borne viruses are also invading new areas. The actual prevalence of expanding arboviruses is unknown in Pakistan due to inappropriate diagnosis and poor testing for arboviral diseases. The primary objective of this study was to document evidence of flavivirus infections as the cause of undifferentiated fever in Pakistan. Through a cooperative effort between the USA and Pakistan, patient exposure to dengue virus (DENV), West Nile virus (WNV), and Japanese encephalitis virus (JEV) was examined in …

Sporadic Early Onset Colorectal Cancer In Pakistan: A Case- Control Analysis Of Microsatellite Instability, Sabeehuddin Siddique, Kanwal Tariq, Sobia Rafiq, Ahmed Raheem, Rashida Ahmed, Munira Shabbir-Moosajee, Kulsoom Ghias

Department of Pathology and Laboratory Medicine

Background: Early onset sporadic colorectal cancer (CRC) is a biologically and clinically distinct entity hypothesized to exhibit differences in histological features and microsatellite instability (MSI) as compared to typical onset CRC. This study compared the MSI status, mismatch repair enzyme deficiency and clinicopathological features of early onset (aged ≤45 years) with controls (>45 years).
Materials and Methods: A total of 30 cases and 30 controls were analyzed for MSI status using the Bethesda marker panel. Using antibodies against hMLH1, hMSH2 and hMSH6, mismatch repair protein expression was assessed by immunohistochemistry. Molecular characteristics were correlated with clinicopathological features.
Results: …

Data Management And Data Facilitation In Multi-Center Large Cohort Health Care Studies, Wei Wang

Dissertations, Master's Theses and Master's Reports

Data management and data facilitation is the foundation and a critical part for scientific investigations, especially with large cohort studies on health care, which may have multiple components collected from different institutes or different areas due to efficiency, cost, enrollment considerations. In this thesis, I consider how to design and to implement data management with multi-center health care research data. The research project that I joined focuses mainly on environmental health science, and the primary goal is to investigate the impact of nutritional and toxicant exposures in environment during fetal and early postnatal life on individual’s health outcomes over the …

Determinants Of Activity Levels In African Americans With Mild Cognitive Impairment., Barry W. Rovner, Md, Robin J. Casten, Phd, Benjamin E. Leiby, Phd

Department of Neurology Faculty Papers

Engaging in cognitive, social, and physical activities may prevent cognitive decline. In a sample of older African Americans with mild cognitive impairment (MCI; N=221), we investigated the cross-sectional relationships between activity levels and participants' demographic, clinical, and neuropsychological characteristics. The average age of participants was 75.4 years (SD, 7.0); 177 (80.1%) were women. Participation in cognitive/social activities was positively associated with education, depression, literacy, mobility, instrumental activities of daily living (IADL), verbal learning, and subcomponents of executive function. A linear regression identified IADLs, education, depression, and verbal learning as independent predictors. Participation in physical activities was positively associated with sex, …

Depression And Anxiety: A Snapshot Of The Situation In Pakistan, Bilaal Ahmed, Syed Faaiz Enam, Zafar Iqbal, Ghulam Murtaza, Shahid Bashir

Medical College Documents

Background: Depression is a great cause of morbidity around the world. Not one person seems to escape the hollow dread that the disease can bring forth.
Aims: Although living in a large extended family which serves as a social support is common in Pakistan, why we still suffer from anxiety and depression just as often if not more than those in other countries?
Method: We checked studies conducted in different localities of Pakistan over the past 10 years to find prevalence values of anxiety and depression. Results: The values of anxiety and depression ranging from 22% to as high as …

The Effects Of Plyometric Training On Spinal And Supraspinal Motor Control, Jeffrey R. Doeringer

Internet Journal of Allied Health Sciences and Practice

Purpose: The purpose of this study was to determine the effects of plyometric training on spinal and supraspinal motor control in healthy active females. Methods: A 2 (Group) x 2 (Session) x 2 (Stance) mixed model design was used for homosynaptic depression (HD) and recurrent inhibition (RI) data. A 2 (Group) x 2 (Session) mixed model design was used for H:M ratios and V-waves (V:M ratios) data. Thirty-one participants were recruited to participate in the study. Participants participated in either the training or control group for 6-weeks. All participants were measured pre- and post-intervention on H:M ratios, HD, RI, …

The Effects Of A Hip Flexor Stretching Program On Running Kinematics In Individuals With Limited Passive Hip Extension, Jeff H. Mettler

Theses and Dissertations--Kinesiology and Health Promotion

INTRODUCTION: Tightness of the hip flexor muscle group may contribute to altered sagittal plane kinematics of the lumbo-pelvic-hip (LPH) complex during dynamic movements. Therefore, the purpose of this study is to analyze the effects of a three-week home-based stretching program on passive hip extension (PHE), as well as on active hip extension (AHE), anterior pelvic tilt (APT), and lumbar spine extension (LSE) when running. METHODS: Twenty healthy subjects with limited PHE underwent a 3D gait analysis both prior (PRE) and following (POST) a three-week static hip flexor stretching program. RESULTS: Following the stretching program, peak PHE increased significantly (P < 0.001), while no significant improvements were reported in AHE, APT, or LSE. In addition, no relationship was found between the change in PHE with either the change in AHE, APT, or LSE. Finally, a high relationship was observed between AHE and APT during running (r = 0.83, p < 0.001), and low relationships were observed between APT and LSE (r = -0.41, p = 0.08) and AHE and LSE (r = -0.34, p = 0.15). CONCLUSION: A three-week static stretching program of the hip flexor musculature resulted in an increase in PHE, but the sagittal plane kinematics of the LPH complex during running remained unchanged. The correlations observed between AHE, APT, and LSE suggest there is a kinematic relationship between the hip, pelvis, and spine.

Diagnostic Practices Of Autism Spectrum Disorders In Brazil, Ana Claudia Vespa Mainer Dias

Master's Theses

In Brazil, in spite of over half a million students with special needs in primary education, little research has been conducted about ASD diagnostic practices. This involves learning about the training that professionals are receiving, what diagnostic practices are being implemented on the field, and whether those are being contextualized according to the Brazilian culture. Students with special needs are directly affected by the results of diagnostic practices, since identifying the individuals is one of the first steps. Lack of understanding about that stage may lead to the problematic realities of underidentification or overidentification, exclusion of children who should receive …

Exploration Of The Srx-Prx Axis As A Small-Molecule Target, Murli Mishra

Theses and Dissertations--Toxicology and Cancer Biology

Lung cancer is a leading cause of cancer-related mortality irrespective of gender. The Sulfiredoxin (Srx) and Peroxiredoxin (Prx) are a group of thiol-based antioxidant proteins that plays an essential role in non-small cell lung cancer. Understanding the molecular characteristics of the Srx-Prx interaction may help design the strategies for future development of therapeutic tools. Based on existing literature and preliminary data from our lab, we hypothesized that the Srx plays a critical role in lung carcinogenesis and targeting the Srx-Prx axis or Srx alone may facilitate future development of targeted therapeutics for prevention and treatment of lung cancer. First, …

Missing The 'Target': Preventing The Unjust Inclusion Of Vulnerable Children For Medical Research Studies, Ruqaiijah Yearby

All Faculty Scholarship

The central purpose of medical research on children is to generate new knowledge that can improve children’s health, subject to ethical standards that promote justice. Incorporated in U.S. law, international law, and European Union law, the Justice Principle prohibits targeting in medical research, which is the selection of research subjects because of their manipulability and compromised position, rather than for reasons directly related to the problem being studied. Unfortunately, medical research studies involving children have too often violated the Justice Principle, by targeting children in a compromised position due to their health status and vulnerable to manipulability because of their …

The Case For Health Literacy Research In Qatar: Identifying Avenues For Progress, Yasar Alani

Theses

Abstract This thesis studies the attitudes of healthcare provider and consumer groups in Qatar towards health literacy via health promotion. Using Q methodology, data from healthcare providers and consumers was analysed to determine relative attitudes towards previous and future health campaign strategies in Qatar. Consumer data was also collected to determine attitudes towards current health promotion campaigns and the perceived effectiveness of campaigns in encouraging behaviour change. The research also investigates the obstacles that prevent healthcare consumers from adopting the healthier lifestyle choices advocated by some of these campaigns. Participants were residents of Qatar.

The concept of health literacy was …

Multifunctional Nanocarriers For Cancer Therapy, Bei Cheng

Theses and Dissertations

Cancer is one of the leading causes of human mortality and mortality in all diseases. There has been a boost in developing nanocarrier-based therapies for treating cancer or other diseases during the past decade. One of the major advantages about nanocarrier (with the size range from 1-1000 nm) lies in its ability to specifically target tumor and maximize drug accumulation in tumor foci through the enhanced permeability and retention effect. Advancement in nanotechnology has opened a new paradigm in pharmaceutical field. But new challenges have to be overcome in order to fully exploit the technology and improve safety in clinical …

Comparison Of The Effects Of Energy Flux On Metabolic Conditions And Satiety In Young Adults, Molly Madison Demello

Theses and Dissertations

Within the United States, 68% of all adults have been classified as overweight to obese, as defined by 25 kg/m2 ≤ BMI ≤ 35 kg/m2. Research has shown that overweight/obese individuals can still gain health benefits through participation in aerobic activity without losing weight. These improvements include improved glucose control, CRF, HDL and quality of life. More research is necessary to understand the health benefits associated with a chronic aerobic intervention under weight stable conditions. We therefore examined the health benefits of an aerobic 6-month intervention under weight stable conditions on body composition, cholesterol and measurements of appetite and satiety …

Factors Influencing The Collagen Fiber Angle Distribution In The Mouse Aorta, Shana Roach Watson

Theses and Dissertations

The aortic extracellular matrix (ECM) consists of microstructural proteins, collagen and elastin, together with proteoglycans and other components. The matrix metalloproteinases (MMPs) are proteolytic enzymes that influence morphological and structural changes in the ECM and can degrade the matrix as it responds to cellular behaviors such as angiogenesis, apoptosis, proliferation, and migration. Collagen is the most important component among the extracellular proteins because it provides strength and stability to the tissue. Changes in collagen content play a major role in the development of atherosclerosis. These changes can be induced by increased or decreased proteinase activity. Therefore, we studied the collagen …

Progesterone-Only Oral Contraceptive Pill, Breast Cancer, Heart Disease, And Stroke, Marsha Ema Samson

Theses and Dissertations

There is evidence from earlier studies that oral contraceptive pills may be a risk factor for certain chronic diseases, including heart disease, stroke, and breast cancer. Previous studies mainly focus on the estrogen component of combined (estrogen+ progestin) oral contraceptives (COCs) due to their popularity. This focus limits our understanding of progestin-only contraceptives and its relationship to commonly occurring chronic diseases. To provide insight into alternative methods of oral contraception, this dissertation explores the relationship between progestin-only oral contraceptive (POC) pills and heart disease, stroke, and breast cancer. We hypothesize that women using POCs are less likely to have certain …

Social Capital And Social Networks: The Importance Of Social Ties For Health Among Residents Of Disadvantaged Communities, Stephanie Child

Theses and Dissertations

Access to social capital via social networks is important for health and may be linked with chronic disease, including obesity and hypertension. Socioeconomic status (SES) may influence access to social capital and social network characteristics, and may also moderate the relationship between social capital, social networks, and health. Yet few studies have explored relationships between social capital, social networks, and chronic disease among resource poor individuals.

Respondent-driven sampling was employed to recruit participants (n=430) from low-income communities in the US South for a household survey as part of the Greenville Healthy Neighborhoods Project. The survey collected information about participants’ SES …

Effect Of Fluid Temperature And Volume On Thermoregulation In The Heat, Michelle M. Johannsen

Graduate Student Theses, Dissertations, & Professional Papers

The link between thermoregulation, hydration status, and exercise performance in hot humid environments is controversial. The purpose of this study was to evaluate the effects of volume and temperature of ingested fluid on hydration status, thermoregulation and exercise performance. Recreationally active males (N=11, 24.7±5.9 years; VO₂max=58.2±6.0 mL/kg/min) completed two 3-hour intermittent exercise trials in the heat (31^o WBGT=35.5°C with 50% humidity). Participants consumed either 1 mL/kg body weight (BW) of room temperature water (35.5°C; ROOM) or 0.5 mL/kg of an ice slurry mixture (~0°C; COLD) every ten minutes throughout the trials in a randomized crossover design. Subjects …

International Consortium On Mammographic Density: Methodology And Population Diversity Captured Across 22 Countries, Valerie A. Mccormacka, Anya Burton, Isabel Dos-Santos-Silva, John H. Hipwell, Caroline Dickens, Dorria Salem, Rasha Kama, Mikael Hartman, Charmaine Pei Ling Lee, Kee-Seng Chia, Vahit Ozmen, Mustafa Erkin Aribal, Anath Arzee Flugelman, Martín Lajous, Ruy Lopez-Riduara, Megan Rice, Isabelle Romieu, Giske Ursin, Samera Qureshi, Huiyan Ma, Eunjung Lee, Carla H. Van Gils, Johanna O.P. Wanders, Sudhir Vinayak, Rose Ndumia, Steve Allen, Sarah Vinnicombe, Sue Moss, Jong Won Lee, Jisun Kim, Ana Pereira, Maria Luisa Garmendia, Reza Sirous, Mehri Sirous, Beata Peplonska, Agnieszka Bukowska, Rulla M. Tamimi, Kimberly Bertrand, Chisato Nagata, Ava Kwong, Celine Vachon, Christopher Scott, Beatriz Perez-Gomez, Marina Pollan, Gertraud Maskarinec, Graham Giles, John Hopper, Jennifer Stone, Nadia Rajaram, Soo-Hwang Teo, Shivaani Mariapun, Martin J. Yaffe, Joachim Schüz, Anna M. Chiarelli, Linda Linton, Norman F. Boyd

Imaging & Diagnostic Radiology, East Africa

Mammographic density (MD) is a quantitative trait, measurable in all women, and is among the strongest markers of breast cancer risk. The population-based epidemiology of MD has revealed genetic, lifestyle and societal/environmental determinants, but studies have largely been conducted in women with similar westernized lifestyles living in countries with high breast cancer incidence rates. To benefit from the heterogeneity in risk factors and their combinations worldwide, we created an International Consortium on Mammographic Density (ICMD) to pool individual-level epidemiological and MD data from general population studies worldwide. ICMD aims to characterize determinants of MD more precisely, and to evaluate whether …

Linking Obesity & Breast Cancer: Role Of Monocyte Chemoattractant Protein-1 And High Fat Diet-Induced Inflammation On Mammary Tumorigenesis, Taryn L. Cranford

Theses and Dissertations

More than two-thirds of the adult population in the United States is classified as overweight or obese. In order to fully comprehend this rapidly increasing dilemma, further understanding of the complex phenomena that are involved with obesity and its many comorbidities is necessary. Chronic inflammation represents a distinctive, recurrent feature of obesity and has been associated with an increased risk of breast cancer. Monocyte chemoattractant protein 1 is a crucial component of the inflammatory process and represents a potential therapeutic treatment target, not only in obesity but also in breast cancer. Using a monocyte chemoattractant protein deficient model, we examined …

An Investigation Of Nurse Education Service Models In Acute Care Metropolitan Hospitals Across Australia, Carolyn Keane

Theses

The provision of continuing professional development for nurses is necessary to support the delivery of safe patient care. Nurse education departments need to function as effectively and efficiently as possible, producing measurable outcomes to justify their cost in regard to the organisation’s financial bottom line. In reviewing the literature, three recognised models of nurse education services within hospitals were identified. These are described as centralised, decentralised and combination models. All of these models have advantages and disadvantages that can affect service delivery, quality of service and cost.

The purpose of this study was to investigate the different nurse education service …

Temporal Trends Of Corporate Sponsorship In Medical Research, Elijah Bodey

Honors Projects

Data will be collected from medical journals to assessed changes in the nature and prevalence of corporate sponsorship. The journals that will be reviewed are the Journal of the American Medical Association (JAMA), the New England Journal of Medicine (NEJM), the British Medical Journal (BMJ), and the Lancet. These journals were chosen because of their high impact on medical research representing both American and British Medical editorials. It has been shown that corporate sponsorship has been associated with bias results (Kjaergard et al 2002). Changes in the nature of corporate sponsorship would be linked to changes in economic climate and …