Medicine and Health Sciences Commons^™

The Psychological Effects Of Cochlear Implants: A Comparison Of One Adult With A Cochlear Implant And One Without., Sarah Schwartzer

Williams Honors College, Honors Research Projects

This study involved the development, implementation and analyzation of two qualitative case studies, with one involving a profoundly deaf individual who possesses a cochlear implant, the other with an individual who possesses normal hearing ranges. Participants were given two quantitative measures of observation, the Acceptance and Action Questionnaire and the Thought Control Questionnaire, before participating in a semi-structured interview that was intended to gather information about the individuals, their life experiences, and the factors of psychological flexibility, adaptability and resiliency as applied to their lives. The semi-structured interview involved a set list of questions that were posed to the individuals; …

The Effects Of Left Vs Right Hemisphere Cerebrovascular Accident, And Treatment, Nellie M. Turner

Williams Honors College, Honors Research Projects

This project takes an in depth look at the various methods of treatment for stroke patients, the results that are gained, and the possible benefits and detriments of each type of treatment when administered properly. It examines the definition of a Cerebrovascular accident (CVA), and the various symptoms that occur when the left versus the right hemisphere is affected. The different causes of strokes are taken into account, along with the wide range of ways the victims may be affected by it, physically and mentally. It is important to be familiar with the different methods of treatment for a patient …

Association Between Personal Exposure To Ambient Metals And Respiratory Disease In Italian Adolescents: A Cross-Sectional Study, Maria José Rosa, Chiara Benedetti, Marco Peli, Filippo Donna, Marco Nazzaro, Chiara Fedrighi, Silvia Zoni, Alessandro Marcon, Neil Zimmerman, Rosalind Wright, Roberto Lucchini

School of Health Sciences Faculty Publications

Background

Release of ambient metals during ferroalloy production may be an important source of environmental exposure for nearby communities and exposure to these metals has been linked to adverse respiratory outcomes. We sought to characterize the association between personal air levels of metals and respiratory health in Italian adolescents living in communities with historic and current ferroalloy activity.

Methods

As part of a study in the industrial province of Brescia, Italy, 410 adolescents aged 11–14 years were recruited. Participants were enrolled from three different communities with varying manganese (Mn) levels: Bagnolo Mella which has current ferroalloy activity, Valcamonica, which has …

Nutrition Education At First Glance, Allison G. Leffler Miss, Sarah O. Ulrich Miss

Williams Honors College, Honors Research Projects

This project is a community-based program conducted in a local community center, First Glance. It specifically worked with the Teen Mom and Young Mom programs as well as with their children in the Tiny Glancers program. Over the course of a year the authors planned, created, and implemented an interdisciplinary nutrition education unit with the objective of increasing their nutrition and health awareness while providing support in education fundamentals such as math skills and social-cultural awareness. The unit included pre-assessment surveys as well as round-table discussions with the participants to establish base knowledge, correlating yet age-appropriate lessons for the moms …

Relationship Among Motivation, Emotion Regulation, And Psychological Well-Being Of Sophomore And Senior Level Baccalaureate Nursing Students, Aryene C. Delgado, Douglas Garner, Nicole Langhals

Williams Honors College, Honors Research Projects

Nursing education and professional work involve stressful circumstances that may indirectly lead to attrition, which can further contribute to the projected nursing shortage. This study examines the relationships between motivation, emotional regulation, psychological well-being and academic performance in baccalaureate sophomore and senior level nursing students at a Midwest urban university in the United States. The non-experimental, correlational study is guided by the self-determination theory (Deci & Ryan, 2000) and uses online survey data collection and convenience sampling. Motivation, emotional regulation, psychological well-being (burnout; inauthenticity), and academic performance (GPA) are measured respectively with Deci and Ryan’s scale, the Emotion Regulation Questionnaire, …

The Relationship Between Stress And Social Support In Baccalaureate Nursing Students, Hannah M. Greczanik, Vincent A. Lupico

Williams Honors College, Honors Research Projects

Nursing students experience high levels of stress throughout their college career. When it comes to managing this stress, the use of social support as a coping mechanism may be a factor. The purpose of this study was to examine the relationship between social support and stress in undergraduate baccalaureate nursing students and to compare social support and stress across levels of education. The study was guided by the Transactional Model of Stress and Coping. This study used a non-experimental descriptive design and a cross-sectional data collection with an online survey. The sample was a convenience sample of second, third, and …

Hydroband: The Continuous Hydration Monitoring System, Karina E. Atkinson, Catherine P. Benedict

Williams Honors College, Honors Research Projects

Dehydration is defined as a mild, moderate, or extreme loss of water in the body. It can result in fever, muscle cramps, headaches, dizziness, or heat stroke in athletes. Ways to determine hydration levels include analysis of the urine, blood, or sweat, body weight changes, skin elasticity tests, and increases in core temperature. Patent search, research journals, and outside studies in the health and fitness market showed that a convenient and continuous hydration monitoring system was not available. Changes in core body temperature proved to be the quickest way to measure hydration levels. The HydroBand system is geared towards athletes …

The Effect Of School Based Nursing On Health Related Outcomes In Children: A Review Of Literature, Alexandra M. Pianalto, Mitchell C. Wall

Williams Honors College, Honors Research Projects

Background: School nursing staff deal with acute, chronic, screening, and education issues in the school based clinic. It is the school nursing staff’s role to provide care and treatment to children during school hours.

Purpose: Conduct a systematic review of the literature comparing disposition outcomes of children seen by school nursing staff to answer the PICO question: How does implementation of school based nursing affect health related outcomes in children within and outside the school environment?

Methods: Integrative literature review

Description of Evidence: Twenty research articles chosen from the database CINAHL, articles published within past nine years

Critical Appraisal: …

A Systematic Review: Effects Of Psychosocial Interventions On Outcomes In Refugee Adolescents Resettled In The Us, Canada, And The Uk, Lauren Herr, Halle Kurtz

Williams Honors College, Honors Research Projects

Abstract

Problem: The number of refugee and displaced people in the United States (US) increases annually. Because of trauma in countries of origin, they may have mental health problems and disrupted adjustments during resettlement, resulting in problems with refugee adolescents and their quality of life, self-esteem, self-efficacy, and overall well-being.

Purpose: To describe and appraise evidence about the effects of psychosocial interventions in refugee adolescents resettled in the US.

Methods: Studies from US, Canada, and the United Kingdom (UK) were identified in four databases. Inclusion criteria included: primary studies, children and/or adolescents, psychosocial health interventions, and refugees.

Review of …

Novel Approaches For Ungual And Trans-Ungual Delivery Of Drugs, Avadhesh Singh Kushwaha

Electronic Theses and Dissertations

Topical therapy is commonly used for the treatment of nail diseases such as onychomycosis and nail psoriasis due to less severe side effects, non-invasiveness, direct drug delivery at the site of infection, patient compliance and lower cost of treatment. However, topical treatment is limited due to poor permeability and hard nature of nail plate. The main objective of first project was to investigate the penetrability of apremilast into and across the nail plate, folloby the preparation of a novel nail lacquer formulation to improve its ungual and trans-ungual permeation for the treatment of nail psoriasis. Dexpanthenol and salicylic acid were …

Ureaplasma Diversum Genome Provides New Insights About The Interaction Of The Surface Molecules Of This Bacterium With The Host, Lucas M. Marques, Izadora S. Rezende, Maysa S. Barbosa, Ana M. Guimarães, Hellen B. Martins, Guilherme B. Campos, Naila C. Do Nascimento, Andrea P. Dos Santos, Aline T. Amorim, Verena M. Santos, Sávio T. Farias, Fernanda A C Carrence, Lauro M. De Souza, Melissa Buzinhani, Victor E. Arana-Chavez, Maria E. Zenteno, Gustavo P. Amarante-Mendes, Joanne Messick, Jorge Timenetsky

Department of Comparative Pathobiology Faculty Publications

Whole genome sequencing and analyses of Ureaplasma diversum ATCC 49782 was undertaken as a step towards understanding U. diversum biology and pathogenicity. The complete genome showed 973,501 bp in a single circular chromosome, with 28.2% of G+C content. A total of 782 coding DNA sequences (CDSs), and 6 rRNA and 32 tRNA genes were predicted and annotated. The metabolic pathways are identical to other human ureaplasmas, including the production of ATP via hydrolysis of the urea. Genes related to pathogenicity, such as urease, phospholipase, hemolysin, and a Mycoplasma Ig binding protein (MIB)—Mycoplasma Ig protease (MIP) system were identified. More …

Under-Reactive But Easily Distracted: An Fmri Investigation Of Attentional Capture In Autism Spectrum Disorder, Brandon Keehn, Aarti K N Nair, Alan J. Lincoln, Jeanne Townsend, Ralph Axel Müller

Department of Speech, Language, and Hearing Sciences Faculty Publications

For individuals with autism spectrum disorder (ASD), salient behaviorally-relevant information often fails to capture attention, while subtle behaviorally-irrelevant details commonly induce a state of distraction. The present study used functional magnetic resonance imaging (fMRI) to investigate the neurocognitive networks underlying attentional capture in sixteen high-functioning children and adolescents with ASD and twenty-one typically developing (TD) individuals. Participants completed a rapid serial visual presentation paradigm designed to investigate activation of attentional networks to behaviorally-relevant targets and contingent attention capture by task-irrelevant distractors. In individuals with ASD, target stimuli failed to trigger bottom-up activation of the ventral attentional network and the cerebellum. …

Reference Ranges And Association Of Age And Lifestyle Characteristics With Testosterone, Sex Hormone Binding Globulin, And Luteinizing Hormone Among 1166 Western Chinese Men, Xubo Shen, Ruifeng Wang, Na Yu, Yongjun Shi, Honggang Li, Chengliang Xiong, Yan Li, Ellen M. Wells, Yuanzhong Zhou

School of Health Sciences Faculty Publications

Decreased total testosterone (TT) is the recommended metric to identify age-related hypogonadism. However, average TT and the extent to which it varies by age, can vary substantially among different populations. Population-specific reference ranges are needed to understand normal versus abnormal TT levels. Therefore, the goal for this study was to describe androgen concentrations and their correlates among Western Chinese men. We completed a population-based, cross-sectional study including 227 young adults (YA) (20–39 years) and 939 older adults (OA) (40–89 years). We measured TT, sex-hormone binding globulin (SHBG), luteinizing hormone (LH), testosterone secreting index (TSI), and calculated free testosterone (cFT). Reference …

Identifying Mechanisms Of Resistance And Potential Therapeutic Targets For Pediatric Acute Myeloid Leukemia, John Timothy Caldwell

Wayne State University Dissertations

Acute myeloid leukemia (AML) is a potentially devastating disease that can affect people of all ages. While there are certain patient groups that typically have favorable outcomes, in the pediatric population, overall survival (OS) is approximately 70%, leaving much progress to be made. Children with Down syndrome (DS) have a substantially elevated risk for developing AML, especially of the megakaryocytic phenotype (AMKL).

Patients with DS AMKL almost universally harbor a mutation in the gene encoding the GATA1 transcription factor, resulting in the translation of a short-form protein GATA1s, which has been shown to contribute to chemotherapy sensitivity. In contrast, in …

Assessing Patient-Centered Communication In Medical Education: A Crystallized Approach To Understanding The Quality, Nature, And Form Of Feedback By Standardized Patients, Simone Kathe Brennan

Wayne State University Dissertations

Patient-centered Communication (PCC) is the gold standard in effective clinical communication. Feedback from Standardized Patients (SPs) provides one strategy to teach PCC. SP feedback is highly valued, but little is understood about its quality, nature, and the form in which it is actually delivered. Methods: Using the meta-method of crystallization (Ellingson, 2009), I conducted three unique studies, content analysis, iterative thematic analysis, and narrative analysis of SP feedback. These analyses were conducted using transcribed SP feedback from a multi-station, residency-based Objective Structured Clinical Exam (OSCE). SPs in this OSCE were trained using the adapted version of the Kalamazoo Essential Elements …

Muscle Metaboreflex And Arterial Baroreflex: Action, Interaction And Altered Control In Heart Failure, Jasdeep Kaur

Wayne State University Dissertations

Stimulation of skeletal muscle afferents by metabolites that accumulate in the exercising muscle elicits a large pressor response, termed the muscle metaboreflex. Muscle metaboreflex activation during submaximal exercise induces large increases in arterial pressure, cardiac output, heart rate and ventricular contractility however, the vascular responses have varied in previous studies. We addressed three specific questions: 1) what are the mechanism(s) regulating the non-ischemic vasculature during muscle metaboreflex activation in normal subjects, 2) whether muscle metaboreflex activation vasoconstricts the ischemic active muscle from which this reflex originates and if this vasoconstriction is exaggerated in heart failure and 3) how do the …

Neural Circuitry Deficits Associated With Dysfunctional Myelin, Kathleen June Maheras

Wayne State University Dissertations

In the current study, we have generated mutant mice that lack Claudin 11 (Cldn11) tight junctions in CNS myelin sheaths. In myelin sheaths, Cldn11 forms tight junctions located along the outer and inner edges of the membrane spiral, preventing ions and small molecules from entering the intramyelinic space. The function of Cldn11 tight junctions is to improve the passive properties of the myelin membrane, by increasing membrane resistance and reducing capacitance, thereby improving the speed of saltatory conduction. In the absence of Cldn11, conduction velocity is slowed, most dramatically in small diameter myelinated fibers, somewhat analogous to reducing myelin thickness. …

Cognitive Health And African American Elders Study: Knowledge, Attitudes And Practices, Shelytia Cocroft

Wayne State University Dissertations

A substantial body of literature suggests that cognitive impairment disproportionately affects African Americans. To date, research has uncovered disturbing racial disparities associated with the prevalence of cognitive impairment and dementia and found prevalence rates of Alzheimer’s disease (AD) to be higher among African Americans (Potter et al., 2009). Furthermore, a 2002 report from the Alzheimer’s Association described AD in the African American community as an “emerging public health crisis”. This dissertation examined the impact of socioeconomic status (SES) on knowledge, attitudes, and practices (KAP) associated with the promotion of cognitive health among a sample of 120 African American women aged …

Role Of Secretory Granule Heterogeneity In Calcium-Triggered Exocytosis, Tejeshwar Rao

Wayne State University Dissertations

The sympathetic nervous system is activated by a variety of threats to organismal homeostasis. The adrenomedullary chromaffin cell is the core effector of sympathetic activity in the peripheral nervous system. By design, the chromaffin cell secretory response is mutable so that release can be rapidly tuned to drive context-dependent changes in physiological function. However, the mechanisms by which this tuning is achieved with such high temporal fidelity and context specificity remain unclear. This represents a major gap in our understanding of the sympatho-adrenal system since it is known to modify the function of nearly every organ system in the body. …

Meta-Synthesis Of Sampling Methods Using Coding Strategies And Social Media For Deaf And Hard Of Hearing Nursing Students, Timberly Robinson Robinson

Wayne State University Dissertations

In 2010, the birth of an aggressive strategy began to emerge aimed to increase the number of Deaf and Hard of Hearing (D/HH) individuals in professional healthcare fields. Employers and higher education admission officials desired more research. Data revealed that the field of nursing had a higher percentage of Deaf and Hard of Hearing professionals than other areas. Yet, there is a gap in the literature related to in-depth accounts about the learning experience and clinical training of D/HH nursing students. A phenomenological study was conducted to examine nursing experiences (homogenous sampling) compared to other clinical and non-clinical D/HH majors …

The Psychology And Neurobiology Of Mediation, Elizabeth E. Bader

Cardozo Journal of Conflict Resolution

This article grew out of a moment in mediation when a party became furious with me after receiving the opening offer from the other side. As I tried to understand what was happening, I suddenly realized it was not about the offer at all. It was about him. He feared a loss of "face" in front of the other parties.

Hot And Cold Executive Functions In Pure Opioid Users Undergoing Methadone Maintenance Treatment: Effects Of Methadone Dose, Treatment Duration, And Time Between Last Methadone Administration And Testing, Usha Barahmand, E. Tavakolian, A. Khazaee, K. Mohammadi

Publications and Research

Context: Methadone maintenance is a standard treatment for opiate‑dependent individuals. However, deficits in cognitive functioning have been associated with this treatment.

Aim: This study aimed to determine the dose and treatment duration‑related effects of methadone on executive functions.

Setting and Design: Pure male opioid users with no considerable history of other drug abuse, undergoing methadone maintenance treatment (MMT) were recruited from a major government‑run de‑addiction center.

Methods: Hot executive functions including decision‑making and emotion recognition were assessed using the Iowa gambling task and Ekman faces test, whereas cold executive functions including working memory (WM), cognitive flexibility, and response inhibition were …

Sedentary Behavior-Inducing Randomized Control Intervention On Various Health-Related Outcomes In Active, Young Adults, Meghan Edwards

Electronic Theses and Dissertations

An expansive body of literature has established the positive effects of physical activity on a number of health-related outcomes, including chronic disease prevention (both physiological and psychological). In addition to growing information regarding the benefits of physical activity, recent research has suggested the need to focus future studies on the effects of sedentary behavior (independent of physical activity) on one’s wellbeing. The majority of existing research on sedentary behavior, however, has used cross-sectional study designs. The few experimental studies on sedentary behavior have primarily focused on minimizing prolonged sedentary behavior among inactive individuals, rather than inducing sedentary behavior. We hypothesized …

Critical Quality Attributes Of Topical Semi-Solid Dosage Forms: Solvent Activity, Muralikrishnan Angamuthu

Electronic Theses and Dissertations

Critical quality attribute has been defined as “a physical, chemical, biological or microbiological property or characteristic that should be within an appropriate limit, range, or distribution to ensure the desired product quality”. Deviations from preset quality metrics may potentially result in drug products with inferior therapeutic efficacy and unacceptable clinical safety profile. Topical cream formulations may possess numerous quality attributes that can affect the permeation of the drug through skin and consequently therapeutic efficacy. CQAs of topical formulations are often aimed at characterizing either the physicochemical properties of APIs or bulk characteristics of the formulation itself. Solvent systems constitute a …

Hot-Melt Extrusion: A Versatile Pharmaceutical Technology, Hemlata Patil

Electronic Theses and Dissertations

Hot-melt extrusion (HME) is a promising technology for the production of new chemical entities in the developmental pipeline and for improving products already on the market. The first objective of this research work was to describe a continuous process for the production of solid lipid nanoparticles (SLN) as drug-carrier systems via hot-melt extrusion (HME) using Quality by Design (QbD) principles. Fenofibrate SLN were prepared by combining two processes: HME technology for melt-emulsification and high-pressure homogenization (HPH) for size reduction. Varying the process parameters enabled the production of SLN below 200 nm. At the end of a 5-h in-vitro dissolution study, …

The Determinants Of Productivity In Medical Testing: Intensity And Allocation Of Care, Jason Abaluck, Leila Agha, Chris Kabrhel, Ali Raja, Arjun Venkatesh

Dartmouth Scholarship

A large body of research has investigated whether physicians overuse care. There is less evidence on whether, for a fixed level of spending, doctors allocate resources to patients with the highest expected returns. We assess both sources of inefficiency exploiting variation in rates of negative imaging tests for pulmonary embolism. We document enormous across-doctor heterogeneity in testing conditional on patient population, which explains the negative relationship between physicians’ testing rates and test yields. Furthermore, doctors do not target testing to the highest risk patients, reducing test yields by one third. Our calibration suggests misallocation is more costly than overuse.

Examining The Association Between Leisure Coping Strategies And Mental Health Among College Students, Karolyne Helen Rehner

Electronic Theses and Dissertations

No abstract provided.

Biological And Psychosocial Risk Factors Of Stroke In African Americans Enrolled In The Jackson Heart Study (Jhs), Sasikiran Nunna

Electronic Theses and Dissertations

Objectives: the objective of this study is to estimate the impact of biological, psychosocial and other risk factors on stroke in African Americans enrolled in the JHS and determine the population attributable risk of risk factors. Methods: this study used a nested case control design. Cases were patients with stroke during the follow up period. Corresponding controls were selected from subjects who are alive at that time period and who are at risk of stroke by matching on the person-years spent in the cohort. Odds ratios (OR) and population attributable risks (PAR) were calculated to understand the association of risk …

Heath And The Homeless Population Of Missoula: “Housing First” As A Solution, Marissa S. Ginnett

Undergraduate Theses, Professional Papers, and Capstone Artifacts

Missoula, Montana has an extremely high rate of homelessness at .75% of the population (compared to other large cities, Seattle, Washington at .23% and Los Angeles, California at .32%). This is due to there not being much done to help chronically inebriated homeless individuals. All are turned away from Missoula's overnight shelters if they are not sober. For an inebriated homeless person, the jail and the hospital are the only two places where they can stay the night. Through comparison to other cities, such as Seattle, Washington, I have identified that Missoula needs a wet housing program. Wet housing provides …

Women In White: A Retrospective Look At Medical Education At One School Before Title Ix, Karen Clancy

Theses and Dissertations--Educational Policy Studies and Evaluation

The Women in White generation of women physicians who graduated from American medical schools between World War II and the enactment of Title IX were trailblazers. They successfully pursued and achieved physician careers during a time when doctoring was still considered “man’s work.” They helped to clear a path to a modern medical student culture where women and men had more choices.

In a 2008 oral history interview, Dr. Jacqueline Noonan, world-renowned pediatric cardiologist, discoverer of the congenital heart condition known as “Noonan Syndrome,” and the first woman appointed to a chairman role at the University of Kentucky College of …