Medicine and Health Sciences Commons^™

Caspase-12 And Lupus: The Curious Case Of The Dog That Didn’T Bark, Evan Hermel

Faculty Publications & Research of the TUC College of Osteopathic Medicine

CASPASE-12 (CASP12) has an anti-inflammatory function during infection, and is a risk factor for sepsis in African-Americans (AA). To determine if CASP12 could be protective for systemic lupus erythematosus (SLE) in AA, we genotyped AA SLE patients and controls. We found that, at best, there was a weak association between CASP12 genotype with the absence of anti-dsDNA autoantibodies in SLE patients. No effect was seen upon serum interleukin-1 beta levels, nor was any other protective effect noted for the CASP12 genotype, whether upon association with SLE, or any of the 11 American College of Rheumatology classification criteria. We concluded that …

Marijuana Compounds: A Nonconventional Approach To Parkinson’S Disease Therapy, Mariana Babayeva, Haregewein Assefa, Paramita Basu, Sanjeda Chumki, Zvi G. Loewy

Touro College of Pharmacy (New York) Publications and Research

Parkinson’s disease (PD), a neurodegenerative disorder, is the second most common neurological illness in United States. Neurologically, it is characterized by the selective degeneration of a unique population of cells, the nigrostriatal dopamine neurons. The current treatment is symptomatic and mainly involves replacement of dopamine deficiency.This therapy improves only motor symptoms of Parkinson’s disease and is associated with a number of adverse effects including dyskinesia. Therefore, there is unmet need for more comprehensive approach in the management of PD. Cannabis and related compounds have created significant research interest as a promising therapy in neurodegenerative and movement disorders. In this review …

Pseudomonas Aeruginosa Outer Membrane Vesicles Triggered By Human Mucosal Fluid And Lysozyme Can Prime Host Tissue Surfaces For Bacterial Adhesion, Matteo M. E. Metruccio, David J. Evans, Manal M. Gabriel, Jagath L. Kadurugamuwa, Suzanne M. J. Fleiszig

Faculty Publications & Research of the TUC College of Pharmacy

Pseudomonas aeruginosa is a leading cause of human morbidity and mortality that often targets epithelial surfaces. Host immunocompromise, or the presence of indwelling medical devices, including contact lenses, can predispose to infection. While medical devices are known to accumulate bacterial biofilms, it is not well understood why resistant epithelial surfaces become susceptible to P. aeruginosa. Many bacteria, including P. aeruginosa, release outer membrane vesicles (OMVs) in response to stress that can fuse with host cells to alter their function. Here, we tested the hypothesis that mucosal fluid can trigger OMV release to compromise an epithelial barrier. This was tested using …

Inadequate Sedation During Therapeutic Paralysis: Use Of Bispectral Index In Critically Ill Patients, Chelsea L. Tasaka, Jeremiah J. Duby, Komal Pandya, Machelle D. Wilson, Kimberly A. Hardin

Faculty Publications & Research of the TUC College of Pharmacy

Background: Patients receiving therapeutic paralysis may experience inadequate sedation due to intrinsic limitations of behavioral sedation assessment. Bispectral index (BISTM) provides an objective measure of sedation; however, the role of BISTM is not well defined in intensive care unit (ICU) patients on neuromuscular blocking agents (NMBA).

Objective: The aim of this study was to delineate the relationship between BISTM and level of sedation for critically ill patients during therapeutic paralysis.

Methods: This was a retrospective observational study conducted in ICU patients receiving continuous infusion NMBA and BISTM monitoring. The primary endpoint was the correlation of BISTM\60 during therapeutic paralysis with …

Isavuconazole In The Treatment Of Invasive Aspergillosis And Mucormycosis Infections, Monica A. Donnelley, Elizabeth S. Zhu, George R. Thompson Iii

Faculty Publications & Research of the TUC College of Pharmacy

We have a limited arsenal with which to treat invasive fungal infections caused by Aspergillus and Mucorales. The morbidity and mortality for both pathogens remains high. A triazole antifungal, isavuconazole, was recently granted approval by the US Food and Drug Administration and the European Medicines Agency for the treatment of invasive aspergillosis and mucormycosis. A randomized double-blind comparison trial for the treatment of invasive aspergillosis found isavuconazole noninferior to voriconazole. A separate, open-label study evaluating the efficacy of isavuconazole in the treatment of mucormycosis found comparable response rates to amphotericin B and posaconazole treated historical controls. The prodrug isavuconazonium sulfate …

The Effect Of Thermacare Heat Wraps On Balance And Mobility In Seniors With Impaired Gait - A Cross Over Study, Jerrold S. Petrofsky, Michael S. Laymon, Iman Akef Khowailed, Haneul Lee

College of Health & Human Services (TUN) Publications and Research

To examine if the use of heat at home can result in better quality and safer mobility in the elderly with gait and balance impairments.

Setting: Randomized longitudinal cross over study design in a clinical setting.

Methods: 20 people with impaired mobility (assessed as a score of more than 4 on the Stepping On questionnaire) were tested with a multi-camera gait analysis system, a treadmill with pressure sensors, a balance platform and the timed up and go and walking speed tests before and after using ThermaCare continuous heat wraps on their legs and knees for 6 days at 4 hours …

Medical Marijuana And Pain Management: The Physician’S Catch 22, James M. Mckivigan

College of Health & Human Services (TUN) Publications and Research

In this paper, concerns connected to the usage of marijuana in treating patients are extensively analyzed. It is revealed that physicians have been in conflict with the federal government as to whether to use cannabis for medical purposes or if they should consider prescribing other drugs. A large percentage of physicians admit that marijuana could be an effective drug in treating patients, especially those with acute pain, nausea, AIDS, muscle spasms, and cancer, among other ailments. However, patients and physicians are scared of the strict laws that criminalize the use of marijuana for medical and recreational purposes. Physicians are also …

Yoga As Complementary Alternative Medicine, Let’S Not Forget What Works!, James M. Mckivigan

College of Health & Human Services (TUN) Publications and Research

Practitioners today have to contend with a stream of new treatment options that are increasing in number almost daily. The patients undeniably win when we incorporate the latest technology with traditional treatment methods but too often the old gets completely pushed out to make room for the new. While many Complementary Alternative Medicine (CAM) therapies may be considered “old” by some practitioners, there is still a steady flow of articles being published showing that they remain effective. What if instead of abandoning the traditional therapies we used them in true compliment to the newest options? Here we will explore some …

Role Of Sulfiredoxin Interacting Proteins In Lung Cancer Development, Hedy Chawsheen

Theses and Dissertations--Toxicology and Cancer Biology

Sulfiredoxin (Srx) is an antioxidant enzyme that can be induced by oxidative stress. It promotes oncogenic phenotypes of cell proliferation, colony formation, migration, and metastasis in lung, skin and colon cancers. Srx reduces the overoxidation of 2-cysteine peroxiredoxins in cells, in addition to its role of removing glutathione modification from several proteins. In this study, I explored additional physiological functions of Srx in lung cancer through studying its interacting proteins. Protein disulfide isomerase (PDI) family members, thioredoxin domain containing protein 5 (TXNDC5) and protein disulfide isomerase family A member 6 (PDIA6), were detected to interact with Srx. Therefore, I proposed …

Aligning Religious And Culturally Relevant Clinical Practice With Policy, Amanda F. Hopkins Phd, Rn, Wendy C. Kooken Phd, Rn, Sana Shafiuddin

Students' Professional Presentations and Publications

This poster was presented at the Midwest Nursing Research Society conference in 2016. The purpose of this study was to evaluate cultural considerations in clinical and educational policies when working with female Muslim nursing students who wear hijab, and to suggest changes to dress code policies within academic and clinical agency settings.

Youth In Pakistan: Priorities, Realities And Policy Responses, Zeba Sathar, Iram Kamran, Maqsood Sadiq, Sabahat Hussain

Poverty, Gender, and Youth

Youth is a pivotal stage during which the right policies and interventions in the health, social, educational, and economic sectors can protect young people against risks, and turn the trajectories of their lives toward a safe and productive path of growth. This report explores some of the key issues facing youth in Pakistan, in the main spheres marking their transition to adult roles. It also presents the results of an age-based segmentation analysis capturing where youth in Pakistan stand in terms of school enrollment, work force participation, and marriage, with a view to identifying the broad developmental priorities for each …

Subacute Effects Of Prallethrin On Behavior Of Mosquitoes (Diptera: Culicidae) And Other Human Disease Vectors, Kyndall C. Dye

Theses and Dissertations--Entomology

The synthetic pyrethroid, prallethrin, is an active ingredient in a widely marketed ultralow volume (ULV) mosquito adulticide. Volatilized prallethrin is intended to stimulate mosquito flight, increasing overall effectiveness of the adulticide. However, field tests using volatilized prallethrin did not produce significant differences in various vector trap catches, suggesting prallethrin’s behavioral effects are not viable. Laboratory tests were conducted to evaluate prallethrin’s effect on flight behavior of adult female Asian tiger mosquitoes (Aedes albopictus). Mosquitoes were divided into three groups; a control, those exposed to volatilized prallethrin, and those exposed to a simulated ULV application at label rates. After …

The Africa Regional Sgbv Network Learning Brief Series: Learning Updates From Uganda (Brief #6), Population Council

Reproductive Health

Sexual and gender-based violence (SGBV) in humanitarian contexts is recognized by the UN Refugee Agency as a global concern and as a priority in its programming. Crisis-affected populations often face multiple forms of SGBV at multiple time periods (during conflict, during flight from conflict, and within post-conflict settings). The Africa Regional SGBV Network, set up in 2006, is addressing SGBV in humanitarian contexts in East and Southern Africa. This Learning Brief is one in a series of two that share critical findings on effective responses to the issue in Uganda. This brief notes that relatively higher screening, disclosure, referral, and …

The Africa Regional Sgbv Network Learning Brief Series: Learning Updates From Swaziland (Brief #3), Population Council

Reproductive Health

Nearly half of girls aged 13–24 in Swaziland suffer some form of sexual violence, according to the country’s 2007 Violence Against Children (VAC) survey. About 10 percent of girls reported experiencing sexual and gender-based violence (SGBV) in school in particular. The Swaziland Action Group Against Abuse (SWAGAA) is recognized as Swaziland’s leading SGBV prevention, response, and advocacy organization. This Learning Brief describes how SWAGAA is tackling SGBV in schools in three different ways: 1) helping girls take more control of their school experience through a new self-efficacy module in the Girls’ Empowerment Clubs; 2) encouraging girls, and giving them the …

Operationalizing National Protocol For Preventing And Managing Pe/E In Community Facilities In Bangladesh, Population Council

Reproductive Health

Considering the maternal deaths associated with pre-eclampsia and eclampsia (PE/E), the Bangladesh Ministry of Health and Family Welfare, with technical assistance from the Obstetrical and Gynecological Society of Bangladesh, developed a national protocol allowing community providers to provide a magnesium sulphate (MgSO4) loading dose. With the approval of the National Technical Committee of the Directorate General of Family Planning, this study operationalized and assessed the ability of community providers to detect and treat PE/E, and administer the loading dose of MgSO4 before referral to higher-level facilities. The study results presented in this brief indicate that with national protocol, training, and …

Formative Research On Factors Influencing Access To Fistula Care And Treatment In Uganda, Pooja Sripad, Charlotte E. Warren

Reproductive Health

This formative research builds upon the results of a systematic review by the Population Council for better understanding of the barriers and enabling factors for fistula repair care and access in Uganda. The study focuses on Fistula Care Plus project-supported treatment facilities where fistula camps are routinely held. Results reveal the nuances of women’s experiences, along with the additional perspectives of their spouses, family members, community stakeholders, and fistula camp care providers including nurses/counselors, surgeons, and facility and district managers. Barriers and enablers to fistula repair care are clustered around the following factors: psychosocial, cultural, social, financial, transportation, facility shortages, …

Adapting A Health Systems Strengthening Model To Improve Access To Health Services In A Factory: A Pilot Project In Haiti, Carolyn Rodehau, David Wofford, Suzanne Brockman

Reproductive Health

The pilot intervention described in this brief took place at an apparel manufacturing company, Caribbean Island Apparel SA, located in Port-au-Prince, Haiti. The project by the USAID-funded RAISE Health Initiative sought to demonstrate the value of a new management approach to workplace health services and practices in a garment factory. Specifically, the pilot looked at how the health systems strengthening model could be adapted to the private sector and could help build the factory’s capacity to manage the health staff and infirmary, institute clinical best practices, and expand the primary care roles for nurses, including providing family planning and reproductive …

Analyzing The Building Blocks Of Resilience: Findings From A Baseline Survey Of The Tuungane Population, Health, And Environment Project In Western Tanzania, Kristin Bietsch, Reshma Naik, Kristen P. Patterson, Cara Honzak, Mustafa Kudrati, Hellen Magige, Cheryl Margoluis, Laura Subramanian, Christopher Hale, Carolyn Lamere, Sebastiaan Hess, Craig Leisher

Reproductive Health

Although the value of population, health, environment (PHE) programs is appreciated by the development community and the conceptual linkages they incorporate are sound, little evidence exists to demonstrate their short- and long-term impacts—particularly the role that the family planning (FP) component of PHE projects plays in building resilience, improving livelihoods, and helping people adapt to climate change. To contribute to filling this gap, the Evidence Project collaborated with Tuungane, a PHE project jointly implemented by The Nature Conservancy and Pathfinder International, to conduct further analysis of their existing data and examine the evidence base around integrated PHE programming, FP, climate …

Landscape Analysis Of The Family Planning Situation In Pakistan—District Profile: Lahore, Population Council

Reproductive Health

This district profile of Lahore is part of the Landscape Analysis of the Family Planning Situation in Pakistan. The factsheet provides a detailed picture of contraceptive use and unmet need; use of antenatal and delivery care services; other socioeconomic indicators; availability of health facilities, pharmacies, and lady health workers; distribution of public static and private facilities by cadre; provision of specific family planning methods by sector; and presence and provision of family planning services/products. The factsheet concludes with a review of consumers’ perspectives on barriers to use of family planning and a chart listing district-specific donors, projects, and implementing partners. …

Oncolog, Volume 61, Number 01, January 2016, Sarah Bronson, Bryan Tutt, Bryan Tutt

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Proactive Management of Li-Fraumeni Syndrome Benefits Patients: Li-Fraumeni syndromes a hereditary disorder that confers an extremely high likelihood of developing cancer on affected individuals.
• Clinical Trial Tests High-Dose Radiation Therapy for Limited Stage Small Cell Lung Cancer: Small cell lung cancer carries a poor prognosis, even for patients without metastatic disease. But a phase III trial of high-dose daily or accelerated twice-daily thoracic radiation therapy for limited stage small cell kung cancer may lead to longer survival.
• Reducing Complications and Hospital Readmissions after Liver Surgery: Hepatectomy carries a risk of complications that can lead to hospital readmission and even death. …

Do Physician-Based Or Hospital-Based Provider Service Networks Better Control Medicaid Expenditures?, Sinyoung Park, Jeffrey S. Harman, Allison G. Hall, R Paul Duncan

Department of Health Administration Faculty Publications

In a recent demonstration project, Florida Medicaid enrollees were required to pick a managed care plan that was either a Health Maintenance Organization (HMO) or a Provider Service Network (PSN). PSNs are a form of managed care very similar to Accountable Care Organizations (ACOs) that provides health care services directly through a provider or network of organizations to a defined population without a “middle man” such as a third party insurance company and health plan. There are two types of PSNs: Physician-based PSNs and Healthcare system-based PSNs. Physician-based PSNs are created and controlled by physicians groups. Healthcare system-based PSNs are …

Evaluating The Effectiveness Of Adult Day Care On Alleviating Caregiver Stress/Burden, Lessep Duncan, Joan Bowla, Rosena Tanis

Florida Public Health Review

Though not extensive, the literature points to the efficacy of Adult Day Care (ADC) in alleviating stress on caregivers in several and differing ways. In line with this evidence, the findings from the evaluation of Northwest Focal Point’s (NWFP) ADC program conducted by the Florida Atlantic University Evaluation Team indicates that ADC provides necessary relief and reduces the strain of caregiving on caregivers. Two measurement instruments: one to measure the level of caregiver strain and one to measure the effectiveness of ADC in alleviating this strain comprising five dimensions of caregiving strain and five dimensions of ADC impact in reducing …

The Relationship Of Sexual Health Education And Sexual Health Risk Behavioral Outcomes Among Florida Teens, Brandon Moton, Rima Tawk

Florida Public Health Review

We examined the relationship between sexual health education and sexual health risk behavioral outcomes among adolescents in Florida using Youth Risk Behavior Survey data from 2001 to 2013. Sexual health risk behavioral outcomes (reported condom use and alcohol and/or drug use during last intercourse) were first examined as a function of sexual health education. Multiple logistic regression analysis was then used to adjust for individual characteristics and behavioral risk factors when associating sexual health education with sexual health risk behavioral outcomes. Reported condom use was strongly associated with sexual education. However, the impact of sexual education was attenuated after adjusting …

A Wellness Needs Assessment Of Persons With Disabilities In Northern Florida: Physical Activity And Nutrition, Stacey Griner, Jessica King, Jamie L. Pomeranz

Florida Public Health Review

Engaging an individual with a disability in health promotion activities may be challenging. This challenge is demonstrated by the prevalence of obesity among people with disabilities (PWDs) being higher than those without, and PWD twice as likely to be physically inactive. The combination of physical inactivity and high prevalence of obesity supports a need for health promotion activities. To examine the need for wellness promotion activities for PWDs, we surveyed consumers at a Center for Independent Living in North Central Florida (CILNCF). A survey was developed with items from the Physical Activity Scale for Individuals with Physical Disability (PASIPD) and …

Assessing Attitudes Toward Nicotine Replacement Therapy For Adolescent Smoking Cessation, Jessica L. King, Tzu-Jung Wong, Julie W. Merten, Jamie L. Pomeranz

Florida Public Health Review

The objective was to ascertain attitudes toward nicotine replacement therapy for adolescent tobacco cessation. The authors created a 17-item survey consisting of demographics, quantitative, and qualitative items which was distributed to middle and high school students in North Central Florida. The authors assessed associations and conducted discriminant analyses to compare results by age. One-hundred ninety-eight students completed the survey (57.6% female, 61.6% white). When asked to select the best way to help teens stop using tobacco, combination of methods was most frequently selected (31.6%), followed by “Cold Turkey” (19.5%), e-cigarettes (16.8%), NRT (14.7%), Counseling (10.5%), and Alternative Therapies (6.8%). Qualitative …

The Relationship Between Substance Abuse And Suicide Among Adolescents, Darren Evans, Rima Tawk

Florida Public Health Review

Suicide, prominent in adolescents, presents a major public health problem. This study examined the relationship between substance abuse and suicide among adolescents after adjusting for socio-demographic, interpersonal violence, and mental health variables. Data were drawn from the Youth Risk Behavior Survey. Suicidal measures included ideation, plan, attempts, and severe attempts. Substance abuse, depression, purging, and forced sex were the major predictors. Our findings may be of value to educators, providers, and policymakers in helping to target teens contemplating suicide. To curb incidence of suicidal thoughts and behavior among teens, routine screenings for substance abuse in schools is recommended.

Duval County 2009, 2011, And 2013 Fruit And Vegetable Intake By Health Zone: Data From The Youth Risk Behavior Survey, Zhiping Yu, Alireza Jahan-Mihan, Corrine A. Labyak, Claudia Sealey-Potts, Catherine Christie, Judith Rodriguez, Janice J. Seabrooks-Blackmore, Karen Patterson, Richard Patterson

Florida Public Health Review

The purpose of this study was to compare the results of fruit and vegetable intake data from the 2009, 2011, 2013 Duval County Youth Risk Surveys (YRBS) by health zone. The survey instrument (questionnaire) is administered using a cluster sample design in all ninth grade classes in public schools (except charter schools) every two (odd) years. The surveys are anonymous and there is parental notification. Oversampling is done to allow for sub-county analysis. There were no statistically significant differences across health zones for any of the fruit and vegetable consumption questions for year 2009 however all health zones were below …

Government Programs For Disabled Children: A Practitioner’S Guide To Policy And Programs In Florida, Leaanne Derigne

Florida Public Health Review

There are many government programs and benefits available to disabled children in the United States and include income-support programs, educational and therapeutic programs, and health services. This paper provides a practice/policy update for practitioners working with disabled children and their families. Doctors, nurses, counselors, and educators need to understand the rights of disabled children and their families. A short case scenario is presented followed by a summary of the federal and state policies that are available. Finally, sources of funding for each program are presented.

Heroin Use And Sex: Some Patterns In Miami-Dade County, Florida, David W. Forrest, Bryan Page, Gabriel Cardenas, Caitlin Marquardt, Robin Morey, Lisa R. Metsch, Daniel J. Feaster, Marlene Lalota

Florida Public Health Review

Much of the literature on heroin and opioid addiction holds that regular, long-term users of heroin and other opioids lose interest in sex as their drug using careers lengthen. Analysis of self-reports collected from IDUs in two cross- sectional surveys on patterns of risk behavior in Miami-Dade County, Florida, reveals that large proportions of IDUs report using heroin before or during sex across a wide range of self-injection experience, from as little as twelve months to over 40 years. One half or more of respondents to both surveys reported using heroin in their recent sexual experiences, with similar proportions reported …

Associations Between Health And Academic Success At A Florida University: An Exploratory Cross-Sectional Study, Jessica Weissman, Sharice Preston, Elena Sebekos, Willmarie Latorre, Bandar Alsaif, Karl Krupp, William Darrow

Florida Public Health Review

The aims of the study were to explore the associations between college students’ perception of their overall physical and psychological health and four measures of academic performance. College students (N = 265) completed a 65-item Web-based survey in a university’s student health services building during the spring 2015 semester. Poorer psychological health was associated with seriously considering dropping out of college and missing more classes during the current school year “due to physical or psychological health reasons.” Poorer physical health was associated with enrollment in more credit hours. Students who reported a grade point average (GPA) below 2.0 missed more …