Medicine and Health Sciences Commons^™

Factors Influencing Diabetes Self-Management Of Filipino Americans With Type 2 Diabetes Mellitus: A Holistic Approach, Jocelyn B. Sonsona

Walden Dissertations and Doctoral Studies

There is an increasing prevalence of Type 2 diabetes mellitus among Filipino Americans. However, how well Filipino Americans with diabetes self-manage their disease and what factors influence their diabetes self-management behaviors remain unknown. Based on a holistic approach, this quantitative study was designed to investigate the diabetes self-management behaviors of this population and the factors influencing their self-management behaviors. The combined roles of diabetes knowledge, diabetes self-efficacy, spirituality, and social support were examined in predicting diabetes self-care behaviors. A convenience sample of 113 Filipino Americans with Type 2 diabetes mellitus completed the Diabetes Knowledge Test, Self-Efficacy for Diabetes Test, Daily …

Analysis Of Medication Workflow In An Intensive Care Unit, Claire Roth

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Conceptualizing Social Determinants Of Maternal And Infant Health Disparities, Susanne Klawetter

School of Social Work Faculty Publications and Presentations

Research demonstrates that women and children within marginalized ethnic and racial groups and those living in poverty experience disparate health outcomes. These disparities have immediate and long-term consequences. Exploring two theories used to examine social determinants of health— life course perspective and historical trauma response, this article will explain the major premises of each, provide application examples, compare and examine utility for practice, and highlight areas for future research. A theoretical critique will be included, as well as insight into how these theories together might address gaps as an approach to maternal and infant health research and practice.

Regulation And Targeting Of Fyn In Human Cutaneous Squamous Cell Carcinoma, Sarah Fenton

Dissertations

Fyn, a member of the Src family kinases, is an oncogene in murine epidermis and is associated with cell-cell adhesion turnover and migration. Introduction of active H-Ras(G12V) into the HaCaT human keratinocyte cell line resulted in upregulation of FYN mRNA (200-fold) and protein, but did not increase the expression of other SFKs. We identified two nucleotides 74 bases upstream of the human FYN gene transcription start site as necessary for FYN upregulation in HaCaT-Ras cells. Further studies identified Lef-1 as the transcription factor most likely binding to this site and mediating FYN upregulation.

Transduction of active Ras or Fyn was …

Β-Alanine Supplementation Improves Tactical Performance But Not Cognitive Function In Combat Soldiers, William Mccormack

Health and Human Sciences Faculty Works

Background: There are no known studies that have examined β-alanine supplementation in military personnel. Considering the physiological and potential neurological effects that have been reported during sustained military operations, it appears that β-alanine supplementation may have a potential benefit in maintaining physical and cognitive performance during high-intensity military activity under stressful conditions. The purpose of this study was to examine the effect of 28 days of β-alanine ingestion in military personnel while fatigued on physical and cognitive performance. Methods: Twenty soldiers (20.1 ± 0.9 years) from an elite combat unit were randomly assigned to either a β-alanine (BA) or placebo …

The Influence Of Exercise Environment And Gender On Mood And Exertion, Thomas G. Plante, Marily A. Opezzo, L. Aislinn Diaz, Selena Pistoresi, Michael Santos, Jacqueline E. Fahey, Elizabeth Kay, Briana Britton, Suheel Khan

Psychology

This study examined the influence of exercise environment and gender on post-exercise mood and exertion. College student participants (55 females, 49 males) were instructed to pedal a stationary bike at a moderate pace for 20 minutes. Participants were randomly assigned to one of three laboratory conditions: (1) exercising in front of a mirror and posters showing ideal fit body types (i.e., celebrity male and female personal trainers), (2) exercising in front of a mirror only, or (3) a control condition in which participants exercised without a mirror or posters. The Activation- Deactivation Adjective Check List (AD-ACL), measuring exercise-induced mood states, …

Department Of Education: Fy 2014 Annual Report, Lehigh Valley Health Network

Department of Education

No abstract provided.

Trunk Coordination In Dancers And Non-Dancers, Danielle N. Jarvis, Jo Armour Smith, Kornelia Kulig

Physical Therapy Faculty Articles and Research

Variability, or how a task changes across trials, may reveal differences between athletes of differing skill levels. The purpose of this study was to examine trunk and lower extremity (LE) single joint kinematic variability and inter-segmental coordination variability in dancers and non-dancers during bipedal vertical dance jumps (sautés). Twenty healthy females, ten with no formal dance training and ten professional dancers, performed 20 consecutive sautés. Single joint kinematic variability was assessed using mean standard deviation of angular displacement, and inter-segmental coordination variability was assessed using angular deviation of the coupling angle between segments. Within the context of the standard error …

The Influence Of Hip Strength On Lower-Limb, Pelvis, And Trunk Kinematics And Coordination Patterns During Walking And Hopping In Healthy Women, Jo Armour Smith, John M. Popovich, Kornelia Kulig

Physical Therapy Faculty Articles and Research

Study Design

Cross-sectional laboratory study.

Objectives

To compare peak lower-limb, pelvis, and trunk kinematics and interjoint and intersegmental coordination in women with strong and weak hip muscle performance.

Background

Persons with lower extremity musculoskeletal disorders often demonstrate a combination of weak hip musculature and altered kinematics during weight-bearing dynamic tasks. However, the association between hip strength and kinematics independent of pathology or pain is unclear.

Methods

Peak hip extensor and abductor torques were measured in 150 healthy young women. Of these, 10 fit the criteria for the strong group and 9 for the weak group, representing those with the strongest …

Agreement In Gait Speed From Smartphone And Stopwatch For Five Meter Walk In Laboratory And Clinical Environments, Rahul Soangra, Thurmon E. Lockhart

Physical Therapy Faculty Articles and Research

Gait speed is suggested as an independent predictor of post-operative morbidity and mortality in elderly cardiovascular disease (CVD) patients. Society of thoracic surgeons has recently classified gait speed as the only important indicator of health for CVD patients. It has been seen that patients with slow gait speed above 70 years of age, taking more than 6 seconds to walk 5 meters are particularly at high risk for adverse outcomes. Twelve young participants walked in their self-selected, slow and fast speed with five reflective markers at sternum and heels and toes of both feet in laboratory environment. A smartphone was …

A Comprehensive Review Of Malaria With An Emphasis On Plasmodium Resistance, Lindsay O. Thomas

Honors Theses

Malaria is a disease that is caused by the Plasmodium genus. It is endemic in tropical areas. There are multiple drugs used for prophylaxis and treatment. However, the parasites have developed resistance towards most antimalarial pharmaceuticals. The pharmaceutical industry is generating new antimalarial pharmaceuticals, but the rate of new Plasmodium resistance is much faster.

Social Networks, Drug Use, And Drug Abuse Help-Seeking: A Test Of The Network Episode Model Among African American Women, Erin L. Pullen

Theses and Dissertations--Sociology

Untreated substance use disorders are a major public health concern that has costly consequences at both the societal and individual level. Identifying the characteristics and resources of those who seek help for substance abuse problems in order to inform more effective intervention and treatment techniques is therefore an important research objective. Using the Network Episode Model (NEM) as a theoretical framework, this dissertation examines both substance abuse help-seeking (i.e. inpatient/outpatient treatment and 12-Step meeting attendance) and patterns of drug use over time among low-income African American women, with a special focus on the role of the social network system in …

Inspiring Change: Exercise Self-Efficacy, Dispositional Optimism, And Perceived Stress In College Seniors, Joshua M. Garrin

Walden Dissertations and Doctoral Studies

Prohealth competencies, positive outcome expectancies, and adaptive stress appraisals have profound implications for the real-world transition of college seniors—a population for which engagement in physical activity reflects a preeminent concern. Prior studies on exercise self-efficacy (ESE), dispositional optimism (DO), perceived stress (PS), and physical activity have yielded inconclusive evidence of the emergent psychosocial challenges encountered during the final year of the college experience. Using a triadic framework of self-efficacy, attribution, and cognitive appraisal theories, this crosssectional, quantitative study was conducted using a web survey to examine (a) the impact of physical activity level on ESE, DO, and PS; (b) the …

Consequences For Nursing Graduates Of Failing The National Council Licensure Examination (Nclex), Julius Atemafac

Walden Dissertations and Doctoral Studies

Little information is available regarding the consequences of new nursing graduates who fail the National Council Licensure Examination for Registered Nurses (NCLEX-RN). The purpose of this study was to understand how these graduates could successfully pass this examination in subsequent attempts. Guided by Fisher's personal change model, the key research questions addressed the consequences of failing the NCLEX-RN exam and the actions the new graduate took after failing it. A phenomenological design was employed with a purposive sample of 17 new nursing graduates in the metropolitan area who had failed the NCLEX-RN. An inductive approach using a constant comparison, content …

Regulation Of Glucose Homeostasis By The Phlpp1 Phosphatase, Kara L. Larson

Theses and Dissertations--Molecular and Cellular Biochemistry

Type 2 diabetes mellitus is a metabolic disease that affects one in ten people in the United States. It is caused by a combination of genetics and lifestyle factors. Disease progression begins with insulin resistance in peripheral tissues followed by pancreatic beta-cell failure. The mechanisms behind disease progression are not completely understood. PH domain leucine rich repeat protein phosphatase 1 (PHLPP1) is a known regulator of Akt and other members of the AGC kinase family. Akt has been established to play a role in numerous metabolic signaling pathways, including insulin action. It is hypothesized that as a regulator of Akt, …

A Curricular Reform Viewed Through Bolman And Deal’S Organizational Frames, Lucinda J. Lyon, Nader A. Nadershahi, A. Nattestad, P. Kachalia, Daniel A. Hammer

All Dugoni School of Dentistry Faculty Articles

Professions exist to serve the needs of society, communities and, in the case of the dental profession, patients. Academic dental institutions strive to help meet these needs by educating and developing future practitioners, educators, researchers, and citizen leaders who serve the community and shape the changing environment in which they practice and provide care. The American Dental Association Commission on Change and Innovation affirms, “If dental educators are to meet these purposes, change and innovation in dental education must be responsive to evolving societal needs, practice patterns, scientific developments, and economic conditions”(Haden, et al., 2006). Guiding any institution through such …

Within-Day Test-Retest Reliability Of Transcranial Magnetic Stimulation Measurements Of Corticomotor Excitability For Gastrocnemius And Tibialis Anterior Muscles, Beth E. Fisher, Ya-Yun Lee, Todd E. Davenport, Stephen F. Reischl, Elizabeth Ruckert, Kornelia Kulig

School of Pharmacy Faculty Articles

Background: Manual therapy interventions targeting the talocrural joint can improve gait and balance functions in individuals following ankle sprains. Less is known about the underlying mechanisms of functional improvements after manual therapy. One hypothesis involves change in corticomotor excitability (CE) following manual therapy procedures. Transcranial magnetic stimulation (TMS) is a brain imaging method that could provide important information regarding potential changes in CE associated with manual therapy techniques applied to the talocrural joint. However, within-day reliability of TMS to measure CE must first be established in order to measure CE changes associated with manual therapy procedures.

Objective: To determine the …

Efficient B Cell Responses To Borrelia Hermsii Infection Depend On Baff And Baffr But Not Taci., Gregory S. Dickinson, Phd, Guizhi Sun, Richard J Bram, Kishore Alugupalli

Department of Microbiology and Immunology Faculty Papers

T cell-independent antibody responses develop rapidly, within 3 to 4 days, and are critical for preventing blood-borne pathogens from evolving into life-threatening infections. The interaction of BAFF, also known as BLyS, with its receptors BAFFR and TACI on B cells is critical for B cell homeostasis and function. Using a synthetic polysaccharide antigen, it has previously been shown that TACI is critical for T cell-independent antibody responses. To examine the role of BAFFR and TACI in T cell-independent antibody responses to an active infection, we utilized the Borrelia hermsii infection system. In this infection system, T cell-independent responses mediated by …

Modified Seed Growth Of Iron Oxide Nanoparticles In Benzyl Alcohol: Magnetic Nanoparticles For Radio Frequency Hyperthermia Treatment Of Cancer, Stanley E. Gilliland Iii

Theses and Dissertations

Iron oxide nanoparticles have received sustained interest for biomedical applications as synthetic approaches are continually developed for precise control of nanoparticle properties. This thesis presents an investigation of parameters in the benzyl alcohol synthesis of iron oxide nanoparticles. A modified seed growth method was designed for obtaining optimal nanoparticle properties for magnetic fluid hyperthermia. With a one or two addition process, iron oxide nanoparticles were produced with crystallite sizes ranging from 5-20 nm using only benzyl alcohol and iron precursor. The effects of reaction environment, temperature, concentration, and modified seed growth parameters were investigated to obtain precise control over properties …

Follow-Up Evaluation Of Treatment For Anxiety And Depression Provided In A University-Based Primary Care Clinic, Renée M. Grinnell

Theses and Dissertations

Although integrated primary care psychology services are becoming increasingly common, the literature lacks adequate research support for the longitudinal durability of treatment effects following the conclusion of brief primary care interventions. This study served as a follow-up program evaluation of psychological services for depression and anxiety provided at the Medical College of Virginia’s Ambulatory Care Center in Richmond, Virginia. Data were collected on 47 adult primary care patients who received treatment for depression and/or anxiety between six and 18 months prior to the follow-up telephone call. Data were collected on the trajectory of depression scores throughout and following treatment, treatment …

Using Structural Analysis To Investigate The Function Of Suppressor Of Ikk-Epsilon (Sike), Sean W. Mckinley

Theses and Dissertations

The innate immune system provides the body’s first line of defense against pathogenic challenge through pathogen recognition and initiation of the immune response. Among the various cellular mechanisms of pathogen recognition in mammals, Toll-like receptor 3 (TLR3) recognizes viral dsRNA. Stimulation of TLR3 signaling pathway leads to transcription of pro-inflammatory cytokines and type-1 Interferons. Suppressor of IKKε (SIKE) interacts with two kinases in the signaling pathway, IKKε and TANK binding kinase 1 (TBK1), inhibiting the transcription of type I interferons. Recently, the Bell Laboratory discovered that SIKE blocks TBK1-mediated activation of type I interferons by acting as a high affinity, …

A Collaborative Approach To Combining Service, Teaching, And Research, Suzanne M. Galal, Sian M. Carr-Lopez, Seth Gomez, Van Duong, Caitlin Mizoshiri, Lauren Ujihara, Tina H. Tran, Rajul A. Patel, Joseph A. Woelfel

School of Pharmacy Faculty Articles

Objective. To describe a faculty-student collaborative model and its outcomes on teaching, service, and scholarship.

Design. A Medicare Part D elective course was offered that consisted of classroom and experiential learning where pharmacy students participated in community outreach events to assist Medicare beneficiaries with Part D plan selection. The course training was expanded to include medication therapy management (MTM) and the administration of immunizations. At the completion of the course, students collaborated with faculty members on research endeavors.

Evaluation. During the first 6 years of this course, the class size more than doubled from 20 to 42 students, and all …

Cost Variability Of Suggested Generic Treatment Alternatives Under The Medicare Part D Benefit, Rajul A. Patel, Mark P. Walberg, Emily Tong, Florence Tan, Ashley E. Rummel, Joseph A. Woelfel, Sian M. Carr-Lopez, Suzanne M. Galal

School of Pharmacy Faculty Articles

BACKGROUND: The substitution of generic treatment alternatives for brand-name drugs is a strategy that can help lower Medicare beneficiary out-of-pocket costs. Beginning in 2011, Medicare beneficiaries reaching the coverage gap received a 50% discount on the full drug cost of brand-name medications and a 7% discount on generic medications filled during the gap. This discount will increase until 2020, when beneficiaries will be responsible for 25% of total drug costs during the coverage gap.

OBJECTIVE: To examine the cost variability of brand and generic drugs within 4 therapeutic classes before and during the coverage gap for each 2011 California stand-alone …

Structural And Functional Support In The Prediction Of Smoking Cessation In Caregivers Of Children With Asthma, Erin M. Tooley, Andrew Busch

Arts & Sciences Faculty Publications

Caregivers of children with asthma smoke at a rate similar to the general population. Research on the relative importance of structural or functional social support in smoking cessation has been mixed. Participants were smokers (N=154) who were caregivers of children with asthma. Both functional (perception of social support measured by the Interpersonal Support Evaluation List) and structural social support (living with another smoker, partner status, and the proportion of smoking friends) were measured at baseline. Participants received an asthma-education and smoking cessation intervention based on Motivational Interviewing. Biochemically-verified abstinence was assessed at 6-months post treatment. Hierarchical logistic regression analyses indicated …

Effects Of Delayed Pharmacological Treatment And Limb Rehabilitation On Infarct Size And Functional Recovery After Stroke, Maria Helen Harley Balch

Browse all Theses and Dissertations

Previous studies show a fluoxetine/simvastatin drug combination successfully reduced infarct size and increased functional recovery when administered 20-26 hours post stroke. This project tested the hypothesis that earlier drug delivery at 6-12 hours post stroke will improve functional recovery and decrease infarct size, and that limb rehabilitation will improve functional recovery.

Pre-stroke function was determined in rats, a stroke was induced, and daily treatment began 6-12 hours post stroke. Baseline functional deficit was established, and additional testing over 90 days monitored functional recovery. Limb rehabilitation was provided for designated animals, and brain analysis measured infarct size.

In animals with no …

Asymmetrical Interference Effects Between Two-Dimensional Geometric Shapes And Their Corresponding Shape Words, Bradley R. Sturz, Joshua E. Edwards, Ty W. Boyer

Psychology: Faculty Publications

Nativists have postulated fundamental geometric knowledge that predates linguistic and symbolic thought. Central to these claims is the proposal for an isolated cognitive system dedicated to processing geometric information. Testing such hypotheses presents challenges due to difficulties in eliminating the combination of geometric and non-geometric information through language. We present evidence using a modified matching interference paradigm that an incongruent shape word interferes with identifying a two-dimensional geometric shape, but an incongruent two-dimensional geometric shape does not interfere with identifying a shape word. This asymmetry in interference effects between two-dimensional geometric shapes and their corresponding shape words suggests that shape …

Restructuring The Michigan Child Care Fund: Reducing Costs And Improving Outcomes, David Wingard, Kieran J. Fogarty, Mary Lagerwey, Joshua Scott

Michigan Journal of Public Health

Michigan’s policy to distribute the Child Care Fund (CCF) to counties at a flat rate of 50% as stated in the Michigan Comprehensive Laws 400.117a provides no structured incentive to the counties to use evidence based practices that are cost-effective for locally based delinquent youth intervention programs. This policy analysis answers the following questions: (1) would retaining delinquent youth in the community produce a cost benefit and/or better outcomes than confinement and (2) is public safety at risk if delinquent youth are retained in the community? Utilizing a policy analysis framework our evidence found that community based services provide better …

Critically Appraised Paper For "Does Cognitive Treatment For Illness Perceptions Increase Patient-Specific Physical Activity Levels Of Patients With Chronic Low Back Pain When Compared To No Intervention?", Jaclyn Fok, Shannon Landau, Liberty Bellah, Kitsum Li

Occupational Therapy | Critically Appraised Papers Series

1. To test the hypothesis that patient-relevant activity limitations can be reduced in patients with CLBP after receiving CTIP.
2. To determine which maladaptive illness perceptions are detected and impacted by the CTIP.

Driving Errors In Parkinson’S Disease: Moving Closer To Predicting On-Road Outcomes, Sherrilene Classen, Babetter Brumback, Miriam Monahan, Irene I. Malaty, Ramon L. Rodriguez, Michael S. Okun, Nikolaus R. Mcfarland

Collected Faculty Scholarship

Age-related medical conditions such as Parkinson’s disease (PD) compromise driver fitness. Results from studies are unclear on the specific driving errors that underlie passing or failing an on-road assessment. In this study, we determined the between-group differences and quantified the on-road driving errors that predicted pass or fail on-road outcomes in 101 drivers with PD (mean age 5 69.38 ± 7.43) and 138 healthy control (HC) drivers (mean age 5 71.76 ± 5.08). Participants with PD had minor differences in demographics and driving habits and history but made more and different driving errors than HC participants. Drivers with PD failed …

For Younger Patients With Stroke, Does Rehabilitation In The Home, Compared To Rehabilitation In The Day Clinic, Improve Early Level Of Activity Participation?, Elizabeth Ashley Brown, Alex Robert Shragg, Jovita Vasquez, Kitsum Li

Occupational Therapy | Critically Appraised Papers Series

The main purpose of this study was to determine if 3 weeks of rehabilitation in the home setting improves activity to a larger extent and facilitates rehabilitation in younger patients following a stroke compared to patients receiving intervention in an outpatient rehabilitation clinic. Cost effectiveness among these interventions was also described.